DE602006014949D1 - Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs - Google Patents

Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs

Info

Publication number
DE602006014949D1
DE602006014949D1 DE602006014949T DE602006014949T DE602006014949D1 DE 602006014949 D1 DE602006014949 D1 DE 602006014949D1 DE 602006014949 T DE602006014949 T DE 602006014949T DE 602006014949 T DE602006014949 T DE 602006014949T DE 602006014949 D1 DE602006014949 D1 DE 602006014949D1
Authority
DE
Germany
Prior art keywords
cancer
treatment
nucleoside compounds
phosphoramidate derivatives
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006014949T
Other languages
English (en)
Inventor
Christopher Mcguigan
Kenneth Mills
Costantino Congiatu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardiff Protides Ltd
Original Assignee
Cardiff Protides Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiff Protides Ltd filed Critical Cardiff Protides Ltd
Publication of DE602006014949D1 publication Critical patent/DE602006014949D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602006014949T 2005-03-21 2006-03-16 Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs Active DE602006014949D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0505781.5A GB0505781D0 (en) 2005-03-21 2005-03-21 Chemical compounds
PCT/GB2006/000932 WO2006100439A1 (en) 2005-03-21 2006-03-16 Phosphoramidate derivatives of nucleoside compounds for use in the treatment of cancer

Publications (1)

Publication Number Publication Date
DE602006014949D1 true DE602006014949D1 (de) 2010-07-29

Family

ID=34531603

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006014949T Active DE602006014949D1 (de) 2005-03-21 2006-03-16 Phosphoramidatderivate von nukleosidverbindungen zur verwendung bei der behandlung von krebs

Country Status (20)

Country Link
US (1) US8263575B2 (de)
EP (1) EP1866324B1 (de)
JP (2) JP5345381B2 (de)
CN (2) CN103936807A (de)
AT (1) ATE471334T1 (de)
AU (1) AU2006226182C1 (de)
BR (1) BRPI0609704B8 (de)
CA (1) CA2602324C (de)
CY (1) CY1111538T1 (de)
DE (1) DE602006014949D1 (de)
DK (1) DK1866324T3 (de)
ES (1) ES2348741T3 (de)
GB (1) GB0505781D0 (de)
IL (1) IL186104A (de)
MX (1) MX2007011666A (de)
PL (1) PL1866324T3 (de)
PT (1) PT1866324E (de)
SI (1) SI1866324T1 (de)
WO (1) WO2006100439A1 (de)
ZA (1) ZA200709011B (de)

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GB0623493D0 (en) * 2006-11-24 2007-01-03 Univ Cardiff Chemical compounds
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010075517A2 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
CL2009002207A1 (es) 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
SG172363A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
BRPI1004575A2 (pt) 2009-01-09 2016-04-05 Inhibitex Inc composto, composição farmacêutica, método de tratamento de infecções virais, método de separação dos diaestereômeros de fósforo
AP3515A (en) 2010-03-31 2016-01-11 Gilead Pharmasset Llc Nucleoside phosphoramidates
GB201016855D0 (en) * 2010-10-06 2010-11-17 Nucana Biomed Ltd Chemical compounds
EP2658857B1 (de) * 2010-12-29 2016-11-02 Inhibitex, Inc. Substituierte purin-nukleoside, phosphoroamidate und phosphorodiamidatderivate zur behandlung von virusinfektionen
US9095599B2 (en) 2011-01-03 2015-08-04 Nanjing Molecular Research, Inc. O-(substituted benzyl) phosphoramidate compounds and therapeutic use
RS62721B1 (sr) 2011-03-01 2022-01-31 NuCana plc Farmaceutska formulacija koja sadrži fosforamidatni derivat 5-fluoro-2’-deoksiuridina za upotrebu u lečenju kancera
WO2012125900A1 (en) 2011-03-16 2012-09-20 Enanta Pharmaceuticals, Inc. 2'-allene-substituted nucleoside derivatives
PT3150616T (pt) 2012-11-16 2017-06-09 Univ College Cardiff Consultants Ltd Mistura de rp/sp gencitabina-[fenil-(benziloxi-l-alaninil)]-fosfato
WO2014197578A1 (en) 2013-06-05 2014-12-11 Idenix Pharmaceuticals, Inc. 1',4'-thio nucleosides for the treatment of hcv
MX2016006919A (es) 2013-11-27 2016-08-17 Idenix Pharmaceuticals Llc Nucleotidos para el tratamiento de cancer de higado.
EP3149017B1 (de) * 2014-05-28 2019-12-11 Idenix Pharmaceuticals LLC Nukleosidderivate zur behandlung von krebs
KR20170005492A (ko) * 2014-05-28 2017-01-13 아이데닉스 파마슈티칼스 엘엘씨 암의 치료를 위한 뉴클레오시드 유도체
IL291927A (en) 2014-11-28 2022-06-01 NuCana plc Oligonucleotides containing modified nucleosides
GEP20247600B (en) 2015-03-06 2024-02-26 Atea Pharmaceuticals Inc B-D-2'-DEOXY-2'a-FLUORO-2'-B-C-SUBSTITUTED-2-MODIFIED-N6-SUBSTITUTED PURINE NUCLEOTIDES FOR HCV TREATMENT
MX2018005872A (es) 2015-11-16 2019-05-16 Ichorion Therapeutics Inc Profarmacos de acido nucleico.
GB201522764D0 (en) * 2015-12-23 2016-02-03 Nucana Biomed Ltd Formulations of phosphate derivatives
GB201609600D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Cancer treatments
GB201609601D0 (en) * 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609602D0 (en) * 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
US10711029B2 (en) 2016-07-14 2020-07-14 Atea Pharmaceuticals, Inc. Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
EP3512863B1 (de) 2016-09-07 2021-12-08 ATEA Pharmaceuticals, Inc. 2'-substituierte-n6-substituierte purinnukleotide zur behandlung von rna-viren
WO2018071675A1 (en) * 2016-10-12 2018-04-19 Georgetown University Cd99 inhibitors and their uses
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201715011D0 (en) 2017-09-18 2017-11-01 Nucana Biomed Ltd Floxuridine synthesis
GB201720279D0 (en) 2017-12-05 2018-01-17 Nucana Biomed Ltd Anticancer compounds
GB201904544D0 (en) 2019-04-01 2019-05-15 NuCana plc Anticancer compounds
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
CN113549076B (zh) * 2021-07-23 2022-12-06 中国药科大学 一种多取代嘌呤类化合物及其制备方法和应用

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KR880000094B1 (ko) 1984-12-07 1988-02-23 보령제약 주식회사 뉴클레오시드 유도체의 제조방법
CA2004695C (en) 1988-12-12 1999-08-10 Rosanne Bonjouklian Phospholipid nucleosides
DE4418690A1 (de) 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Neue Lipidester von Nucleosid-Monophosphaten und deren Verwendung als immunsuppressive Arzneimittel
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
DE69534745T2 (de) 1995-04-21 2006-10-05 University Of South Florida, Tampa Immunopotenzierende 5'-nucleotidase-resistente inosinmonophosphat-derivate und ihre verwendung
JP3761958B2 (ja) 1996-03-12 2006-03-29 彰 松田 ３′−カルバモイルアルキルヌクレオシド誘導体
IL137164A0 (en) * 1998-01-23 2001-07-24 Newbiotics Inc Enzyme catalyzed therapeutic agents
GB9821058D0 (en) * 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
JP4768909B2 (ja) 2000-09-29 2011-09-07 扶桑薬品工業株式会社 トポイソメラーゼ阻害剤
US20030073618A1 (en) * 2001-02-08 2003-04-17 Kozhemyakin Leonid A. Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof
DE10108851A1 (de) * 2001-02-23 2002-09-12 Resprotect Gmbh Verwendung von 5'-substituierten Nukleosiden und/oder deren Prodrugs zur resistenzfreien Therapie von Infektionskrankheiten
AU2002322325A1 (en) * 2001-06-22 2003-01-08 Emory University Beta-2'-or 3'-halonucleosides
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
GB0401088D0 (en) * 2004-01-19 2004-02-18 Univ Cardiff Phosphoramidate derivatives
US20070265222A1 (en) * 2004-06-24 2007-11-15 Maccoss Malcolm Nucleoside Aryl Phosphoramidates for the Treatment of Rna-Dependent Rna Viral Infection
CA2618335C (en) * 2005-08-15 2015-03-31 F.Hoffmann-La Roche Ag Antiviral phosphoramidates of 4'-substituted pronucleotides

Also Published As

Publication number Publication date
GB0505781D0 (en) 2005-04-27
AU2006226182B2 (en) 2011-09-01
ZA200709011B (en) 2009-01-28
EP1866324A1 (de) 2007-12-19
ES2348741T3 (es) 2010-12-13
PL1866324T3 (pl) 2010-12-31
JP2013173786A (ja) 2013-09-05
US20090215715A1 (en) 2009-08-27
CY1111538T1 (el) 2015-08-05
WO2006100439A1 (en) 2006-09-28
SI1866324T1 (sl) 2010-10-29
JP2008533191A (ja) 2008-08-21
CN101175763A (zh) 2008-05-07
AU2006226182C1 (en) 2012-06-14
BRPI0609704B8 (pt) 2021-09-28
PT1866324E (pt) 2010-09-16
IL186104A0 (en) 2008-01-20
DK1866324T3 (da) 2010-09-27
US8263575B2 (en) 2012-09-11
JP5863702B2 (ja) 2016-02-17
AU2006226182A1 (en) 2006-09-28
CN103936807A (zh) 2014-07-23
MX2007011666A (es) 2007-11-14
EP1866324B1 (de) 2010-06-16
IL186104A (en) 2013-06-27
CA2602324A1 (en) 2006-09-28
BRPI0609704A2 (pt) 2010-04-20
ATE471334T1 (de) 2010-07-15
CA2602324C (en) 2015-02-24
JP5345381B2 (ja) 2013-11-20
BRPI0609704B1 (pt) 2020-12-01

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