IL256377A - Diaryl chiral macrocycles as protein kinase modulators - Google Patents
Diaryl chiral macrocycles as protein kinase modulatorsInfo
- Publication number
- IL256377A IL256377A IL256377A IL25637717A IL256377A IL 256377 A IL256377 A IL 256377A IL 256377 A IL256377 A IL 256377A IL 25637717 A IL25637717 A IL 25637717A IL 256377 A IL256377 A IL 256377A
- Authority
- IL
- Israel
- Prior art keywords
- modulators
- protein kinases
- chiral diaryl
- macrocycles
- diaryl macrocycles
- Prior art date
Links
- 102000001253 Protein Kinase Human genes 0.000 title 1
- -1 diaryl macrocycles Chemical class 0.000 title 1
- 108060006633 protein kinase Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188043P | 2015-07-02 | 2015-07-02 | |
| US201662353728P | 2016-06-23 | 2016-06-23 | |
| PCT/US2016/040329 WO2017004342A1 (en) | 2015-07-02 | 2016-06-30 | Chiral diaryl macrocycles as modulators of protein kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL256377A true IL256377A (en) | 2018-02-28 |
Family
ID=57609146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL256377A IL256377A (en) | 2015-07-02 | 2017-12-18 | Diaryl chiral macrocycles as protein kinase modulators |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10316044B2 (https=) |
| EP (1) | EP3317285B1 (https=) |
| JP (1) | JP6871903B2 (https=) |
| KR (1) | KR102599788B1 (https=) |
| CN (1) | CN107735399B (https=) |
| AU (2) | AU2016287568B2 (https=) |
| CA (1) | CA2989327A1 (https=) |
| ES (1) | ES2864839T3 (https=) |
| IL (1) | IL256377A (https=) |
| MX (1) | MX2017017097A (https=) |
| RU (1) | RU2732405C2 (https=) |
| TW (1) | TW201716415A (https=) |
| WO (1) | WO2017004342A1 (https=) |
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| NZ604708A (en) | 2010-05-20 | 2015-05-29 | Array Biopharma Inc | Macrocyclic compounds as trk kinase inhibitors |
| PL3636649T3 (pl) | 2014-01-24 | 2024-05-06 | Turning Point Therapeutics, Inc. | Diaryle makrocykliczne jako modulatory kinaz białkowych |
| HUE061448T2 (hu) | 2014-11-16 | 2023-07-28 | Array Biopharma Inc | (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid-hidrogénszulfát kristályos formája |
| ES2864839T3 (es) | 2015-07-02 | 2021-10-14 | Turning Point Therapeutics Inc | Macrociclos de diarilo quirales como moduladores de proteína quinasas |
| JP6917974B2 (ja) * | 2015-07-06 | 2021-08-11 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ジアリール大環状多形 |
| FI3733187T3 (fi) * | 2015-07-21 | 2024-12-18 | Turning Point Therapeutics Inc | Kiraalinen diaryylimakrosykli ja sen käyttö syövän hoidossa |
| CN108697708A (zh) | 2015-10-26 | 2018-10-23 | 洛克索肿瘤学股份有限公司 | Trk抑制剂抗性癌症中的点突变以及与此相关的方法 |
| US10045991B2 (en) | 2016-04-04 | 2018-08-14 | Loxo Oncology, Inc. | Methods of treating pediatric cancers |
| ES2987474T3 (es) | 2016-04-04 | 2024-11-15 | Loxo Oncology Inc | Formulaciones líquidas de (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-IL)-pirazolo[1,5-A]pirimidin-3-IL)-3-hidroxipirrolidina-1-carboxamida |
| ES2836222T3 (es) | 2016-05-18 | 2021-06-24 | Loxo Oncology Inc | Preparación de (S)-N-(5-((R)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida |
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-
2016
- 2016-06-30 ES ES16818768T patent/ES2864839T3/es active Active
- 2016-06-30 RU RU2018103907A patent/RU2732405C2/ru active
- 2016-06-30 WO PCT/US2016/040329 patent/WO2017004342A1/en not_active Ceased
- 2016-06-30 JP JP2018500297A patent/JP6871903B2/ja active Active
- 2016-06-30 CA CA2989327A patent/CA2989327A1/en active Pending
- 2016-06-30 EP EP16818768.0A patent/EP3317285B1/en active Active
- 2016-06-30 US US15/740,462 patent/US10316044B2/en active Active
- 2016-06-30 MX MX2017017097A patent/MX2017017097A/es unknown
- 2016-06-30 CN CN201680038613.1A patent/CN107735399B/zh active Active
- 2016-06-30 AU AU2016287568A patent/AU2016287568B2/en not_active Ceased
- 2016-06-30 KR KR1020187002777A patent/KR102599788B1/ko active Active
- 2016-07-01 TW TW105121035A patent/TW201716415A/zh unknown
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2017
- 2017-12-18 IL IL256377A patent/IL256377A/en unknown
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2019
- 2019-05-29 US US16/425,407 patent/US11008337B2/en active Active
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2020
- 2020-08-11 AU AU2020217336A patent/AU2020217336A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3317285A4 (en) | 2019-02-27 |
| ES2864839T3 (es) | 2021-10-14 |
| JP6871903B2 (ja) | 2021-05-19 |
| KR20180023970A (ko) | 2018-03-07 |
| US10316044B2 (en) | 2019-06-11 |
| US20180186813A1 (en) | 2018-07-05 |
| TW201716415A (zh) | 2017-05-16 |
| JP2018519343A (ja) | 2018-07-19 |
| AU2016287568A1 (en) | 2018-01-04 |
| RU2732405C2 (ru) | 2020-09-16 |
| KR102599788B1 (ko) | 2023-11-07 |
| RU2018103907A3 (https=) | 2019-10-07 |
| AU2020217336A1 (en) | 2020-08-27 |
| US11008337B2 (en) | 2021-05-18 |
| CN107735399B (zh) | 2021-01-26 |
| AU2016287568B2 (en) | 2020-08-20 |
| WO2017004342A1 (en) | 2017-01-05 |
| EP3317285B1 (en) | 2021-01-27 |
| US20190284209A1 (en) | 2019-09-19 |
| EP3317285A1 (en) | 2018-05-09 |
| CA2989327A1 (en) | 2017-01-05 |
| CN107735399A (zh) | 2018-02-23 |
| RU2018103907A (ru) | 2019-08-05 |
| MX2017017097A (es) | 2018-05-23 |
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