IL186104A - Phosphoramidate History of Nucleoside Compounds - Google Patents

Phosphoramidate History of Nucleoside Compounds

Info

Publication number
IL186104A
IL186104A IL186104A IL18610407A IL186104A IL 186104 A IL186104 A IL 186104A IL 186104 A IL186104 A IL 186104A IL 18610407 A IL18610407 A IL 18610407A IL 186104 A IL186104 A IL 186104A
Authority
IL
Israel
Prior art keywords
cancer
treatment
processes
preparation
pharmaceutical compositions
Prior art date
Application number
IL186104A
Other languages
English (en)
Hebrew (he)
Other versions
IL186104A0 (en
Inventor
Christopher Mcguigan
Kenneth Mills
Costantino Congiatu
Original Assignee
Christopher Mcguigan
Kenneth Mills
Costantino Congiatu
Nucana Biomed Ltd
Univ Cardiff
Cardiff Protides Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christopher Mcguigan, Kenneth Mills, Costantino Congiatu, Nucana Biomed Ltd, Univ Cardiff, Cardiff Protides Ltd filed Critical Christopher Mcguigan
Publication of IL186104A0 publication Critical patent/IL186104A0/en
Publication of IL186104A publication Critical patent/IL186104A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL186104A 2005-03-21 2007-09-20 Phosphoramidate History of Nucleoside Compounds IL186104A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0505781.5A GB0505781D0 (en) 2005-03-21 2005-03-21 Chemical compounds
PCT/GB2006/000932 WO2006100439A1 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer

Publications (2)

Publication Number Publication Date
IL186104A0 IL186104A0 (en) 2008-01-20
IL186104A true IL186104A (en) 2013-06-27

Family

ID=34531603

Family Applications (1)

Application Number Title Priority Date Filing Date
IL186104A IL186104A (en) 2005-03-21 2007-09-20 Phosphoramidate History of Nucleoside Compounds

Country Status (20)

Country Link
US (1) US8263575B2 (enExample)
EP (1) EP1866324B1 (enExample)
JP (2) JP5345381B2 (enExample)
CN (2) CN101175763A (enExample)
AT (1) ATE471334T1 (enExample)
AU (1) AU2006226182C1 (enExample)
BR (1) BRPI0609704B8 (enExample)
CA (1) CA2602324C (enExample)
CY (1) CY1111538T1 (enExample)
DE (1) DE602006014949D1 (enExample)
DK (1) DK1866324T3 (enExample)
ES (1) ES2348741T3 (enExample)
GB (1) GB0505781D0 (enExample)
IL (1) IL186104A (enExample)
MX (1) MX2007011666A (enExample)
PL (1) PL1866324T3 (enExample)
PT (1) PT1866324E (enExample)
SI (1) SI1866324T1 (enExample)
WO (1) WO2006100439A1 (enExample)
ZA (1) ZA200709011B (enExample)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
AU2012216500B2 (en) * 2006-11-24 2013-06-20 Katholieke Universiteit Leuven Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AR074897A1 (es) 2008-12-23 2011-02-23 Pharmasset Inc Fosforamidatos de nucleosidos
CL2009002206A1 (es) 2008-12-23 2011-08-26 Gilead Pharmasset Llc Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
MX2011006890A (es) 2008-12-23 2011-07-20 Pharmasset Inc Analogos de nucleosidos.
BRPI1004575A2 (pt) 2009-01-09 2016-04-05 Inhibitex Inc composto, composição farmacêutica, método de tratamento de infecções virais, método de separação dos diaestereômeros de fósforo
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
GB201016855D0 (en) * 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
WO2012092484A2 (en) * 2010-12-29 2012-07-05 Inhibitex, Inc. Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections
US9095599B2 (en) 2011-01-03 2015-08-04 Nanjing Molecular Research, Inc. O-(substituted benzyl) phosphoramidate compounds and therapeutic use
ES2569185T3 (es) 2011-03-01 2016-05-09 Nucana Biomed Limited Derivados de fosforamidato de 5-fluoro-2'-desoxiuridina para uso en el tratamiento del cáncer
US9085599B2 (en) 2011-03-16 2015-07-21 Enanta Pharmaceuticals, Inc. 2′allene-substituted nucleoside derivatives
AU2013346515B2 (en) * 2012-11-16 2017-05-25 NuCana plc Process for preparing nucleoside prodrugs
EP3004130B1 (en) 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thio nucleosides for the treatment of hcv
JP2017504572A (ja) * 2013-11-27 2017-02-09 アイデニクス・ファーマシューティカルズ・エルエルシー 肝臓癌治療のためのヌクレオチド類
US20170101431A1 (en) * 2014-05-28 2017-04-13 Idenix Pharmaceuticals Llc Nucleoside derivatives for the treatment of cancer
AU2015265607A1 (en) * 2014-05-28 2016-11-17 Idenix Pharmaceuticals Llc Nucleoside derivatives for the treatment of cancer
HRP20191461T1 (hr) 2014-11-28 2019-11-15 NuCana plc Novi 2' i/ili 5' derivati 3'-deoksi adenozina supstituirani aminokiselinskim esterom fosforamidata, kao antikancerogenog spoja
FI3265102T3 (fi) 2015-03-06 2025-10-31 Atea Pharmaceuticals Inc Beta-d-2'-deoksi-2'-alfa-fluori-2'-beta-c-substituoituja-2-modifioituja-n6-substituoituja puriininukleotideja hcv-hoitoa varten
EP3377512A4 (en) * 2015-11-16 2019-09-18 Ichorion Therapeutics, Inc. Nucleic Acid PRODRUGS
GB201522764D0 (en) * 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609602D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
WO2018013937A1 (en) 2016-07-14 2018-01-18 Atea Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
WO2018071675A1 (en) * 2016-10-12 2018-04-19 Georgetown University Cd99 inhibitors and their uses
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
JP2020164521A (ja) * 2019-03-29 2020-10-08 国立大学法人 長崎大学 抗ウィルス薬
GB201904544D0 (en) 2019-04-01 2019-05-15 NuCana plc Anticancer compounds
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
CN113549076B (zh) * 2021-07-23 2022-12-06 中国药科大学 一种多取代嘌呤类化合物及其制备方法和应用
WO2026151964A1 (en) 2025-01-10 2026-07-16 Atea Pharmaceuticals, Inc. Compositions and use thereof in treating hepatitis e infections with beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR880000094B1 (ko) 1984-12-07 1988-02-23 보령제약 주식회사 뉴클레오시드 유도체의 제조방법
CA2004695C (en) 1988-12-12 1999-08-10 Rosanne Bonjouklian Phospholipid nucleosides
DE4418690A1 (de) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
EP0821692B1 (en) 1995-04-21 2006-01-11 University Of South Florida Immunopotentiating inosine monophosphate 5'-nucleotidase resistant derivatives and uses thereof
JP3761958B2 (ja) 1996-03-12 2006-03-29 彰 松田 ３′−カルバモイルアルキルヌクレオシド誘導体
ES2172303T3 (es) * 1998-01-23 2002-09-16 Newbiotics Inc Agentes terapeuticos obtenidos por catalisis enzimatica.
GB9821058D0 (en) * 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
JP4768909B2 (ja) 2000-09-29 2011-09-07 扶桑薬品工業株式会社 トポイソメラーゼ阻害剤
US20030073618A1 (en) * 2001-02-08 2003-04-17 Kozhemyakin Leonid A. Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof
DE10108851A1 (de) * 2001-02-23 2002-09-12 Resprotect Gmbh Verwendung von 5'-substituierten Nukleosiden und/oder deren Prodrugs zur resistenzfreien Therapie von Infektionskrankheiten
WO2003000200A2 (en) * 2001-06-22 2003-01-03 Pharmasset Ltd. β-2'-OR 3'-HALONUCLEOSIDES
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
GB0401088D0 (en) * 2004-01-19 2004-02-18 Univ Cardiff Phosphoramidate derivatives
US20070265222A1 (en) * 2004-06-24 2007-11-15 Maccoss Malcolm Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection
CN101287472B (zh) * 2005-08-15 2011-10-12 弗·哈夫曼-拉罗切有限公司 抗病毒的4'-取代前核苷酸的氨基磷酸酯类化合物

Also Published As

Publication number Publication date
JP2008533191A (ja) 2008-08-21
DE602006014949D1 (de) 2010-07-29
CN101175763A (zh) 2008-05-07
US8263575B2 (en) 2012-09-11
BRPI0609704A2 (pt) 2010-04-20
BRPI0609704B8 (pt) 2021-09-28
CA2602324A1 (en) 2006-09-28
CY1111538T1 (el) 2015-08-05
AU2006226182A1 (en) 2006-09-28
ATE471334T1 (de) 2010-07-15
ES2348741T3 (es) 2010-12-13
US20090215715A1 (en) 2009-08-27
AU2006226182B2 (en) 2011-09-01
IL186104A0 (en) 2008-01-20
JP5863702B2 (ja) 2016-02-17
PL1866324T3 (pl) 2010-12-31
AU2006226182C1 (en) 2012-06-14
GB0505781D0 (en) 2005-04-27
WO2006100439A1 (en) 2006-09-28
EP1866324A1 (en) 2007-12-19
BRPI0609704B1 (pt) 2020-12-01
PT1866324E (pt) 2010-09-16
JP2013173786A (ja) 2013-09-05
JP5345381B2 (ja) 2013-11-20
CA2602324C (en) 2015-02-24
ZA200709011B (en) 2009-01-28
MX2007011666A (es) 2007-11-14
SI1866324T1 (sl) 2010-10-29
DK1866324T3 (da) 2010-09-27
CN103936807A (zh) 2014-07-23
EP1866324B1 (en) 2010-06-16

Similar Documents

Publication Publication Date Title
IL186104A0 (en) Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer
TW200736262A (en) Heteroalkyl linked pyrimidine derivatives
SG164368A1 (en) Treatment of cancer
IL204732A (en) @@@@@ - Diplooro - @@ - Deoxy @ tetrahydro uridines, preparations containing them and their use in making @ drugs
CY1112889T1 (el) Αναλογα αζετιδινης αναστολεων νουκλεοσιδασης και φωσφορυλασης
MX2022008744A (es) Nuevos derivados de ester fosforamidato 3'-desoxiadenosina de 2' y/o 5' aminoacido como compuestos anti-cancer.
MX2009010047A (es) Compuestos quimicos.
MY145447A (en) Use of 2-6(3-amino-piperidin-1-yl)-3-methyl-2, 4-dioxo-3, 4-dihydrp-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile
MY146112A (en) Long-term feed - cancer patient
TW200716646A (en) (S)-N-methylnaltrexone
MX2009010045A (es) Compuestos quimicos.
MY143795A (en) Tetrahydropyridoindole derivatives
IL170834A (en) Imidazo-pyridine derivatives and their use as medicaments
MY198880A (en) Phosphoramidate nucleoside derivatives as anticancer agents
TW200738659A (en) Novel compounds
TW200730518A (en) Crystalline forms of docetaxel and processes for their preparation
WO2007056596A3 (en) Phosphoramidate derivatives of fau
NO20074780L (no) Heterocyklylamidsubstituerte imidazoler
IL192454A (en) Solid Pharmaceuticals Containing S-Adenosylmethionine
CL2008003933A1 (es) Compuestos derivados de n-heterociclo-[1,2-a]-piridina-2-carboxamida; procedimiento de preparacion; composicion farmaceutica; utiles en el tratamiento y/o prevencion de enfermedades neurodegenerativas, inflamatorias, epilepsia, osteoporosis, tumores malignos, entre otras.
SE0300457D0 (sv) Novel compounds
IL197769A (en) The history of morphine, medicinal preparations containing them and their use in the preparation of pain medication
NO20085189L (no) 2-alkoksy-3,4,5-trihydroksy-alkylamid-benzotaizepiner, fremstilling og anvendelse derav sammensetninger inneholdende samme
WO2007052300A3 (en) Processes for the preparation of different forms of (s)-(+)-clopidogrel besylate
WO2010146370A3 (en) Sox11 activating agents and uses thereof

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed