IL263767B - Carbamoyl–oxymethyltriazole cyclohexyl acids as lpa antagonists - Google Patents
Carbamoyl–oxymethyltriazole cyclohexyl acids as lpa antagonistsInfo
- Publication number
- IL263767B IL263767B IL263767A IL26376718A IL263767B IL 263767 B IL263767 B IL 263767B IL 263767 A IL263767 A IL 263767A IL 26376718 A IL26376718 A IL 26376718A IL 263767 B IL263767 B IL 263767B
- Authority
- IL
- Israel
- Prior art keywords
- cyclohexyl acids
- lpa antagonists
- carbamoyloxymethyl
- triazole cyclohexyl
- carbamoyloxymethyl triazole
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
- C07C62/10—Saturated compounds containing ether groups, groups, groups, or groups with a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nutrition Science (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662352792P | 2016-06-21 | 2016-06-21 | |
| PCT/US2017/038216 WO2017223016A1 (en) | 2016-06-21 | 2017-06-20 | Carbamoyloxymethyl triazole cyclohexyl acids as lpa antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL263767A IL263767A (en) | 2019-01-31 |
| IL263767B true IL263767B (en) | 2021-08-31 |
Family
ID=59258388
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL263767A IL263767B (en) | 2016-06-21 | 2018-12-17 | Carbamoyl–oxymethyltriazole cyclohexyl acids as lpa antagonists |
Country Status (32)
| Country | Link |
|---|---|
| US (8) | US10071078B2 (OSRAM) |
| EP (2) | EP3666771B1 (OSRAM) |
| JP (2) | JP7073281B2 (OSRAM) |
| KR (2) | KR102463621B1 (OSRAM) |
| CN (2) | CN114601830A (OSRAM) |
| AR (1) | AR108838A1 (OSRAM) |
| AU (2) | AU2017281439B2 (OSRAM) |
| CA (1) | CA3029202C (OSRAM) |
| CL (1) | CL2018003708A1 (OSRAM) |
| CO (1) | CO2019000471A2 (OSRAM) |
| CY (2) | CY1123443T1 (OSRAM) |
| DK (2) | DK3666771T3 (OSRAM) |
| EA (1) | EA037585B1 (OSRAM) |
| ES (2) | ES2895385T3 (OSRAM) |
| HR (2) | HRP20200586T1 (OSRAM) |
| HU (2) | HUE049944T2 (OSRAM) |
| IL (1) | IL263767B (OSRAM) |
| LT (2) | LT3666771T (OSRAM) |
| ME (1) | ME03804B (OSRAM) |
| MX (1) | MX381205B (OSRAM) |
| MY (1) | MY195782A (OSRAM) |
| PE (1) | PE20190211A1 (OSRAM) |
| PL (2) | PL3666771T3 (OSRAM) |
| PT (2) | PT3472148T (OSRAM) |
| RS (2) | RS60347B1 (OSRAM) |
| SG (1) | SG11201811321TA (OSRAM) |
| SI (2) | SI3666771T1 (OSRAM) |
| SM (2) | SMT202100614T1 (OSRAM) |
| TW (2) | TWI725200B (OSRAM) |
| UY (1) | UY37302A (OSRAM) |
| WO (1) | WO2017223016A1 (OSRAM) |
| ZA (1) | ZA201808580B (OSRAM) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR108838A1 (es) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
| CN112189010A (zh) * | 2017-12-19 | 2021-01-05 | 百时美施贵宝公司 | 作为lpa拮抗剂的三唑n-连接的氨基甲酰基环己基酸 |
| US11319309B2 (en) | 2017-12-19 | 2022-05-03 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azines as LPA antagonists |
| WO2019126089A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Cyclohexyl acid pyrazole azines as lpa antagonists |
| EP3728242B1 (en) | 2017-12-19 | 2023-03-01 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azoles as lpa antagonists |
| JP7202383B2 (ja) * | 2017-12-19 | 2023-01-11 | ブリストル－マイヤーズ スクイブ カンパニー | Ｌｐａアンタゴニストとしてのピラゾールｏ－架橋カルバモイルシクロヘキシル酸 |
| EP3728240B1 (en) * | 2017-12-19 | 2022-06-29 | Bristol-Myers Squibb Company | Isoxazole o-linked carbamoyl cyclohexyl acids as lpa antagonists |
| JP7301840B2 (ja) | 2017-12-19 | 2023-07-03 | ブリストル－マイヤーズ スクイブ カンパニー | Ｌｐａアンタゴニストとしてのイソキサゾールｎ結合カルバモイルシクロヘキシル酸 |
| KR102726939B1 (ko) * | 2017-12-19 | 2024-11-05 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 피라졸 아졸 |
| KR102777148B1 (ko) * | 2017-12-19 | 2025-03-05 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 트리아졸 아진 |
| CN111699180B (zh) | 2017-12-19 | 2024-11-29 | 百时美施贵宝公司 | 作为lpa拮抗剂的吡唑n-连接的氨基甲酰基环己基酸 |
| CN111712492B (zh) * | 2017-12-19 | 2024-05-31 | 百时美施贵宝公司 | 作为lpa拮抗剂的环己基酸三唑唑类 |
| EP3853232B1 (en) * | 2018-09-18 | 2023-03-01 | Bristol-Myers Squibb Company | Oxabicyclo acids as lpa antagonists |
| KR20210061383A (ko) * | 2018-09-18 | 2021-05-27 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로펜틸 산 |
| CN112702998A (zh) * | 2018-09-18 | 2021-04-23 | 百时美施贵宝公司 | 作为lpa拮抗剂的环庚酸 |
| SG11202103731QA (en) * | 2018-10-15 | 2021-05-28 | Bristol Myers Squibb Co | Radioligands for imaging the lpa1 receptor |
| CN111434655A (zh) | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 溶血磷脂酸受体拮抗剂及其制备方法 |
| CN111434653A (zh) | 2019-01-15 | 2020-07-21 | 武汉朗来科技发展有限公司 | 三氮唑类化合物及其制备方法与用途 |
| JP7447143B2 (ja) * | 2019-04-16 | 2024-03-11 | ブリストル－マイヤーズ スクイブ カンパニー | カルバモイルオキシメチルトリアゾールシクロヘキシル酸の化合物の製造方法 |
| WO2020257138A1 (en) * | 2019-06-18 | 2020-12-24 | Bristol-Myers Squibb Company | Isoxazole carboxylic acids as lpa antagonists |
| WO2020257139A1 (en) | 2019-06-18 | 2020-12-24 | Bristol-Myers Squibb Company | Cyclobutyl carboxylic acids as lpa antagonists |
| CN114599648A (zh) | 2019-06-18 | 2022-06-07 | 百时美施贵宝公司 | 作为lpa拮抗剂的三唑羧酸 |
| CN114206832B (zh) | 2019-07-30 | 2025-04-04 | 大正制药株式会社 | 拮抗lpa1受体的脲化合物 |
| EP4058144A1 (en) | 2019-11-15 | 2022-09-21 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
| US20230014137A1 (en) * | 2019-11-29 | 2023-01-19 | Ono Pharmaceutical Co., Ltd. | Compound having lysophosphatidic acid receptor agonist activity and pharmaceutical use thereof |
| WO2021116259A1 (en) | 2019-12-12 | 2021-06-17 | Chiesi Farmaceutici S.P.A. | Aromatic amido derivatives as lpa receptor 2 inhibitors |
| CN114746425A (zh) | 2019-12-12 | 2022-07-12 | 奇斯药制品公司 | 作为lpa受体2抑制剂的噻吩并嘧啶衍生物 |
| US12404270B2 (en) | 2019-12-12 | 2025-09-02 | Chiesi Farmaceutici S.P.A. | Quinazoline derivatives as LPA receptor 2 inhibitors |
| CN111195254B (zh) * | 2020-02-25 | 2021-03-16 | 中国医学科学院阜外医院 | Lpa2及其激动剂的应用 |
| KR102393079B1 (ko) | 2020-02-28 | 2022-04-29 | 한국화학연구원 | 가축 호흡기 질환의 예방 또는 치료용 조성물 |
| AU2021282986B2 (en) | 2020-06-03 | 2024-03-07 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
| TWI838626B (zh) * | 2020-06-03 | 2024-04-11 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
| ES2991765T3 (es) | 2020-07-16 | 2024-12-04 | Chiesi Farm Spa | Derivados del ácido amido ciclohexano como inhibidores del receptor de LPA |
| CN116583501A (zh) * | 2020-10-22 | 2023-08-11 | 罗特斯生物公司 | 用于治疗与lpa受体活性相关的病症的化合物和组合物 |
| CN114456147B (zh) * | 2020-11-10 | 2025-07-15 | 武汉人福创新药物研发中心有限公司 | 氧取代氨基碳酸酯噻吩类化合物 |
| WO2022100625A1 (zh) * | 2020-11-10 | 2022-05-19 | 武汉人福创新药物研发中心有限公司 | 氮取代氨基碳酸酯噻吩类化合物及其用途 |
| CN114456159A (zh) * | 2020-11-10 | 2022-05-10 | 武汉人福创新药物研发中心有限公司 | 氮取代杂环噻吩类化合物及其用途 |
| CN114621135B (zh) * | 2020-12-11 | 2024-01-30 | 上海拓界生物医药科技有限公司 | 一种lpa1小分子拮抗剂 |
| CN112778187B (zh) * | 2021-01-06 | 2022-10-28 | 烟台舜康生物科技有限公司 | 一种海那替尼中间体的合成方法及所得的海纳替尼中间体 |
| WO2022174882A1 (en) | 2021-02-16 | 2022-08-25 | Chiesi Farmaceutici S.P.A. | 5-membered heterocyclyl carbamate derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors |
| WO2022174883A1 (en) | 2021-02-16 | 2022-08-25 | Chiesi Farmaceutici S.P.A. | 5-membered heterocyclyl derivatives as dual lpa receptor 1 and lpa receptor 2 inhibitors |
| US20240190860A1 (en) | 2021-03-24 | 2024-06-13 | Chiesi Farmaceutici S.P.A. | 8-cyclo-substituted quinazoline derivatives as lpa receptor 2 inhibitors |
| AU2022273631B2 (en) | 2021-05-11 | 2025-04-17 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
| KR20240007233A (ko) | 2021-05-13 | 2024-01-16 | 길리애드 사이언시즈, 인코포레이티드 | Lpa 수용체 길항제 및 이의 용도 |
| CN118055777A (zh) * | 2021-06-25 | 2024-05-17 | 公益财团法人癌研究会 | 抑制骨肉瘤和神经胶质瘤的转移和增殖的新型治疗药物 |
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