IL252613B - Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells - Google Patents

Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Info

Publication number
IL252613B
IL252613B IL252613A IL25261317A IL252613B IL 252613 B IL252613 B IL 252613B IL 252613 A IL252613 A IL 252613A IL 25261317 A IL25261317 A IL 25261317A IL 252613 B IL252613 B IL 252613B
Authority
IL
Israel
Prior art keywords
lgr4
lgr5
development
methods
stem cells
Prior art date
Application number
IL252613A
Other languages
English (en)
Hebrew (he)
Other versions
IL252613A0 (en
Original Assignee
Polarityte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56078499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL252613(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polarityte Inc filed Critical Polarityte Inc
Publication of IL252613A0 publication Critical patent/IL252613A0/en
Publication of IL252613B publication Critical patent/IL252613B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
IL252613A 2014-12-02 2017-06-01 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells IL252613B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086526P 2014-12-02 2014-12-02
US14/954,335 US10926001B2 (en) 2014-12-02 2015-11-30 Methods related to minimally polarized functional units
PCT/US2015/063114 WO2016089825A1 (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Publications (2)

Publication Number Publication Date
IL252613A0 IL252613A0 (en) 2017-07-31
IL252613B true IL252613B (en) 2021-12-01

Family

ID=56078499

Family Applications (2)

Application Number Title Priority Date Filing Date
IL252613A IL252613B (en) 2014-12-02 2017-06-01 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells
IL287488A IL287488B2 (en) 2014-12-02 2021-10-21 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL287488A IL287488B2 (en) 2014-12-02 2021-10-21 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Country Status (21)

Country Link
US (7) US10926001B2 (enExample)
EP (2) EP3227431B1 (enExample)
JP (3) JP6791854B2 (enExample)
KR (5) KR20210043024A (enExample)
CN (1) CN107250348B (enExample)
AU (3) AU2015355187C1 (enExample)
BR (1) BR112017011808A2 (enExample)
CA (1) CA2969707C (enExample)
CO (1) CO2017006640A2 (enExample)
CR (1) CR20170296A (enExample)
EA (1) EA201791125A1 (enExample)
GB (2) GB2549872A (enExample)
HK (1) HK1250515A1 (enExample)
IL (2) IL252613B (enExample)
MX (2) MX2017007243A (enExample)
MY (1) MY184931A (enExample)
NZ (2) NZ755260A (enExample)
PH (1) PH12017501009B1 (enExample)
SG (2) SG10201914058QA (enExample)
WO (1) WO2016089825A1 (enExample)
ZA (1) ZA201703907B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3595440A2 (en) * 2017-03-14 2020-01-22 Juno Therapeutics, Inc. Methods for cryogenic storage
CR20200366A (es) * 2018-01-26 2020-10-05 Polarityte Inc Sustrato acelarante de biomaterial con interfaz compuesta
AU2019212976A1 (en) * 2018-01-26 2020-07-23 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (CLICSAM)
FR3082123B1 (fr) 2018-06-07 2020-10-16 Urgo Rech Innovation Et Developpement Pansement cellularise et son procede de fabrication
JP2024006681A (ja) * 2022-07-04 2024-01-17 学校法人近畿大学 生体材料
WO2025166131A1 (en) * 2024-02-01 2025-08-07 Board Of Regents, The University Of Texas System Compositions and methods for treating bone and muscle injuries

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010112678A1 (en) * 2009-04-01 2010-10-07 Helsingin Yliopisto Regenerative matrix comprising cells activated by nemosis and/or factors released from such cells
EP2412800A1 (en) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US20120196312A1 (en) * 2009-02-03 2012-08-02 Toshiro Sato Culture medium for epithelial stem cells and organoids comprising the stem cells

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040126881A1 (en) * 2002-09-06 2004-07-01 Vincent Ronfard Fibrin cell supports and methods of use thereof
WO2006008009A2 (en) 2004-07-23 2006-01-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with leucine-rich repeat-containing gpcr 6 (lgr6)
US20060154365A1 (en) 2004-08-30 2006-07-13 Anthony Ratcliffe Cultured three dimensional tissues and uses thereof
EP1942957B1 (en) * 2005-10-27 2012-07-11 Coloplast A/S Biodegradable scaffold with ecm material
WO2008008009A1 (en) 2006-07-13 2008-01-17 St. Jude Medical Ab Medical information management in a patient information hub system
US8366723B2 (en) 2006-08-03 2013-02-05 Rassman Licensing, Llc Hair harvesting device and method with localized subsurface dermal fluid insertion
US7998737B2 (en) 2006-09-12 2011-08-16 Deutsches Krebsforschungszentrum Cell culture of keratinocytes under non-differentiating conditions
GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
US20110076303A1 (en) 2009-06-25 2011-03-31 Tokuro Iwabuchi Methods for Screening for Anti-Graying Agents on the Basis of AFF-4
US20110130711A1 (en) 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
WO2012000180A1 (zh) 2010-06-30 2012-01-05 Chen Jinxi 一种皮肤组织细胞聚合物的制备方法及其用途
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
EP2771454B1 (en) 2011-10-27 2019-07-24 Universität Leipzig Method for deriving melanocytes from the hair follicle outer root sheath and preparation for grafting
JP6186997B2 (ja) 2012-08-07 2017-08-30 日油株式会社 塗布型帯電防止剤
US9655930B2 (en) 2012-10-01 2017-05-23 Aderans Research Institute, Inc. Compositions and methods for producing reconstituted skin
US20140106447A1 (en) 2012-10-12 2014-04-17 Mimedx Group, Inc. Compositions and methods for recruiting stem cells
CA3184040A1 (en) 2013-03-14 2014-10-02 The Brigham And Women's Hospital, Inc. Compositions and methods for epithelial stem cell expansion comprising a wnt agonist and a histone deacetylase inhibitor
US9592257B2 (en) 2013-10-11 2017-03-14 MWV Cell, LLC Complete human skin organ generated from culture-expanded cells
CN103550828B (zh) * 2013-10-17 2016-01-27 中国科学院动物研究所 一种基于毛囊干细胞和硅凝胶敷料的皮肤重建方法
TWI548413B (zh) 2014-11-07 2016-09-11 國立臺灣大學 誘導毛囊新生的皮膚萃取物、組合物及其用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120196312A1 (en) * 2009-02-03 2012-08-02 Toshiro Sato Culture medium for epithelial stem cells and organoids comprising the stem cells
WO2010112678A1 (en) * 2009-04-01 2010-10-07 Helsingin Yliopisto Regenerative matrix comprising cells activated by nemosis and/or factors released from such cells
EP2412800A1 (en) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them

Also Published As

Publication number Publication date
AU2019240603A1 (en) 2019-10-17
IL287488A (en) 2021-12-01
MX2023001655A (es) 2023-04-24
ZA201703907B (en) 2023-03-29
CO2017006640A2 (es) 2017-11-21
CR20170296A (es) 2018-01-25
EP3227431A4 (en) 2019-01-02
JP6791854B2 (ja) 2020-11-25
AU2023202857A1 (en) 2023-05-25
US10926001B2 (en) 2021-02-23
AU2015355187B2 (en) 2019-10-03
EP4438128A2 (en) 2024-10-02
CA2969707A1 (en) 2016-06-09
IL252613A0 (en) 2017-07-31
GB201902819D0 (en) 2019-04-17
NZ733433A (en) 2019-08-30
US20220241464A1 (en) 2022-08-04
US20180154043A1 (en) 2018-06-07
MX2017007243A (es) 2018-01-25
GB201710646D0 (en) 2017-08-16
KR20180136588A (ko) 2018-12-24
AU2015355187C1 (en) 2020-02-20
US20190046691A1 (en) 2019-02-14
AU2015355187A1 (en) 2017-06-29
SG10201914058QA (en) 2020-03-30
US11596714B2 (en) 2023-03-07
KR20210043024A (ko) 2021-04-20
SG11201704502RA (en) 2017-06-29
GB2569056B (en) 2020-01-01
CN107250348A (zh) 2017-10-13
EP4438128A3 (en) 2024-11-13
US12465669B2 (en) 2025-11-11
WO2016089825A1 (en) 2016-06-09
CA2969707C (en) 2019-08-20
US20160151540A1 (en) 2016-06-02
US11266765B2 (en) 2022-03-08
EP3227431A1 (en) 2017-10-11
KR20190111167A (ko) 2019-10-01
EP3227431C0 (en) 2025-01-29
PH12017501009B1 (en) 2022-01-21
JP2020182880A (ja) 2020-11-12
US20230181797A1 (en) 2023-06-15
IL287488B2 (en) 2023-06-01
EA201791125A1 (ru) 2018-06-29
AU2019240603B2 (en) 2023-02-09
MY184931A (en) 2021-04-30
HK1245327A1 (zh) 2018-08-24
US20210322643A1 (en) 2021-10-21
HK1250515A1 (zh) 2018-12-21
US11000629B2 (en) 2021-05-11
KR20170098844A (ko) 2017-08-30
NZ755260A (en) 2021-12-24
US20180154044A1 (en) 2018-06-07
GB2549872A (en) 2017-11-01
JP2017538411A (ja) 2017-12-28
GB2569056A (en) 2019-06-05
BR112017011808A2 (pt) 2018-02-27
CN107250348B (zh) 2021-09-03
JP2019088299A (ja) 2019-06-13
EP3227431B1 (en) 2025-01-29
PH12017501009A1 (en) 2017-12-11
US11338060B2 (en) 2022-05-24
KR20180136587A (ko) 2018-12-24

Similar Documents

Publication Publication Date Title
IL287488A (en) Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells
EP3171445A4 (en) Non-aqueous electrolyte solution and electricity storage device in which same is used
PL3261166T3 (pl) Elektrolit do niewodnego ogniwa elektrolitowego i ogniwo z niewodnym elektrolitem, w którym jest on stosowany
EP3129465A4 (en) Hydrogel compositions for use in cell expansion and differentiation
EP3333962A4 (en) Non-aqueous electrolyte solution and non-aqueous electrolyte battery in which same is used
HUE045872T2 (hu) Sejteket penetráló peptidek és ezek elõállítására és alkalmazására szolgáló eljárások
EP3723180A4 (en) &XC9; LECTROLYTIC SOLUTION FOR BATTERY &XC0; &XC9; NON AQUEOUS LECTROLYTE, AND BATTERY &XC0; &XC9; NON-AQUEOUS LECTROLYTE ENABLING &X152; UVRE THIS ONE
EP3070163A4 (en) Method for preparing induced pluripotent stem cell, composition used in method, and uses thereof
EP3151326A4 (en) Nonaqueous electrolyte and electricity-storing device in which same is used
EP3091603A4 (en) Electrolytic solution and electrochemical device
EP3569697B8 (en) Stem cell therapy in endometrial pathologies
EP3107996A4 (en) Tscm cells and methods for use
SG11201702377QA (en) Blood sample management using open cell foam
EP3094956A4 (en) Preparation of cells, cell aggregates, and tissue fragments
EP3125352A4 (en) Electrolyte and electrochemical device
EP3212213A4 (en) Methods and compositions using gdf15 polypeptides for increasing red blood cells
SG11201606297UA (en) Blood sample management using open cell foam
IL269252A (en) Expression constructs and methods for expressing polypeptides in eukaryotic cells
EP3401975A4 (en) SEALANT FOR ELECTROCHEMICAL DEVICE USING A WATER-FREE ELECTROLYTIC SOLUTION AND SEALANT COMPOSITION FOR ELECTROCHEMICAL DEVICE
EP3188203A4 (en) Electrolyte solution and electrochemical device
PL3195397T3 (pl) Membrana elektrolitowa do zastosowania w ogniwie elektrochemicznym
EP3203835A4 (en) Method and composition for hypothermic storage of placental tissue
EP3152297A4 (en) Use of anti-aging glycopeptides to enhance pancreatic cell health, survival and improve transplant outcome
PL3126546T3 (pl) Ogniwo elektrochemiczne do elektrolizy wody w postaci cieczy lub pary, sposób wytwarzania i zastosowania
EP2970883B8 (en) Enhanced placental stem cells and uses thereof