IL223163A0 - Monoclonal antibodies against her2 epitope - Google Patents
Monoclonal antibodies against her2 epitopeInfo
- Publication number
- IL223163A0 IL223163A0 IL223163A IL22316312A IL223163A0 IL 223163 A0 IL223163 A0 IL 223163A0 IL 223163 A IL223163 A IL 223163A IL 22316312 A IL22316312 A IL 22316312A IL 223163 A0 IL223163 A0 IL 223163A0
- Authority
- IL
- Israel
- Prior art keywords
- monoclonal antibodies
- antibodies against
- against her2
- her2 epitope
- epitope
- Prior art date
Links
- 101100314454 Caenorhabditis elegans tra-1 gene Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34918210P | 2010-05-27 | 2010-05-27 | |
| DKPA201000468 | 2010-05-27 | ||
| PCT/EP2011/058772 WO2011147982A2 (en) | 2010-05-27 | 2011-05-27 | Monoclonal antibodies against her2 epitope |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL223163A0 true IL223163A0 (en) | 2013-02-03 |
Family
ID=44533416
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL223163A IL223163A0 (en) | 2010-05-27 | 2012-11-20 | Monoclonal antibodies against her2 epitope |
| IL245274A IL245274B (en) | 2010-05-27 | 2016-04-21 | Monoclonal antibodies against the 2her epitope |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL245274A IL245274B (en) | 2010-05-27 | 2016-04-21 | Monoclonal antibodies against the 2her epitope |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9714294B2 (enExample) |
| EP (1) | EP2575880B1 (enExample) |
| JP (2) | JP6082344B2 (enExample) |
| CN (1) | CN103153339B (enExample) |
| CA (1) | CA2800769C (enExample) |
| IL (2) | IL223163A0 (enExample) |
| NZ (1) | NZ604007A (enExample) |
| WO (1) | WO2011147982A2 (enExample) |
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| AU2011325833C1 (en) | 2010-11-05 | 2017-07-13 | Zymeworks Bc Inc. | Stable heterodimeric antibody design with mutations in the Fc domain |
| US9499605B2 (en) | 2011-03-03 | 2016-11-22 | Zymeworks Inc. | Multivalent heteromultimer scaffold design and constructs |
| AU2012245116A1 (en) * | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| KR20140048881A (ko) * | 2011-05-09 | 2014-04-24 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 암 치료 조성물 및 방법 |
| UA117901C2 (uk) | 2011-07-06 | 2018-10-25 | Ґенмаб Б.В. | Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування |
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| KR20150008171A (ko) * | 2012-05-10 | 2015-01-21 | 자임워크스 인코포레이티드 | 단일군 일가 항체 구조물 및 그의 용도 |
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| WO2014012082A2 (en) | 2012-07-13 | 2014-01-16 | Zymeworks Inc. | Multivalent heteromultimer scaffold design an constructs |
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| US9914785B2 (en) | 2012-11-28 | 2018-03-13 | Zymeworks Inc. | Engineered immunoglobulin heavy chain-light chain pairs and uses thereof |
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| US9738726B2 (en) | 2013-06-11 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HER2-specific monoclonal antibodies and conjugates thereof |
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| JP6817064B2 (ja) | 2013-11-27 | 2021-01-20 | ザイムワークス,インコーポレイテッド | Her2を標的とする二重特異性抗原結合性コンストラクト |
| SG10201809385RA (en) | 2013-12-17 | 2018-11-29 | Genentech Inc | Anti-cd3 antibodies and methods of use |
| EP3327038B1 (en) | 2013-12-20 | 2020-09-23 | F. Hoffmann-La Roche AG | Bispecific her2 antibodies and methods of use |
| CN105899236B (zh) * | 2014-01-10 | 2019-07-26 | 斯索恩生物制药有限公司 | 表现出改进的体内抗肿瘤活性的倍癌霉素adc |
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-
2011
- 2011-05-27 JP JP2013511701A patent/JP6082344B2/ja active Active
- 2011-05-27 US US13/700,246 patent/US9714294B2/en active Active
- 2011-05-27 WO PCT/EP2011/058772 patent/WO2011147982A2/en not_active Ceased
- 2011-05-27 NZ NZ60400711A patent/NZ604007A/en not_active IP Right Cessation
- 2011-05-27 CN CN201180036931.1A patent/CN103153339B/zh active Active
- 2011-05-27 EP EP11723427.8A patent/EP2575880B1/en active Active
- 2011-05-27 CA CA2800769A patent/CA2800769C/en active Active
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2012
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2016
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- 2016-09-12 JP JP2016177734A patent/JP6438442B2/ja active Active
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2017
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- 2020-08-26 US US17/003,442 patent/US20210122830A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| JP2013534809A (ja) | 2013-09-09 |
| EP2575880B1 (en) | 2019-01-16 |
| CA2800769A1 (en) | 2011-12-01 |
| US20210122830A1 (en) | 2021-04-29 |
| US20130171148A1 (en) | 2013-07-04 |
| IL245274A0 (en) | 2016-06-30 |
| US9714294B2 (en) | 2017-07-25 |
| EP2575880A2 (en) | 2013-04-10 |
| JP6438442B2 (ja) | 2018-12-12 |
| WO2011147982A3 (en) | 2012-03-15 |
| CN103153339B (zh) | 2021-05-04 |
| IL245274B (en) | 2019-08-29 |
| NZ604007A (en) | 2015-03-27 |
| CN103153339A (zh) | 2013-06-12 |
| CA2800769C (en) | 2021-11-02 |
| US20180022816A1 (en) | 2018-01-25 |
| JP6082344B2 (ja) | 2017-02-15 |
| US10793640B2 (en) | 2020-10-06 |
| JP2017046694A (ja) | 2017-03-09 |
| WO2011147982A2 (en) | 2011-12-01 |
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