IL245713A0 - A method for the detection and quantitative analysis by hplc of impurities in the product obtained in the preparation of dianhydrogalactitol - Google Patents

A method for the detection and quantitative analysis by hplc of impurities in the product obtained in the preparation of dianhydrogalactitol

Info

Publication number
IL245713A0
IL245713A0 IL245713A IL24571316A IL245713A0 IL 245713 A0 IL245713 A0 IL 245713A0 IL 245713 A IL245713 A IL 245713A IL 24571316 A IL24571316 A IL 24571316A IL 245713 A0 IL245713 A0 IL 245713A0
Authority
IL
Israel
Prior art keywords
dianhydrogalactitol
impurities
hplc analysis
hplc
analysis
Prior art date
Application number
IL245713A
Other languages
English (en)
Hebrew (he)
Inventor
Lu Xiaoyun
Tso-Ping Li Mike
Original Assignee
Del Mar Pharmaceuticals
Lu Xiaoyun
Tso-Ping Li Mike
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/083,135 external-priority patent/US9029164B2/en
Application filed by Del Mar Pharmaceuticals, Lu Xiaoyun, Tso-Ping Li Mike filed Critical Del Mar Pharmaceuticals
Publication of IL245713A0 publication Critical patent/IL245713A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/84—Preparation of the fraction to be distributed
    • G01N2030/8447—Nebulising, aerosol formation or ionisation
    • G01N2030/8494—Desolvation chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
IL245713A 2013-11-18 2016-05-18 A method for the detection and quantitative analysis by hplc of impurities in the product obtained in the preparation of dianhydrogalactitol IL245713A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14/083,135 US9029164B2 (en) 2012-02-27 2013-11-18 Analytical methods for analyzing and determining impurities in dianhydrogalactitol
PCT/US2014/066087 WO2015074025A1 (en) 2013-11-18 2014-11-18 Hplc analysis of impurities in dianhydrogalactitol

Publications (1)

Publication Number Publication Date
IL245713A0 true IL245713A0 (en) 2016-08-02

Family

ID=53058168

Family Applications (1)

Application Number Title Priority Date Filing Date
IL245713A IL245713A0 (en) 2013-11-18 2016-05-18 A method for the detection and quantitative analysis by hplc of impurities in the product obtained in the preparation of dianhydrogalactitol

Country Status (10)

Country Link
EP (1) EP3071555A4 (enExample)
JP (1) JP2016538574A (enExample)
KR (1) KR20160108315A (enExample)
CN (1) CN107529337B (enExample)
AU (1) AU2014348232A1 (enExample)
CA (1) CA2931088A1 (enExample)
CL (1) CL2016001197A1 (enExample)
IL (1) IL245713A0 (enExample)
MX (1) MX2016006457A (enExample)
WO (1) WO2015074025A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106397360A (zh) * 2015-07-29 2017-02-15 广西梧州制药（集团）股份有限公司 叔丁醇在去水卫矛醇或其组合物冷冻干燥过程中的应用
MX379918B (es) * 2015-11-25 2025-03-11 Del Mar Pharmaceuticals Bc Ltd Metodos para analisis y resolucion de preparaciones de dianhidrogalactitol y derivados o analogos del mismo.
CN105445407B (zh) * 2015-12-29 2017-04-19 成都普思生物科技股份有限公司 一种山桐子中脂肪酸和维生素e的检测方法
US10927363B2 (en) 2016-04-04 2021-02-23 Mie University DNA sequence and expression vector for alginate lyase
KR102270026B1 (ko) * 2020-01-31 2021-06-28 현대약품 주식회사 (3s)-3-(4-(3-(1,4-다이옥사스파이로[4,5]데스-7-엔-8-일)벤질옥시)페닐)헥스-4-이노익산의 품질 평가 방법
CN114113352A (zh) * 2020-08-28 2022-03-01 深圳波顿香料有限公司 发酵液中内酯型槐糖酯含量的测定方法
US12295919B2 (en) 2022-03-16 2025-05-13 Mie University Methods of treatment and prevention using 4-deoxy-L-erythro-5-hexoseulose uronic acid
CN120741731B (zh) * 2025-09-08 2025-11-14 天津中医药大学 一种基于uplc-qtrap-ms/ms检测扶芳藤或复方扶芳藤合剂中化学成分的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04297868A (ja) * 1991-03-27 1992-10-21 Tonen Corp オリゴ糖の分析方法
JPH09229920A (ja) * 1996-02-26 1997-09-05 Kao Corp グラジェント液体クロマトグラフィー溶離液の処理方法
US6060525A (en) * 1996-03-01 2000-05-09 Dionix Corporation Removal of borate in chromatography
CA2359337C (en) * 1999-01-14 2005-09-13 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Process for the separation of sugars
US20060148732A1 (en) * 2000-11-17 2006-07-06 Gutterman Jordan U Inhibition of NF-kappaB by triterpene compositions
JP2004294384A (ja) * 2003-03-28 2004-10-21 National Agriculture & Bio-Oriented Research Organization １−デオキシノジリマイシンの測定方法
CA2819769C (en) * 2003-07-18 2016-06-28 Oakwood Laboratories, L.L.C. Prevention of molecular weight reduction of the polymer, impurity formation and gelling in polymer compositions
EP1747457B1 (en) * 2004-05-20 2011-11-30 Novartis AG Analysis of liquid chromatography eluates
JP2008076340A (ja) * 2006-09-25 2008-04-03 Toppan Printing Co Ltd 高感度検出方法およびその検出装置
SI2074120T1 (sl) * 2007-10-25 2010-06-30 Exelixis Inc Tropan spojine
US8772279B2 (en) * 2010-01-29 2014-07-08 Nerviano Medical Sciences S.R.L. 6,7-dihydroimidazo[1,5-a]pyrazin-8(5H)-one derivatives as protein kinase modulators
AU2011292045B2 (en) * 2010-08-18 2016-03-24 Del Mar Pharmaceuticals Method of synthesis of substituted hexitols such as dianhydrogalactitol
CN102008541B (zh) * 2010-10-08 2012-07-04 广西中医学院 无糖型复方扶芳藤制剂中3种主要活性成分的同时检测方法
CN104428664B (zh) * 2012-02-27 2018-09-21 德玛医药 用于分析和测定在卫康醇中杂质的改良分析方法
BE1020835A5 (nl) * 2012-03-20 2014-06-03 Maes Francis N V Werkwijze voor het vervaardigen van een plantenextract, i.h.b. uit desmodium.

Also Published As

Publication number Publication date
CL2016001197A1 (es) 2017-06-30
AU2014348232A1 (en) 2016-06-30
KR20160108315A (ko) 2016-09-19
CN107529337A (zh) 2017-12-29
JP2016538574A (ja) 2016-12-08
CN107529337B (zh) 2021-11-16
WO2015074025A1 (en) 2015-05-21
MX2016006457A (es) 2017-01-06
EP3071555A4 (en) 2017-05-31
CA2931088A1 (en) 2015-05-21
WO2015074025A9 (en) 2015-12-17
EP3071555A1 (en) 2016-09-28

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