IL252613B - Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells - Google Patents

Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

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Publication number
IL252613B
IL252613B IL252613A IL25261317A IL252613B IL 252613 B IL252613 B IL 252613B IL 252613 A IL252613 A IL 252613A IL 25261317 A IL25261317 A IL 25261317A IL 252613 B IL252613 B IL 252613B
Authority
IL
Israel
Prior art keywords
lgr4
lgr5
development
methods
stem cells
Prior art date
Application number
IL252613A
Other languages
English (en)
Hebrew (he)
Other versions
IL252613A0 (en
Original Assignee
Polarityte Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56078499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL252613(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polarityte Inc filed Critical Polarityte Inc
Publication of IL252613A0 publication Critical patent/IL252613A0/en
Publication of IL252613B publication Critical patent/IL252613B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
IL252613A 2014-12-02 2017-06-01 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells IL252613B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086526P 2014-12-02 2014-12-02
US14/954,335 US10926001B2 (en) 2014-12-02 2015-11-30 Methods related to minimally polarized functional units
PCT/US2015/063114 WO2016089825A1 (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Publications (2)

Publication Number Publication Date
IL252613A0 IL252613A0 (en) 2017-07-31
IL252613B true IL252613B (en) 2021-12-01

Family

ID=56078499

Family Applications (2)

Application Number Title Priority Date Filing Date
IL252613A IL252613B (en) 2014-12-02 2017-06-01 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells
IL287488A IL287488B2 (en) 2014-12-02 2021-10-21 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL287488A IL287488B2 (en) 2014-12-02 2021-10-21 Methods for the development and use of minimally polarized microaggregate cell units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Country Status (21)

Country Link
US (7) US10926001B2 (enExample)
EP (2) EP3227431B1 (enExample)
JP (3) JP6791854B2 (enExample)
KR (5) KR20180136588A (enExample)
CN (1) CN107250348B (enExample)
AU (3) AU2015355187C1 (enExample)
BR (1) BR112017011808A2 (enExample)
CA (1) CA2969707C (enExample)
CO (1) CO2017006640A2 (enExample)
CR (1) CR20170296A (enExample)
EA (1) EA201791125A1 (enExample)
GB (2) GB2569056B (enExample)
HK (1) HK1250515A1 (enExample)
IL (2) IL252613B (enExample)
MX (2) MX2017007243A (enExample)
MY (1) MY184931A (enExample)
NZ (2) NZ733433A (enExample)
PH (1) PH12017501009B1 (enExample)
SG (2) SG11201704502RA (enExample)
WO (1) WO2016089825A1 (enExample)
ZA (1) ZA201703907B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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BR112019019005A2 (pt) * 2017-03-14 2020-04-14 Sara Elizabeth Church métodos para armazenagem criogênica
EP3743125A4 (en) * 2018-01-26 2022-03-02 Polarityte, Inc. BIOMATERIAL ACCELERATING SUBSTRATE WITH COMPOSITE INTERFACE
EP3743080A4 (en) * 2018-01-26 2021-10-27 Polarityte, Inc. SELF-ASSEMBLY MATERIALS COORDINATED WITH A COMPLEX LIVING INTERFACE (CLICSAM)
FR3082123B1 (fr) 2018-06-07 2020-10-16 Urgo Rech Innovation Et Developpement Pansement cellularise et son procede de fabrication
JP2024006681A (ja) * 2022-07-04 2024-01-17 学校法人近畿大学 生体材料
WO2025166131A1 (en) * 2024-02-01 2025-08-07 Board Of Regents, The University Of Texas System Compositions and methods for treating bone and muscle injuries

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WO2010112678A1 (en) * 2009-04-01 2010-10-07 Helsingin Yliopisto Regenerative matrix comprising cells activated by nemosis and/or factors released from such cells
EP2412800A1 (en) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US20120196312A1 (en) * 2009-02-03 2012-08-02 Toshiro Sato Culture medium for epithelial stem cells and organoids comprising the stem cells

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WO2006008009A2 (en) 2004-07-23 2006-01-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with leucine-rich repeat-containing gpcr 6 (lgr6)
WO2006026617A2 (en) 2004-08-30 2006-03-09 Iken Tissue Therapeutics, Inc. Compositions and methods of promoting hair growth
EP1942957B1 (en) * 2005-10-27 2012-07-11 Coloplast A/S Biodegradable scaffold with ecm material
EP2043731A4 (en) 2006-07-13 2010-07-21 St Jude Medical MEDICAL INFORMATION MANAGEMENT IN A PATIENT INFORMATION HUD SYSTEM
US8366723B2 (en) 2006-08-03 2013-02-05 Rassman Licensing, Llc Hair harvesting device and method with localized subsurface dermal fluid insertion
WO2008031767A1 (en) 2006-09-12 2008-03-20 Dkfz Deutsches Krebsforschungszentrum, Stiftung Des Öffentlichen Rechts Cell culture of keratinocytes under non-differentiating conditions
GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
CN102498221A (zh) 2009-06-25 2012-06-13 株式会社资生堂 基于aff-4表达筛选抗白发剂的方法
US20110130711A1 (en) 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
JP6023049B2 (ja) 2010-06-30 2016-11-09 チェン，ジンシー 皮膚組織細胞の集合体の製造方法及びその用途
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US20120196312A1 (en) * 2009-02-03 2012-08-02 Toshiro Sato Culture medium for epithelial stem cells and organoids comprising the stem cells
WO2010112678A1 (en) * 2009-04-01 2010-10-07 Helsingin Yliopisto Regenerative matrix comprising cells activated by nemosis and/or factors released from such cells
EP2412800A1 (en) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them

Also Published As

Publication number Publication date
JP6791854B2 (ja) 2020-11-25
BR112017011808A2 (pt) 2018-02-27
GB201902819D0 (en) 2019-04-17
EP3227431C0 (en) 2025-01-29
JP2017538411A (ja) 2017-12-28
KR20210043024A (ko) 2021-04-20
US12465669B2 (en) 2025-11-11
US20180154043A1 (en) 2018-06-07
HK1245327A1 (zh) 2018-08-24
JP2019088299A (ja) 2019-06-13
US11596714B2 (en) 2023-03-07
JP2020182880A (ja) 2020-11-12
HK1250515A1 (zh) 2018-12-21
MY184931A (en) 2021-04-30
US20190046691A1 (en) 2019-02-14
US20220241464A1 (en) 2022-08-04
NZ733433A (en) 2019-08-30
US20230181797A1 (en) 2023-06-15
US20210322643A1 (en) 2021-10-21
EP3227431B1 (en) 2025-01-29
KR20180136588A (ko) 2018-12-24
PH12017501009B1 (en) 2022-01-21
US11338060B2 (en) 2022-05-24
CO2017006640A2 (es) 2017-11-21
IL287488A (en) 2021-12-01
EP3227431A1 (en) 2017-10-11
AU2019240603A1 (en) 2019-10-17
AU2023202857A1 (en) 2023-05-25
US10926001B2 (en) 2021-02-23
NZ755260A (en) 2021-12-24
PH12017501009A1 (en) 2017-12-11
IL287488B2 (en) 2023-06-01
AU2015355187A1 (en) 2017-06-29
CN107250348A (zh) 2017-10-13
GB2569056B (en) 2020-01-01
ZA201703907B (en) 2023-03-29
CA2969707A1 (en) 2016-06-09
CN107250348B (zh) 2021-09-03
CR20170296A (es) 2018-01-25
WO2016089825A1 (en) 2016-06-09
AU2015355187B2 (en) 2019-10-03
US20160151540A1 (en) 2016-06-02
GB2549872A (en) 2017-11-01
GB2569056A (en) 2019-06-05
KR20170098844A (ko) 2017-08-30
GB201710646D0 (en) 2017-08-16
IL252613A0 (en) 2017-07-31
KR20180136587A (ko) 2018-12-24
AU2015355187C1 (en) 2020-02-20
SG11201704502RA (en) 2017-06-29
AU2019240603B2 (en) 2023-02-09
US11000629B2 (en) 2021-05-11
MX2017007243A (es) 2018-01-25
US20180154044A1 (en) 2018-06-07
EA201791125A1 (ru) 2018-06-29
EP4438128A3 (en) 2024-11-13
US11266765B2 (en) 2022-03-08
EP3227431A4 (en) 2019-01-02
EP4438128A2 (en) 2024-10-02
SG10201914058QA (en) 2020-03-30
KR20190111167A (ko) 2019-10-01
MX2023001655A (es) 2023-04-24
CA2969707C (en) 2019-08-20

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