HK1223628A1 - The use of novel 7-ketone-6-alkylcholanic acid derivative in preparation of obeticholic acid, and the use thereof in medical field 7--6- - Google Patents

The use of novel 7-ketone-6-alkylcholanic acid derivative in preparation of obeticholic acid, and the use thereof in medical field 7--6-

Info

Publication number
HK1223628A1
HK1223628A1 HK16111868.8A HK16111868A HK1223628A1 HK 1223628 A1 HK1223628 A1 HK 1223628A1 HK 16111868 A HK16111868 A HK 16111868A HK 1223628 A1 HK1223628 A1 HK 1223628A1
Authority
HK
Hong Kong
Prior art keywords
alkylcholanic
ketone
novel
preparation
acid
Prior art date
Application number
HK16111868.8A
Other languages
Chinese (zh)
Inventor
程興棟張愛明張喜全楊玉雷朱雪焱袁哲東夏春光
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of HK1223628A1 publication Critical patent/HK1223628A1/en

Links

HK16111868.8A 2014-11-17 2016-10-14 The use of novel 7-ketone-6-alkylcholanic acid derivative in preparation of obeticholic acid, and the use thereof in medical field 7--6- HK1223628A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410652460.2A CN105669811B (en) 2014-11-17 2014-11-17 New 7-keto-6 beta-alkyl cholanic acid derivative in preparation of obeticholic acid and application thereof in medical field

Publications (1)

Publication Number Publication Date
HK1223628A1 true HK1223628A1 (en) 2017-08-04

Family

ID=56944525

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16111868.8A HK1223628A1 (en) 2014-11-17 2016-10-14 The use of novel 7-ketone-6-alkylcholanic acid derivative in preparation of obeticholic acid, and the use thereof in medical field 7--6-

Country Status (2)

Country Link
CN (2) CN111944006B (en)
HK (1) HK1223628A1 (en)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
KR102681304B1 (en) 2015-03-31 2024-07-03 이난타 파마슈티칼스, 인코포레이티드 Bile acid derivatives as FXR/TGR5 agonists and methods of using the same
CN106589039B (en) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 preparation method of obeticholic acid and related compound
EP3464316A4 (en) * 2016-06-01 2020-02-19 Dr. Reddy's Laboratories Ltd. Process for preparation of obeticholic acid
CA3027761A1 (en) * 2016-07-13 2018-01-18 Jiangsu Hengrui Medicine Co., Ltd. Method for manufacturing obeticholic acid and intermediate thereof
CN106279336A (en) * 2016-08-18 2017-01-04 合肥诺瑞吉医药科技有限公司 A kind of synthetic method of shellfish cholic acid difficult to understand
CN107936078A (en) * 2016-10-13 2018-04-20 上海科胜药物研发有限公司 A kind of new method for preparing shellfish cholic acid difficult to understand
CA3045023A1 (en) * 2016-11-29 2018-06-07 Enanta Pharmaceuticals, Inc. Process for preparation of sulfonylurea bile acid derivatives
CN108614038B (en) * 2016-12-13 2022-05-17 亚宝药业集团股份有限公司 Method for determining related substances of obeticholic acid raw material medicine
CN106749472B (en) * 2016-12-30 2019-02-22 江苏开元医药化工有限公司 A kind of -6 α of 3 Alpha-hydroxy--5 β of ethyl -7- ketone-cholane -24- acid preparation method
CN106645497A (en) * 2017-01-03 2017-05-10 山东省药学科学院 Obeticholic acid and detection method for related substances in preparation of obeticholic acid
CN108456238A (en) * 2017-02-20 2018-08-28 浙江京新药业股份有限公司 The preparation method of shellfish chlolic acid derivatives difficult to understand and shellfish cholic acid difficult to understand
EP3606533B1 (en) * 2017-04-07 2023-11-15 Enanta Pharmaceuticals, Inc. Process for preparation of sulfonyl carbamate bile acid derivatives
WO2018220513A1 (en) * 2017-05-31 2018-12-06 Alembic Pharmaceuticals Limited An improved process for preparation of obeticholic acid
CZ201869A3 (en) * 2018-02-12 2019-09-04 Farmak, A.S. Process for preparing obeticholic acid
CN108680696B (en) * 2018-05-15 2020-06-30 南京正大天晴制药有限公司 Detection method of obeticholic acid starting material
CN116178473A (en) * 2018-12-10 2023-05-30 江西青峰药业有限公司 Preparation method of obeticholic acid
CN109485686B (en) * 2018-12-27 2021-08-27 重庆华邦胜凯制药有限公司 Method for improving content of key intermediate 6 beta in methylprednisolone succinate impurity synthesis
CN109655571B (en) * 2019-01-08 2021-07-13 丽珠集团新北江制药股份有限公司 High performance liquid chromatography analysis method of obeticholic acid
CN111718388A (en) * 2019-03-19 2020-09-29 苏州泽璟生物制药股份有限公司 Preparation method of chenodeoxycholic acid derivative
CN112898369B (en) * 2019-12-04 2024-09-17 博瑞生物医药（苏州）股份有限公司 Method for preparing obeticholic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60205891T2 (en) * 2001-03-12 2006-06-22 Intercept Pharmaceuticals, Inc. STEROIDS AS AGONISTS FOR FXR
ITMI20050912A1 (en) * 2005-05-19 2006-11-20 Erregierre Spa PROCESS OF PREPARATION OF ACIDS 3-A-YA (B) -DIDROSSI-6-A (B) -ALCHIL-5B-COLANICI
US20140206657A1 (en) * 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists
CN104876995B (en) * 2014-02-27 2016-09-07 人福医药集团股份公司 The preparation method of chenodeoxycholic acid derivatives
WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
SI3149019T1 (en) * 2014-05-29 2020-03-31 Bar Pharmaceuticals S.R.L. Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases

Also Published As

Publication number Publication date
CN105669811B (en) 2020-09-04
CN111944006A (en) 2020-11-17
CN105669811A (en) 2016-06-15
CN111944006B (en) 2021-12-17

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