IL173965A - Peptide compounds, pharmaceutical preparations containing them, uses and methods in vitro and ex vivo to activate a thrombopoietin receptor in the cell - Google Patents
Peptide compounds, pharmaceutical preparations containing them, uses and methods in vitro and ex vivo to activate a thrombopoietin receptor in the cellInfo
- Publication number
- IL173965A IL173965A IL173965A IL17396506A IL173965A IL 173965 A IL173965 A IL 173965A IL 173965 A IL173965 A IL 173965A IL 17396506 A IL17396506 A IL 17396506A IL 173965 A IL173965 A IL 173965A
- Authority
- IL
- Israel
- Prior art keywords
- vitro
- activating
- cell
- pharmaceutical compositions
- peptide compounds
- Prior art date
Links
- 102000005763 Thrombopoietin Receptors Human genes 0.000 title 1
- 108010070774 Thrombopoietin Receptors Proteins 0.000 title 1
- 230000003213 activating effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49874003P | 2003-08-28 | 2003-08-28 | |
| PCT/US2004/026422 WO2005023834A2 (en) | 2003-08-28 | 2004-08-13 | Peptides and compounds that bind to thrombopoietin receptors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL173965A0 IL173965A0 (en) | 2006-07-05 |
| IL173965A true IL173965A (en) | 2015-10-29 |
Family
ID=34272720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL173965A IL173965A (en) | 2003-08-28 | 2006-02-27 | Peptide compounds, pharmaceutical preparations containing them, uses and methods in vitro and ex vivo to activate a thrombopoietin receptor in the cell |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US7576056B2 (https=) |
| EP (1) | EP1675606B1 (https=) |
| JP (1) | JP4848277B2 (https=) |
| KR (2) | KR101183875B1 (https=) |
| CN (2) | CN102241742B (https=) |
| AR (1) | AR045530A1 (https=) |
| AU (1) | AU2004270656B2 (https=) |
| BR (1) | BRPI0414008B8 (https=) |
| CA (1) | CA2537421C (https=) |
| CY (1) | CY1118965T1 (https=) |
| DK (1) | DK1675606T3 (https=) |
| EA (1) | EA009286B1 (https=) |
| EC (1) | ECSP066396A (https=) |
| ES (1) | ES2626107T3 (https=) |
| HR (1) | HRP20170810T1 (https=) |
| HU (1) | HUE032370T2 (https=) |
| IL (1) | IL173965A (https=) |
| IS (1) | IS8300A (https=) |
| LT (1) | LT1675606T (https=) |
| ME (1) | ME00313B (https=) |
| MX (1) | MXPA06002292A (https=) |
| NO (1) | NO344233B1 (https=) |
| NZ (1) | NZ545455A (https=) |
| PL (1) | PL1675606T3 (https=) |
| PT (1) | PT1675606T (https=) |
| RS (2) | RS56387B1 (https=) |
| SG (1) | SG131110A1 (https=) |
| SI (1) | SI1675606T1 (https=) |
| TW (1) | TWI348375B (https=) |
| UA (1) | UA82710C2 (https=) |
| WO (1) | WO2005023834A2 (https=) |
| ZA (1) | ZA200602495B (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| PT1783222E (pt) | 1998-10-23 | 2012-07-26 | Kirin Amgen Inc | Péptidos diméricos de trombopoietina que simulam a ligação ao receptor mpl e têm actividade trombopoiética |
| KR20050093759A (ko) * | 2002-09-18 | 2005-09-23 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 혈소판 및 조혈 줄기세포의 생산을 증가시키는 방법 |
| US20040149235A1 (en) * | 2002-10-04 | 2004-08-05 | Pogue Albert S. | Apparatus and method for removal of waste from animal production facilities |
| US7576056B2 (en) | 2003-08-28 | 2009-08-18 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
| US7723295B2 (en) * | 2003-08-28 | 2010-05-25 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
| US7615533B2 (en) | 2004-08-16 | 2009-11-10 | Janssen Pharmaceutica N.V. | TPO peptide compounds for treatment of anemia |
| US20090053242A1 (en) * | 2006-01-25 | 2009-02-26 | Amgen Inc. | Thrombopoietic compounds |
| MY151332A (en) * | 2006-02-14 | 2014-05-15 | Janssen Pharmaceutica Nv | Use of tpo peptide compounds and pharmaceutical compositions in the treatment of anemia |
| WO2007094781A1 (en) * | 2006-02-14 | 2007-08-23 | Janssen Pharmaceutica N.V. | Use of tpo peptide compounds and pharmaceutical compositions in the treatment of anemia |
| US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| KR20110015448A (ko) * | 2008-06-03 | 2011-02-15 | 얀센 파마슈티카 엔.브이. | 암 치료와 관련된 혈액 질환을 예방하기 위한 ｔｐｏ 모방 펩티드 |
| EP2725053B1 (en) | 2011-06-23 | 2016-02-10 | Shimadzu Corporation | Branched amphipathic block polymer and molecular aggregate and drug delivery system using same |
| CA3070442A1 (en) * | 2017-07-26 | 2019-01-31 | Janssen Pharmaceutica Nv | Methods of protecting vascular integrity induced by targeted radiation therapy |
| CN113905754B (zh) | 2019-01-25 | 2025-03-11 | 詹森药业有限公司 | 减轻起疱剂和腐蚀性气体毒性作用的方法 |
| CN113766926A (zh) | 2019-01-25 | 2021-12-07 | 詹森药业有限公司 | 与放射和/或放射模拟物治疗结合的减轻肝损伤和促进肝肥大、再生和细胞植入的方法 |
| MX2021008928A (es) * | 2019-01-25 | 2021-11-04 | Janssen Pharmaceutica Nv | Métodos para mejorar la protección contra lesiones vasculares y de organos, la recuperación hematopoyética y la supervivencia en respuesta a la radiacion corporal total/exposicion química. |
| WO2023056444A1 (en) | 2021-10-01 | 2023-04-06 | Janssen Pharmaceutica N.V. | Methods of increasing progenitor cell production |
| WO2024095178A1 (en) | 2022-11-01 | 2024-05-10 | Janssen Pharmaceutica Nv | Thrombopoietin mimetic for use in the treatment of acute liver failure |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5326558A (en) | 1989-08-08 | 1994-07-05 | Genetics Institute, Inc. | Megakaryocytopoietic factor |
| IL96477A0 (en) | 1989-12-01 | 1991-08-16 | Amgen Inc | Megakaryocyte production |
| DK167813B1 (da) | 1989-12-07 | 1993-12-20 | Carlbiotech Ltd As | Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
| US5571508A (en) | 1989-12-18 | 1996-11-05 | Amrad Corporation Limited | Method for the treatment of thrombocytopenia and pharmaceutical compositions useful therefor |
| IT1241395B (it) | 1990-04-02 | 1994-01-10 | Eniricerche Spa | Composti immunogenici,il procedimento per la loro sintesi e loro impiego per la preparazione di vaccini antimalaria |
| US5141851A (en) | 1990-04-18 | 1992-08-25 | Board Of Regents, The University Of Texas System | Isolated farnesyl protein transferase enzyme |
| US5250732A (en) | 1991-07-18 | 1993-10-05 | Genentech, Inc. | Ketamine analogues for treatment of thrombocytopenia |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| ES2181691T5 (es) | 1992-06-11 | 2007-10-01 | Alkermes Controlled Therapeutics, Inc. | Sistema de distribucion de proteina eritropoyetina. |
| JP3401005B2 (ja) | 1992-12-11 | 2003-04-28 | ユニバーシティ オブ フロリダ | 有害生物の防除のための材料および方法 |
| AU8124694A (en) | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| SG47030A1 (en) | 1994-01-03 | 1998-03-20 | Genentech Inc | Thrombopoietin |
| SK100896A3 (en) | 1994-02-14 | 1997-10-08 | Zymogenetics Inc | Hematopoietic protein and materials and methods for making it |
| WO1995021626A1 (en) | 1994-02-14 | 1995-08-17 | University Of Washington | Methods for stimulating erythropoiesis using thrombopoietin |
| WO1995021919A2 (en) | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| EP0668352A1 (en) | 1994-02-14 | 1995-08-23 | Kirin Brewery Company, Ltd. | Protein having TPO activity |
| CN1229385C (zh) | 1994-03-31 | 2005-11-30 | 安姆根有限公司 | 刺激巨核细胞生长和分化的组合物及方法 |
| US5571686A (en) | 1994-04-14 | 1996-11-05 | Massachusetts Institute Of Technology | Method of using megapoietin for prolonging the survival & viability of platlets |
| WO1996014293A1 (en) * | 1994-11-04 | 1996-05-17 | Santen Pharmaceutical Co., Ltd. | Novel 1,3-dialkylurea derivative having hydroxyl group |
| US5641655A (en) | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
| AU4163196A (en) | 1994-11-30 | 1996-06-19 | Zymogenetics Inc. | Low molecular weight thrombopoietin |
| AU705064B2 (en) | 1995-04-26 | 1999-05-13 | Kyowa Hakko Kogyo Co. Ltd. | Novel polypeptides |
| TR199701526T1 (xx) | 1995-06-07 | 1998-03-21 | Glaxo Group Limited | Bir trombopoietin resept�r�ne ba�lanan peptitler ve bile�ikler. |
| US6251864B1 (en) * | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US6060052A (en) | 1995-10-30 | 2000-05-09 | Systemix, Inc. | Methods for use of Mpl ligands with primitive human hematopoietic stem cells |
| US5932546A (en) | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
| ATE350044T1 (de) | 1999-09-24 | 2007-01-15 | Smithkline Beecham Corp | Thrombopoietinmimetika |
| HU229701B1 (en) * | 2000-12-22 | 2014-05-28 | Ipsen Manufactoring Ireland Ltd | Process for the synthesis of a peptide having a trp residue |
| AU2002307062A1 (en) | 2001-04-02 | 2002-10-15 | Purdue Pharma L.P. | Thrombopoietin (tpo) synthebody for stimulation of platelet production |
| KR20050093759A (ko) | 2002-09-18 | 2005-09-23 | 오르토-맥네일 파마슈티칼, 인코퍼레이티드 | 혈소판 및 조혈 줄기세포의 생산을 증가시키는 방법 |
| US7576056B2 (en) | 2003-08-28 | 2009-08-18 | Ortho-Mcneil Pharmaceutical, Inc. | Peptides and compounds that bind to a receptor |
-
2004
- 2004-08-13 US US10/918,561 patent/US7576056B2/en not_active Expired - Lifetime
- 2004-08-13 HU HUE04781153A patent/HUE032370T2/en unknown
- 2004-08-13 AU AU2004270656A patent/AU2004270656B2/en not_active Expired
- 2004-08-13 NZ NZ545455A patent/NZ545455A/en not_active IP Right Cessation
- 2004-08-13 PT PT47811534T patent/PT1675606T/pt unknown
- 2004-08-13 RS YU20060141A patent/RS56387B1/sr unknown
- 2004-08-13 PL PL04781153T patent/PL1675606T3/pl unknown
- 2004-08-13 EP EP04781153.4A patent/EP1675606B1/en not_active Expired - Lifetime
- 2004-08-13 KR KR1020067003755A patent/KR101183875B1/ko not_active Expired - Fee Related
- 2004-08-13 UA UAA200602523A patent/UA82710C2/uk unknown
- 2004-08-13 JP JP2006524705A patent/JP4848277B2/ja not_active Expired - Lifetime
- 2004-08-13 CN CN201110134196.XA patent/CN102241742B/zh not_active Expired - Lifetime
- 2004-08-13 SI SI200432391A patent/SI1675606T1/sl unknown
- 2004-08-13 WO PCT/US2004/026422 patent/WO2005023834A2/en not_active Ceased
- 2004-08-13 DK DK04781153.4T patent/DK1675606T3/en active
- 2004-08-13 CA CA2537421A patent/CA2537421C/en not_active Expired - Lifetime
- 2004-08-13 MX MXPA06002292A patent/MXPA06002292A/es active IP Right Grant
- 2004-08-13 RS YUP-2006/0141A patent/RS20060141A/sr unknown
- 2004-08-13 HR HRP20170810TT patent/HRP20170810T1/hr unknown
- 2004-08-13 KR KR1020127014067A patent/KR20120078742A/ko not_active Withdrawn
- 2004-08-13 BR BRPI0414008A patent/BRPI0414008B8/pt active IP Right Grant
- 2004-08-13 CN CN2004800314520A patent/CN1871022B/zh not_active Expired - Lifetime
- 2004-08-13 ME MEP-2008-485A patent/ME00313B/me unknown
- 2004-08-13 LT LTEP04781153.4T patent/LT1675606T/lt unknown
- 2004-08-13 ES ES04781153.4T patent/ES2626107T3/es not_active Expired - Lifetime
- 2004-08-13 EA EA200600477A patent/EA009286B1/ru unknown
- 2004-08-13 SG SG200701488-9A patent/SG131110A1/en unknown
- 2004-08-27 AR ARP040103101A patent/AR045530A1/es active IP Right Grant
- 2004-08-27 TW TW093125674A patent/TWI348375B/zh not_active IP Right Cessation
-
2006
- 2006-02-14 IS IS8300A patent/IS8300A/is unknown
- 2006-02-24 EC EC2006006396A patent/ECSP066396A/es unknown
- 2006-02-27 IL IL173965A patent/IL173965A/en active IP Right Grant
- 2006-03-24 NO NO20061346A patent/NO344233B1/no unknown
- 2006-03-27 ZA ZA200602495A patent/ZA200602495B/en unknown
-
2017
- 2017-06-15 CY CY20171100628T patent/CY1118965T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed |