GB201902819D0 - Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6 - Google Patents

Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6

Info

Publication number
GB201902819D0
GB201902819D0 GBGB1902819.0A GB201902819A GB201902819D0 GB 201902819 D0 GB201902819 D0 GB 201902819D0 GB 201902819 A GB201902819 A GB 201902819A GB 201902819 D0 GB201902819 D0 GB 201902819D0
Authority
GB
United Kingdom
Prior art keywords
lgr4
lgr6
lgr5
development
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB1902819.0A
Other versions
GB2569056A (en
GB2569056B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RegenETP Inc
Original Assignee
PolarityTE Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56078499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB201902819(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by PolarityTE Inc filed Critical PolarityTE Inc
Publication of GB201902819D0 publication Critical patent/GB201902819D0/en
Publication of GB2569056A publication Critical patent/GB2569056A/en
Application granted granted Critical
Publication of GB2569056B publication Critical patent/GB2569056B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
GB201902819A 2014-12-02 2015-12-01 Methods for development and use of minimally polarized functional units in tissue applications using LGR4, LGR5 and LGR6 expressing epithelial stem cells Active GB2569056B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462086526P 2014-12-02 2014-12-02
US14/954,335 US10926001B2 (en) 2014-12-02 2015-11-30 Methods related to minimally polarized functional units
GB1710646.9A GB2549872A (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6

Publications (3)

Publication Number Publication Date
GB201902819D0 true GB201902819D0 (en) 2019-04-17
GB2569056A GB2569056A (en) 2019-06-05
GB2569056B GB2569056B (en) 2020-01-01

Family

ID=56078499

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1710646.9A Withdrawn GB2549872A (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6
GB201902819A Active GB2569056B (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized functional units in tissue applications using LGR4, LGR5 and LGR6 expressing epithelial stem cells

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1710646.9A Withdrawn GB2549872A (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using LGR4, LGR5 and LGR6

Country Status (21)

Country Link
US (7) US10926001B2 (en)
EP (1) EP3227431A4 (en)
JP (3) JP6791854B2 (en)
KR (5) KR20180136587A (en)
CN (1) CN107250348B (en)
AU (3) AU2015355187C1 (en)
BR (1) BR112017011808A2 (en)
CA (1) CA2969707C (en)
CO (1) CO2017006640A2 (en)
CR (1) CR20170296A (en)
EA (1) EA201791125A1 (en)
GB (2) GB2549872A (en)
HK (2) HK1250515A1 (en)
IL (2) IL252613B (en)
MX (2) MX2017007243A (en)
MY (1) MY184931A (en)
NZ (2) NZ755260A (en)
PH (1) PH12017501009A1 (en)
SG (2) SG10201914058QA (en)
WO (1) WO2016089825A1 (en)
ZA (1) ZA201703907B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021511936A (en) * 2018-01-26 2021-05-13 ポラリティー・ティー・イー・インコーポレーテッド Mixed Interfacial Connection Biomaterial Accelerator Substrate
CA3088130A1 (en) * 2018-01-26 2019-08-01 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (clicsam)
FR3082123B1 (en) 2018-06-07 2020-10-16 Urgo Rech Innovation Et Developpement CELLULARIZED DRESSING AND ITS MANUFACTURING PROCESS

Family Cites Families (23)

* Cited by examiner, † Cited by third party
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US20040126881A1 (en) * 2002-09-06 2004-07-01 Vincent Ronfard Fibrin cell supports and methods of use thereof
WO2006008009A2 (en) 2004-07-23 2006-01-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with leucine-rich repeat-containing gpcr 6 (lgr6)
US20060115460A1 (en) 2004-08-30 2006-06-01 Naughton Gail K Compositions and methods comprising WNT proteins to promote repair of damaged tissue
WO2007048831A2 (en) * 2005-10-27 2007-05-03 Coloplast A/S Biodegradable scaffold with ecm material
US20100328320A1 (en) 2006-07-13 2010-12-30 Kerstna Juergen Medical information management in a patient information hub system
US8366723B2 (en) 2006-08-03 2013-02-05 Rassman Licensing, Llc Hair harvesting device and method with localized subsurface dermal fluid insertion
EP2066787A1 (en) 2006-09-12 2009-06-10 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Cell culture of keratinocytes under non-differentiating conditions
GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
EP2412800A1 (en) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Liver organoid, uses thereof and culture method for obtaining them
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
FI20095355A0 (en) 2009-04-01 2009-04-01 Helsingin Yliopisto Regenerative active matrix and its uses
KR20120047864A (en) 2009-06-25 2012-05-14 더 제너럴 하스피톨 코포레이션 Methods for screening for anti-graying agents on the basis of aff-4 expression
US20110130711A1 (en) 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
JP6023049B2 (en) 2010-06-30 2016-11-09 チェン，ジンシー Method for producing aggregate of skin tissue cells and use thereof
GB201106395D0 (en) 2011-04-14 2011-06-01 Hubrecht Inst Compounds
KR102025636B1 (en) 2011-10-27 2019-11-04 우니베르지태트 라이치히 Method for deriving Melanocytes from the hair follicle outer root sheath and preparation for grafting
JP6186997B2 (en) 2012-08-07 2017-08-30 日油株式会社 Coating type antistatic agent
US9655930B2 (en) 2012-10-01 2017-05-23 Aderans Research Institute, Inc. Compositions and methods for producing reconstituted skin
US20140106447A1 (en) 2012-10-12 2014-04-17 Mimedx Group, Inc. Compositions and methods for recruiting stem cells
DK3702443T3 (en) 2013-03-14 2022-04-04 Brigham & Womens Hospital Inc COMPOSITIONS AND METHODS FOR THE PRODUCTION AND CULTIVATION OF EPITELIAL STEM CELLS
US9592257B2 (en) 2013-10-11 2017-03-14 MWV Cell, LLC Complete human skin organ generated from culture-expanded cells
CN103550828B (en) * 2013-10-17 2016-01-27 中国科学院动物研究所 A kind of skin renewal method based on hair follicle stem cells and Silica hydrogel dressing
TWI548413B (en) 2014-11-07 2016-09-11 國立臺灣大學 Skin extract and composition for inducing hair follicle neogenesis and applications thereof

Also Published As

Publication number Publication date
US11596714B2 (en) 2023-03-07
WO2016089825A1 (en) 2016-06-09
KR20190111167A (en) 2019-10-01
AU2019240603A1 (en) 2019-10-17
US20230181797A1 (en) 2023-06-15
MX2023001655A (en) 2023-04-24
CA2969707A1 (en) 2016-06-09
IL252613A0 (en) 2017-07-31
EA201791125A1 (en) 2018-06-29
US10926001B2 (en) 2021-02-23
CO2017006640A2 (en) 2017-11-21
JP2017538411A (en) 2017-12-28
US20180154043A1 (en) 2018-06-07
JP6791854B2 (en) 2020-11-25
MX2017007243A (en) 2018-01-25
IL287488A (en) 2021-12-01
AU2019240603B2 (en) 2023-02-09
KR20180136588A (en) 2018-12-24
GB201710646D0 (en) 2017-08-16
PH12017501009B1 (en) 2017-12-11
PH12017501009A1 (en) 2017-12-11
GB2549872A (en) 2017-11-01
GB2569056A (en) 2019-06-05
US11338060B2 (en) 2022-05-24
SG10201914058QA (en) 2020-03-30
US11266765B2 (en) 2022-03-08
MY184931A (en) 2021-04-30
CN107250348B (en) 2021-09-03
CA2969707C (en) 2019-08-20
GB2569056B (en) 2020-01-01
US20210322643A1 (en) 2021-10-21
JP2020182880A (en) 2020-11-12
US11000629B2 (en) 2021-05-11
HK1250515A1 (en) 2018-12-21
AU2015355187A1 (en) 2017-06-29
KR20180136587A (en) 2018-12-24
US20180154044A1 (en) 2018-06-07
NZ755260A (en) 2021-12-24
IL252613B (en) 2021-12-01
CR20170296A (en) 2018-01-25
KR20210043024A (en) 2021-04-20
US20160151540A1 (en) 2016-06-02
EP3227431A1 (en) 2017-10-11
CN107250348A (en) 2017-10-13
BR112017011808A2 (en) 2018-02-27
US20220241464A1 (en) 2022-08-04
AU2023202857A1 (en) 2023-05-25
KR20170098844A (en) 2017-08-30
JP2019088299A (en) 2019-06-13
NZ733433A (en) 2019-08-30
IL287488B2 (en) 2023-06-01
US20190046691A1 (en) 2019-02-14
AU2015355187B2 (en) 2019-10-03
AU2015355187C1 (en) 2020-02-20
HK1245327A1 (en) 2018-08-24
ZA201703907B (en) 2023-03-29
EP3227431A4 (en) 2019-01-02
SG11201704502RA (en) 2017-06-29

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