DK1866324T3 - Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancer - Google Patents
Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancerInfo
- Publication number
- DK1866324T3 DK1866324T3 DK06710096.6T DK06710096T DK1866324T3 DK 1866324 T3 DK1866324 T3 DK 1866324T3 DK 06710096 T DK06710096 T DK 06710096T DK 1866324 T3 DK1866324 T3 DK 1866324T3
- Authority
- DK
- Denmark
- Prior art keywords
- cancer
- treatment
- nucleoside compounds
- phosphoramidate derivatives
- compounds
- Prior art date
Links
- -1 nucleoside compounds Chemical class 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 239000002777 nucleoside Substances 0.000 title abstract 2
- 150000008298 phosphoramidates Chemical class 0.000 title abstract 2
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 abstract 1
- 229960002436 cladribine Drugs 0.000 abstract 1
- 229960000928 clofarabine Drugs 0.000 abstract 1
- WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960000390 fludarabine Drugs 0.000 abstract 1
- GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0505781.5A GB0505781D0 (en) | 2005-03-21 | 2005-03-21 | Chemical compounds |
| PCT/GB2006/000932 WO2006100439A1 (en) | 2005-03-21 | 2006-03-16 | Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1866324T3 true DK1866324T3 (da) | 2010-09-27 |
Family
ID=34531603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06710096.6T DK1866324T3 (da) | 2005-03-21 | 2006-03-16 | Phosphoramidatderivater af nukleosidforbindelser til anvendelse i behandlingen af cancer |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8263575B2 (enExample) |
| EP (1) | EP1866324B1 (enExample) |
| JP (2) | JP5345381B2 (enExample) |
| CN (2) | CN101175763A (enExample) |
| AT (1) | ATE471334T1 (enExample) |
| AU (1) | AU2006226182C1 (enExample) |
| BR (1) | BRPI0609704B8 (enExample) |
| CA (1) | CA2602324C (enExample) |
| CY (1) | CY1111538T1 (enExample) |
| DE (1) | DE602006014949D1 (enExample) |
| DK (1) | DK1866324T3 (enExample) |
| ES (1) | ES2348741T3 (enExample) |
| GB (1) | GB0505781D0 (enExample) |
| IL (1) | IL186104A (enExample) |
| MX (1) | MX2007011666A (enExample) |
| PL (1) | PL1866324T3 (enExample) |
| PT (1) | PT1866324E (enExample) |
| SI (1) | SI1866324T1 (enExample) |
| WO (1) | WO2006100439A1 (enExample) |
| ZA (1) | ZA200709011B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0623493D0 (en) * | 2006-11-24 | 2007-01-03 | Univ Cardiff | Chemical compounds |
| AU2012216500B2 (en) * | 2006-11-24 | 2013-06-20 | Katholieke Universiteit Leuven | Nucleoside aryl phosphoramidates and their use as anti-viral agents for the treatment of hepatitis C virus |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| TW201026715A (en) | 2008-12-23 | 2010-07-16 | Pharmasset Inc | Nucleoside phosphoramidates |
| JP6104504B2 (ja) | 2008-12-23 | 2017-03-29 | ギリアド ファーマセット エルエルシー | ヌクレオシド類似体 |
| CL2009002206A1 (es) | 2008-12-23 | 2011-08-26 | Gilead Pharmasset Llc | Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales. |
| CN102348712A (zh) | 2009-01-09 | 2012-02-08 | 卡迪夫大学学院顾问有限公司 | 用于治疗病毒感染的鸟苷核苷类化合物的磷酰胺酯衍生物 |
| CL2011000716A1 (es) | 2010-03-31 | 2012-04-20 | Gilead Pharmasset Llc | Formas cristalinas 1 6 de (s)-isopropil-2-(((s)-(((2r.3r.4r.5r)-5-(2,4-dioxo-3,4-dihidropirimidin-1(2h)-il)-4-fluoro-3-hidroxi-4-metil tetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato; composicion y combinacion farmaceutica; y su uso para tratar una infeccion por el virus de la hepatitis c. |
| GB201016855D0 (en) * | 2010-10-06 | 2010-11-17 | Nucana Biomed Ltd | Chemical compounds |
| EP2658857B1 (en) | 2010-12-29 | 2016-11-02 | Inhibitex, Inc. | Substituted purine nucleosides, phosphoroamidate and phosphorodiamidate derivatives for treatment of viral infections |
| CN103403014B (zh) * | 2011-01-03 | 2016-07-06 | 河南美泰宝生物制药有限公司 | O-(经取代的苯甲基)氨基磷酸酯化合物及其治疗用途 |
| DK3447061T3 (da) | 2011-03-01 | 2022-01-03 | NuCana plc | Farmaceutisk formulering omfattende et phosphoramidatderivat af 5-fluor-2'-deoxyuridin til anvendelse i cancerbehandling |
| WO2012125900A1 (en) | 2011-03-16 | 2012-09-20 | Enanta Pharmaceuticals, Inc. | 2'-allene-substituted nucleoside derivatives |
| HUE044605T2 (hu) * | 2012-11-16 | 2019-11-28 | Univ College Cardiff Consultants Ltd | RP/SP gemcitabin-[fenil-(benziloxi-L-alaninil)]-foszfát keveréke |
| US10005779B2 (en) | 2013-06-05 | 2018-06-26 | Idenix Pharmaceuticals Llc | 1′,4′-thio nucleosides for the treatment of HCV |
| BR112016011949A8 (pt) | 2013-11-27 | 2020-04-28 | Idenix Pharmaceuticals Llc | composto, composição farmacêutica, e, uso dos mesmos |
| AU2015265607A1 (en) * | 2014-05-28 | 2016-11-17 | Idenix Pharmaceuticals Llc | Nucleoside derivatives for the treatment of cancer |
| MX2016015568A (es) * | 2014-05-28 | 2017-07-04 | Idenix Pharmaceuticals Llc | Derivados de nucleosidos para el tratamiento del cancer. |
| CN111909231B (zh) | 2014-11-28 | 2025-10-17 | 努卡那有限公司 | 作为抗癌化合物的新的2’和/或5’-氨基酸酯氨基磷酸酯3’-脱氧腺苷衍生物 |
| GEP20217282B (en) | 2015-03-06 | 2021-08-10 | Atea Pharmaceuticals Inc | β-D-2'-DEOXY-2'α-FLUORO-2'-β-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT |
| CA3005444A1 (en) * | 2015-11-16 | 2017-05-26 | Ichorion Therapeutics, Inc. | Nucleic acid prodrugs |
| GB201522764D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| GB201609602D0 (en) * | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Chemical compounds |
| GB201609600D0 (en) * | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| PT3512863T (pt) | 2016-09-07 | 2022-03-09 | Atea Pharmaceuticals Inc | Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna |
| WO2018071675A1 (en) * | 2016-10-12 | 2018-04-19 | Georgetown University | Cd99 inhibitors and their uses |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| GB201715011D0 (en) | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
| GB201720279D0 (en) | 2017-12-05 | 2018-01-17 | Nucana Biomed Ltd | Anticancer compounds |
| JP2020164521A (ja) * | 2019-03-29 | 2020-10-08 | 国立大学法人 長崎大学 | 抗ウィルス薬 |
| GB201904544D0 (en) | 2019-04-01 | 2019-05-15 | NuCana plc | Anticancer compounds |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CN113549076B (zh) * | 2021-07-23 | 2022-12-06 | 中国药科大学 | 一种多取代嘌呤类化合物及其制备方法和应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR880000094B1 (ko) | 1984-12-07 | 1988-02-23 | 보령제약 주식회사 | 뉴클레오시드 유도체의 제조방법 |
| CA2004695C (en) | 1988-12-12 | 1999-08-10 | Rosanne Bonjouklian | Phospholipid nucleosides |
| DE4418690A1 (de) * | 1994-05-28 | 1996-01-11 | Boehringer Mannheim Gmbh | Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| EP0821692B1 (en) * | 1995-04-21 | 2006-01-11 | University Of South Florida | Immunopotentiating inosine monophosphate 5'-nucleotidase resistant derivatives and uses thereof |
| JP3761958B2 (ja) | 1996-03-12 | 2006-03-29 | 彰 松田 | ３′−カルバモイルアルキルヌクレオシド誘導体 |
| AU753155B2 (en) * | 1998-01-23 | 2002-10-10 | Kiadis Pharma Intellectual Property B.V. | Enzyme catalyzed therapeutic agents |
| GB9821058D0 (en) * | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| JP4768909B2 (ja) | 2000-09-29 | 2011-09-07 | 扶桑薬品工業株式会社 | トポイソメラーゼ阻害剤 |
| US20030073618A1 (en) * | 2001-02-08 | 2003-04-17 | Kozhemyakin Leonid A. | Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof |
| DE10108851A1 (de) * | 2001-02-23 | 2002-09-12 | Resprotect Gmbh | Verwendung von 5'-substituierten Nukleosiden und/oder deren Prodrugs zur resistenzfreien Therapie von Infektionskrankheiten |
| US6949522B2 (en) | 2001-06-22 | 2005-09-27 | Pharmasset, Inc. | β-2′- or 3′-halonucleosides |
| GB0317009D0 (en) * | 2003-07-21 | 2003-08-27 | Univ Cardiff | Chemical compounds |
| GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| CA2571079A1 (en) * | 2004-06-24 | 2006-02-02 | Merck & Co., Inc. | Nucleoside aryl phosphoramidates for the treatment of rna-dependent rna viral infection |
| JP2009504704A (ja) * | 2005-08-15 | 2009-02-05 | エフ．ホフマン−ラ ロシュ アーゲー | 抗ウイルス４′−置換プロヌクレオチドホスホルアミダート |
-
2005
- 2005-03-21 GB GBGB0505781.5A patent/GB0505781D0/en not_active Ceased
-
2006
- 2006-03-16 MX MX2007011666A patent/MX2007011666A/es active IP Right Grant
- 2006-03-16 DK DK06710096.6T patent/DK1866324T3/da active
- 2006-03-16 AT AT06710096T patent/ATE471334T1/de active
- 2006-03-16 BR BRPI0609704A patent/BRPI0609704B8/pt not_active IP Right Cessation
- 2006-03-16 CN CNA200680016708XA patent/CN101175763A/zh active Pending
- 2006-03-16 US US11/886,931 patent/US8263575B2/en not_active Expired - Fee Related
- 2006-03-16 ZA ZA200709011A patent/ZA200709011B/xx unknown
- 2006-03-16 AU AU2006226182A patent/AU2006226182C1/en not_active Ceased
- 2006-03-16 DE DE602006014949T patent/DE602006014949D1/de not_active Expired - Lifetime
- 2006-03-16 ES ES06710096T patent/ES2348741T3/es not_active Expired - Lifetime
- 2006-03-16 WO PCT/GB2006/000932 patent/WO2006100439A1/en not_active Ceased
- 2006-03-16 CA CA2602324A patent/CA2602324C/en not_active Expired - Lifetime
- 2006-03-16 JP JP2008502453A patent/JP5345381B2/ja not_active Expired - Fee Related
- 2006-03-16 CN CN201410186829.5A patent/CN103936807A/zh active Pending
- 2006-03-16 PL PL06710096T patent/PL1866324T3/pl unknown
- 2006-03-16 EP EP06710096A patent/EP1866324B1/en not_active Expired - Lifetime
- 2006-03-16 PT PT06710096T patent/PT1866324E/pt unknown
- 2006-03-16 SI SI200630762T patent/SI1866324T1/sl unknown
-
2007
- 2007-09-20 IL IL186104A patent/IL186104A/en active IP Right Grant
-
2010
- 2010-09-10 CY CY20101100826T patent/CY1111538T1/el unknown
-
2013
- 2013-05-07 JP JP2013097919A patent/JP5863702B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0609704B1 (pt) | 2020-12-01 |
| CY1111538T1 (el) | 2015-08-05 |
| EP1866324A1 (en) | 2007-12-19 |
| DE602006014949D1 (de) | 2010-07-29 |
| ATE471334T1 (de) | 2010-07-15 |
| JP2008533191A (ja) | 2008-08-21 |
| JP5863702B2 (ja) | 2016-02-17 |
| AU2006226182A1 (en) | 2006-09-28 |
| EP1866324B1 (en) | 2010-06-16 |
| IL186104A0 (en) | 2008-01-20 |
| PT1866324E (pt) | 2010-09-16 |
| AU2006226182C1 (en) | 2012-06-14 |
| BRPI0609704B8 (pt) | 2021-09-28 |
| AU2006226182B2 (en) | 2011-09-01 |
| CN103936807A (zh) | 2014-07-23 |
| ES2348741T3 (es) | 2010-12-13 |
| CN101175763A (zh) | 2008-05-07 |
| PL1866324T3 (pl) | 2010-12-31 |
| IL186104A (en) | 2013-06-27 |
| BRPI0609704A2 (pt) | 2010-04-20 |
| GB0505781D0 (en) | 2005-04-27 |
| ZA200709011B (en) | 2009-01-28 |
| JP2013173786A (ja) | 2013-09-05 |
| US8263575B2 (en) | 2012-09-11 |
| CA2602324A1 (en) | 2006-09-28 |
| CA2602324C (en) | 2015-02-24 |
| WO2006100439A1 (en) | 2006-09-28 |
| MX2007011666A (es) | 2007-11-14 |
| SI1866324T1 (sl) | 2010-10-29 |
| JP5345381B2 (ja) | 2013-11-20 |
| US20090215715A1 (en) | 2009-08-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL186104A0 (en) | Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer | |
| NL301145I2 (nl) | Tirbanibulin | |
| CY1122522T1 (el) | Μετα αρσενικωδες νατριο για χρηση στην αγωγη του πολλαπλου μυελωματος | |
| CL2008001234A1 (es) | Compuestos derivados de heterociclos nitrogenados, inhibidores de las proteinas de apoptosis; y uso en el tratamiento del cancer. | |
| NO20090047L (no) | Anti-DLL4-antistoffer og fremgangsmater for anvendelse av disse | |
| BRPI0513310A (pt) | análogos de tetrapeptìdeo | |
| MX339822B (es) | Derivados de fosforoamidato de 5-fluoro-2'-desoxiuridina para uso en el tratamiento contra el cancer. | |
| ECSP088440A (es) | Imidazopirazinas como inhibidores de proteinquinasa | |
| DE602006005475D1 (de) | Katheter | |
| TR200906131T1 (tr) | Aktivin -actrIIa antagonistleri ve göğüs kanserinin tedavi e | |
| CY1112781T1 (el) | 2'-φθορο-2'-δεοξυτετραϋδροουριδινες ως αναστολεις αποαμινασης κυτιδινης | |
| TW200737269A (en) | Ion sources, systems and methods | |
| NO20080622L (no) | Disykloalkylurea-glukokinase aktivatorer | |
| DOP2010000304A (es) | Composiciones y metodos de preparacion y uso de las mismas | |
| CL2008003309A1 (es) | Compuestos derivados de citosina (=4-amino-pirimidin-2-ona) sustituida, moduladores de quinasas de punto de control del ciclo celular; composicion farmaceutica; combinacion farmaceutica; y su uso en el tratamiento o la disminucion de la progresion del cancer. | |
| NO20083147L (no) | Anti-OX40L-antistoffer og fremgangsmater for anvendelse av disse | |
| NO20083397L (no) | Anti-EphB4-antistoffer og fremgangsmater for anvendelse av disse | |
| HN2005029978A (es) | Formulaciones | |
| MY146112A (en) | Long-term feed - cancer patient | |
| NO20083593L (no) | Anti-EphrinB2-antistoffer og fremgangsmater for anvendelse av disse | |
| NO20055130L (no) | Aminocykloheksyleter-forbindelser og deres anvendelse | |
| NO20074780L (no) | Heterocyklylamidsubstituerte imidazoler | |
| CL2008001837A1 (es) | Uso de compuestos derivados de cinolin-3-carboxamida en el tratamiento de la esquizofrenia. | |
| EA200971067A1 (ru) | Триазолиламинопиримидиновые соединения | |
| WO2009074253A3 (en) | Clofarabine dietherphospholipid derivatives |