IL169370A - Thienopyrimidinediones and their use in the modulation of autoimmune disease - Google Patents

Thienopyrimidinediones and their use in the modulation of autoimmune disease

Info

Publication number
IL169370A
IL169370A IL169370A IL16937005A IL169370A IL 169370 A IL169370 A IL 169370A IL 169370 A IL169370 A IL 169370A IL 16937005 A IL16937005 A IL 16937005A IL 169370 A IL169370 A IL 169370A
Authority
IL
Israel
Prior art keywords
methyl
compound
formula
optionally substituted
hydroxy
Prior art date
Application number
IL169370A
Other languages
English (en)
Other versions
IL169370A0 (en
Inventor
Simon David Guile
Original Assignee
Astrazeneca Ab
Simon David Guile
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Simon David Guile filed Critical Astrazeneca Ab
Publication of IL169370A0 publication Critical patent/IL169370A0/en
Publication of IL169370A publication Critical patent/IL169370A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL169370A 2003-01-17 2005-06-23 Thienopyrimidinediones and their use in the modulation of autoimmune disease IL169370A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0300119A SE0300119D0 (sv) 2003-01-17 2003-01-17 Novel compounds
PCT/SE2004/000052 WO2004065394A1 (en) 2003-01-17 2004-01-15 Thienopyrimidinediones and their use in the modulation of autoimmune disease

Publications (2)

Publication Number Publication Date
IL169370A0 IL169370A0 (en) 2007-07-04
IL169370A true IL169370A (en) 2011-05-31

Family

ID=20290154

Family Applications (1)

Application Number Title Priority Date Filing Date
IL169370A IL169370A (en) 2003-01-17 2005-06-23 Thienopyrimidinediones and their use in the modulation of autoimmune disease

Country Status (23)

Country Link
US (2) US7384951B2 (enExample)
EP (1) EP1587812B1 (enExample)
JP (1) JP4519121B2 (enExample)
KR (2) KR20110125256A (enExample)
CN (1) CN100334093C (enExample)
AT (1) ATE335748T1 (enExample)
AU (1) AU2004206012B2 (enExample)
BR (1) BRPI0406801B8 (enExample)
CA (1) CA2512441C (enExample)
DE (1) DE602004001857T2 (enExample)
EG (1) EG25613A (enExample)
ES (1) ES2270337T3 (enExample)
IL (1) IL169370A (enExample)
IS (1) IS2376B (enExample)
MX (1) MXPA05007496A (enExample)
NO (1) NO333702B1 (enExample)
NZ (1) NZ541217A (enExample)
PL (1) PL214682B1 (enExample)
RU (1) RU2331647C2 (enExample)
SE (1) SE0300119D0 (enExample)
UA (1) UA81788C2 (enExample)
WO (1) WO2004065394A1 (enExample)
ZA (1) ZA200505364B (enExample)

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GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) * 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
JP2006515880A (ja) * 2003-01-17 2006-06-08 アストラゼネカ・アクチエボラーグ 自己免疫疾患の調節におけるチエノピリダジノンとその使用
SE0300120D0 (sv) * 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
US7504509B2 (en) 2003-12-19 2009-03-17 Plexxikon, Inc. Compounds and methods for development of Ret modulators
US7498342B2 (en) 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
WO2007013896A2 (en) 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
TWI473808B (zh) 2005-06-22 2015-02-21 Plexxikon Inc 用於激酶調節的化合物及方法及其適應症
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
PE20121126A1 (es) 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
JP2010514695A (ja) 2006-12-21 2010-05-06 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物および方法およびそのための適応症
WO2008079909A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
GB0713479D0 (en) * 2007-07-11 2007-08-22 Syngenta Participations Ag Substituted aromatic heterocyclic compounds as fungicides
SG183036A1 (en) 2007-07-17 2012-08-30 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
WO2010089580A1 (en) 2009-02-06 2010-08-12 Astrazeneca Ab Use of a mct1 inhibitor in the treatment of cancers expressing mct1 over mct4
SG184766A1 (en) * 2009-03-23 2012-10-30 Glenmark Pharmaceuticals Sa Isothiazolo-pyrimidinedione derivatives as trpa1 modulators
CN102361874A (zh) * 2009-03-23 2012-02-22 格兰马克药品股份有限公司 作为trpa1调节剂的呋喃并嘧啶二酮衍生物
AU2010232670B2 (en) 2009-04-03 2015-07-09 F. Hoffmann-La Roche Ag Propane- I-sulfonic acid {3- [5- (4 -chloro-phenyl) -1H-pyrrolo [2, 3-b] pyridine-3-carbonyl] -2, 4-difluoro-pheny l } -amide compositions and uses thereof
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
MX2012005284A (es) 2009-11-06 2012-06-28 Plexxikon Inc Compuestos y metodos para la modulacion de cinasas. e indicaciones para ello.
KR101911972B1 (ko) 2011-02-07 2018-10-25 플렉시콘 인코퍼레이티드 키나제 조절을 위한 화합물 및 방법, 및 그에 대한 적응증
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
EP2804852A2 (en) 2012-01-20 2014-11-26 Regents Of The University Of Minnesota Therapeutic compounds
US10085987B2 (en) 2012-01-27 2018-10-02 Thomas Jefferson University MCT protein inhibitor-related prognostic and therapeutic methods
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
US10022372B2 (en) 2013-04-19 2018-07-17 Thomas Jefferson University Caveolin-1 related methods for treating glioblastoma with temozolomide
PT3060562T (pt) * 2013-10-21 2021-09-02 Genosco Compostos de pirimidina substituídos e sua utilização como inibidores da syk
US10329303B2 (en) 2015-01-22 2019-06-25 The Scripps Research Institute Heterocyclic inhibitors of monocarboxylate transporter
UY36586A (es) * 2015-03-26 2016-10-31 Bayer Pharma AG Heterociclilmetiltienouracilos y uso de los mismos
KR101730536B1 (ko) * 2016-03-17 2017-05-02 주식회사 골프존 스크린 골프 시스템에서 구현되는 컨텐츠 전송 서비스 방법, 컨텐츠 전송 서비스를 위한 모바일 단말기의 제어방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록매체
KR101712836B1 (ko) * 2016-03-17 2017-03-22 주식회사 골프존 가상 골프 시뮬레이션 장치, 가상 골프를 위한 영상 구현 방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록 매체
KR101712838B1 (ko) * 2016-03-17 2017-03-07 주식회사 골프존 가상 골프 시뮬레이션 장치, 가상 골프를 위한 영상 구현 방법 및 이를 기록한 컴퓨팅 장치에 의해 판독 가능한 기록 매체
TWI823932B (zh) * 2018-05-11 2023-12-01 中國大陸商迪哲（江蘇）醫藥有限公司 三唑并嘧啶化合物及其在治療癌症中之用途
CN119080799B (zh) * 2024-09-27 2025-12-05 山东大学 一种n-羟基噻吩并嘧啶二酮类衍生物及其制备方法与应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US738495A (en) * 1902-12-26 1903-09-08 William E Sherwood Thill-coupling.
SE9702001D0 (sv) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
US6469014B1 (en) * 1997-05-28 2002-10-22 Astrazeneca Ab Thieno[2,3-d] pyrimidinediones, their preparation and use in therapy
JP2001525413A (ja) 1997-12-05 2001-12-11 アストラゼネカ ユーケイ リミテッド 新規化合物
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
ES2211161T3 (es) * 1998-08-28 2004-07-01 Astrazeneca Ab Tieno(2,3-d)pirimidindionas novedosas, procedimiento para su preparacion y uso de las mismas en terapia.
WO2001083489A1 (en) * 2000-05-04 2001-11-08 Astrazeneca Ab THIENO[2,3-d]PYRIMIDINEDIONES AND THEIR USE AS PHARMACEUTICALS
GB0117583D0 (en) * 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
GB0118479D0 (en) 2001-07-28 2001-09-19 Astrazeneca Ab Novel compounds
SE0300120D0 (sv) 2003-01-17 2003-01-17 Astrazeneca Ab Novel compounds
JP2006515880A (ja) 2003-01-17 2006-06-08 アストラゼネカ・アクチエボラーグ 自己免疫疾患の調節におけるチエノピリダジノンとその使用

Also Published As

Publication number Publication date
ZA200505364B (en) 2006-09-27
CA2512441C (en) 2012-01-03
NO20053826L (no) 2005-10-17
JP2006516974A (ja) 2006-07-13
DE602004001857T2 (de) 2007-05-24
SE0300119D0 (sv) 2003-01-17
EP1587812B1 (en) 2006-08-09
JP4519121B2 (ja) 2010-08-04
KR101107486B1 (ko) 2012-01-19
CN100334093C (zh) 2007-08-29
EP1587812A1 (en) 2005-10-26
NZ541217A (en) 2008-05-30
IS7965A (is) 2005-07-29
CA2512441A1 (en) 2004-08-05
KR20050092760A (ko) 2005-09-22
DE602004001857D1 (de) 2006-09-21
US20060052400A1 (en) 2006-03-09
HK1081959A1 (en) 2006-05-26
PL378222A1 (pl) 2006-03-20
AU2004206012A1 (en) 2004-08-05
BRPI0406801B8 (pt) 2021-05-25
KR20110125256A (ko) 2011-11-18
US20080214579A1 (en) 2008-09-04
RU2005121494A (ru) 2006-02-10
MXPA05007496A (es) 2005-09-21
UA81788C2 (uk) 2008-02-11
WO2004065394A1 (en) 2004-08-05
RU2331647C2 (ru) 2008-08-20
IL169370A0 (en) 2007-07-04
EG25613A (en) 2012-03-22
US7384951B2 (en) 2008-06-10
AU2004206012B2 (en) 2007-06-14
BRPI0406801A (pt) 2006-01-17
NO20053826D0 (no) 2005-08-15
CN1761672A (zh) 2006-04-19
NO333702B1 (no) 2013-08-26
BRPI0406801B1 (pt) 2018-04-03
IS2376B (is) 2008-07-15
PL214682B1 (pl) 2013-09-30
ATE335748T1 (de) 2006-09-15
ES2270337T3 (es) 2007-04-01

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