KR102923234B1 - 키메라 항원 수용체 및 이의 사용 방법 - Google Patents

키메라 항원 수용체 및 이의 사용 방법

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Publication number
KR102923234B1
KR102923234B1 KR1020177020045A KR20177020045A KR102923234B1 KR 102923234 B1 KR102923234 B1 KR 102923234B1 KR 1020177020045 A KR1020177020045 A KR 1020177020045A KR 20177020045 A KR20177020045 A KR 20177020045A KR 102923234 B1 KR102923234 B1 KR 102923234B1
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South Korea
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amino acid
seq
cells
cell
cdrs
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Korean (ko)
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KR20170090506A (ko
Inventor
웨인 에이 마라스코
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다나-파버 캔서 인스티튜트 인크.
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020177020045A 2014-12-19 2015-12-21 키메라 항원 수용체 및 이의 사용 방법 Active KR102923234B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US62/094,625 2014-12-19
US201562252083P 2015-11-06 2015-11-06
US62/252,083 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020267003069A Division KR20260038272A (ko) 2014-12-19 2015-12-21 키메라 항원 수용체 및 이의 사용 방법

Publications (2)

Publication Number Publication Date
KR20170090506A KR20170090506A (ko) 2017-08-07
KR102923234B1 true KR102923234B1 (ko) 2026-02-04

Family

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Family Applications (1)

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KR1020177020045A Active KR102923234B1 (ko) 2014-12-19 2015-12-21 키메라 항원 수용체 및 이의 사용 방법

Country Status (11)

Country Link
US (3) US20170362297A1 (enExample)
EP (1) EP3233900A2 (enExample)
JP (3) JP2018504894A (enExample)
KR (1) KR102923234B1 (enExample)
CN (1) CN108064252A (enExample)
AU (3) AU2015364245B2 (enExample)
BR (1) BR112017013176A2 (enExample)
CA (1) CA2968412A1 (enExample)
IL (3) IL320860A (enExample)
RU (1) RU2017125531A (enExample)
WO (1) WO2016100985A2 (enExample)

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AU2022200257B2 (en) 2023-11-16
JP7548950B2 (ja) 2024-09-10
US20170362297A1 (en) 2017-12-21
US12195514B2 (en) 2025-01-14
IL252295A0 (en) 2017-07-31
WO2016100985A3 (en) 2016-08-18
CA2968412A1 (en) 2016-06-23
IL302660B2 (en) 2025-10-01
WO2016100985A2 (en) 2016-06-23
US20250243259A1 (en) 2025-07-31
JP2018504894A (ja) 2018-02-22
CN108064252A (zh) 2018-05-22
JP2024163140A (ja) 2024-11-21
IL252295B2 (en) 2023-10-01
US20210061877A1 (en) 2021-03-04
RU2017125531A (ru) 2019-01-21
AU2015364245A1 (en) 2017-06-08
KR20170090506A (ko) 2017-08-07
AU2015364245B2 (en) 2020-04-02
JP7833003B2 (ja) 2026-03-18
BR112017013176A2 (en) 2018-05-15
IL320860A (en) 2025-07-01
JP2022064952A (ja) 2022-04-26
AU2022200257A1 (en) 2022-02-10
AU2024200592A1 (en) 2024-02-22
AU2020204373B2 (en) 2021-10-21
EP3233900A2 (en) 2017-10-25
IL302660A (en) 2023-07-01
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IL252295B1 (en) 2023-06-01
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