BR112017011808A2 - métodos para o desenvolvimento e uso de unidades micro-agregadas de células funcionais minimamente polarizadas em aplicações de tecidos usando lgr4, lgr5 e lgr6 que expressam células tronco epiteliais - Google Patents
métodos para o desenvolvimento e uso de unidades micro-agregadas de células funcionais minimamente polarizadas em aplicações de tecidos usando lgr4, lgr5 e lgr6 que expressam células tronco epiteliaisInfo
- Publication number
- BR112017011808A2 BR112017011808A2 BR112017011808A BR112017011808A BR112017011808A2 BR 112017011808 A2 BR112017011808 A2 BR 112017011808A2 BR 112017011808 A BR112017011808 A BR 112017011808A BR 112017011808 A BR112017011808 A BR 112017011808A BR 112017011808 A2 BR112017011808 A2 BR 112017011808A2
- Authority
- BR
- Brazil
- Prior art keywords
- applications
- cells
- lgr4
- lgr6
- lgr5
- Prior art date
Links
- 101150081517 LGR4 gene Proteins 0.000 title 1
- 210000004027 cell Anatomy 0.000 title 1
- 210000000130 stem cell Anatomy 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 238000002659 cell therapy Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000001172 regenerating effect Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/362—Skin, e.g. dermal papillae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2513/00—3D culture
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
a presente invenção refere-se a construções de enxertos minimamente polarizados microagregados multicelulares contendo proteína g com repetições ricas em leucina acopladas a receptores (lgr) expressando células para aplicação de terapia de feridas, engenharia de tecidos, aplicações de terapia celular, aplicações de medicina regenerativa, aplicações médicas / terapêuticas, aplicações de cura de tecidos, aplicações em terapias imunes e aplicações em terapias de transplante de tecidos, os quais são de preferência associados a um vetor / substrato / suporte / armação de liberação para administração direta.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462086526P | 2014-12-02 | 2014-12-02 | |
| US14/954,335 US10926001B2 (en) | 2014-12-02 | 2015-11-30 | Methods related to minimally polarized functional units |
| PCT/US2015/063114 WO2016089825A1 (en) | 2014-12-02 | 2015-12-01 | Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017011808A2 true BR112017011808A2 (pt) | 2018-02-27 |
Family
ID=56078499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017011808A BR112017011808A2 (pt) | 2014-12-02 | 2015-12-01 | métodos para o desenvolvimento e uso de unidades micro-agregadas de células funcionais minimamente polarizadas em aplicações de tecidos usando lgr4, lgr5 e lgr6 que expressam células tronco epiteliais |
Country Status (21)
| Country | Link |
|---|---|
| US (7) | US10926001B2 (pt) |
| EP (2) | EP4438128A2 (pt) |
| JP (3) | JP6791854B2 (pt) |
| KR (5) | KR20180136588A (pt) |
| CN (1) | CN107250348B (pt) |
| AU (3) | AU2015355187C1 (pt) |
| BR (1) | BR112017011808A2 (pt) |
| CA (1) | CA2969707C (pt) |
| CO (1) | CO2017006640A2 (pt) |
| CR (1) | CR20170296A (pt) |
| EA (1) | EA201791125A1 (pt) |
| GB (2) | GB2569056B (pt) |
| HK (2) | HK1250515A1 (pt) |
| IL (2) | IL252613B (pt) |
| MX (2) | MX2017007243A (pt) |
| MY (1) | MY184931A (pt) |
| NZ (2) | NZ733433A (pt) |
| PH (1) | PH12017501009B1 (pt) |
| SG (2) | SG10201914058QA (pt) |
| WO (1) | WO2016089825A1 (pt) |
| ZA (1) | ZA201703907B (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3743125A4 (en) * | 2018-01-26 | 2022-03-02 | Polarityte, Inc. | BIOMATERIAL ACCELERATING SUBSTRATE WITH COMPOSITE INTERFACE |
| EP3743080A4 (en) * | 2018-01-26 | 2021-10-27 | Polarityte, Inc. | SELF-ASSEMBLY MATERIALS COORDINATED WITH A COMPLEX LIVING INTERFACE (CLICSAM) |
| FR3082123B1 (fr) | 2018-06-07 | 2020-10-16 | Urgo Rech Innovation Et Developpement | Pansement cellularise et son procede de fabrication |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040126881A1 (en) | 2002-09-06 | 2004-07-01 | Vincent Ronfard | Fibrin cell supports and methods of use thereof |
| WO2006008009A2 (en) | 2004-07-23 | 2006-01-26 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with leucine-rich repeat-containing gpcr 6 (lgr6) |
| US20060154365A1 (en) | 2004-08-30 | 2006-07-13 | Anthony Ratcliffe | Cultured three dimensional tissues and uses thereof |
| BRPI0617818A2 (pt) | 2005-10-27 | 2011-08-09 | Coloplast As | suporte polimérico biodegradável com material de ecm |
| US20100328320A1 (en) | 2006-07-13 | 2010-12-30 | Kerstna Juergen | Medical information management in a patient information hub system |
| US8366723B2 (en) | 2006-08-03 | 2013-02-05 | Rassman Licensing, Llc | Hair harvesting device and method with localized subsurface dermal fluid insertion |
| US7998737B2 (en) | 2006-09-12 | 2011-08-16 | Deutsches Krebsforschungszentrum | Cell culture of keratinocytes under non-differentiating conditions |
| EP2412800A1 (en) | 2010-07-29 | 2012-02-01 | Koninklijke Nederlandse Akademie van Wetenschappen | Liver organoid, uses thereof and culture method for obtaining them |
| US9752124B2 (en) | 2009-02-03 | 2017-09-05 | Koninklijke Nederlandse Akademie Van Wetenschappen | Culture medium for epithelial stem cells and organoids comprising the stem cells |
| GB201111244D0 (en) | 2011-06-30 | 2011-08-17 | Konink Nl Akademie Van Wetenschappen Knaw | Culture media for stem cells |
| FI20095355A0 (fi) | 2009-04-01 | 2009-04-01 | Helsingin Yliopisto | Regeneroituva aktiivinen matriisi ja sen käytöt |
| US20110076303A1 (en) | 2009-06-25 | 2011-03-31 | Tokuro Iwabuchi | Methods for Screening for Anti-Graying Agents on the Basis of AFF-4 |
| US20110130711A1 (en) | 2009-11-19 | 2011-06-02 | Follica, Inc. | Hair growth treatment |
| US20130101564A1 (en) | 2010-06-30 | 2013-04-25 | Jinxi Chen | Method for preparing dermis tissue cells aggregation and uses thereof |
| GB201106395D0 (en) | 2011-04-14 | 2011-06-01 | Hubrecht Inst | Compounds |
| KR102025636B1 (ko) | 2011-10-27 | 2019-11-04 | 우니베르지태트 라이치히 | 모낭 외모낭초로부터 멜라닌세포를 유도하기 위한 방법 및 이식을 위한 제조 |
| JP6186997B2 (ja) | 2012-08-07 | 2017-08-30 | 日油株式会社 | 塗布型帯電防止剤 |
| US9655930B2 (en) | 2012-10-01 | 2017-05-23 | Aderans Research Institute, Inc. | Compositions and methods for producing reconstituted skin |
| US20140106447A1 (en) | 2012-10-12 | 2014-04-17 | Mimedx Group, Inc. | Compositions and methods for recruiting stem cells |
| HUE049377T2 (hu) | 2013-03-14 | 2020-09-28 | Brigham & Womens Hospital Inc | Készítmények és eljárások epiteliális õssejtek expanziójára és tenyésztésére |
| US9592257B2 (en) | 2013-10-11 | 2017-03-14 | MWV Cell, LLC | Complete human skin organ generated from culture-expanded cells |
| CN103550828B (zh) * | 2013-10-17 | 2016-01-27 | 中国科学院动物研究所 | 一种基于毛囊干细胞和硅凝胶敷料的皮肤重建方法 |
| TWI548413B (zh) | 2014-11-07 | 2016-09-11 | 國立臺灣大學 | 誘導毛囊新生的皮膚萃取物、組合物及其用途 |
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2015
- 2015-11-30 US US14/954,335 patent/US10926001B2/en active Active
- 2015-12-01 EP EP24181160.3A patent/EP4438128A2/en active Pending
- 2015-12-01 NZ NZ733433A patent/NZ733433A/en unknown
- 2015-12-01 CR CR20170296A patent/CR20170296A/es unknown
- 2015-12-01 WO PCT/US2015/063114 patent/WO2016089825A1/en active Application Filing
- 2015-12-01 MX MX2017007243A patent/MX2017007243A/es unknown
- 2015-12-01 KR KR1020187036619A patent/KR20180136588A/ko not_active Application Discontinuation
- 2015-12-01 MY MYPI2017701990A patent/MY184931A/en unknown
- 2015-12-01 JP JP2017530217A patent/JP6791854B2/ja active Active
- 2015-12-01 CA CA2969707A patent/CA2969707C/en active Active
- 2015-12-01 KR KR1020187036618A patent/KR20180136587A/ko not_active Application Discontinuation
- 2015-12-01 BR BR112017011808A patent/BR112017011808A2/pt not_active Application Discontinuation
- 2015-12-01 EA EA201791125A patent/EA201791125A1/ru unknown
- 2015-12-01 AU AU2015355187A patent/AU2015355187C1/en active Active
- 2015-12-01 KR KR1020177017887A patent/KR20170098844A/ko active Application Filing
- 2015-12-01 CN CN201580075326.3A patent/CN107250348B/zh active Active
- 2015-12-01 NZ NZ755260A patent/NZ755260A/en unknown
- 2015-12-01 SG SG10201914058QA patent/SG10201914058QA/en unknown
- 2015-12-01 KR KR1020217010934A patent/KR20210043024A/ko not_active Application Discontinuation
- 2015-12-01 KR KR1020197028100A patent/KR20190111167A/ko not_active Application Discontinuation
- 2015-12-01 GB GB201902819A patent/GB2569056B/en active Active
- 2015-12-01 EP EP15865131.5A patent/EP3227431A4/en active Pending
- 2015-12-01 GB GB1710646.9A patent/GB2549872A/en not_active Withdrawn
- 2015-12-01 SG SG11201704502RA patent/SG11201704502RA/en unknown
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2017
- 2017-05-31 PH PH12017501009A patent/PH12017501009B1/en unknown
- 2017-06-01 IL IL252613A patent/IL252613B/en unknown
- 2017-06-05 MX MX2023001655A patent/MX2023001655A/es unknown
- 2017-06-07 ZA ZA2017/03907A patent/ZA201703907B/en unknown
- 2017-06-30 CO CONC2017/0006640A patent/CO2017006640A2/es unknown
- 2017-07-14 US US15/650,659 patent/US11266765B2/en active Active
- 2017-07-14 US US15/650,656 patent/US20180154043A1/en not_active Abandoned
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2018
- 2018-04-10 HK HK18104680.7A patent/HK1250515A1/zh unknown
- 2018-04-10 HK HK18104679.0A patent/HK1245327A1/zh unknown
- 2018-10-19 US US16/165,169 patent/US11000629B2/en active Active
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2019
- 2019-01-16 JP JP2019004921A patent/JP2019088299A/ja active Pending
- 2019-10-02 AU AU2019240603A patent/AU2019240603B2/en active Active
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2020
- 2020-07-30 JP JP2020129610A patent/JP2020182880A/ja active Pending
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2021
- 2021-05-21 US US17/326,734 patent/US11338060B2/en active Active
- 2021-10-21 IL IL287488A patent/IL287488B2/en unknown
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2022
- 2022-04-19 US US17/723,748 patent/US11596714B2/en active Active
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2023
- 2023-02-03 US US18/164,308 patent/US20230181797A1/en active Pending
- 2023-05-08 AU AU2023202857A patent/AU2023202857A1/en active Pending
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