IL33393A - History of Coinazoline - Google Patents
History of CoinazolineInfo
- Publication number
- IL33393A IL33393A IL33393A IL3339369A IL33393A IL 33393 A IL33393 A IL 33393A IL 33393 A IL33393 A IL 33393A IL 3339369 A IL3339369 A IL 3339369A IL 33393 A IL33393 A IL 33393A
- Authority
- IL
- Israel
- Prior art keywords
- quinazoline
- dimethyl
- tetrahydr0
- tetrahydro
- difference
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000013078 crystal Substances 0.000 description 6
- 239000007858 starting material Substances 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 230000003001 depressive effect Effects 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 238000002425 crystallisation Methods 0.000 description 2
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 2
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- CWRVKFFCRWGWCS-UHFFFAOYSA-N Pentrazole Chemical compound C1CCCCC2=NN=NN21 CWRVKFFCRWGWCS-UHFFFAOYSA-N 0.000 description 1
- 241001279009 Strychnos toxifera Species 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 description 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229960004815 meprobamate Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2416068 | 1968-11-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL33393A0 IL33393A0 (en) | 1970-01-29 |
| IL33393A true IL33393A (en) | 1973-04-30 |
Family
ID=11212294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL33393A IL33393A (en) | 1968-11-26 | 1969-11-21 | History of Coinazoline |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3660322A (is") |
| AT (1) | AT290542B (is") |
| BE (1) | BE742205A (is") |
| BR (1) | BR6914433D0 (is") |
| CH (1) | CH523892A (is") |
| DE (1) | DE1958515B2 (is") |
| DK (1) | DK123239B (is") |
| ES (1) | ES373909A1 (is") |
| FR (1) | FR2024241B1 (is") |
| GB (1) | GB1231959A (is") |
| IE (1) | IE33406B1 (is") |
| IL (1) | IL33393A (is") |
| NL (1) | NL147140B (is") |
| NO (1) | NO123430B (is") |
| SE (1) | SE360659B (is") |
| YU (1) | YU33286B (is") |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE31617E (en) * | 1972-02-04 | 1984-06-26 | Bristol-Myers Company | Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones |
| DE3815767A1 (de) * | 1988-05-09 | 1989-11-23 | Karl Niggemeier | Abhefter fuer einzelblaetter |
| KR950701322A (ko) * | 1992-05-07 | 1995-03-23 | 조셉 에프. 디프리마 | 사람면역결핍바이러스 역전사효소의 억제제로서의 신규한 퀴나졸린(New quinazolines as inhibitors of HIV reversetranscriptase) |
| US6124302A (en) * | 1997-04-09 | 2000-09-26 | Dupont Pharmaceuticals | 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones useful as HIV reverse transcriptase inhibitors |
| EP1068189A1 (en) * | 1998-03-27 | 2001-01-17 | Bristol-Myers Squibb Pharma Company | 4,4-disubstituted-3,4-dihydro-2(1h)-quinazolinthione derivatives, their preparation and their use as hiv reverse transcriptase inhibitors |
-
1969
- 1969-11-13 NL NL696917085A patent/NL147140B/xx unknown
- 1969-11-21 IL IL33393A patent/IL33393A/en unknown
- 1969-11-21 YU YU2922/69A patent/YU33286B/xx unknown
- 1969-11-21 IE IE1581/69A patent/IE33406B1/xx unknown
- 1969-11-21 FR FR696940093A patent/FR2024241B1/fr not_active Expired
- 1969-11-21 US US878880A patent/US3660322A/en not_active Expired - Lifetime
- 1969-11-21 AT AT1088169A patent/AT290542B/de not_active IP Right Cessation
- 1969-11-21 DE DE19691958515 patent/DE1958515B2/de active Granted
- 1969-11-24 SE SE16089/69A patent/SE360659B/xx unknown
- 1969-11-24 NO NO4649/69A patent/NO123430B/no unknown
- 1969-11-24 DK DK621469AA patent/DK123239B/da unknown
- 1969-11-24 BR BR214433/69A patent/BR6914433D0/pt unknown
- 1969-11-24 GB GB1231959D patent/GB1231959A/en not_active Expired
- 1969-11-25 BE BE742205D patent/BE742205A/xx unknown
- 1969-11-25 ES ES373909A patent/ES373909A1/es not_active Expired
- 1969-11-25 CH CH1754469A patent/CH523892A/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NL6917085A (is") | 1970-05-28 |
| IE33406L (en) | 1970-05-26 |
| DE1958515A1 (de) | 1970-07-09 |
| AT290542B (de) | 1971-06-11 |
| DE1958515B2 (de) | 1976-06-24 |
| SE360659B (is") | 1973-10-01 |
| ES373909A1 (es) | 1972-08-16 |
| CH523892A (de) | 1972-06-15 |
| BR6914433D0 (pt) | 1973-02-22 |
| BE742205A (is") | 1970-05-25 |
| YU33286B (en) | 1976-08-31 |
| FR2024241B1 (is") | 1973-07-13 |
| DK123239B (da) | 1972-05-29 |
| IL33393A0 (en) | 1970-01-29 |
| NL147140B (nl) | 1975-09-15 |
| YU292269A (en) | 1976-03-31 |
| IE33406B1 (en) | 1974-06-12 |
| NO123430B (is") | 1971-11-15 |
| US3660322A (en) | 1972-05-02 |
| FR2024241A1 (is") | 1970-08-28 |
| GB1231959A (is") | 1971-05-12 |
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