IL182351A - Rated oboe - Google Patents
Rated oboeInfo
- Publication number
- IL182351A IL182351A IL182351A IL18235107A IL182351A IL 182351 A IL182351 A IL 182351A IL 182351 A IL182351 A IL 182351A IL 18235107 A IL18235107 A IL 18235107A IL 182351 A IL182351 A IL 182351A
- Authority
- IL
- Israel
- Prior art keywords
- cannula
- tubing
- lumen
- segments
- brain
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3417—Details of tips or shafts, e.g. grooves, expandable, bendable; Multiple coaxial sliding cannulas, e.g. for dilating
- A61B17/3421—Cannulas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/34—Trocars; Puncturing needles
- A61B17/3478—Endoscopic needles, e.g. for infusion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/007—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for contrast media
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
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Landscapes
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- Surgical Instruments (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI406690B (zh) * | 2004-02-26 | 2013-09-01 | Semiconductor Energy Lab | 運動器具,娛樂工具,和訓練工具 |
| RU2424792C2 (ru) | 2004-05-03 | 2011-07-27 | Хермес Байесайенсиз, Инк. | Липосомы, используемые для доставки лекарственных средств |
| US8658203B2 (en) | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| CA2581714C (en) | 2004-10-05 | 2017-09-12 | Avigen, Inc. | Stepped cannula |
| US20060253101A1 (en) * | 2005-03-16 | 2006-11-09 | Andreas Hartlep | Intracranial catheter |
| WO2007024841A2 (en) * | 2005-08-23 | 2007-03-01 | The Regents Of The University Of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
| EP2023949A4 (en) * | 2006-04-26 | 2009-08-26 | Univ California | COMPOSITIONS AND METHODS FOR CONVECTION-REINFORCED RELEASE OF NEUROTHERAPEUTICS WITH HIGH MOLECULAR WEIGHT |
| GB0616411D0 (en) * | 2006-08-18 | 2006-09-27 | Renishaw Plc | Neurosurgical instruments |
| US7837668B2 (en) * | 2006-10-10 | 2010-11-23 | Ceregene, Inc. | Needle assembly for use in delivering precise dosages of proteinaceous pharmaceutical compositions and methods for use of same |
| US7766394B2 (en) | 2006-10-30 | 2010-08-03 | Medtronic, Inc. | Breakaway connectors and systems |
| EP1970001B1 (de) * | 2007-03-16 | 2014-07-23 | Brainlab AG | Katheter mit Drucksensorik |
| US20080275466A1 (en) * | 2007-05-01 | 2008-11-06 | James Grant Skakoon | Dual cannula system and method for using same |
| WO2008144585A1 (en) * | 2007-05-17 | 2008-11-27 | Medgenesis Therapeutix Inc. | Convection-enhanced delivery catheter with removable stiffening member and method for using same |
| WO2009029508A1 (en) * | 2007-08-28 | 2009-03-05 | Johnnie B. Byrd, Sr. Alzheimer's Center And Research Institute, Inc. | Intracranial catheter and methods of use |
| US7766875B2 (en) * | 2007-09-28 | 2010-08-03 | Codman & Shurtleff, Inc. | Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent |
| US8147480B2 (en) | 2007-09-28 | 2012-04-03 | Codman & Shurtleff, Inc. | Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent |
| US8480626B2 (en) * | 2007-11-30 | 2013-07-09 | Medtronic, Inc. | Infusion catheter assembly with reduced backflow |
| WO2009094389A1 (en) * | 2008-01-22 | 2009-07-30 | Medtronic, Inc. | Burr hole anchors, systems, and methods |
| BRPI1007155A2 (pt) | 2009-01-29 | 2017-05-30 | Univ Of California San Francisco | métodos para tratar um distúrbio neurológico cortical, e para dispensar um agente terapêutico para o córtex em um primata |
| US7985188B2 (en) | 2009-05-13 | 2011-07-26 | Cv Holdings Llc | Vessel, coating, inspection and processing apparatus |
| DK2251454T3 (da) | 2009-05-13 | 2014-10-13 | Sio2 Medical Products Inc | Coating og inspektion af beholder |
| WO2010144419A2 (en) | 2009-06-08 | 2010-12-16 | Surgivision, Inc. | Mri-guided interventional systems that can track and generate dynamic visualizations of flexible intrabody devices in near real time |
| EP2442717B1 (en) | 2009-06-16 | 2020-11-25 | ClearPoint Neuro, Inc. | Mri-guided devices and mri-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time |
| US9458536B2 (en) | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
| US20110046540A1 (en) * | 2009-08-24 | 2011-02-24 | Alterman Ron L | Apparatus for Trans-Cerebral Electrophoresis and Methods of Use Thereof |
| WO2011130107A2 (en) | 2010-04-16 | 2011-10-20 | Surgivision, Inc. | Mri surgical systems including mri-compatible surgical cannulae for transferring a substance to and/or from a patient |
| US8738151B2 (en) | 2010-04-28 | 2014-05-27 | Medtronic, Inc. | Body portal anchors and systems |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US9272095B2 (en) | 2011-04-01 | 2016-03-01 | Sio2 Medical Products, Inc. | Vessels, contact surfaces, and coating and inspection apparatus and methods |
| CA3125150A1 (en) | 2011-08-01 | 2013-02-07 | Alcyone Lifesciences, Inc. | Microfluidic drug delivery devices |
| AU2012318242A1 (en) | 2011-11-11 | 2013-05-30 | Sio2 Medical Products, Inc. | Passivation, pH protective or lubricity coating for pharmaceutical package, coating process and apparatus |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| EP2830515A2 (en) * | 2012-03-30 | 2015-02-04 | Koninklijke Philips N.V. | Nested cannula tips |
| EP2846755A1 (en) | 2012-05-09 | 2015-03-18 | SiO2 Medical Products, Inc. | Saccharide protective coating for pharmaceutical package |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| US10751513B2 (en) | 2012-07-24 | 2020-08-25 | Renishaw Plc | Neurosurgical apparatus and methods |
| US8992427B2 (en) | 2012-09-07 | 2015-03-31 | Gynesonics, Inc. | Methods and systems for controlled deployment of needle structures in tissue |
| US20140243783A1 (en) * | 2012-10-06 | 2014-08-28 | Raghu Raghavan | Method of backflow reduction during material delivery through a needle into tissue |
| CA2890066C (en) | 2012-11-01 | 2021-11-09 | Sio2 Medical Products, Inc. | Coating inspection method |
| WO2014078666A1 (en) | 2012-11-16 | 2014-05-22 | Sio2 Medical Products, Inc. | Method and apparatus for detecting rapid barrier coating integrity characteristics |
| EP2925903B1 (en) | 2012-11-30 | 2022-04-13 | Si02 Medical Products, Inc. | Controlling the uniformity of pecvd deposition on medical syringes, cartridges, and the like |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| US9919129B2 (en) | 2012-12-18 | 2018-03-20 | Alcyone Lifesciences, Inc. | Systems and methods for reducing or preventing backflow in a delivery system |
| EP2961858B1 (en) | 2013-03-01 | 2022-09-07 | Si02 Medical Products, Inc. | Coated syringe. |
| CN105392916B (zh) | 2013-03-11 | 2019-03-08 | Sio2医药产品公司 | 涂布包装材料 |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| EP2971227B1 (en) | 2013-03-15 | 2017-11-15 | Si02 Medical Products, Inc. | Coating method. |
| EP2991560B1 (en) | 2013-04-30 | 2020-07-29 | Cedars-Sinai Medical Center | Stabilization apparatuses for medical procedures |
| WO2014204954A1 (en) | 2013-06-17 | 2014-12-24 | Alcyone Lifesciences, Inc. | Methods and devices for protecting catheter tips and stereotactic fixtures for microcatheters |
| ES2738298T3 (es) | 2013-07-31 | 2020-01-21 | Alcyone Lifesciences Inc | Sistemas y métodos de suministro de fármacos, tratamiento y monitoreo |
| US9891296B2 (en) | 2013-09-13 | 2018-02-13 | MRI Interventions, Inc. | Intrabody fluid transfer devices, systems and methods |
| EP3107610B1 (en) * | 2014-02-20 | 2018-05-30 | Brainlab AG | Agent delivery catheter |
| EP3693493A1 (en) | 2014-03-28 | 2020-08-12 | SiO2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| EP4600255A3 (en) | 2014-05-02 | 2025-10-22 | Genzyme Corporation | Aav vectors for retinal and cns gene therapy |
| WO2015191508A1 (en) | 2014-06-09 | 2015-12-17 | Voyager Therapeutics, Inc. | Chimeric capsids |
| WO2016069936A1 (en) * | 2014-10-29 | 2016-05-06 | Cedars-Sinai Medical Center | Apparatuses, systems and methods for controlled delivery of therapeutics and related substances |
| CN107106689A (zh) | 2014-11-05 | 2017-08-29 | 沃雅戈治疗公司 | 用于治疗帕金森病的aadc多核苷酸 |
| US10758264B2 (en) | 2014-11-13 | 2020-09-01 | The Regents Of The University Of California | Adjustable stepped cannula |
| MX2017006216A (es) | 2014-11-14 | 2018-08-29 | Voyager Therapeutics Inc | Composiciones y métodos para tratar la esclerosis lateral amiotrófica (ela). |
| KR102584655B1 (ko) | 2014-11-14 | 2023-10-06 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| US11697825B2 (en) | 2014-12-12 | 2023-07-11 | Voyager Therapeutics, Inc. | Compositions and methods for the production of scAAV |
| US10806396B2 (en) | 2015-01-26 | 2020-10-20 | Alcyone Lifesciences, Inc. | Drug delivery methods with tracer |
| AU2016219398A1 (en) | 2015-02-10 | 2017-09-28 | Genzyme Corporation | Enhanced delivery of viral particles to the striatum and cortex |
| WO2016183123A1 (en) | 2015-05-11 | 2016-11-17 | Alcyone Lifesciences, Inc. | Drug delivery systems and methods |
| US11077233B2 (en) | 2015-08-18 | 2021-08-03 | Sio2 Medical Products, Inc. | Pharmaceutical and other packaging with low oxygen transmission rate |
| SI3352776T1 (sl) | 2015-09-23 | 2025-08-29 | Sangamo Therapeutics, Inc. | Represorji Htt in njihove uporabe |
| BR112018006922B1 (pt) | 2015-10-16 | 2023-11-21 | Ipsen Biopharm Ltd | Composições de irinotecano lipossômico estabilizado para armazenamento |
| JP2019502473A (ja) | 2016-01-04 | 2019-01-31 | アルキオーネ・ライフサイエンシズ・インコーポレイテッドAlcyone Lifesciences, Inc. | 脳卒中を治療するための方法および装置 |
| WO2017142698A1 (en) | 2016-02-17 | 2017-08-24 | MRI Interventions, Inc. | Intrabody surgical fluid transfer assemblies with adjustable exposed cannula to needle tip length, related systems and methods |
| WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| US11326182B2 (en) | 2016-04-29 | 2022-05-10 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
| AU2017268382B2 (en) | 2016-05-18 | 2023-09-28 | Voyager Therapeutics, Inc. | Compositions and methods of treating Huntington's disease |
| RU2758488C2 (ru) | 2016-05-18 | 2021-10-28 | Вояджер Терапьютикс, Инк. | Модулирующие полинуклеотиды |
| JP2019531787A (ja) | 2016-08-30 | 2019-11-07 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 生物医学的ターゲティング及びデリバリーの方法並びにそれを実行するための装置及びシステム |
| WO2018089523A1 (en) | 2016-11-11 | 2018-05-17 | Gynesonics, Inc. | Controlled treatment of tissue and dynamic interaction with, and comparison of, tissue and/or treatment data |
| MX2019006426A (es) | 2016-12-01 | 2019-08-14 | Sangamo Therapeutics Inc | Reguladores de tau, y composiciones y metodos para su administracion. |
| CN114887153A (zh) | 2016-12-21 | 2022-08-12 | 亚克安娜治疗学有限公司 | 药物递送系统和方法 |
| AU2018261790B2 (en) | 2017-05-05 | 2024-10-03 | Voyager Therapeutics, Inc. | Compositions and methods of treating amyotrophic lateral sclerosis (ALS) |
| WO2018204803A1 (en) | 2017-05-05 | 2018-11-08 | Voyager Therapeutics, Inc. | Compositions and methods of treating huntington's disease |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CN111132626B (zh) | 2017-07-17 | 2024-01-30 | 沃雅戈治疗公司 | 轨迹阵列引导系统 |
| EP3687582A4 (en) | 2017-09-29 | 2021-07-14 | Voyager Therapeutics, Inc. | RESCUE OF CENTRAL AND PERIPHERAL NEUROLOGICAL PHENOTYPE OF FRIEDREICH ATAXIA BY INTRAVENOUS ADMINISTRATION |
| EP4454654A3 (en) | 2017-10-16 | 2025-02-19 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (als) |
| US11434502B2 (en) | 2017-10-16 | 2022-09-06 | Voyager Therapeutics, Inc. | Treatment of amyotrophic lateral sclerosis (ALS) |
| EP3781074A1 (en) * | 2018-05-09 | 2021-02-24 | ClearPoint Neuro, Inc. | Mri compatible intrabody fluid transfer systems and related devices and methods |
| US11253237B2 (en) | 2018-05-09 | 2022-02-22 | Clearpoint Neuro, Inc. | MRI compatible intrabody fluid transfer systems and related devices and methods |
| MX2020012077A (es) | 2018-05-15 | 2021-03-09 | Voyager Therapeutics Inc | Composiciones y metodos para el tratamiento de la enfermedad de parkinson. |
| WO2020010035A1 (en) * | 2018-07-02 | 2020-01-09 | Voyager Therapeutics, Inc. | Cannula system |
| SG11202103151RA (en) | 2018-09-28 | 2021-04-29 | Voyager Therapeutics Inc | Frataxin expression constructs having engineered promoters and methods of use thereof |
| CN113226333A (zh) | 2018-10-02 | 2021-08-06 | 桑格摩生物治疗股份有限公司 | 用于调控Tau蛋白的方法和组合物 |
| AU2020219357B2 (en) * | 2019-02-08 | 2025-03-20 | Rebound Therapeutics Corporation | Lighted cannula system |
| PE20212332A1 (es) | 2019-04-23 | 2021-12-14 | Sangamo Therapeutics Inc | Moduladores de la expresioon del gen de marco de lectura abierto 72 del cromosoma 9 y usos de los mismos |
| CA3142345A1 (en) * | 2019-05-31 | 2020-12-03 | The Trustees Of The University Of Pennsylvania | Infusion device and method for drug delivery |
| US11684750B2 (en) | 2019-10-08 | 2023-06-27 | Clearpoint Neuro, Inc. | Extension tube assembly and related medical fluid transfer systems and methods |
| US20210318397A1 (en) * | 2020-04-08 | 2021-10-14 | Clearpoint Neuro, Inc. | Mri surgical systems including mri-compatible surgical cannulas for transferring a substance to and/or from a patient |
| GB2601752A (en) | 2020-12-08 | 2022-06-15 | Maavrx Ltd | Expression vector |
| WO2025004001A1 (en) | 2023-06-30 | 2025-01-02 | Takeda Pharmaceutical Company Limited | Htt repressors and uses thereof |
Family Cites Families (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1255551A (en) | 1968-03-30 | 1971-12-01 | Heraeus Schott Quarzschmelze | Improvements in or relating to externally coated fused silica tube |
| LU77252A1 (enExample) * | 1976-05-06 | 1977-08-22 | ||
| US4239042A (en) * | 1979-04-05 | 1980-12-16 | Dow Corning K.K. | Catheter placement system |
| DE3025785C2 (de) * | 1980-07-08 | 1984-08-16 | Storz, Karl, 7200 Tuttlingen | Dilatator, Verfahren zu seiner Verwendung und Vorrichtung zur Durchführung des Verfahrens |
| US4335718A (en) * | 1980-10-02 | 1982-06-22 | Becton, Dickinson And Company | Needle cannula |
| US4448532A (en) * | 1981-03-31 | 1984-05-15 | Kla Instruments Corporation | Automatic photomask inspection method and system |
| DE8222222U1 (de) * | 1982-08-06 | 1982-11-25 | Mehler, Doron, Dr., 3000 Hannover | Katheterset |
| JPS60234671A (ja) * | 1984-05-09 | 1985-11-21 | テルモ株式会社 | カテ−テル導入具 |
| US4597421A (en) * | 1984-11-19 | 1986-07-01 | Varian Associates, Inc. | Method and device for on-column injection of a liquid sample into small diameter columns |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US4739768B2 (en) * | 1986-06-02 | 1995-10-24 | Target Therapeutics Inc | Catheter for guide-wire tracking |
| US4738658A (en) * | 1986-09-19 | 1988-04-19 | Aries Medical Incorporated | Tapered hemostatic device for use in conjunction with a catheter for alleviating blood leakage and method for using same |
| US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
| US4781691A (en) * | 1987-07-17 | 1988-11-01 | The Kendall Company | Stepped needle |
| US4909800A (en) * | 1987-07-17 | 1990-03-20 | The Kendall Company | Stepped needle |
| DE8714069U1 (de) * | 1987-10-21 | 1987-12-03 | Richard Wolf Gmbh, 7134 Knittlingen | Endoskopischer Instrumentensatz |
| US4978334A (en) * | 1988-09-08 | 1990-12-18 | Toye Frederic J | Apparatus and method for providing passage into body viscus |
| US5069673A (en) * | 1990-02-07 | 1991-12-03 | Cordis Corporation | Catheter with double step-down bore |
| WO1992001070A1 (en) | 1990-07-09 | 1992-01-23 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5256157A (en) * | 1991-01-31 | 1993-10-26 | Baxter International Inc. | Automated infusion pump with replaceable memory cartridges |
| DE69233013T2 (de) | 1991-08-20 | 2004-03-04 | The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer | Adenovirus vermittelter gentransfer in den gastrointestinaltrakt |
| AU7676894A (en) * | 1993-08-27 | 1995-03-21 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Convection-enhanced drug delivery |
| NL9301642A (nl) * | 1993-09-22 | 1995-04-18 | Cordis Europ | Microcatheter. |
| US5626862A (en) * | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| JP3573531B2 (ja) * | 1994-08-03 | 2004-10-06 | 鐘淵化学工業株式会社 | マイクロカテーテル |
| EP1445322B2 (en) | 1995-06-15 | 2012-06-06 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| US6001650A (en) | 1995-08-03 | 1999-12-14 | Avigen, Inc. | High-efficiency wild-type-free AAV helper functions |
| US5622856A (en) | 1995-08-03 | 1997-04-22 | Avigen | High efficiency helper system for AAV vector production |
| US5593393A (en) * | 1995-09-07 | 1997-01-14 | Trudell; Roger J. | Lacrimal irrigating cannula |
| US6351659B1 (en) * | 1995-09-28 | 2002-02-26 | Brainlab Med. Computersysteme Gmbh | Neuro-navigation system |
| US6004797A (en) | 1995-11-09 | 1999-12-21 | Avigen, Inc. | Adenovirus helper-free recombinant AAV Virion production |
| US6020196A (en) * | 1996-05-09 | 2000-02-01 | Baxter International Inc. | Devices for harvesting and homogenizing adipose tissue containing autologous endothelial cells |
| US5902282A (en) * | 1996-12-26 | 1999-05-11 | Johnson & Johnson Medical, Inc. | Step-down catheter |
| US6048551A (en) | 1997-03-27 | 2000-04-11 | Hilfinger; John M. | Microsphere encapsulation of gene transfer vectors |
| US6458088B1 (en) * | 1997-03-27 | 2002-10-01 | Cordis Corporation | Glass core guidewire compatible with magnetic resonance |
| US6524299B1 (en) * | 1997-04-09 | 2003-02-25 | Target Therapeutics, Inc. | Flow-directed catheter |
| US6042579A (en) * | 1997-04-30 | 2000-03-28 | Medtronic, Inc. | Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain |
| US6026316A (en) * | 1997-05-15 | 2000-02-15 | Regents Of The University Of Minnesota | Method and apparatus for use with MR imaging |
| US6030369A (en) * | 1997-07-03 | 2000-02-29 | Target Therapeutics Inc. | Micro catheter shaft |
| US6186986B1 (en) * | 1998-01-21 | 2001-02-13 | St. Jude Medical Cardiovascular Group, Inc. | Micro-catheters and methods of their manufacture |
| US6199554B1 (en) * | 1998-03-27 | 2001-03-13 | The Brigham And Women's Hospital, Inc. | Method and apparatus for combining injury-mediated therapy and drug delivery |
| ES2326893T3 (es) * | 1998-05-27 | 2009-10-21 | Genzyme Corporation | Vectores aav para la fabricacion de medicamentos para administracion potenciada por conveccion. |
| US6210392B1 (en) * | 1999-01-15 | 2001-04-03 | Interventional Technologies, Inc. | Method for treating a wall of a blood vessel |
| US6663606B1 (en) * | 1999-10-28 | 2003-12-16 | Scimed Life Systems, Inc. | Biocompatible medical devices |
| US6579484B1 (en) * | 1999-12-16 | 2003-06-17 | Advanced Cardiovascular Systems, Inc. | Co-extruded taper shaft |
| US20040092879A1 (en) * | 2000-11-06 | 2004-05-13 | Medamicus, Inc. | Safety introducer apparatus and method therefor |
| US6641564B1 (en) * | 2000-11-06 | 2003-11-04 | Medamicus, Inc. | Safety introducer apparatus and method therefor |
| CA2327208A1 (en) * | 2000-11-30 | 2002-05-30 | The Government Of The United States Of America | Methods of increasing distribution of therapeutic agents |
| US20020087152A1 (en) * | 2001-01-04 | 2002-07-04 | Endocare, Inc. | Systems and methods for delivering a probe into tissue |
| US6533751B2 (en) * | 2001-01-09 | 2003-03-18 | Andrew Cragg | Micro catheter and guidewire system having improved pushability and control |
| JP4271444B2 (ja) * | 2001-01-31 | 2009-06-03 | 富士通株式会社 | 歪補償装置 |
| US7182944B2 (en) * | 2001-04-25 | 2007-02-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of increasing distribution of nucleic acids |
| US20030073934A1 (en) * | 2001-10-17 | 2003-04-17 | David A. Putz | Double slotted-cannula device and method of use |
| EP1491154A1 (en) | 2002-01-22 | 2004-12-29 | JFE Steel Corporation | Ceramic-coated instruments for medical use, ceramic-coated instruments for studying living organisms and process for producing the same |
| JP2004147830A (ja) * | 2002-10-30 | 2004-05-27 | Jfe Steel Kk | 遺伝子制御用セラミック被覆針およびその製造方法およびその製造装置 |
| GB0205772D0 (en) * | 2002-03-12 | 2002-04-24 | Gill Steven S | Catheter |
| US20050256503A1 (en) * | 2002-05-07 | 2005-11-17 | Cardiac Pacemakers, Inc. | Tapered catheter delivery system |
| ES2581781T3 (es) * | 2002-09-24 | 2016-09-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Método por imágenes para administración mejorada por convección de agentes terapéuticos |
| EP1572262B1 (en) | 2002-10-10 | 2010-03-10 | Becton Dickinson and Company | Needle assembly of delivering local anesthesia |
| US20040209810A1 (en) * | 2003-02-24 | 2004-10-21 | Gill Steven S. | Method of treating Parkinson's disease in humans by intraputaminal infusion of glial cell-line derived neurotrophic factor |
| US7241283B2 (en) * | 2003-04-25 | 2007-07-10 | Ad-Tech Medical Instrument Corp. | Method for intracranial catheter treatment of brain tissue |
| US8658203B2 (en) * | 2004-05-03 | 2014-02-25 | Merrimack Pharmaceuticals, Inc. | Liposomes useful for drug delivery to the brain |
| JP4449587B2 (ja) * | 2004-06-09 | 2010-04-14 | 富士フイルム株式会社 | 画像マッピング方法及び画像マッピングプログラム |
| US20060073119A1 (en) * | 2004-09-01 | 2006-04-06 | Avigen, Inc. | Methods for treating neurodegenerative disorders |
| CA2581714C (en) * | 2004-10-05 | 2017-09-12 | Avigen, Inc. | Stepped cannula |
| US20060217664A1 (en) * | 2004-11-15 | 2006-09-28 | Hattler Brack G | Telescoping vascular dilator |
| US20060129126A1 (en) * | 2004-11-19 | 2006-06-15 | Kaplitt Michael G | Infusion device and method for infusing material into the brain of a patient |
| WO2007024841A2 (en) * | 2005-08-23 | 2007-03-01 | The Regents Of The University Of California | Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery |
| SI2019683T2 (sl) * | 2006-04-25 | 2022-10-28 | The Regents Of The University Of California | Dajanje rastnih faktorjev za zdravljenje motenj CŽS |
| GB0616411D0 (en) * | 2006-08-18 | 2006-09-27 | Renishaw Plc | Neurosurgical instruments |
| EP1974755A1 (de) * | 2007-03-16 | 2008-10-01 | BrainLAB AG | Katheter mit sich ändernden Materialeigenschaften |
| US7766875B2 (en) * | 2007-09-28 | 2010-08-03 | Codman & Shurtleff, Inc. | Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent |
| US8147480B2 (en) * | 2007-09-28 | 2012-04-03 | Codman & Shurtleff, Inc. | Catheter for reduced reflux in targeted tissue delivery of a therapeutic agent |
| US8480626B2 (en) * | 2007-11-30 | 2013-07-09 | Medtronic, Inc. | Infusion catheter assembly with reduced backflow |
-
2005
- 2005-10-05 CA CA2581714A patent/CA2581714C/en not_active Expired - Lifetime
- 2005-10-05 EP EP12189626.0A patent/EP2572661B1/en not_active Expired - Lifetime
- 2005-10-05 JP JP2007535832A patent/JP4838255B2/ja not_active Expired - Lifetime
- 2005-10-05 DK DK05823438.6T patent/DK1807009T3/en active
- 2005-10-05 MX MX2007003850A patent/MX2007003850A/es active IP Right Grant
- 2005-10-05 AU AU2005294247A patent/AU2005294247B2/en not_active Expired
- 2005-10-05 SI SI200531937T patent/SI1807009T1/sl unknown
- 2005-10-05 US US11/243,756 patent/US7815623B2/en active Active
- 2005-10-05 BR BRPI0516463-0A patent/BRPI0516463B1/pt active IP Right Grant
- 2005-10-05 CN CN2012100734364A patent/CN102626336A/zh active Pending
- 2005-10-05 PL PL05823438T patent/PL1807009T3/pl unknown
- 2005-10-05 PL PL12189626T patent/PL2572661T3/pl unknown
- 2005-10-05 WO PCT/US2005/036110 patent/WO2006042090A1/en not_active Ceased
- 2005-10-05 ES ES05823438T patent/ES2531425T3/es not_active Expired - Lifetime
- 2005-10-05 MX MX2013001394A patent/MX349748B/es unknown
- 2005-10-05 PT PT58234386T patent/PT1807009E/pt unknown
- 2005-10-05 EP EP05823438.6A patent/EP1807009B1/en not_active Expired - Lifetime
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- 2007-04-01 IL IL182351A patent/IL182351A/en active IP Right Grant
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2010
- 2010-09-27 US US12/891,043 patent/US8337458B2/en not_active Expired - Lifetime
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- 2012-03-25 IL IL218812A patent/IL218812A0/en unknown
- 2012-11-16 US US13/679,762 patent/US9302070B2/en not_active Expired - Lifetime
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- 2016-02-26 US US15/055,065 patent/US20160296694A1/en not_active Abandoned
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|---|---|
| US20130079748A1 (en) | 2013-03-28 |
| CA2581714A1 (en) | 2006-04-20 |
| IL218812A0 (en) | 2012-05-31 |
| ES2531425T3 (es) | 2015-03-13 |
| US20060135945A1 (en) | 2006-06-22 |
| AU2005294247A1 (en) | 2006-04-20 |
| WO2006042090A1 (en) | 2006-04-20 |
| US20110046552A1 (en) | 2011-02-24 |
| MX2007003850A (es) | 2007-11-21 |
| MX349748B (es) | 2017-08-09 |
| CA2581714C (en) | 2017-09-12 |
| US7815623B2 (en) | 2010-10-19 |
| JP2008515554A (ja) | 2008-05-15 |
| JP4838255B2 (ja) | 2011-12-14 |
| SI1807009T1 (sl) | 2015-04-30 |
| EP1807009A1 (en) | 2007-07-18 |
| EP2572661A1 (en) | 2013-03-27 |
| BRPI0516463A (pt) | 2008-09-02 |
| PL2572661T3 (pl) | 2020-06-01 |
| BRPI0516463B1 (pt) | 2021-05-11 |
| US20160296694A1 (en) | 2016-10-13 |
| US8337458B2 (en) | 2012-12-25 |
| US9302070B2 (en) | 2016-04-05 |
| EP1807009B1 (en) | 2014-11-26 |
| EP2572661B1 (en) | 2019-11-20 |
| CN102626336A (zh) | 2012-08-08 |
| DK1807009T3 (en) | 2015-03-02 |
| PL1807009T3 (pl) | 2015-06-30 |
| PT1807009E (pt) | 2015-02-25 |
| AU2005294247B2 (en) | 2011-08-11 |
| IL182351A0 (en) | 2007-07-24 |
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