JP2018504894A5 - - Google Patents
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- JP2018504894A5 JP2018504894A5 JP2017532639A JP2017532639A JP2018504894A5 JP 2018504894 A5 JP2018504894 A5 JP 2018504894A5 JP 2017532639 A JP2017532639 A JP 2017532639A JP 2017532639 A JP2017532639 A JP 2017532639A JP 2018504894 A5 JP2018504894 A5 JP 2018504894A5
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- JP
- Japan
- Prior art keywords
- cell
- car
- antibody
- nucleic acid
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022011441A JP7548950B2 (ja) | 2014-12-19 | 2022-01-28 | キメラ抗原受容体およびその使用方法 |
| JP2024147204A JP7833003B2 (ja) | 2014-12-19 | 2024-08-29 | キメラ抗原受容体およびその使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462094625P | 2014-12-19 | 2014-12-19 | |
| US62/094,625 | 2014-12-19 | ||
| US201562252083P | 2015-11-06 | 2015-11-06 | |
| US62/252,083 | 2015-11-06 | ||
| PCT/US2015/067225 WO2016100985A2 (en) | 2014-12-19 | 2015-12-21 | Chimeric antigen receptors and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022011441A Division JP7548950B2 (ja) | 2014-12-19 | 2022-01-28 | キメラ抗原受容体およびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018504894A JP2018504894A (ja) | 2018-02-22 |
| JP2018504894A5 true JP2018504894A5 (enExample) | 2019-02-07 |
Family
ID=55229842
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017532639A Pending JP2018504894A (ja) | 2014-12-19 | 2015-12-21 | キメラ抗原受容体およびその使用方法 |
| JP2022011441A Active JP7548950B2 (ja) | 2014-12-19 | 2022-01-28 | キメラ抗原受容体およびその使用方法 |
| JP2024147204A Active JP7833003B2 (ja) | 2014-12-19 | 2024-08-29 | キメラ抗原受容体およびその使用方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022011441A Active JP7548950B2 (ja) | 2014-12-19 | 2022-01-28 | キメラ抗原受容体およびその使用方法 |
| JP2024147204A Active JP7833003B2 (ja) | 2014-12-19 | 2024-08-29 | キメラ抗原受容体およびその使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20170362297A1 (enExample) |
| EP (1) | EP3233900A2 (enExample) |
| JP (3) | JP2018504894A (enExample) |
| KR (2) | KR102923234B1 (enExample) |
| CN (1) | CN108064252A (enExample) |
| AU (4) | AU2015364245B2 (enExample) |
| BR (1) | BR112017013176A2 (enExample) |
| CA (1) | CA2968412A1 (enExample) |
| IL (3) | IL252295B2 (enExample) |
| RU (1) | RU2017125531A (enExample) |
| WO (1) | WO2016100985A2 (enExample) |
Families Citing this family (52)
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| BR112015007672A2 (pt) * | 2012-10-04 | 2017-08-08 | Dana Farber Cancer Inst Inc | anticorpos anti-pd-l1 monoclonais humanos e métodos de uso |
| WO2014117121A1 (en) | 2013-01-28 | 2014-07-31 | St. Jude Children's Research Hospital, Inc. | A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease |
| EP3134111B1 (en) * | 2014-04-25 | 2022-06-08 | Dana-Farber Cancer Institute, Inc. | Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof |
| KR102211120B1 (ko) | 2014-05-15 | 2021-02-03 | 내셔널 유니버시티 오브 싱가포르 | 변형된 천연 살해 세포 및 그의 용도 |
| DK3148579T3 (da) | 2014-05-28 | 2021-03-08 | Agenus Inc | Anti-gitr antistoffer og fremgangsmåder til anvendelse deraf |
| SG10201912984WA (en) | 2015-12-02 | 2020-03-30 | Agenus Inc | Antibodies and methods of use thereof |
| EP4086285A1 (en) | 2016-02-25 | 2022-11-09 | Cell Medica Switzerland AG | Binding members to pd-l1 |
| US11549099B2 (en) * | 2016-03-23 | 2023-01-10 | Novartis Ag | Cell secreted minibodies and uses thereof |
| SMT202600123T1 (it) | 2016-06-29 | 2026-05-12 | Checkpoint Therapeutics Inc | Anticorpi specifici per il pd-l1 e metodi di utilizzo degli stessi |
| MX2019000149A (es) | 2016-07-07 | 2019-09-23 | Iovance Biotherapeutics Inc | Proteinas de union a ligando 1 de muerte programada 1 (pd-l1) y metodos de uso de las mismas. |
| WO2018057585A1 (en) * | 2016-09-21 | 2018-03-29 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric antigen receptor (car) that targets chemokine receptor ccr4 and its use |
| AU2017338846B2 (en) * | 2016-10-04 | 2020-09-24 | Precision Biosciences, Inc. | Co-stimulatory domains for use in genetically-modified cells |
| MA46770A (fr) | 2016-11-09 | 2019-09-18 | Agenus Inc | Anticorps anti-ox40, anticorps anti-gitr, et leurs procédés d'utilisation |
| WO2018089829A1 (en) | 2016-11-10 | 2018-05-17 | Fortis Therapeutics, Inc. | Cd46-specific effector cells and uses thereof |
| CN108148862B (zh) * | 2016-12-05 | 2019-03-08 | 上海优卡迪生物医药科技有限公司 | 一种封闭pdl1的用于抑制免疫逃脱的car-t转基因载体及其构建方法和应用 |
| IL269553B2 (en) | 2017-03-27 | 2025-10-01 | Nat Univ Singapore | Truncated NKG2D chimeric receptors and their uses in immunotherapy with natural killer cells |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| US11166985B2 (en) | 2017-05-12 | 2021-11-09 | Crispr Therapeutics Ag | Materials and methods for engineering cells and uses thereof in immuno-oncology |
| BR112019023608A2 (pt) | 2017-05-12 | 2020-05-26 | Crispr Therapeutics Ag | Materiais e métodos para células manipuladas e seus usos em imuno-oncologia |
| CN107337736B (zh) * | 2017-06-06 | 2019-07-26 | 上海优卡迪生物医药科技有限公司 | Octs-car双靶向嵌合抗原受体、编码基因、重组表达载体及其构建和应用 |
| CN111801348A (zh) | 2018-02-09 | 2020-10-20 | 新加坡国立大学 | 活化性嵌合受体及其在自然杀伤细胞免疫疗法中的用途 |
| WO2019178356A1 (en) * | 2018-03-14 | 2019-09-19 | Dana-Farber Cancer Institute, Inc. | Engineered cells, t cell immune modulating antibodies and methods for using the same |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| CA3097152A1 (en) * | 2018-04-16 | 2019-10-24 | Memorial Sloan Kettering Cancer Center | T-cell exhaustion, & methods & compositions relating thereto |
| EP3790629A1 (en) | 2018-05-11 | 2021-03-17 | CRISPR Therapeutics AG | Methods and compositions for treating cancer |
| KR20210031898A (ko) * | 2018-07-13 | 2021-03-23 | 난징 레전드 바이오테크 씨오., 엘티디. | 전염병을 치료하기 위한 공동수용체 시스템 |
| JP7262568B2 (ja) * | 2018-07-24 | 2023-04-21 | クレージュ メディカル カンパニー,リミテッド | 免疫エフェクター細胞を使用して腫瘍を治療する方法 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| FI3856775T3 (fi) * | 2018-09-27 | 2024-12-04 | Autolus Ltd | Kimeerinen antigeenireseptori |
| CA3120563A1 (en) * | 2018-11-26 | 2020-06-04 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| AU2019387566A1 (en) | 2018-11-30 | 2021-06-17 | Dana-Farber Cancer Institute, Inc. | Chimeric antigen receptor factories and methods of use thereof |
| WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| US11104732B2 (en) * | 2019-04-24 | 2021-08-31 | Innovative Cellular Therapeutics Holdings, Ltd. | Reducing immune inhibition induced by SIGLEC-15 |
| US12479890B2 (en) * | 2019-04-26 | 2025-11-25 | The University Of North Carolina At Chapel Hill | Chimeric antigen receptor constructs and their use in CAR-T cells |
| WO2020223445A1 (en) | 2019-04-30 | 2020-11-05 | Senti Biosciences, Inc. | Chimeric receptors and methods of use thereof |
| AU2020267057A1 (en) | 2019-04-30 | 2021-11-18 | Crispr Therapeutics Ag | Allogeneic cell therapy of B cell malignancies using genetically engineered T cells targeting CD19 |
| WO2020252472A2 (en) | 2019-06-14 | 2020-12-17 | Dana-Farber Cancer Institute, Inc. | Antibodies against muc1 and methods of use thereof |
| AU2020315213A1 (en) * | 2019-07-17 | 2022-02-03 | National University Of Singapore | Functional binders synthesized and secreted by immune cells |
| WO2021016606A1 (en) * | 2019-07-24 | 2021-01-28 | Eureka Therapeutics, Inc. | Chimeric antigen receptor t cells and uses thereof |
| AU2020396896A1 (en) * | 2019-12-02 | 2022-06-09 | Dana-Farber Cancer Institute, Inc. | Antibodies against PD-L1 and methods of use thereof |
| WO2021142835A1 (zh) * | 2020-01-19 | 2021-07-22 | 北京卡替医疗技术有限公司 | 一种提升免疫细胞功能的增强受体 |
| WO2021225399A1 (ko) * | 2020-05-08 | 2021-11-11 | (주)에스엠티바이오 | 암 치료를 위한 키메라 항원 수용체 |
| AU2021320333A1 (en) | 2020-08-07 | 2023-03-30 | Fortis Therapeutics, Inc. | Immunoconjugates targeting CD46 and methods of use thereof |
| WO2022173950A1 (en) * | 2021-02-11 | 2022-08-18 | The Trustees Of The University Of Pennsylvania | Ccr4-targeting chimeric antigen receptor cell therapy |
| KR20220136876A (ko) | 2021-04-01 | 2022-10-11 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
| TWI867291B (zh) * | 2021-04-12 | 2024-12-21 | 中央研究院 | 經改良之冠狀病毒疫苗 |
| KR20220144000A (ko) | 2021-04-16 | 2022-10-26 | 주식회사 이뮤노로지컬디자이닝랩 | Programmed death-ligand 1(PD-L1)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도 |
| US20240262917A1 (en) | 2021-05-06 | 2024-08-08 | Dana-Farber Cancer Institute, Inc. | Antibodies against alk and methods of use thereof |
| KR20230089464A (ko) | 2021-12-13 | 2023-06-20 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
| KR20230089462A (ko) | 2021-12-13 | 2023-06-20 | 주식회사 이뮤노로지컬디자이닝랩 | 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도 |
| CA3245511A1 (en) * | 2022-03-08 | 2025-06-13 | Vaxcell-Bio Co., Ltd. | Pd-l1-specific chimeric antigen receptor and immune cell comprising same |
| WO2025059162A1 (en) | 2023-09-11 | 2025-03-20 | Dana-Farber Cancer Institute, Inc. | Car-engager containing il-2 variants to enhance the functionality of car t cells |
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| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
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| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| US20050113564A1 (en) * | 2003-11-05 | 2005-05-26 | St. Jude Children's Research Hospital | Chimeric receptors with 4-1BB stimulatory signaling domain |
| CN1914226B (zh) | 2003-11-25 | 2012-02-01 | 达纳-法伯癌症研究院有限公司 | SARS-CoV抗体及其使用方法 |
| CA2597717C (en) | 2005-02-18 | 2014-10-21 | Dana-Farber Cancer Institute | Antibodies against cxcr4 and methods of use thereof |
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| BRPI0819971A2 (pt) | 2007-12-06 | 2017-06-27 | Burnham Institute For Medical Res | anticorpos contra vírus influenza e métodos de seu uso |
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| US9402865B2 (en) | 2011-01-18 | 2016-08-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
| EP3594245A1 (en) * | 2012-02-13 | 2020-01-15 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| ES3065694T3 (en) * | 2012-04-11 | 2026-05-07 | Us Health | Chimeric antigen receptors targeting b-cell maturation antigen |
| WO2013166500A1 (en) | 2012-05-04 | 2013-11-07 | Dana-Farber Cancer Institute, Inc. | Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use |
| AU2013289971A1 (en) * | 2012-07-13 | 2015-01-22 | The Trustees Of The University Of Pennsylvania | Enhancing activity of CAR T cells by co-introducing a bispecific antibody |
| BR112015007672A2 (pt) * | 2012-10-04 | 2017-08-08 | Dana Farber Cancer Inst Inc | anticorpos anti-pd-l1 monoclonais humanos e métodos de uso |
| BR112015020516A2 (pt) * | 2013-02-26 | 2017-10-10 | Memorial Sloan Kettering Cancer Center | composições e métodos para imunoterapia |
| SG11201507359SA (en) | 2013-03-15 | 2015-10-29 | Dana Farber Cancer Inst Inc | Flavivirus neutralizing antibodies and methods of use thereof |
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| EP3134111B1 (en) | 2014-04-25 | 2022-06-08 | Dana-Farber Cancer Institute, Inc. | Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof |
| RU2017115315A (ru) | 2014-10-03 | 2018-11-08 | Дана-Фарбер Кэнсер Инститьют, Инк. | Антитела к рецептору глюкокортикоид-индуцированного фактора некроза опухоли (gitr) и способы их применения |
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| RU2017125735A (ru) * | 2014-12-19 | 2019-01-22 | Дана-Фарбер Кэнсер Инститьют, Инк. | Химерные антигенные рецепторы против карбоангидразы ix и способы их применения |
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-
2015
- 2015-12-21 KR KR1020177020045A patent/KR102923234B1/ko active Active
- 2015-12-21 AU AU2015364245A patent/AU2015364245B2/en active Active
- 2015-12-21 IL IL252295A patent/IL252295B2/en unknown
- 2015-12-21 KR KR1020267003069A patent/KR20260038272A/ko active Pending
- 2015-12-21 WO PCT/US2015/067225 patent/WO2016100985A2/en not_active Ceased
- 2015-12-21 RU RU2017125531A patent/RU2017125531A/ru not_active Application Discontinuation
- 2015-12-21 JP JP2017532639A patent/JP2018504894A/ja active Pending
- 2015-12-21 US US15/537,779 patent/US20170362297A1/en not_active Abandoned
- 2015-12-21 IL IL302660A patent/IL302660B2/en unknown
- 2015-12-21 CN CN201580069023.0A patent/CN108064252A/zh active Pending
- 2015-12-21 CA CA2968412A patent/CA2968412A1/en active Pending
- 2015-12-21 BR BR112017013176-5A patent/BR112017013176A2/en not_active Application Discontinuation
- 2015-12-21 EP EP15828615.3A patent/EP3233900A2/en active Pending
- 2015-12-21 IL IL320860A patent/IL320860A/en unknown
-
2020
- 2020-06-30 AU AU2020204373A patent/AU2020204373B2/en active Active
- 2020-08-06 US US16/986,913 patent/US12195514B2/en active Active
-
2022
- 2022-01-17 AU AU2022200257A patent/AU2022200257B2/en active Active
- 2022-01-28 JP JP2022011441A patent/JP7548950B2/ja active Active
-
2024
- 2024-01-31 AU AU2024200592A patent/AU2024200592B2/en active Active
- 2024-08-29 JP JP2024147204A patent/JP7833003B2/ja active Active
- 2024-12-05 US US18/970,194 patent/US20250243259A1/en active Pending
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