IL232072B - Use of semaphorin-4d binding molecules to regulate blood-brain barrier permeability - Google Patents

Use of semaphorin-4d binding molecules to regulate blood-brain barrier permeability

Info

Publication number
IL232072B
IL232072B IL232072A IL23207214A IL232072B IL 232072 B IL232072 B IL 232072B IL 232072 A IL232072 A IL 232072A IL 23207214 A IL23207214 A IL 23207214A IL 232072 B IL232072 B IL 232072B
Authority
IL
Israel
Prior art keywords
semaphorin
modulation
binding molecules
brain barrier
blood brain
Prior art date
Application number
IL232072A
Other languages
English (en)
Hebrew (he)
Other versions
IL232072A0 (en
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Publication of IL232072A0 publication Critical patent/IL232072A0/en
Publication of IL232072B publication Critical patent/IL232072B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL232072A 2011-10-11 2014-04-10 Use of semaphorin-4d binding molecules to regulate blood-brain barrier permeability IL232072B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161545809P 2011-10-11 2011-10-11
US201161555726P 2011-11-04 2011-11-04
US201261593641P 2012-02-01 2012-02-01
PCT/US2012/059757 WO2013055922A1 (en) 2011-10-11 2012-10-11 Use of semaphorin-4d binding molecules for modulation of blood brain barrier permeability

Publications (2)

Publication Number Publication Date
IL232072A0 IL232072A0 (en) 2014-05-28
IL232072B true IL232072B (en) 2021-01-31

Family

ID=48082436

Family Applications (1)

Application Number Title Priority Date Filing Date
IL232072A IL232072B (en) 2011-10-11 2014-04-10 Use of semaphorin-4d binding molecules to regulate blood-brain barrier permeability

Country Status (16)

Country Link
US (2) US20130095118A1 (enExample)
EP (1) EP2766093B1 (enExample)
JP (2) JP6395606B2 (enExample)
KR (1) KR101999872B1 (enExample)
CN (2) CN104168956A (enExample)
AU (1) AU2012322721B2 (enExample)
BR (1) BR112014008885B1 (enExample)
CA (1) CA2851805C (enExample)
DK (1) DK2766093T3 (enExample)
EA (1) EA029023B1 (enExample)
ES (1) ES2669209T3 (enExample)
IL (1) IL232072B (enExample)
MX (1) MX353550B (enExample)
PT (1) PT2766093T (enExample)
SG (1) SG11201401458UA (enExample)
WO (1) WO2013055922A1 (enExample)

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BR112015032690B1 (pt) 2013-06-25 2020-03-10 Vaccinex, Inc. Uso de moléculas inibidoras de semaforina-4d em combinação com uma terapia imunomoduladora para inibir o crescimento tumoral e metástase
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WO2018156509A1 (en) * 2017-02-22 2018-08-30 Vaccinex, Inc. Early detection of glial cell activation in neurodegenerative or neuroinflammatory diseases
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KR20230007557A (ko) * 2017-09-22 2023-01-12 카이트 파마 인코포레이티드 키메라 폴리펩티드 및 그의 용도
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WO2020154374A1 (en) * 2019-01-22 2020-07-30 Massachusetts Institute Of Technology In vitro human blood brain barrier
TWI859192B (zh) * 2019-03-29 2024-10-21 日商中外製藥股份有限公司 包含抗il-6受體抗體之bbb功能低下之抑制劑
CN117597360A (zh) * 2020-06-25 2024-02-23 瓦西尼斯公司 脑信号蛋白-4d结合分子在rett综合征治疗中的应用
EP3973979A1 (en) * 2020-09-25 2022-03-30 The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth A tight junction (zonulae occludentes) protein for use in treating or preventing epilepsy
CN113456813A (zh) * 2021-07-26 2021-10-01 苏州大学 Semaphorin7A单克隆抗体在制备用于治疗血栓及脑血管疾病药物方面的应用
WO2023012314A1 (en) * 2021-08-05 2023-02-09 Lifearc Anti-plexin-b1 antibodies
CN114539204B (zh) * 2022-03-23 2023-08-22 福建金兰厚普生物科技有限公司 己糖激酶抑制剂及其合成方法和应用
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Also Published As

Publication number Publication date
EA029023B1 (ru) 2018-01-31
MX2014004457A (es) 2014-06-05
DK2766093T3 (en) 2018-06-06
EP2766093A1 (en) 2014-08-20
NZ623856A (en) 2016-04-29
PT2766093T (pt) 2018-05-18
US11534488B2 (en) 2022-12-27
BR112014008885B1 (pt) 2021-02-17
AU2012322721B2 (en) 2016-05-05
WO2013055922A1 (en) 2013-04-18
KR101999872B1 (ko) 2019-07-12
AU2012322721A1 (en) 2013-05-16
BR112014008885A2 (pt) 2017-04-18
CN110105452A (zh) 2019-08-09
CA2851805C (en) 2021-12-28
MX353550B (es) 2018-01-18
CN104168956A (zh) 2014-11-26
US20130095118A1 (en) 2013-04-18
EA201490768A1 (ru) 2014-09-30
EP2766093B1 (en) 2018-02-21
EP2766093A4 (en) 2015-03-25
IL232072A0 (en) 2014-05-28
US20190358321A1 (en) 2019-11-28
JP2017193569A (ja) 2017-10-26
JP2014530239A (ja) 2014-11-17
CA2851805A1 (en) 2013-04-18
ES2669209T3 (es) 2018-05-24
SG11201401458UA (en) 2014-07-30
KR20140076616A (ko) 2014-06-20
JP6395606B2 (ja) 2018-09-26

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