IL219325B - Compounds for targeting gadd45beta and uses thereof - Google Patents
Compounds for targeting gadd45beta and uses thereofInfo
- Publication number
- IL219325B IL219325B IL219325A IL21932512A IL219325B IL 219325 B IL219325 B IL 219325B IL 219325 A IL219325 A IL 219325A IL 21932512 A IL21932512 A IL 21932512A IL 219325 B IL219325 B IL 219325B
- Authority
- IL
- Israel
- Prior art keywords
- targeting compounds
- gadd45 beta
- gadd45
- beta targeting
- compounds
- Prior art date
Links
- 101150033270 Gadd45a gene Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0918579.4A GB0918579D0 (en) | 2009-10-22 | 2009-10-22 | Gadd45beta targeting agents |
| PCT/GB2010/001970 WO2011048390A2 (en) | 2009-10-22 | 2010-10-22 | Gadd45beta targeting agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL219325A0 IL219325A0 (en) | 2012-06-28 |
| IL219325B true IL219325B (en) | 2019-02-28 |
Family
ID=41426579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL219325A IL219325B (en) | 2009-10-22 | 2012-04-22 | Compounds for targeting gadd45beta and uses thereof |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8993717B2 (enExample) |
| EP (2) | EP2491051A2 (enExample) |
| JP (2) | JP5961113B2 (enExample) |
| KR (1) | KR20120099440A (enExample) |
| CN (1) | CN102741269B (enExample) |
| AU (1) | AU2010309594B2 (enExample) |
| BR (1) | BR112012011332B1 (enExample) |
| CA (2) | CA3034860A1 (enExample) |
| GB (1) | GB0918579D0 (enExample) |
| IL (1) | IL219325B (enExample) |
| IN (1) | IN2012DN03310A (enExample) |
| MX (1) | MX357801B (enExample) |
| RU (2) | RU2577311C2 (enExample) |
| WO (1) | WO2011048390A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0918579D0 (en) | 2009-10-22 | 2009-12-09 | Imp Innovations Ltd | Gadd45beta targeting agents |
| PL219569B1 (pl) | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
| GB201107118D0 (en) * | 2011-04-27 | 2011-06-08 | Imp Innovations Ltd | Method of diagnosis and prognosis |
| KR101745766B1 (ko) * | 2011-10-14 | 2017-06-09 | 서울대학교산학협력단 | 펩타이드 나노구조체 및 그 제조 방법 |
| EP3777876B1 (en) * | 2011-10-28 | 2023-08-09 | NeoStrata Company, Inc. | N-acyldipeptide derivatives and their uses |
| EP2827861A4 (en) * | 2012-03-19 | 2016-03-16 | Aposignal Bioscience Llc | COMPOSITION AND METHODS FOR CELLULAR MODULATION |
| CN104817618B (zh) * | 2014-01-30 | 2018-07-03 | 陈光健 | 寡肽cd01及其制备方法和应用 |
| CN104817616A (zh) * | 2014-01-30 | 2015-08-05 | 陈光健 | 寡肽cd02及其制备方法和应用 |
| GB201414542D0 (en) * | 2014-08-15 | 2014-10-01 | Imp Innovations Ltd | Novel therapy |
| CN111606972B (zh) * | 2019-01-30 | 2022-04-05 | 浙江省医学科学院 | 一种鳕鱼皮寡肽及其分离纯化和在制备ɑ-葡萄糖苷酶抑制剂及抗Ⅱ型糖尿病药物中的应用 |
| RU2716258C1 (ru) * | 2019-07-30 | 2020-03-11 | Автономная некоммерческая образовательная организация высшего образования Сколковский институт науки и технологий | Пептидный антагонист нмда-рецептора |
| KR102417496B1 (ko) * | 2019-11-29 | 2022-07-06 | (주)수파드엘릭사 | 안드로겐 수용체의 활성을 억제하는 폡타이드 및 이를 이용하는 화장료 조성물 |
| KR102348728B1 (ko) * | 2020-03-23 | 2022-01-12 | 주식회사 엘베이스 | 암의 예방 또는 치료용 약학적 조성물 |
| WO2021194228A1 (ko) * | 2020-03-23 | 2021-09-30 | 주식회사 엘베이스 | 암의 예방 또는 치료용 약학적 조성물 |
| US11952365B2 (en) | 2020-06-10 | 2024-04-09 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| WO2022203219A1 (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 엘베이스 | 암의 예방 또는 치료용 약학적 조성물 |
| US20230159587A1 (en) * | 2021-03-22 | 2023-05-25 | L-Base Co., Ltd. | Pharmaceutical composition for preventing or treating cancer |
| US11851422B2 (en) | 2021-07-09 | 2023-12-26 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| IT202100023357A1 (it) * | 2021-09-09 | 2023-03-09 | Cheirontech S R L | Peptidi con attività anti-angiogenica |
| KR102786112B1 (ko) * | 2021-09-17 | 2025-03-27 | 주식회사 엘베이스 | 항암제의 항암 효과 증진용 약학적 조성물 |
| WO2023043261A1 (ko) * | 2021-09-17 | 2023-03-23 | 주식회사 엘베이스 | 항암제의 항암 효과 증진용 약학적 조성물 |
| KR102494749B1 (ko) * | 2021-09-17 | 2023-02-06 | 주식회사 엘베이스 | 암 치료용 cage 저해제에 대한 반응자 특성화 방법 |
| US20250213645A1 (en) * | 2021-09-17 | 2025-07-03 | L-Base Co., Ltd. | Pharmaceutical composition for modulating immune response |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
| CN116350746B (zh) * | 2023-05-16 | 2024-03-22 | 海口桥水联合科技有限责任公司 | 沙丁鱼肽组合物在治疗过敏性鼻炎的药物中的应用 |
| CN119874809A (zh) * | 2025-01-13 | 2025-04-25 | 广东工业大学 | 一类抗氧化肽及其制备方法和应用 |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| HU187461B (en) * | 1981-10-22 | 1986-01-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing n-nitrozo-n-bracket-beta-chloroethyl-bracket closed-carbamoyl-peptides of citostatic activity |
| CA1257199A (en) | 1986-05-20 | 1989-07-11 | Paul Y. Wang | Preparation containing bioactive macromolecular substance for multi-months release in vivo |
| DE3813989A1 (de) * | 1987-04-29 | 1988-11-10 | Hoechst Ag | Peptide mit phospholipase a(pfeil abwaerts)2(pfeil abwaerts)-hemmender wirkung |
| IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
| US5907030A (en) | 1995-01-25 | 1999-05-25 | University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
| US5962270A (en) | 1996-02-06 | 1999-10-05 | Bionebraska, Inc. | Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
| US6737408B1 (en) * | 1997-08-07 | 2004-05-18 | University Of Cincinnati | Compounds for control of appetite, blood pressure, cardiovascular response, libido, and circadian rhythm |
| US6093692A (en) | 1997-09-25 | 2000-07-25 | The University Of Southern California | Method and compositions for lipidization of hydrophilic molecules |
| FR2774674B1 (fr) | 1998-02-10 | 2000-03-24 | Atochem Elf Sa | Procede de preparation d'une solution aqueuse de peroxyde d'hydrogene directement a partir d'hydrogene et d'oxygene et dispositif permettant sa mise en oeuvre |
| US5993414A (en) | 1998-04-23 | 1999-11-30 | Medtronic, Inc. | Implantable device |
| US20030162223A1 (en) * | 1999-10-22 | 2003-08-28 | Lowery David E. | Drosophila G protein coupled receptors, nucleic acids, and methods related to the same |
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| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| CA2447314A1 (en) * | 2001-05-15 | 2002-11-21 | Atsuro Nakazato | Arginine derivatives |
| PT1790655E (pt) | 2001-07-13 | 2010-07-09 | Cms Peptides Patent Holding Co | PéPTIDOS BIOLOGICAMENTE ACTIVOS |
| WO2003028659A2 (en) | 2001-10-02 | 2003-04-10 | University Of Chicago | Methods and compositions for modulating apoptosis |
| US7354898B2 (en) * | 2001-10-02 | 2008-04-08 | University Of Chicago | Identification of novel factors that block programmed cell death or apoptosis by targeting JNK |
| JP2006506975A (ja) | 2002-08-19 | 2006-03-02 | イェン、ユン | 肝疾患の治療 |
| EP1615954A2 (en) | 2003-04-22 | 2006-01-18 | Avanir Pharmaceuticals | Mediators of reverse cholesterol transport for the treatment of hypercholesterolemia |
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| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7951782B2 (en) * | 2005-09-29 | 2011-05-31 | Maruha Nichiro Seafoods, Inc | Composition effective to prevent or treat adult disease |
| JP2007217358A (ja) * | 2006-02-17 | 2007-08-30 | Nippon Meat Packers Inc | 抗酸化性ペプチド |
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| US20090312396A1 (en) | 2006-07-10 | 2009-12-17 | Astrazeneca Ab | Methods for cancer treatment using tak1 inhibitors |
| CA2659655A1 (en) * | 2006-08-08 | 2008-02-21 | Alan M. Fogelman | Salicylanilides enhance oral delivery of therapeutic peptides |
| CN101153053B (zh) * | 2006-09-28 | 2012-02-01 | 中国医学科学院药物研究所 | 骨生肽、其制备方法和其药物组合物与用途 |
| EP1964560A1 (en) | 2007-02-28 | 2008-09-03 | Helmholtz-Zentrum für Infektionsforschung GmbH | Use of inhibitors of the degradation of p27 for the treatment of cancer |
| CN104474529A (zh) | 2008-02-08 | 2015-04-01 | 爱勒让治疗公司 | 治疗性的拟肽大环化合物 |
| GB0918579D0 (en) | 2009-10-22 | 2009-12-09 | Imp Innovations Ltd | Gadd45beta targeting agents |
| EP2390662A1 (en) | 2010-05-27 | 2011-11-30 | Erasmus University Medical Center Rotterdam | Molecular classification of multiple myeloma |
-
2009
- 2009-10-22 GB GBGB0918579.4A patent/GB0918579D0/en not_active Ceased
-
2010
- 2010-10-22 RU RU2012120905/04A patent/RU2577311C2/ru active
- 2010-10-22 US US13/502,781 patent/US8993717B2/en active Active
- 2010-10-22 CA CA3034860A patent/CA3034860A1/en not_active Abandoned
- 2010-10-22 CN CN201080058254.9A patent/CN102741269B/zh active Active
- 2010-10-22 JP JP2012534766A patent/JP5961113B2/ja active Active
- 2010-10-22 MX MX2012004755A patent/MX357801B/es active IP Right Grant
- 2010-10-22 KR KR1020127013065A patent/KR20120099440A/ko not_active Ceased
- 2010-10-22 EP EP10781977A patent/EP2491051A2/en not_active Withdrawn
- 2010-10-22 CA CA2778236A patent/CA2778236A1/en not_active Abandoned
- 2010-10-22 AU AU2010309594A patent/AU2010309594B2/en active Active
- 2010-10-22 IN IN3310DEN2012 patent/IN2012DN03310A/en unknown
- 2010-10-22 EP EP16185463.3A patent/EP3178836B1/en active Active
- 2010-10-22 WO PCT/GB2010/001970 patent/WO2011048390A2/en not_active Ceased
- 2010-10-22 RU RU2016102083A patent/RU2016102083A/ru not_active Application Discontinuation
- 2010-10-22 BR BR112012011332-1A patent/BR112012011332B1/pt active IP Right Grant
-
2012
- 2012-04-22 IL IL219325A patent/IL219325B/en not_active IP Right Cessation
-
2015
- 2015-02-10 US US14/618,613 patent/US9518083B2/en active Active
-
2016
- 2016-03-25 JP JP2016060994A patent/JP2016166211A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016166211A (ja) | 2016-09-15 |
| EP2491051A2 (en) | 2012-08-29 |
| KR20120099440A (ko) | 2012-09-10 |
| WO2011048390A3 (en) | 2011-11-03 |
| US20150368294A1 (en) | 2015-12-24 |
| RU2016102083A (ru) | 2018-11-20 |
| EP3178836A1 (en) | 2017-06-14 |
| RU2577311C2 (ru) | 2016-03-20 |
| IN2012DN03310A (enExample) | 2015-10-23 |
| JP2013508346A (ja) | 2013-03-07 |
| CA2778236A1 (en) | 2011-04-28 |
| GB0918579D0 (en) | 2009-12-09 |
| BR112012011332B1 (pt) | 2022-07-05 |
| IL219325A0 (en) | 2012-06-28 |
| WO2011048390A2 (en) | 2011-04-28 |
| EP3178836B1 (en) | 2019-12-25 |
| US20120277164A1 (en) | 2012-11-01 |
| CA3034860A1 (en) | 2011-04-28 |
| CN102741269B (zh) | 2017-08-29 |
| US9518083B2 (en) | 2016-12-13 |
| JP5961113B2 (ja) | 2016-08-02 |
| MX2012004755A (es) | 2012-11-22 |
| BR112012011332A2 (pt) | 2016-11-22 |
| CN102741269A (zh) | 2012-10-17 |
| AU2010309594A1 (en) | 2012-05-17 |
| US8993717B2 (en) | 2015-03-31 |
| AU2010309594B2 (en) | 2016-01-07 |
| RU2012120905A (ru) | 2013-11-27 |
| MX357801B (es) | 2018-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |