CN107250348B - 使用表达lgr4、lgr5和lgr6的上皮干细胞在组织应用中开发和使用最小极性化功能细胞微聚集体单元的方法 - Google Patents

使用表达lgr4、lgr5和lgr6的上皮干细胞在组织应用中开发和使用最小极性化功能细胞微聚集体单元的方法 Download PDF

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CN107250348B
CN107250348B CN201580075326.3A CN201580075326A CN107250348B CN 107250348 B CN107250348 B CN 107250348B CN 201580075326 A CN201580075326 A CN 201580075326A CN 107250348 B CN107250348 B CN 107250348B
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lgr
lgr6
wound
cells expressing
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CN107250348A (zh
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D.M.洛
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RegenETP Inc
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • A—HUMAN NECESSITIES
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    • A01N1/12—Chemical aspects of preservation
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/362—Skin, e.g. dermal papillae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
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    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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CN201580075326.3A 2014-12-02 2015-12-01 使用表达lgr4、lgr5和lgr6的上皮干细胞在组织应用中开发和使用最小极性化功能细胞微聚集体单元的方法 Active CN107250348B (zh)

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US201462086526P 2014-12-02 2014-12-02
US62/086526 2014-12-02
US14/954335 2015-11-30
US14/954,335 US10926001B2 (en) 2014-12-02 2015-11-30 Methods related to minimally polarized functional units
PCT/US2015/063114 WO2016089825A1 (en) 2014-12-02 2015-12-01 Methods for development and use of minimally polarized function cell micro-aggregate units in tissue applications using lgr4, lgr5 and lgr6 expressing epithelial stem cells

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CN107250348B true CN107250348B (zh) 2021-09-03

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CR20200366A (es) * 2018-01-26 2020-10-05 Polarityte Inc Sustrato acelarante de biomaterial con interfaz compuesta
AU2019212976A1 (en) * 2018-01-26 2020-07-23 Polarityte, Inc. Complex living interface-coordinated self-assembling materials (CLICSAM)
FR3082123B1 (fr) 2018-06-07 2020-10-16 Urgo Rech Innovation Et Developpement Pansement cellularise et son procede de fabrication
JP2024006681A (ja) * 2022-07-04 2024-01-17 学校法人近畿大学 生体材料
WO2025166131A1 (en) * 2024-02-01 2025-08-07 Board Of Regents, The University Of Texas System Compositions and methods for treating bone and muscle injuries

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CO2017006640A2 (es) 2017-11-21
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US10926001B2 (en) 2021-02-23
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IL252613A0 (en) 2017-07-31
GB201902819D0 (en) 2019-04-17
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US20220241464A1 (en) 2022-08-04
US20180154043A1 (en) 2018-06-07
MX2017007243A (es) 2018-01-25
GB201710646D0 (en) 2017-08-16
KR20180136588A (ko) 2018-12-24
AU2015355187C1 (en) 2020-02-20
US20190046691A1 (en) 2019-02-14
AU2015355187A1 (en) 2017-06-29
SG10201914058QA (en) 2020-03-30
US11596714B2 (en) 2023-03-07
KR20210043024A (ko) 2021-04-20
SG11201704502RA (en) 2017-06-29
GB2569056B (en) 2020-01-01
CN107250348A (zh) 2017-10-13
IL252613B (en) 2021-12-01
EP4438128A3 (en) 2024-11-13
US12465669B2 (en) 2025-11-11
WO2016089825A1 (en) 2016-06-09
CA2969707C (en) 2019-08-20
US20160151540A1 (en) 2016-06-02
US11266765B2 (en) 2022-03-08
EP3227431A1 (en) 2017-10-11
KR20190111167A (ko) 2019-10-01
EP3227431C0 (en) 2025-01-29
PH12017501009B1 (en) 2022-01-21
JP2020182880A (ja) 2020-11-12
US20230181797A1 (en) 2023-06-15
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EA201791125A1 (ru) 2018-06-29
AU2019240603B2 (en) 2023-02-09
MY184931A (en) 2021-04-30
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US20210322643A1 (en) 2021-10-21
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US11000629B2 (en) 2021-05-11
KR20170098844A (ko) 2017-08-30
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US20180154044A1 (en) 2018-06-07
GB2549872A (en) 2017-11-01
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GB2569056A (en) 2019-06-05
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US11338060B2 (en) 2022-05-24
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