HK1223628A1 - β- 新的 -酮- β-烷基膽烷酸衍生物在製備奧貝膽酸以及其在醫藥領域的用途 - Google Patents

β- 新的 -酮- β-烷基膽烷酸衍生物在製備奧貝膽酸以及其在醫藥領域的用途

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Publication number
HK1223628A1
HK1223628A1 HK16111868.8A HK16111868A HK1223628A1 HK 1223628 A1 HK1223628 A1 HK 1223628A1 HK 16111868 A HK16111868 A HK 16111868A HK 1223628 A1 HK1223628 A1 HK 1223628A1
Authority
HK
Hong Kong
Prior art keywords
alkylcholanic
ketone
novel
preparation
acid
Prior art date
Application number
HK16111868.8A
Other languages
English (en)
Inventor
程興棟張愛明張喜全楊玉雷朱雪焱袁哲東夏春光
Original Assignee
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chia Tai Tianqing Pharmaceutical Group Co Ltd filed Critical Chia Tai Tianqing Pharmaceutical Group Co Ltd
Publication of HK1223628A1 publication Critical patent/HK1223628A1/zh

Links

HK16111868.8A 2014-11-17 2016-10-14 β- 新的 -酮- β-烷基膽烷酸衍生物在製備奧貝膽酸以及其在醫藥領域的用途 HK1223628A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410652460.2A CN105669811B (zh) 2014-11-17 2014-11-17 新的7-酮-6β-烷基胆烷酸衍生物在制备奥贝胆酸以及其在医药领域的用途

Publications (1)

Publication Number Publication Date
HK1223628A1 true HK1223628A1 (zh) 2017-08-04

Family

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Country Status (2)

Country Link
CN (2) CN105669811B (zh)
HK (1) HK1223628A1 (zh)

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US10208081B2 (en) 2014-11-26 2019-02-19 Enanta Pharmaceuticals, Inc. Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof
SG10201910670RA (en) 2015-03-31 2020-01-30 Enanta Pharm Inc Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof
CN106589039B (zh) * 2015-10-15 2019-12-17 苏州朗科生物技术股份有限公司 一种奥贝胆酸的制备方法及相关化合物
WO2017208165A1 (en) * 2016-06-01 2017-12-07 Dr. Reddy’S Laboratories Limited Process for preparation of obeticholic acid
WO2018010651A1 (zh) * 2016-07-13 2018-01-18 江苏恒瑞医药股份有限公司 一种奥贝胆酸及其中间体的制备方法
CN106279336A (zh) * 2016-08-18 2017-01-04 合肥诺瑞吉医药科技有限公司 一种奥贝胆酸的合成方法
CN107936078A (zh) * 2016-10-13 2018-04-20 上海科胜药物研发有限公司 一种制备奥贝胆酸的新方法
CN110121347A (zh) * 2016-11-29 2019-08-13 英安塔制药有限公司 制备磺酰脲胆汁酸衍生物的方法
CN108614038B (zh) * 2016-12-13 2022-05-17 亚宝药业集团股份有限公司 一种测定奥贝胆酸原料药有关物质的方法
CN106749472B (zh) * 2016-12-30 2019-02-22 江苏开元医药化工有限公司 一种3α-羟基-6α-乙基-7-酮-5β-胆烷-24-酸的制备方法
CN106645497A (zh) * 2017-01-03 2017-05-10 山东省药学科学院 一种奥贝胆酸及其制剂中有关物质的检测方法
CN108456238A (zh) * 2017-02-20 2018-08-28 浙江京新药业股份有限公司 奥贝胆酸衍生物及奥贝胆酸的制备方法
WO2018187804A1 (en) * 2017-04-07 2018-10-11 Enanta Pharmaceuticals, Inc. Process for preparation of sulfonyl carbamate bile acid derivatives
WO2018220513A1 (en) * 2017-05-31 2018-12-06 Alembic Pharmaceuticals Limited An improved process for preparation of obeticholic acid
CZ307944B6 (cs) * 2018-02-12 2019-09-04 Farmak, A.S. Způsob přípravy kyseliny obeticholové
CN108680696B (zh) * 2018-05-15 2020-06-30 南京正大天晴制药有限公司 一种奥贝胆酸起始物料的检测方法
CN111285914B (zh) * 2018-12-10 2023-02-17 江西青峰药业有限公司 一种奥贝胆酸的制备方法
CN109485686B (zh) * 2018-12-27 2021-08-27 重庆华邦胜凯制药有限公司 一种提高琥珀酸甲泼尼龙杂质合成中关键中间体6β含量的方法
CN109655571B (zh) * 2019-01-08 2021-07-13 丽珠集团新北江制药股份有限公司 一种奥贝胆酸的高效液相色谱分析方法
CN111718388A (zh) * 2019-03-19 2020-09-29 苏州泽璟生物制药股份有限公司 鹅去氧胆酸衍生物的制备方法
CN112898369A (zh) * 2019-12-04 2021-06-04 博瑞生物医药（苏州）股份有限公司 用于制备奥贝胆酸的方法

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EP1392714B1 (en) * 2001-03-12 2005-08-31 Intercept Pharmaceuticals, Inc. Steroids as agonists for fxr
ITMI20050912A1 (it) * 2005-05-19 2006-11-20 Erregierre Spa Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici
US20140206657A1 (en) * 2013-01-18 2014-07-24 City Of Hope Bile acid analog tgr5 agonists
CN104876995B (zh) * 2014-02-27 2016-09-07 人福医药集团股份公司 鹅去氧胆酸衍生物的制备方法
US10166246B2 (en) * 2014-05-27 2019-01-01 City Of Hope TGR5 agonist complexes for treating diabetes and cancer
DK3626725T3 (da) * 2014-05-29 2023-02-27 Bar Pharmaceuticals S R L Cholan-derivater til anvendelse ved behandlingen og/eller forebyggelsen af fxr- og tgr5/gpbar1-medierede sygdomme

Also Published As

Publication number Publication date
CN105669811B (zh) 2020-09-04
CN111944006A (zh) 2020-11-17
CN111944006B (zh) 2021-12-17
CN105669811A (zh) 2016-06-15

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