JP2018504894A5 - - Google Patents

Download PDF

Info

Publication number
JP2018504894A5
JP2018504894A5 JP2017532639A JP2017532639A JP2018504894A5 JP 2018504894 A5 JP2018504894 A5 JP 2018504894A5 JP 2017532639 A JP2017532639 A JP 2017532639A JP 2017532639 A JP2017532639 A JP 2017532639A JP 2018504894 A5 JP2018504894 A5 JP 2018504894A5
Authority
JP
Japan
Prior art keywords
cell
car
antibody
nucleic acid
domain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017532639A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018504894A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/067225 external-priority patent/WO2016100985A2/en
Publication of JP2018504894A publication Critical patent/JP2018504894A/ja
Publication of JP2018504894A5 publication Critical patent/JP2018504894A5/ja
Priority to JP2022011441A priority Critical patent/JP7548950B2/ja
Priority to JP2024147204A priority patent/JP7833003B2/ja
Pending legal-status Critical Current

Links

JP2017532639A 2014-12-19 2015-12-21 キメラ抗原受容体およびその使用方法 Pending JP2018504894A (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022011441A JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法
JP2024147204A JP7833003B2 (ja) 2014-12-19 2024-08-29 キメラ抗原受容体およびその使用方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US62/094,625 2014-12-19
US201562252083P 2015-11-06 2015-11-06
US62/252,083 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022011441A Division JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法

Publications (2)

Publication Number Publication Date
JP2018504894A JP2018504894A (ja) 2018-02-22
JP2018504894A5 true JP2018504894A5 (enExample) 2019-02-07

Family

ID=55229842

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017532639A Pending JP2018504894A (ja) 2014-12-19 2015-12-21 キメラ抗原受容体およびその使用方法
JP2022011441A Active JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法
JP2024147204A Active JP7833003B2 (ja) 2014-12-19 2024-08-29 キメラ抗原受容体およびその使用方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2022011441A Active JP7548950B2 (ja) 2014-12-19 2022-01-28 キメラ抗原受容体およびその使用方法
JP2024147204A Active JP7833003B2 (ja) 2014-12-19 2024-08-29 キメラ抗原受容体およびその使用方法

Country Status (11)

Country Link
US (3) US20170362297A1 (enExample)
EP (1) EP3233900A2 (enExample)
JP (3) JP2018504894A (enExample)
KR (1) KR102923234B1 (enExample)
CN (1) CN108064252A (enExample)
AU (3) AU2015364245B2 (enExample)
BR (1) BR112017013176A2 (enExample)
CA (1) CA2968412A1 (enExample)
IL (3) IL320860A (enExample)
RU (1) RU2017125531A (enExample)
WO (1) WO2016100985A2 (enExample)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2886433C (en) * 2012-10-04 2022-01-04 Dana-Farber Cancer Institute, Inc. Human monoclonal anti-pd-l1 antibodies and methods of use
WO2014117121A1 (en) 2013-01-28 2014-07-31 St. Jude Children's Research Hospital, Inc. A chimeric receptor with nkg2d specificity for use in cell therapy against cancer and infectious disease
EP4112070A1 (en) * 2014-04-25 2023-01-04 Dana Farber Cancer Institute, Inc. Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof
KR20210014210A (ko) 2014-05-15 2021-02-08 내셔널 유니버시티 오브 싱가포르 변형된 천연 살해 세포 및 그의 용도
AU2015266958A1 (en) 2014-05-28 2016-12-08 Agenus Inc. Anti-GITR antibodies and methods of use thereof
SG10201912984WA (en) 2015-12-02 2020-03-30 Agenus Inc Antibodies and methods of use thereof
KR20180111870A (ko) 2016-02-25 2018-10-11 셀 메디카 스위처란트 아게 Pd-l1에 대한 결합 성분
US11549099B2 (en) * 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
FI3478723T3 (fi) 2016-06-29 2026-03-17 Checkpoint Therapeutics Inc Pd-l1-spesifisiä vasta-aineita ja niiden käyttömenetelmiä
CN109843921B (zh) * 2016-07-07 2023-05-26 艾欧凡斯生物治疗公司 程序性死亡1配体1(pd-l1)结合蛋白及其应用方法
EP3515475B1 (en) 2016-09-21 2024-05-01 The U.S.A. as represented by the Secretary, Department of Health and Human Services Chimeric antigen receptor (car) that targets chemokine receptor ccr4 and its use
ES2811500T3 (es) * 2016-10-04 2021-03-12 Prec Biosciences Inc Dominios coestimuladores para su uso en células genéticamente modificadas
EP3538152A4 (en) 2016-11-09 2020-09-30 Agenus Inc. ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND PROCESSES FOR USE
EP3538551A4 (en) * 2016-11-10 2020-11-11 Fortis Therapeutics, Inc. CD46 SPECIFIC EFFECTOR CELLS AND USES THEREOF
CN108148862B (zh) * 2016-12-05 2019-03-08 上海优卡迪生物医药科技有限公司 一种封闭pdl1的用于抑制免疫逃脱的car-t转基因载体及其构建方法和应用
CA3056439A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
AU2018245749A1 (en) 2017-03-27 2019-10-03 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
IL270415B2 (en) 2017-05-12 2024-08-01 Crispr Therapeutics Ag Materials and methods for cell engineering and their uses in immuno-oncology
US11166985B2 (en) 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
CN107337736B (zh) * 2017-06-06 2019-07-26 上海优卡迪生物医药科技有限公司 Octs-car双靶向嵌合抗原受体、编码基因、重组表达载体及其构建和应用
SG11202007156QA (en) 2018-02-09 2020-08-28 Nat Univ Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
US12258378B2 (en) 2018-03-14 2025-03-25 Dana-Farber Cancer Institute, Inc. Engineered cells, T cell immune modulating antibodies and methods for using the same
SG11202008976YA (en) 2018-04-02 2020-10-29 Nat Univ Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
KR20200144569A (ko) * 2018-04-16 2020-12-29 메모리얼 슬로안 케터링 캔서 센터 T-세포 탈진, 및 이와 관련된 방법 및 조성물
WO2019215500A1 (en) 2018-05-11 2019-11-14 Crispr Therapeutics Ag Methods and compositions for treating cancer
US20210275589A1 (en) * 2018-07-13 2021-09-09 Nanjing Legend Biotech Co. Ltd. Co-receptor systems for treating infectious diseases
US20210292427A1 (en) * 2018-07-24 2021-09-23 Cafa Therapeutics Limited Method for treating tumor using immune effector cell
US12486514B2 (en) 2018-08-29 2025-12-02 National University Of Singapore Method to specifically stimulate survival and expansion of genetically-modified immune cells
PL3856775T3 (pl) 2018-09-27 2025-06-09 Autolus Limited Chimeryczny receptor antygenowy
AU2019385873B2 (en) * 2018-11-26 2026-02-05 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
KR20210135475A (ko) 2018-11-30 2021-11-15 다나-파버 캔서 인스티튜트 인크. 키메라 항원 수용체 팩토리 및 이의 사용 방법
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
US11104732B2 (en) * 2019-04-24 2021-08-31 Innovative Cellular Therapeutics Holdings, Ltd. Reducing immune inhibition induced by SIGLEC-15
US12479890B2 (en) * 2019-04-26 2025-11-25 The University Of North Carolina At Chapel Hill Chimeric antigen receptor constructs and their use in CAR-T cells
US20220249558A1 (en) 2019-04-30 2022-08-11 Crispr Therapeutics Ag Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19
CA3133333A1 (en) 2019-04-30 2020-04-30 Brian Scott GARRISON Chimeric receptors and methods of use thereof
AU2020290579B2 (en) 2019-06-14 2026-02-12 Dana-Farber Cancer Institute, Inc. Antibodies against MUC1 and methods of use thereof
AU2020315213A1 (en) * 2019-07-17 2022-02-03 National University Of Singapore Functional binders synthesized and secreted by immune cells
JP2022541320A (ja) * 2019-07-24 2022-09-22 エウレカ セラピューティクス インコーポレイテッド キメラ抗原受容体ｔ細胞及びその使用
WO2021113307A2 (en) * 2019-12-02 2021-06-10 Dana-Farber Cancer Institute, Inc. Antibodies against pd-l1 and methods of use thereof
EP4431110A3 (en) * 2020-01-19 2025-01-15 Chineo Medical Technology Co., Ltd. Enhanced receptor for improving immune cell function
US20230227525A1 (en) * 2020-05-08 2023-07-20 Smt Bio Co., Ltd. Chimeric antigen receptor for treatment of cancer
US11484604B2 (en) 2020-08-07 2022-11-01 Fortis Therapeutics, Inc. Immunoconjugates targeting CD46 and methods of use thereof
CN117500838A (zh) * 2021-02-11 2024-02-02 宾夕法尼亚大学董事会 Ccr4靶向嵌合抗原受体细胞疗法
KR20220136876A (ko) 2021-04-01 2022-10-11 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
IL318755A (en) * 2021-04-12 2025-04-01 Academia Sinica Improved vaccine for the coronavirus
KR20220144000A (ko) 2021-04-16 2022-10-26 주식회사 이뮤노로지컬디자이닝랩 Programmed death-ligand 1(PD-L1)에 특이적으로 결합하는 키메릭 항원 수용체 및 이의 용도
EP4334354A1 (en) 2021-05-06 2024-03-13 Dana-Farber Cancer Institute, Inc. Antibodies against alk and methods of use thereof
KR20230089462A (ko) 2021-12-13 2023-06-20 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
KR20230089464A (ko) 2021-12-13 2023-06-20 주식회사 이뮤노로지컬디자이닝랩 키메릭 항원 수용체(car)를 포함하는 형질전환된 항원 특이적 전문적 항원표출세포 및 이의 용도
US20250186495A1 (en) * 2022-03-08 2025-06-12 Vaxcell-Bio Co., Ltd. Pd-l1-specific chimeric antigen receptor and immune cell comprising same
WO2025059162A1 (en) 2023-09-11 2025-03-20 Dana-Farber Cancer Institute, Inc. Car-engager containing il-2 variants to enhance the functionality of car t cells

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US20050113564A1 (en) * 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
US7750123B2 (en) 2003-11-25 2010-07-06 Dana Farber Cancer Institute, Inc. Antibodies against SARS-CoV and methods of use thereof
US8329178B2 (en) 2005-02-18 2012-12-11 Dana-Farber Cancer Institute, Inc. Antibodies against CXCR4 and methods of use thereof
US8466263B2 (en) 2005-12-02 2013-06-18 Dana-Farber Cancer Institute, Inc. Carbonic anhydrase IX (G250) anitbodies
MX2010006148A (es) 2007-12-06 2011-02-23 Dana Farber Cancer Inst Inc Anti-cuerpos contra el virus de la influenza y metodos de uso de los mismos.
US8962806B2 (en) 2007-12-28 2015-02-24 Dana-Farber Cancer Institute, Inc. Humanized monoclonal antibodies and methods of use
EP3957653A1 (en) 2010-06-02 2022-02-23 Dana Farber Cancer Institute, Inc. Humanized monoclonal antibodies and methods of use
BR112013018311A2 (pt) * 2011-01-18 2017-03-21 Univ Pennsylvania sequência de ácido nucleico isolada, receptor de antígeno quimérico isolado, célula t geneticamente modificada, vetor, e, uso de uma célula t geneticamente modificada.
EP2814846B1 (en) * 2012-02-13 2020-01-08 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
EA201990959A1 (ru) * 2012-04-11 2020-02-10 Дзе Юнайтед Стейтс Оф Америка, Эз Репрезентед Бай Дзе Секретари, Департмент Оф Хелс Энд Хьюман Сёрвисез Химерные антигенные рецепторы, нацеленные на антиген созревания b-клеток
EP3511343A1 (en) 2012-05-04 2019-07-17 Dana Farber Cancer Institute, Inc. Affinity matured anti-ccr4 humanized monoclonal antibodies and methods of use
SG11201408787PA (en) * 2012-07-13 2015-01-29 Univ Pennsylvania Enhancing activity of car t cells by co-introducing a bispecific antibody
CA2886433C (en) * 2012-10-04 2022-01-04 Dana-Farber Cancer Institute, Inc. Human monoclonal anti-pd-l1 antibodies and methods of use
EP2961831B1 (en) * 2013-02-26 2020-06-10 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
SG11201507359SA (en) 2013-03-15 2015-10-29 Dana Farber Cancer Inst Inc Flavivirus neutralizing antibodies and methods of use thereof
AU2015231164B2 (en) 2014-03-19 2020-04-09 Dana-Farber Cancer Institute, Inc. Immunogenetic restriction on elicitation of antibodies
EP4112070A1 (en) 2014-04-25 2023-01-04 Dana Farber Cancer Institute, Inc. Middle east respiratory syndrome coronavirus neutralizing antibodies and methods of use thereof
RU2017115315A (ru) 2014-10-03 2018-11-08 Дана-Фарбер Кэнсер Инститьют, Инк. Антитела к рецептору глюкокортикоид-индуцированного фактора некроза опухоли (gitr) и способы их применения
CA2962949C (en) 2014-10-06 2024-03-05 Dana-Farber Cancer Institute, Inc. Humanized cc chemokine receptor 4 (ccr4) antibodies and methods of use thereof
JP2018500337A (ja) * 2014-12-19 2018-01-11 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 炭酸脱水酵素ｉｘ特異的キメラ抗原受容体およびその使用方法
WO2017075537A1 (en) 2015-10-30 2017-05-04 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer

Similar Documents

Publication Publication Date Title
JP2018504894A5 (enExample)
RU2017125531A (ru) Химерные антигенные рецепторы и способы их применения
HRP20240357T1 (hr) Stanica
WO2019090003A9 (en) Chimeric antigen receptors specific for b-cell maturation antigen (bcma)
MX370788B (es) Receptores de antígeno quimérico específico de cd33 para inmunoterapia de cáncer.
FI3896091T3 (fi) BCMA:han kohdentuvia kimeerisiä antigeenireseptoreita ja menetelmiä niiden käyttämiseksi
JP2020114264A5 (enExample)
JP2018500337A5 (enExample)
JP2019527557A5 (enExample)
JP2016508518A5 (enExample)
BR112018008442A2 (pt) receptores quiméricos contendo domínios induto-res de traf e composições e métodos relacionados
MX2014010183A (es) Composiciones y metodos para generar una poblacion persistente de celulas t utiles para el tratamiento de cancer.
HK1252235A1 (zh) 表达γ-δT细胞受体(TCR)和嵌合抗原受体(CAR)的T细胞
ZA201607060B (en) Drug related transgene expression
WO2017130223A3 (en) A chimeric antigen receptor specific to b-cell maturation antigen, a recombinant expression vector and a method thereof
EP4477748A3 (en) Methods of making chimeric antigen receptor-expressing cells
WO2016109410A3 (en) Methods of making chimeric antigen receptor-expressing cells
JP2017513478A5 (enExample)
FI4219687T3 (fi) Menetelmiä immuunisolupopulaatioiden eristämiseksi, viljelemiseksi ja geneettiseksi muokkaamiseksi adoptiivista terapiaa varten
WO2011130491A3 (en) Methods and compositions for treating hiv
WO2023150698A3 (en) Chimeric ilt receptor compositions and methods
IL274806B1 (en) T-cells comprising anti-cd38 and anti-cd138 chimeric antigen receptors and uses thereof
MX2021015967A (es) Receptor de antigeno quimerico con dominio coestimulador 4-1bb.
PE20240117A1 (es) Polipeptido especifico para mucina 1 y sus usos
NZ758571A (en) Chimeric antigen receptors based on single-domain antibodies and methods of use thereof