IL298107B2 - Compounds containing stem cells derived from adipose tissue for use in the treatment of recurrent symptoms of complex rectal abscesses in Crohn's disease - Google Patents

Compounds containing stem cells derived from adipose tissue for use in the treatment of recurrent symptoms of complex rectal abscesses in Crohn's disease

Info

Publication number
IL298107B2
IL298107B2 IL298107A IL29810722A IL298107B2 IL 298107 B2 IL298107 B2 IL 298107B2 IL 298107 A IL298107 A IL 298107A IL 29810722 A IL29810722 A IL 29810722A IL 298107 B2 IL298107 B2 IL 298107B2
Authority
IL
Israel
Prior art keywords
adipose tissue
cells
fistula
stem cells
derived stromal
Prior art date
Application number
IL298107A
Other languages
English (en)
Hebrew (he)
Other versions
IL298107B1 (en
IL298107A (en
Inventor
Eduardo Bravo
Maria Pascual
Original Assignee
Takeda Pharmaceuticals Co
Eduardo Bravo
Maria Pascual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co, Eduardo Bravo, Maria Pascual filed Critical Takeda Pharmaceuticals Co
Publication of IL298107A publication Critical patent/IL298107A/en
Publication of IL298107B1 publication Critical patent/IL298107B1/en
Publication of IL298107B2 publication Critical patent/IL298107B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0653—Adipocytes; Adipose tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL298107A 2016-03-14 2017-03-14 Compounds containing stem cells derived from adipose tissue for use in the treatment of recurrent symptoms of complex rectal abscesses in Crohn's disease IL298107B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1604304.4A GB201604304D0 (en) 2016-03-14 2016-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
PCT/IB2017/051468 WO2017158509A1 (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease

Publications (3)

Publication Number Publication Date
IL298107A IL298107A (en) 2023-01-01
IL298107B1 IL298107B1 (en) 2023-10-01
IL298107B2 true IL298107B2 (en) 2024-02-01

Family

ID=55952284

Family Applications (2)

Application Number Title Priority Date Filing Date
IL261730A IL261730B2 (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn’s disease
IL298107A IL298107B2 (en) 2016-03-14 2017-03-14 Compounds containing stem cells derived from adipose tissue for use in the treatment of recurrent symptoms of complex rectal abscesses in Crohn's disease

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL261730A IL261730B2 (en) 2016-03-14 2017-03-14 Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn’s disease

Country Status (27)

Country Link
US (3) US10357518B2 (OSRAM)
EP (2) EP4074322A1 (OSRAM)
JP (2) JP6931656B2 (OSRAM)
KR (1) KR102277789B1 (OSRAM)
CN (2) CN115569151A (OSRAM)
AU (1) AU2017232718B2 (OSRAM)
BE (1) BE1024781B1 (OSRAM)
CA (1) CA3017694C (OSRAM)
CY (1) CY1125513T1 (OSRAM)
DE (1) DE102017002458B4 (OSRAM)
DK (1) DK3219321T3 (OSRAM)
ES (2) ES2681774B1 (OSRAM)
FR (1) FR3048614B1 (OSRAM)
GB (2) GB201604304D0 (OSRAM)
HR (1) HRP20220539T1 (OSRAM)
HU (1) HUE058739T2 (OSRAM)
IL (2) IL261730B2 (OSRAM)
LT (1) LT3219321T (OSRAM)
MX (1) MX2018010699A (OSRAM)
NL (1) NL2018512B1 (OSRAM)
NO (1) NO345415B1 (OSRAM)
PL (1) PL3219321T3 (OSRAM)
RS (1) RS63163B1 (OSRAM)
RU (1) RU2742308C2 (OSRAM)
SG (2) SG10202008992YA (OSRAM)
SI (1) SI3219321T1 (OSRAM)
WO (1) WO2017158509A1 (OSRAM)

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US20220202868A1 (en) * 2019-02-27 2022-06-30 Tigenix S.A.U. Improved stem cell populations for allogeneic therapy
US20230172991A1 (en) * 2020-03-11 2023-06-08 Mesoblast International Sárl Method for treating inflammatory bowel disease i
KR20220152240A (ko) * 2020-03-11 2022-11-15 메조블라스트 인터내셔널 에스에이알엘 염증성 장 질환 ii의 치료 방법
CN111481573A (zh) * 2020-03-26 2020-08-04 卡替（上海）生物技术股份有限公司 牙髓间充质干细胞在制备克罗恩病治疗药物中的用途
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EP4531879A1 (en) * 2022-05-25 2025-04-09 Flagship Pioneering Innovations VI, LLC Compositions of secretory and/or catalytic cells and methods using the same

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Also Published As

Publication number Publication date
DE102017002458B4 (de) 2019-04-25
ES2681774B1 (es) 2019-12-26
IL261730B1 (en) 2024-01-01
RU2018131519A (ru) 2020-04-15
US10357518B2 (en) 2019-07-23
EP3219321B1 (en) 2022-03-30
GB201604304D0 (en) 2016-04-27
FR3048614A1 (OSRAM) 2017-09-15
JP2019508455A (ja) 2019-03-28
BR112018068493A2 (pt) 2019-01-22
PL3219321T3 (pl) 2022-05-30
GB201704065D0 (en) 2017-04-26
EP4074322A1 (en) 2022-10-19
DE102017002458A1 (de) 2017-09-14
ES2911718T3 (es) 2022-05-20
CN108883135B (zh) 2022-11-04
SG11201807404XA (en) 2018-09-27
BE1024781B1 (de) 2018-07-02
US20170258851A1 (en) 2017-09-14
RU2742308C2 (ru) 2021-02-04
RU2018131519A3 (OSRAM) 2020-07-10
KR102277789B1 (ko) 2021-07-15
GB2548490A (en) 2017-09-20
ES2681774A1 (es) 2018-09-14
AU2017232718A1 (en) 2018-10-04
LT3219321T (lt) 2022-05-10
CN108883135A (zh) 2018-11-23
CA3017694C (en) 2024-02-27
JP2021119789A (ja) 2021-08-19
WO2017158509A1 (en) 2017-09-21
AU2017232718B2 (en) 2024-01-18
FR3048614B1 (fr) 2020-02-21
MX2018010699A (es) 2019-01-14
HRP20220539T1 (hr) 2022-06-10
NO20170376A1 (en) 2017-09-15
CY1125513T1 (el) 2024-12-13
IL298107B1 (en) 2023-10-01
US20190381106A1 (en) 2019-12-19
CA3017694A1 (en) 2017-09-21
NO345415B1 (en) 2021-01-18
IL261730B2 (en) 2024-05-01
BE1024781A1 (de) 2018-06-27
NL2018512B1 (en) 2017-09-07
GB2548490B (en) 2020-09-02
EP3219321A1 (en) 2017-09-20
HUE058739T2 (hu) 2022-09-28
RS63163B1 (sr) 2022-05-31
SI3219321T1 (sl) 2022-05-31
US11273182B2 (en) 2022-03-15
US12213998B2 (en) 2025-02-04
BR112018068493A8 (pt) 2022-06-28
IL298107A (en) 2023-01-01
IL261730A (en) 2018-10-31
US20220249574A1 (en) 2022-08-11
NL2018512A (en) 2017-03-30
SG10202008992YA (en) 2020-10-29
JP6931656B2 (ja) 2021-09-08
DK3219321T3 (da) 2022-04-25
CN115569151A (zh) 2023-01-06
KR20180120261A (ko) 2018-11-05

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