JP2018504894A - キメラ抗原受容体およびその使用方法 - Google Patents

キメラ抗原受容体およびその使用方法 Download PDF

Info

Publication number
JP2018504894A
JP2018504894A JP2017532639A JP2017532639A JP2018504894A JP 2018504894 A JP2018504894 A JP 2018504894A JP 2017532639 A JP2017532639 A JP 2017532639A JP 2017532639 A JP2017532639 A JP 2017532639A JP 2018504894 A JP2018504894 A JP 2018504894A
Authority
JP
Japan
Prior art keywords
amino acid
seq
cells
cell
caix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017532639A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504894A5 (enExample
Inventor
ウェイン エー． マラスコ
ウェイン エー． マラスコ
Original Assignee
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド, デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド filed Critical デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
Publication of JP2018504894A publication Critical patent/JP2018504894A/ja
Publication of JP2018504894A5 publication Critical patent/JP2018504894A5/ja
Priority to JP2022011441A priority Critical patent/JP7548950B2/ja
Priority to JP2024147204A priority patent/JP2024163140A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017532639A 2014-12-19 2015-12-21 キメラ抗原受容体およびその使用方法 Pending JP2018504894A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022011441A JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法
JP2024147204A JP2024163140A (ja) 2014-12-19 2024-08-29 キメラ抗原受容体およびその使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US62/094,625 2014-12-19
US201562252083P 2015-11-06 2015-11-06
US62/252,083 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022011441A Division JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法

Publications (2)

Publication Number Publication Date
JP2018504894A true JP2018504894A (ja) 2018-02-22
JP2018504894A5 JP2018504894A5 (enExample) 2019-02-07

Family

ID=55229842

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017532639A Pending JP2018504894A (ja) 2014-12-19 2015-12-21 キメラ抗原受容体およびその使用方法
JP2022011441A Active JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法
JP2024147204A Pending JP2024163140A (ja) 2014-12-19 2024-08-29 キメラ抗原受容体およびその使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022011441A Active JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法
JP2024147204A Pending JP2024163140A (ja) 2014-12-19 2024-08-29 キメラ抗原受容体およびその使用方法

Country Status (11)

Country Link
US (3) US20170362297A1 (enExample)
EP (1) EP3233900A2 (enExample)
JP (3) JP2018504894A (enExample)
KR (1) KR20170090506A (enExample)
CN (1) CN108064252A (enExample)
AU (4) AU2015364245B2 (enExample)
BR (1) BR112017013176A2 (enExample)
CA (1) CA2968412A1 (enExample)
IL (3) IL320860A (enExample)
RU (1) RU2017125531A (enExample)
WO (1) WO2016100985A2 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021521778A (ja) * 2018-04-16 2021-08-30 メモリアル スローン ケタリング キャンサー センター Ｔ細胞枯渇、およびそれに関連する方法および組成物
JP2021524264A (ja) * 2018-07-13 2021-09-13 ナンジン レジェンド バイオテック カンパニー，リミテッドＮａｎｊｉｎｇ Ｌｅｇｅｎｄ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 感染性疾患の治療のための共受容体システム
JP2022502036A (ja) * 2018-09-27 2022-01-11 オートラス リミテッド キメラ抗原受容体
JP2022513131A (ja) * 2018-11-26 2022-02-07 ンカルタ・インコーポレイテッド 複数の免疫細胞タイプの同時増殖のための方法、関連する組成物および癌免疫療法におけるそれらの使用
JP2022541016A (ja) * 2019-07-17 2022-09-21 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞によって合成され、分泌される機能的バインダー
JP2023519647A (ja) * 2020-01-19 2023-05-12 キネオ メディカル テクノロジー カンパニー リミテッド 免疫細胞の機能を向上させる強化受容体

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6461800B2 (ja) * 2012-10-04 2019-01-30 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド ヒトモノクローナル抗ｐｄ−ｌ１抗体および使用方法
SG11201505858VA (en) 2013-01-28 2015-09-29 St Jude Childrens Res Hospital A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
KR20160145813A (ko) * 2014-04-25 2016-12-20 다나-파버 캔서 인스티튜트 인크. 중동 호흡기 증후군 코로나바이러스 중화 항체 및 이의 사용 방법
EP3143134B1 (en) 2014-05-15 2020-10-28 National University of Singapore Modified natural killer cells and uses thereof
SMT202100116T1 (it) 2014-05-28 2021-05-07 Agenus Inc Anticorpi anti-gitr e metodi di utilizzo degli stessi
EP3383430A4 (en) 2015-12-02 2019-12-18 Agenus Inc. ANTIBODIES AND METHOD FOR USE THEREOF
KR20180111870A (ko) 2016-02-25 2018-10-11 셀 메디카 스위처란트 아게 Pd-l1에 대한 결합 성분
EP3432924A1 (en) * 2016-03-23 2019-01-30 Novartis AG Cell secreted minibodies and uses thereof
IL321335A (en) 2016-06-29 2025-08-01 Checkpoint Therapeutics Inc PD-L1-specific antibodies and methods of using them
SG11201900138TA (en) 2016-07-07 2019-02-27 Iovance Biotherapeutics Inc Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof
US11077178B2 (en) 2016-09-21 2021-08-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptor (CAR) that targets chemokine receptor CCR4 and its use
JP6887492B6 (ja) * 2016-10-04 2021-07-14 プレシジョン バイオサイエンシズ，インク． 遺伝子改変細胞で使用するための共刺激ドメイン
MA46770A (fr) 2016-11-09 2019-09-18 Agenus Inc Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation
WO2018089829A1 (en) 2016-11-10 2018-05-17 Fortis Therapeutics, Inc. Cd46-specific effector cells and uses thereof
CN108148862B (zh) * 2016-12-05 2019-03-08 上海优卡迪生物医药科技有限公司 一种封闭pdl1的用于抑制免疫逃脱的car-t转基因载体及其构建方法和应用
SG11201908492PA (en) 2017-03-27 2019-10-30 Nat Univ Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
EP3601537A4 (en) 2017-03-27 2021-01-13 National University of Singapore STIMULATING CELL LINES FOR EX VIVO EXPANSION AND ACTIVATION OF NATURAL KILLER CELLS
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
MY201573A (en) 2017-05-12 2024-03-02 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
CN107337736B (zh) * 2017-06-06 2019-07-26 上海优卡迪生物医药科技有限公司 Octs-car双靶向嵌合抗原受体、编码基因、重组表达载体及其构建和应用
CN111801348A (zh) 2018-02-09 2020-10-20 新加坡国立大学 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途
WO2019178356A1 (en) * 2018-03-14 2019-09-19 Dana-Farber Cancer Institute, Inc. Engineered cells, t cell immune modulating antibodies and methods for using the same
KR20200138741A (ko) 2018-04-02 2020-12-10 내셔널 유니버시티 오브 싱가포르 면역 세포에서 발현되는 막-결합 항-사이토카인 비-신호전달 결합제를 이용한 인간 사이토카인의 중화
JP7542441B2 (ja) 2018-05-11 2024-08-30 クリスパー セラピューティクス アクチェンゲゼルシャフト 癌を治療するための方法及び組成物
CN112930199B (zh) * 2018-07-24 2024-08-13 恺兴生命科技(上海)有限公司 免疫效应细胞治疗肿瘤的方法
JP7560882B2 (ja) 2018-08-29 2024-10-03 ナショナル ユニヴァーシティー オブ シンガポール 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. ANTI-CD19 CHEMERIC ANTIGEN RECEPTORS AND THEIR USE IN IMMUNOTHERAPY
US11104732B2 (en) * 2019-04-24 2021-08-31 Innovative Cellular Therapeutics Holdings, Ltd. Reducing immune inhibition induced by SIGLEC-15
JP2022529380A (ja) * 2019-04-26 2022-06-21 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル キメラ抗原受容体構築物およびｃａｒ－ｔ細胞におけるそれらの使用
US20220249558A1 (en) 2019-04-30 2022-08-11 Crispr Therapeutics Ag Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
SG11202111130SA (en) 2019-04-30 2021-11-29 Senti Biosciences Inc Chimeric receptors and methods of use thereof
EP3983447A4 (en) 2019-06-14 2023-06-28 Dana-Farber Cancer Institute, Inc. Antibodies against muc1 and methods of use thereof
JP2022541320A (ja) * 2019-07-24 2022-09-22 エウレカ セラピューティクス インコーポレイテッド キメラ抗原受容体ｔ細胞及びその使用
JP2023504271A (ja) * 2019-12-02 2023-02-02 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｐｄ－ｌ１に対する抗体およびその使用方法
EP4148065A4 (en) * 2020-05-08 2024-05-29 SMT Bio Co., Ltd. Chimeric antigen receptor for treatment of cancer
KR20230066149A (ko) 2020-08-07 2023-05-12 포티스 테라퓨틱스, 인크. Cd46을 표적화하는 면역접합체 및 이의 사용 방법
WO2022173950A1 (en) * 2021-02-11 2022-08-18 The Trustees Of The University Of Pennsylvania Ccr4-targeting chimeric antigen receptor cell therapy
KR20220136876A (ko) 2021-04-01 2022-10-11 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
EP4164687A4 (en) * 2021-04-12 2024-08-14 Academia Sinica IMPROVED CORONAVIRUS VACCINE
KR20220144000A (ko) 2021-04-16 2022-10-26 주식회사 이뮤노로지컬디자이닝랩 Programmed death-ligand 1(PD-L1)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도
US20240262917A1 (en) 2021-05-06 2024-08-08 Dana-Farber Cancer Institute, Inc. Antibodies against alk and methods of use thereof
KR20230089462A (ko) 2021-12-13 2023-06-20 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
KR20230089464A (ko) 2021-12-13 2023-06-20 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
CA3245511A1 (en) * 2022-03-08 2025-06-13 Vaxcell Bio Co Ltd PD-L1 SPECIFIC CHIMERIC ANTIGENIC RECEPTOR AND IMMUNE CELL CONTAINING IT
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013123061A1 (en) * 2012-02-13 2013-08-22 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2014055897A2 (en) * 2012-10-04 2014-04-10 Dana-Farber Cancer Institute, Inc. Human monoclonal anti-pd-l1 antibodies and methods of use
WO2014134165A1 (en) * 2013-02-26 2014-09-04 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US20050113564A1 (en) * 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
US7750123B2 (en) 2003-11-25 2010-07-06 Dana Farber Cancer Institute, Inc. Antibodies against SARS-CoV and methods of use thereof
EP1871807B1 (en) 2005-02-18 2012-11-28 Dana-Farber Cancer Institute, Inc. Antibodies against cxcr4 and methods of use thereof
EP1979379B1 (en) 2005-12-02 2013-09-18 Dana-Farber Cancer Institute Carbonic anhydrase ix (g250) antibodies and methods of use thereof
RU2010127156A (ru) 2007-12-06 2012-01-20 Дана-Фарбер Кэнсер Инститьют, Инк. (Us) Антитела против вируса гриппа и их применение
WO2009086514A1 (en) 2007-12-28 2009-07-09 Dana-Farber Cancer Institute, Inc. Humanized monoclonal antibodies and methods of use
AU2011261396B2 (en) 2010-06-02 2015-11-05 Dana-Farber Cancer Institute, Inc. Humanized monoclonal antibodies and methods of use
AU2012207356A1 (en) 2011-01-18 2013-08-01 The Trustees Of The University Of Pennsylvania Compositions and methods for treating cancer
WO2013154760A1 (en) * 2012-04-11 2013-10-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting b-cell maturation antigen
HK1207655A1 (en) 2012-05-04 2016-02-05 Dana-Farber Cancer Institute, Inc. Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use
CN104583230A (zh) * 2012-07-13 2015-04-29 宾夕法尼亚大学董事会 通过共同引入双特异性抗体增强car t细胞的活性
EP4292657A3 (en) 2013-03-15 2024-03-20 Dana Farber Cancer Institute, Inc. Flavivirus neutralizing antibodies and methods of use thereof
WO2015143194A2 (en) 2014-03-19 2015-09-24 Dana-Farber Cancer Institute, Inc. Immunogenetic restriction on elicitation of antibodies
KR20160145813A (ko) 2014-04-25 2016-12-20 다나-파버 캔서 인스티튜트 인크. 중동 호흡기 증후군 코로나바이러스 중화 항체 및 이의 사용 방법
JP2017531427A (ja) 2014-10-03 2017-10-26 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド グルココルチコイド誘導腫瘍壊死因子受容体（ｇｉｔｒ）抗体およびその使用法
EP3699196A1 (en) 2014-10-06 2020-08-26 Dana Farber Cancer Institute, Inc. Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof
BR112017013177A2 (pt) * 2014-12-19 2018-05-15 Dana Farber Cancer Inst Inc receptores de antígeno quiméricos de anidrase carbônica ix e métodos de uso dos mesmos
CA3002674A1 (en) * 2015-10-30 2017-05-04 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013123061A1 (en) * 2012-02-13 2013-08-22 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
WO2014055897A2 (en) * 2012-10-04 2014-04-10 Dana-Farber Cancer Institute, Inc. Human monoclonal anti-pd-l1 antibodies and methods of use
WO2014134165A1 (en) * 2013-02-26 2014-09-04 Memorial Sloan-Kettering Cancer Center Compositions and methods for immunotherapy

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
EUR. UROL., vol. 58, JPN6019051697, 2010, pages 75 - 83, ISSN: 0004602439 *
HEMATOL. ONCOL. STEM CELL THER., vol. Vol.7, Issue 1, JPN6019051700, March 2014 (2014-03-01), pages 1 - 17, ISSN: 0004602441 *
J. CANCER, vol. 5, no. 3, JPN7019004232, January 2014 (2014-01-01), pages 166 - 172, ISSN: 0004602440 *
MOL. THER. ONCOLYTICS, vol. Vol.1, 14003, JPN6019051696, 10 December 2014 (2014-12-10), ISSN: 0004602438 *
PLOS ONE, vol. Vol.7, Issue 9, JPN7020004253, 2012, pages 44455, ISSN: 0004602442 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021521778A (ja) * 2018-04-16 2021-08-30 メモリアル スローン ケタリング キャンサー センター Ｔ細胞枯渇、およびそれに関連する方法および組成物
JP7447388B2 (ja) 2018-07-13 2024-03-12 ナンジン レジェンド バイオテック カンパニー，リミテッド 感染性疾患の治療のための共受容体システム
JP2021524264A (ja) * 2018-07-13 2021-09-13 ナンジン レジェンド バイオテック カンパニー，リミテッドＮａｎｊｉｎｇ Ｌｅｇｅｎｄ Ｂｉｏｔｅｃｈ Ｃｏ．，Ｌｔｄ． 感染性疾患の治療のための共受容体システム
JP2022502036A (ja) * 2018-09-27 2022-01-11 オートラス リミテッド キメラ抗原受容体
JP7594067B2 (ja) 2018-09-27 2024-12-03 オートラス リミテッド キメラ抗原受容体
JP7458382B2 (ja) 2018-09-27 2024-03-29 オートラス リミテッド キメラ抗原受容体
JP2023169370A (ja) * 2018-09-27 2023-11-29 オートラス リミテッド キメラ抗原受容体
JP2022513131A (ja) * 2018-11-26 2022-02-07 ンカルタ・インコーポレイテッド 複数の免疫細胞タイプの同時増殖のための方法、関連する組成物および癌免疫療法におけるそれらの使用
JP7584414B2 (ja) 2018-11-26 2024-11-15 ンカルタ・インコーポレイテッド 複数の免疫細胞タイプの同時増殖のための方法、関連する組成物および癌免疫療法におけるそれらの使用
JP2022541016A (ja) * 2019-07-17 2022-09-21 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞によって合成され、分泌される機能的バインダー
JP7702143B2 (ja) 2019-07-17 2025-07-03 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞によって合成され、分泌される機能的バインダー
JP2023519647A (ja) * 2020-01-19 2023-05-12 キネオ メディカル テクノロジー カンパニー リミテッド 免疫細胞の機能を向上させる強化受容体
JP7727326B2 (ja) 2020-01-19 2025-08-21 キネオ メディカル テクノロジー カンパニー リミテッド 免疫細胞の機能を向上させる強化受容体
JP7727326B6 (ja) 2020-01-19 2025-09-08 北京▲峠▼替医療技術有限公司 免疫細胞の機能を向上させる強化受容体

Also Published As

Publication number Publication date
US20250243259A1 (en) 2025-07-31
KR20170090506A (ko) 2017-08-07
EP3233900A2 (en) 2017-10-25
AU2015364245B2 (en) 2020-04-02
JP2024163140A (ja) 2024-11-21
IL302660B1 (en) 2025-06-01
IL302660A (en) 2023-07-01
AU2024200592A1 (en) 2024-02-22
CN108064252A (zh) 2018-05-22
AU2020204373A1 (en) 2020-07-23
IL252295B1 (en) 2023-06-01
IL252295A0 (en) 2017-07-31
CA2968412A1 (en) 2016-06-23
US12195514B2 (en) 2025-01-14
JP2022064952A (ja) 2022-04-26
US20170362297A1 (en) 2017-12-21
WO2016100985A2 (en) 2016-06-23
JP7548950B2 (ja) 2024-09-10
IL302660B2 (en) 2025-10-01
AU2022200257A1 (en) 2022-02-10
IL320860A (en) 2025-07-01
IL252295B2 (en) 2023-10-01
WO2016100985A3 (en) 2016-08-18
AU2022200257B2 (en) 2023-11-16
AU2015364245A1 (en) 2017-06-08
BR112017013176A2 (en) 2018-05-15
RU2017125531A (ru) 2019-01-21
US20210061877A1 (en) 2021-03-04
AU2020204373B2 (en) 2021-10-21

Similar Documents

Publication Publication Date Title
JP7548950B2 (ja) キメラ抗原受容体およびその使用方法
US11845794B2 (en) CS1-specific chimeric antigen receptor engineered immune effector cells
US12024567B2 (en) Method of treating a tumor expressing carbonic anhydrase IX (G250) by administering a G250-specific chimeric antigen receptor
EP3286225B1 (en) Cd5 chimeric antigen receptor for adoptive t cell therapy
JP2024054286A (ja) 操作された細胞、ｔ細胞免疫調節抗体、およびそれらの使用方法
CN119278049A (zh) 遗传工程化b细胞及其使用方法
HK40026612A (en) Novel platforms for co-stimulation, novel car designs and other enhancements for adoptive cellular therapy
HK1218925B (en) Cs1-specific chimeric antigen receptor engineered immune effector cells

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20170616

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181220

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181220

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200108

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200406

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200707

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210106

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210401

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20210520

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20210929