IL235832A0 - Fibroblastic growth factor 21 proteins - Google Patents

Fibroblastic growth factor 21 proteins

Info

Publication number
IL235832A0
IL235832A0 IL235832A IL23583214A IL235832A0 IL 235832 A0 IL235832 A0 IL 235832A0 IL 235832 A IL235832 A IL 235832A IL 23583214 A IL23583214 A IL 23583214A IL 235832 A0 IL235832 A0 IL 235832A0
Authority
IL
Israel
Prior art keywords
proteins
growth factor
fibroblast growth
fibroblast
factor
Prior art date
Application number
IL235832A
Other languages
English (en)
Hebrew (he)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48670814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL235832(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IL235832A0 publication Critical patent/IL235832A0/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1825Fibroblast growth factor [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813Carrier is a saccharide
    • Y10S530/814Cellulose or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
IL235832A 2012-06-11 2014-11-20 Fibroblastic growth factor 21 proteins IL235832A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261658104P 2012-06-11 2012-06-11
US201361777386P 2013-03-12 2013-03-12
PCT/US2013/044190 WO2013188181A1 (en) 2012-06-11 2013-06-05 Fibroblast growth factor 21 proteins

Publications (1)

Publication Number Publication Date
IL235832A0 true IL235832A0 (en) 2015-01-29

Family

ID=48670814

Family Applications (1)

Application Number Title Priority Date Filing Date
IL235832A IL235832A0 (en) 2012-06-11 2014-11-20 Fibroblastic growth factor 21 proteins

Country Status (24)

Country Link
US (2) US8741841B2 (OSRAM)
EP (1) EP2858662B1 (OSRAM)
JP (1) JP6182600B2 (OSRAM)
KR (1) KR20150006060A (OSRAM)
CN (1) CN104394882B (OSRAM)
AR (1) AR091216A1 (OSRAM)
AU (1) AU2013274638A1 (OSRAM)
BR (1) BR112014029966A2 (OSRAM)
CA (1) CA2871145A1 (OSRAM)
CL (1) CL2014003078A1 (OSRAM)
CO (1) CO7151525A2 (OSRAM)
EA (1) EA201492053A1 (OSRAM)
EC (1) ECSP14030742A (OSRAM)
ES (1) ES2644787T3 (OSRAM)
HK (1) HK1203357A1 (OSRAM)
IL (1) IL235832A0 (OSRAM)
IN (1) IN2014MN02132A (OSRAM)
MX (1) MX2014015257A (OSRAM)
PE (1) PE20150201A1 (OSRAM)
PH (1) PH12014502766A1 (OSRAM)
SG (1) SG11201408095XA (OSRAM)
TN (1) TN2014000439A1 (OSRAM)
TW (1) TWI513705B (OSRAM)
WO (1) WO2013188181A1 (OSRAM)

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ES2385114T3 (es) 2007-03-30 2012-07-18 Ambrx, Inc. Polipéptidos de FGF-21 modificados y sus usos
ES2748038T3 (es) 2011-07-01 2020-03-12 Ngm Biopharmaceuticals Inc Composiciones, usos y métodos para el tratamiento de trastornos y enfermedades metabólicos
EA201492064A1 (ru) * 2012-06-11 2015-02-27 Эли Лилли Энд Компани Варианты фактора роста фибробластов 21
TWI513705B (zh) 2012-06-11 2015-12-21 Lilly Co Eli 纖維母細胞生長因子21蛋白質
US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
EP2925775B1 (en) 2012-11-28 2020-09-16 NGM Biopharmaceuticals, Inc. Compositions and methods for treatment of metabolic disorders and diseases
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
EP2938740B1 (en) 2012-12-27 2022-04-20 NGM Biopharmaceuticals, Inc. Chimeric fgf19 peptides for use in treating bile acid disorders
KR102178945B1 (ko) 2013-10-28 2020-11-13 엔지엠 바이오파마슈티컬스, 아이엔씨. 암 모델 및 관련 방법
PE20170256A1 (es) 2014-01-24 2017-04-22 Ngm Biopharmaceuticals Inc Proteinas de union y sus metodos de uso
EP3107937A4 (en) 2014-02-21 2017-11-15 MedImmune, LLC Anti-pcsk9~glp-1 fusions and methods for use
US20170065678A1 (en) 2014-03-11 2017-03-09 Novartis Ag Methods of treating metabolic disorders associated with lipodystrophies and defects in insulin production or signaling
EP3122776B1 (en) 2014-03-25 2021-04-28 Regeneron Pharmaceuticals, Inc. Fgf21 receptor agonists and uses thereof
US10398758B2 (en) 2014-05-28 2019-09-03 Ngm Biopharmaceuticals, Inc. Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
WO2015195509A2 (en) 2014-06-16 2015-12-23 Ngm Biopharmaceuticals, Inc. Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
US10293026B2 (en) 2014-09-08 2019-05-21 Osaka University Agent for preventing or treating demyelinating disease
IL251834B2 (en) 2014-10-23 2023-09-01 Ngm Biopharmaceuticals Inc Pharmaceutical compositions containing peptide variants and methods of using them
SG11201702824UA (en) 2014-10-24 2017-05-30 Bristol Myers Squibb Co Modified fgf-21 polypeptides and uses thereof
US10434144B2 (en) 2014-11-07 2019-10-08 Ngm Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
KR20160088656A (ko) * 2015-01-16 2016-07-26 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
WO2016187558A2 (en) 2015-05-20 2016-11-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Method to improve neurologic outcomes in temperature managed patients
WO2017019957A2 (en) 2015-07-29 2017-02-02 Ngm Biopharmaceuticals, Inc. Binding proteins and methods of use thereof
KR102670157B1 (ko) 2015-10-28 2024-05-29 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
KR102668200B1 (ko) * 2015-10-28 2024-05-23 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
ES2871036T3 (es) 2015-11-09 2021-10-28 Ngm Biopharmaceuticals Inc Método para el tratamiento de trastornos relacionados con ácidos biliares
CN105348380B (zh) * 2015-12-28 2019-03-01 江苏康缘瑞翱生物医药科技有限公司 犬成纤维细胞生长因子21及其在治疗犬内分泌疾病中的用途
US11123438B2 (en) 2016-08-19 2021-09-21 Ampsource Biopharma Shanghai Inc. Linker peptide for constructing fusion protein
CN107759697B (zh) 2016-08-19 2023-03-24 安源医药科技(上海)有限公司 制备融合蛋白的方法
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技(上海)有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
WO2018039557A1 (en) 2016-08-26 2018-03-01 Ngm Biopharmaceuticals, Inc. Methods of treating fibroblast growth factor 19-mediated cancers and tumors
BR112019009581A2 (pt) * 2016-11-10 2019-10-08 Yuhan Corp composição farmacêutica para evitar ou tratar hepatite, fibrose hepática, e cirrose hepática que compreende proteínas de fusão
JP7181886B2 (ja) 2017-03-14 2022-12-01 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 免疫グロブリンのFc部分を含む二重標的融合タンパク質
JP7191850B2 (ja) 2017-04-21 2022-12-19 ユーハン・コーポレイション デュアル機能タンパク質およびその誘導体を生産するための方法
CN107385020A (zh) * 2017-06-23 2017-11-24 西安医学院 瘦素在人重组fgf21蛋白活性检测中的应用
JP2020533304A (ja) 2017-09-08 2020-11-19 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 改変型線維芽細胞成長因子21(fgf−21)を用いる非アルコール性脂肪性肝炎(nash)の処置方法
CN119386162A (zh) 2017-12-22 2025-02-07 诺华股份有限公司 用fgf21变体治疗代谢障碍的方法
CN110128525B (zh) 2018-02-08 2022-08-26 广东东阳光药业有限公司 Fgf21变体、融合蛋白及其应用
CN112601517A (zh) 2018-07-03 2021-04-02 百时美施贵宝公司 Fgf-21配制品
CN111195234B (zh) * 2018-11-16 2022-08-26 鲁南制药集团股份有限公司 一种重组FGF21-Fc融合蛋白冻干粉制剂
CN118388627A (zh) * 2019-03-05 2024-07-26 广东东阳光药业股份有限公司 一种多肽分子及其应用
US20230053119A1 (en) * 2019-04-23 2023-02-16 Lg Chem, Ltd. FUSION POLYPEPTIDE COMPRISING Fc REGION OF IMMUNOGLOBULIN AND GDF15
CA3167062A1 (en) 2020-01-08 2021-07-15 Bristol-Myers Squibb Company Fgf-21 conjugate formulations
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JP2023538533A (ja) 2020-08-07 2023-09-08 ブリストル-マイヤーズ スクイブ カンパニー 線維症の処置のための、ccr2/5拮抗剤と組み合わせたfgf21
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KR102495299B1 (ko) * 2020-11-03 2023-02-06 토드제약 주식회사 Fgf21의 열탄력성을 이용한 fgf21 생산 방법
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KR102631925B1 (ko) * 2021-06-10 2024-02-01 토드제약 주식회사 신규 fgf21 변이체 개발 및 이의 생산기법과 용도

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TWI513705B (zh) 2012-06-11 2015-12-21 Lilly Co Eli 纖維母細胞生長因子21蛋白質

Also Published As

Publication number Publication date
EP2858662A1 (en) 2015-04-15
TW201408693A (zh) 2014-03-01
AR091216A1 (es) 2015-01-21
US20130330336A1 (en) 2013-12-12
ES2644787T3 (es) 2017-11-30
JP2015527974A (ja) 2015-09-24
CL2014003078A1 (es) 2015-02-27
SG11201408095XA (en) 2015-01-29
CO7151525A2 (es) 2014-12-29
US8741841B2 (en) 2014-06-03
PH12014502766A1 (en) 2015-02-09
JP6182600B2 (ja) 2017-08-16
CA2871145A1 (en) 2013-12-19
CN104394882A (zh) 2015-03-04
CN104394882B (zh) 2016-06-22
TWI513705B (zh) 2015-12-21
BR112014029966A2 (pt) 2017-09-12
KR20150006060A (ko) 2015-01-15
WO2013188181A1 (en) 2013-12-19
PE20150201A1 (es) 2015-02-19
MX2014015257A (es) 2015-03-05
HK1203357A1 (en) 2015-10-30
US20140228282A1 (en) 2014-08-14
US8927492B2 (en) 2015-01-06
ECSP14030742A (es) 2015-09-30
TN2014000439A1 (en) 2016-03-30
EA201492053A1 (ru) 2015-02-27
AU2013274638A1 (en) 2014-11-06
EP2858662B1 (en) 2017-08-09
IN2014MN02132A (OSRAM) 2015-09-11

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