AU2015364245B2 - Chimeric antigen receptors and methods of use thereof - Google Patents

Chimeric antigen receptors and methods of use thereof Download PDF

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Publication number
AU2015364245B2
AU2015364245B2 AU2015364245A AU2015364245A AU2015364245B2 AU 2015364245 B2 AU2015364245 B2 AU 2015364245B2 AU 2015364245 A AU2015364245 A AU 2015364245A AU 2015364245 A AU2015364245 A AU 2015364245A AU 2015364245 B2 AU2015364245 B2 AU 2015364245B2
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amino acid
cells
seq
cell
caix
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AU2015364245A1 (en
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Wayne A. Marasco
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Priority to AU2022200257A priority patent/AU2022200257B2/en
Priority to AU2024200592A priority patent/AU2024200592A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2015364245A 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof Active AU2015364245B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020204373A AU2020204373B2 (en) 2014-12-19 2020-06-30 Chimeric antigen receptors and methods of use thereof
AU2022200257A AU2022200257B2 (en) 2014-12-19 2022-01-17 Chimeric antigen receptors and methods of use thereof
AU2024200592A AU2024200592A1 (en) 2014-12-19 2024-01-31 Chimeric antigen receptors and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462094625P 2014-12-19 2014-12-19
US62/094,625 2014-12-19
US201562252083P 2015-11-06 2015-11-06
US62/252,083 2015-11-06
PCT/US2015/067225 WO2016100985A2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof

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AU2020204373A Division AU2020204373B2 (en) 2014-12-19 2020-06-30 Chimeric antigen receptors and methods of use thereof

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AU2015364245A1 AU2015364245A1 (en) 2017-06-08
AU2015364245B2 true AU2015364245B2 (en) 2020-04-02

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AU2015364245A Active AU2015364245B2 (en) 2014-12-19 2015-12-21 Chimeric antigen receptors and methods of use thereof
AU2020204373A Active AU2020204373B2 (en) 2014-12-19 2020-06-30 Chimeric antigen receptors and methods of use thereof
AU2022200257A Active AU2022200257B2 (en) 2014-12-19 2022-01-17 Chimeric antigen receptors and methods of use thereof
AU2024200592A Pending AU2024200592A1 (en) 2014-12-19 2024-01-31 Chimeric antigen receptors and methods of use thereof

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AU2020204373A Active AU2020204373B2 (en) 2014-12-19 2020-06-30 Chimeric antigen receptors and methods of use thereof
AU2022200257A Active AU2022200257B2 (en) 2014-12-19 2022-01-17 Chimeric antigen receptors and methods of use thereof
AU2024200592A Pending AU2024200592A1 (en) 2014-12-19 2024-01-31 Chimeric antigen receptors and methods of use thereof

Country Status (11)

Country Link
US (3) US20170362297A1 (enExample)
EP (1) EP3233900A2 (enExample)
JP (3) JP2018504894A (enExample)
KR (1) KR20170090506A (enExample)
CN (1) CN108064252A (enExample)
AU (4) AU2015364245B2 (enExample)
BR (1) BR112017013176A2 (enExample)
CA (1) CA2968412A1 (enExample)
IL (3) IL320860A (enExample)
RU (1) RU2017125531A (enExample)
WO (1) WO2016100985A2 (enExample)

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