IL223161A0 - Processes for preparing macrolides and ketolides and intermediates therefor - Google Patents

Processes for preparing macrolides and ketolides and intermediates therefor

Info

Publication number
IL223161A0
IL223161A0 IL223161A IL22316112A IL223161A0 IL 223161 A0 IL223161 A0 IL 223161A0 IL 223161 A IL223161 A IL 223161A IL 22316112 A IL22316112 A IL 22316112A IL 223161 A0 IL223161 A0 IL 223161A0
Authority
IL
Israel
Prior art keywords
ketolides
processes
intermediates therefor
macrolides
preparing
Prior art date
Application number
IL223161A
Other languages
English (en)
Original Assignee
Cempra Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cempra Pharmaceuticals Inc filed Critical Cempra Pharmaceuticals Inc
Publication of IL223161A0 publication Critical patent/IL223161A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL223161A 2010-05-20 2012-11-20 Processes for preparing macrolides and ketolides and intermediates therefor IL223161A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34666410P 2010-05-20 2010-05-20
PCT/US2011/037330 WO2011146829A1 (en) 2010-05-20 2011-05-20 Processes for preparing macrolides and ketolides and intermediates therefor

Publications (1)

Publication Number Publication Date
IL223161A0 true IL223161A0 (en) 2013-02-03

Family

ID=44992076

Family Applications (1)

Application Number Title Priority Date Filing Date
IL223161A IL223161A0 (en) 2010-05-20 2012-11-20 Processes for preparing macrolides and ketolides and intermediates therefor

Country Status (15)

Country Link
US (4) US9051346B2 (cg-RX-API-DMAC7.html)
EP (1) EP2571506B1 (cg-RX-API-DMAC7.html)
JP (1) JP6184319B2 (cg-RX-API-DMAC7.html)
KR (1) KR101945324B1 (cg-RX-API-DMAC7.html)
CN (2) CN105198944B (cg-RX-API-DMAC7.html)
AU (1) AU2011255464C1 (cg-RX-API-DMAC7.html)
BR (1) BR112012029586A2 (cg-RX-API-DMAC7.html)
CA (1) CA2799937A1 (cg-RX-API-DMAC7.html)
DK (1) DK2571506T3 (cg-RX-API-DMAC7.html)
ES (1) ES2636948T3 (cg-RX-API-DMAC7.html)
IL (1) IL223161A0 (cg-RX-API-DMAC7.html)
PL (1) PL2571506T3 (cg-RX-API-DMAC7.html)
RU (1) RU2608390C2 (cg-RX-API-DMAC7.html)
SI (1) SI2571506T1 (cg-RX-API-DMAC7.html)
WO (1) WO2011146829A1 (cg-RX-API-DMAC7.html)

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US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
CA2703475A1 (en) 2007-10-25 2009-04-30 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN102223794B (zh) 2008-10-24 2017-12-22 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
CN108310000A (zh) 2009-09-10 2018-07-24 森普拉制药公司 治疗疟疾、结核病和mac疾病的方法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
MX353408B (es) 2010-04-22 2018-01-11 Vertex Pharma Proceso para producir compuestos de cicloalquilcarboxamido-indol.
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NZ700182A (en) 2012-03-27 2017-02-24 Cempra Pharmaceuticals Inc Parenteral formulations for administering macrolide antibiotics
CN103897002A (zh) * 2012-12-31 2014-07-02 菏泽市方明制药有限公司 一种粗品硫氰酸红霉素制备红霉素a9-肟的方法
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
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CN105246334A (zh) 2013-04-04 2016-01-13 哈佛大学的校长及成员们 大环内酯及其制备和使用方法
MX387720B (es) 2014-04-15 2025-03-12 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de conductancia de transmembrana de fibrosis quística.
CN104151382B (zh) * 2014-08-08 2016-09-14 广东东阳光药业有限公司 一种固态大环内酯的晶型
CN104311611B (zh) * 2014-08-13 2017-01-18 广东东阳光药业有限公司 一种制备固态大环内酯的方法
JP2017531663A (ja) 2014-10-08 2017-10-26 プレジデント アンド フェローズ オブ ハーバード カレッジ １４員ケトライドならびにそれらの調製および使用の方法
CA2980315A1 (en) 2015-03-25 2016-09-29 President And Fellows Of Harvard College Macrolides with modified desosamine sugars and uses thereof
CN106554381A (zh) * 2015-09-25 2017-04-05 苏州鹏旭医药科技有限公司 酮内酯类抗生素中间体及其制备方法和应用
TW201811811A (zh) * 2016-09-02 2018-04-01 森普拉製藥公司 製備氟酮內酯之方法

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Also Published As

Publication number Publication date
WO2011146829A1 (en) 2011-11-24
RU2012150753A (ru) 2014-06-27
KR20130120374A (ko) 2013-11-04
EP2571506B1 (en) 2017-05-10
SI2571506T1 (sl) 2017-12-29
AU2011255464B2 (en) 2016-06-16
CN105198944B (zh) 2018-06-01
US20130066056A1 (en) 2013-03-14
JP6184319B2 (ja) 2017-08-23
ES2636948T3 (es) 2017-10-10
CN102917708A (zh) 2013-02-06
KR101945324B1 (ko) 2019-02-07
AU2011255464C1 (en) 2017-02-23
CN105198944A (zh) 2015-12-30
HK1181672A1 (zh) 2013-11-15
EP2571506A4 (en) 2014-04-02
BR112012029586A2 (pt) 2016-08-02
CN102917708B (zh) 2015-11-25
PL2571506T3 (pl) 2017-10-31
US20200087335A1 (en) 2020-03-19
CA2799937A1 (en) 2011-11-24
RU2608390C2 (ru) 2017-01-18
AU2011255464A1 (en) 2012-12-13
EP2571506A1 (en) 2013-03-27
US20150232500A1 (en) 2015-08-20
US9051346B2 (en) 2015-06-09
DK2571506T3 (en) 2017-08-28
JP2013527187A (ja) 2013-06-27
US20190048035A1 (en) 2019-02-14
HK1218919A1 (zh) 2017-03-17

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