CA2968412A1 - Chimeric antigen receptors and methods of use thereof - Google Patents

Chimeric antigen receptors and methods of use thereof Download PDF

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Publication number
CA2968412A1
CA2968412A1 CA2968412A CA2968412A CA2968412A1 CA 2968412 A1 CA2968412 A1 CA 2968412A1 CA 2968412 A CA2968412 A CA 2968412A CA 2968412 A CA2968412 A CA 2968412A CA 2968412 A1 CA2968412 A1 CA 2968412A1
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Prior art keywords
amino acid
cells
seq
cell
cdrs
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Pending
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CA2968412A
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English (en)
French (fr)
Inventor
Wayne A. Marasco
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of CA2968412A1 publication Critical patent/CA2968412A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Materials For Medical Uses (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
CA2968412A 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof Pending CA2968412A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US62/094,625 2014-12-19
US201562252083P 2015-11-06 2015-11-06
US62/252,083 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

Publications (1)

Publication Number Publication Date
CA2968412A1 true CA2968412A1 (en) 2016-06-23

Family

ID=55229842

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2968412A Pending CA2968412A1 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

Country Status (11)

Country Link
US (3) US20170362297A1 (enExample)
EP (1) EP3233900A2 (enExample)
JP (4) JP2018504894A (enExample)
KR (2) KR102923234B1 (enExample)
CN (1) CN108064252A (enExample)
AU (5) AU2015364245B2 (enExample)
BR (1) BR112017013176A2 (enExample)
CA (1) CA2968412A1 (enExample)
IL (3) IL302660B2 (enExample)
RU (1) RU2017125531A (enExample)
WO (1) WO2016100985A2 (enExample)

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Publication number Publication date
KR20260038272A (ko) 2026-03-18
IL320860A (en) 2025-07-01
AU2022200257B2 (en) 2023-11-16
US20170362297A1 (en) 2017-12-21
IL302660A (en) 2023-07-01
WO2016100985A2 (en) 2016-06-23
WO2016100985A3 (en) 2016-08-18
RU2017125531A (ru) 2019-01-21
IL302660B1 (en) 2025-06-01
JP2022064952A (ja) 2022-04-26
IL252295B1 (en) 2023-06-01
IL252295B2 (en) 2023-10-01
AU2024200592B2 (en) 2026-03-12
US20250243259A1 (en) 2025-07-31
BR112017013176A2 (en) 2018-05-15
US20210061877A1 (en) 2021-03-04
JP2026088143A (ja) 2026-05-28
AU2020204373A1 (en) 2020-07-23
AU2015364245A1 (en) 2017-06-08
JP2018504894A (ja) 2018-02-22
JP7548950B2 (ja) 2024-09-10
EP3233900A2 (en) 2017-10-25
IL252295A0 (en) 2017-07-31
KR20170090506A (ko) 2017-08-07
AU2024200592A1 (en) 2024-02-22
AU2026204528A1 (en) 2026-07-02
IL302660B2 (en) 2025-10-01
JP7833003B2 (ja) 2026-03-18
AU2020204373B2 (en) 2021-10-21
CN108064252A (zh) 2018-05-22
AU2015364245B2 (en) 2020-04-02
KR102923234B1 (ko) 2026-02-04
JP2024163140A (ja) 2024-11-21
AU2022200257A1 (en) 2022-02-10
US12195514B2 (en) 2025-01-14

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