HK1250515A1 - 使用lgr4，lgr5和lgr6在组织应用中开发和使用最小极化功能细胞微集合体单元的方法 - Google Patents

使用lgr4，lgr5和lgr6在组织应用中开发和使用最小极化功能细胞微集合体单元的方法 Download PDF

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Publication number
HK1250515A1
HK1250515A1 HK18104680.7A HK18104680A HK1250515A1 HK 1250515 A1 HK1250515 A1 HK 1250515A1 HK 18104680 A HK18104680 A HK 18104680A HK 1250515 A1 HK1250515 A1 HK 1250515A1
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Hong Kong
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applications
lgr4
lgr6
lgr5
development
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HK18104680.7A
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English (en)
Chinese (zh)
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M. LOUGH Denver
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Polarityte, Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56078499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1250515(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polarityte, Inc. filed Critical Polarityte, Inc.
Publication of HK1250515A1 publication Critical patent/HK1250515A1/zh

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Botany (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
HK18104680.7A 2014-12-02 2015-12-01 使用lgr4，lgr5和lgr6在组织应用中开发和使用最小极化功能细胞微集合体单元的方法 HK1250515A1 (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462086526P 2014-12-02 2014-12-02
US62/086,526 2014-12-02
US14/954,335 2015-11-30
US14/954,335 US10926001B2 (en) 2014-12-02 2015-11-30 Methods related to minimally polarized functional units
PCT/US2015/063114 WO2016089825A1 (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
HK19132587.7A Division HK40009324B (en) 2014-12-02 2018-04-10 Methods for development and use of minimally polarized functional units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
HK19132587.7A Addition HK40009324B (en) 2014-12-02 2018-04-10 Methods for development and use of minimally polarized functional units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

Publications (1)

Publication Number Publication Date
HK1250515A1 true HK1250515A1 (zh) 2018-12-21

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HK18104680.7A HK1250515A1 (zh) 2014-12-02 2015-12-01 使用lgr4，lgr5和lgr6在组织应用中开发和使用最小极化功能细胞微集合体单元的方法

Country Status (21)

Country Link
US (7) US10926001B2 (enExample)
EP (2) EP3227431B1 (enExample)
JP (3) JP6791854B2 (enExample)
KR (5) KR20210043024A (enExample)
CN (1) CN107250348B (enExample)
AU (3) AU2015355187C1 (enExample)
BR (1) BR112017011808A2 (enExample)
CA (1) CA2969707C (enExample)
CO (1) CO2017006640A2 (enExample)
CR (1) CR20170296A (enExample)
EA (1) EA201791125A1 (enExample)
GB (2) GB2549872A (enExample)
HK (1) HK1250515A1 (enExample)
IL (2) IL252613B (enExample)
MX (2) MX2017007243A (enExample)
MY (1) MY184931A (enExample)
NZ (2) NZ755260A (enExample)
PH (1) PH12017501009B1 (enExample)
SG (2) SG10201914058QA (enExample)
WO (1) WO2016089825A1 (enExample)
ZA (1) ZA201703907B (enExample)

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EP3595440A2 (en) * 2017-03-14 2020-01-22 Juno Therapeutics, Inc. Methods for cryogenic storage
CR20200366A (es) * 2018-01-26 2020-10-05 Polarityte Inc Sustrato acelarante de biomaterial con interfaz compuesta
AU2019212976A1 (en) * 2018-01-26 2020-07-23 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (CLICSAM)
FR3082123B1 (fr) 2018-06-07 2020-10-16 Urgo Rech Innovation Et Developpement Pansement cellularise et son procede de fabrication
JP2024006681A (ja) * 2022-07-04 2024-01-17 学校法人近畿大学 生体材料
WO2025166131A1 (en) * 2024-02-01 2025-08-07 Board Of Regents, The University Of Texas System Compositions and methods for treating bone and muscle injuries

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US20040126881A1 (en) * 2002-09-06 2004-07-01 Vincent Ronfard Fibrin cell supports and methods of use thereof
WO2006008009A2 (en) 2004-07-23 2006-01-26 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with leucine-rich repeat-containing gpcr 6 (lgr6)
US20060154365A1 (en) 2004-08-30 2006-07-13 Anthony Ratcliffe Cultured three dimensional tissues and uses thereof
EP1942957B1 (en) * 2005-10-27 2012-07-11 Coloplast A/S Biodegradable scaffold with ecm material
WO2008008009A1 (en) 2006-07-13 2008-01-17 St. Jude Medical Ab Medical information management in a patient information hub system
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GB201111244D0 (en) 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
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Publication number Publication date
AU2019240603A1 (en) 2019-10-17
IL287488A (en) 2021-12-01
MX2023001655A (es) 2023-04-24
ZA201703907B (en) 2023-03-29
CO2017006640A2 (es) 2017-11-21
CR20170296A (es) 2018-01-25
EP3227431A4 (en) 2019-01-02
JP6791854B2 (ja) 2020-11-25
AU2023202857A1 (en) 2023-05-25
US10926001B2 (en) 2021-02-23
AU2015355187B2 (en) 2019-10-03
EP4438128A2 (en) 2024-10-02
CA2969707A1 (en) 2016-06-09
IL252613A0 (en) 2017-07-31
GB201902819D0 (en) 2019-04-17
NZ733433A (en) 2019-08-30
US20220241464A1 (en) 2022-08-04
US20180154043A1 (en) 2018-06-07
MX2017007243A (es) 2018-01-25
GB201710646D0 (en) 2017-08-16
KR20180136588A (ko) 2018-12-24
AU2015355187C1 (en) 2020-02-20
US20190046691A1 (en) 2019-02-14
AU2015355187A1 (en) 2017-06-29
SG10201914058QA (en) 2020-03-30
US11596714B2 (en) 2023-03-07
KR20210043024A (ko) 2021-04-20
SG11201704502RA (en) 2017-06-29
GB2569056B (en) 2020-01-01
CN107250348A (zh) 2017-10-13
IL252613B (en) 2021-12-01
EP4438128A3 (en) 2024-11-13
US12465669B2 (en) 2025-11-11
WO2016089825A1 (en) 2016-06-09
CA2969707C (en) 2019-08-20
US20160151540A1 (en) 2016-06-02
US11266765B2 (en) 2022-03-08
EP3227431A1 (en) 2017-10-11
KR20190111167A (ko) 2019-10-01
EP3227431C0 (en) 2025-01-29
PH12017501009B1 (en) 2022-01-21
JP2020182880A (ja) 2020-11-12
US20230181797A1 (en) 2023-06-15
IL287488B2 (en) 2023-06-01
EA201791125A1 (ru) 2018-06-29
AU2019240603B2 (en) 2023-02-09
MY184931A (en) 2021-04-30
HK1245327A1 (zh) 2018-08-24
US20210322643A1 (en) 2021-10-21
US11000629B2 (en) 2021-05-11
KR20170098844A (ko) 2017-08-30
NZ755260A (en) 2021-12-24
US20180154044A1 (en) 2018-06-07
GB2549872A (en) 2017-11-01
JP2017538411A (ja) 2017-12-28
GB2569056A (en) 2019-06-05
BR112017011808A2 (pt) 2018-02-27
CN107250348B (zh) 2021-09-03
JP2019088299A (ja) 2019-06-13
EP3227431B1 (en) 2025-01-29
PH12017501009A1 (en) 2017-12-11
US11338060B2 (en) 2022-05-24
KR20180136587A (ko) 2018-12-24

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