IL302660B2 - Chimeric antigen receptors and methods of using them - Google Patents

Chimeric antigen receptors and methods of using them

Info

Publication number
IL302660B2
IL302660B2 IL302660A IL30266023A IL302660B2 IL 302660 B2 IL302660 B2 IL 302660B2 IL 302660 A IL302660 A IL 302660A IL 30266023 A IL30266023 A IL 30266023A IL 302660 B2 IL302660 B2 IL 302660B2
Authority
IL
Israel
Prior art keywords
amino acid
cells
seq
cell
cdrs
Prior art date
Application number
IL302660A
Other languages
English (en)
Hebrew (he)
Other versions
IL302660A (en
IL302660B1 (en
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of IL302660A publication Critical patent/IL302660A/en
Publication of IL302660B1 publication Critical patent/IL302660B1/en
Publication of IL302660B2 publication Critical patent/IL302660B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
IL302660A 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of using them IL302660B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US201562252083P 2015-11-06 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

Publications (3)

Publication Number Publication Date
IL302660A IL302660A (en) 2023-07-01
IL302660B1 IL302660B1 (en) 2025-06-01
IL302660B2 true IL302660B2 (en) 2025-10-01

Family

ID=55229842

Family Applications (3)

Application Number Title Priority Date Filing Date
IL302660A IL302660B2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of using them
IL252295A IL252295B2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of using them
IL320860A IL320860A (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of using them

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL252295A IL252295B2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of using them
IL320860A IL320860A (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of using them

Country Status (11)

Country Link
US (3) US20170362297A1 (enExample)
EP (1) EP3233900A2 (enExample)
JP (4) JP2018504894A (enExample)
KR (2) KR102923234B1 (enExample)
CN (1) CN108064252A (enExample)
AU (5) AU2015364245B2 (enExample)
BR (1) BR112017013176A2 (enExample)
CA (1) CA2968412A1 (enExample)
IL (3) IL302660B2 (enExample)
RU (1) RU2017125531A (enExample)
WO (1) WO2016100985A2 (enExample)

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Also Published As

Publication number Publication date
KR20260038272A (ko) 2026-03-18
IL320860A (en) 2025-07-01
AU2022200257B2 (en) 2023-11-16
US20170362297A1 (en) 2017-12-21
IL302660A (en) 2023-07-01
WO2016100985A2 (en) 2016-06-23
WO2016100985A3 (en) 2016-08-18
RU2017125531A (ru) 2019-01-21
IL302660B1 (en) 2025-06-01
JP2022064952A (ja) 2022-04-26
IL252295B1 (en) 2023-06-01
IL252295B2 (en) 2023-10-01
AU2024200592B2 (en) 2026-03-12
US20250243259A1 (en) 2025-07-31
BR112017013176A2 (en) 2018-05-15
US20210061877A1 (en) 2021-03-04
JP2026088143A (ja) 2026-05-28
AU2020204373A1 (en) 2020-07-23
AU2015364245A1 (en) 2017-06-08
JP2018504894A (ja) 2018-02-22
JP7548950B2 (ja) 2024-09-10
EP3233900A2 (en) 2017-10-25
IL252295A0 (en) 2017-07-31
KR20170090506A (ko) 2017-08-07
AU2024200592A1 (en) 2024-02-22
AU2026204528A1 (en) 2026-07-02
JP7833003B2 (ja) 2026-03-18
AU2020204373B2 (en) 2021-10-21
CN108064252A (zh) 2018-05-22
AU2015364245B2 (en) 2020-04-02
KR102923234B1 (ko) 2026-02-04
JP2024163140A (ja) 2024-11-21
CA2968412A1 (en) 2016-06-23
AU2022200257A1 (en) 2022-02-10
US12195514B2 (en) 2025-01-14

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