IL164599A0 - Combination therapy for the treatment of cancer - Google Patents
Combination therapy for the treatment of cancerInfo
- Publication number
- IL164599A0 IL164599A0 IL16459903A IL16459903A IL164599A0 IL 164599 A0 IL164599 A0 IL 164599A0 IL 16459903 A IL16459903 A IL 16459903A IL 16459903 A IL16459903 A IL 16459903A IL 164599 A0 IL164599 A0 IL 164599A0
- Authority
- IL
- Israel
- Prior art keywords
- cancer
- treatment
- combination therapy
- therapy
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37303302P | 2002-04-15 | 2002-04-15 | |
PCT/US2003/011812 WO2003088954A1 (en) | 2002-04-15 | 2003-04-15 | Combination therapy for the treatment of cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
IL164599A0 true IL164599A0 (en) | 2005-12-18 |
Family
ID=29250948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16459903A IL164599A0 (en) | 2002-04-15 | 2003-04-15 | Combination therapy for the treatment of cancer |
Country Status (12)
Country | Link |
---|---|
US (2) | US20040018968A1 (xx) |
EP (1) | EP1501489A4 (xx) |
JP (2) | JP2005530734A (xx) |
CN (1) | CN100566711C (xx) |
AU (1) | AU2003226408B2 (xx) |
BR (1) | BR0309280A (xx) |
CA (1) | CA2482508A1 (xx) |
EC (1) | ECSP045430A (xx) |
HK (1) | HK1086488A1 (xx) |
IL (1) | IL164599A0 (xx) |
MX (1) | MXPA04010199A (xx) |
WO (1) | WO2003088954A1 (xx) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA007649B1 (ru) * | 1999-09-08 | 2006-12-29 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Ингибиторы гистондеацетилазы, вызывающие дифференцировку клеток, и их применение |
US20040087657A1 (en) * | 2001-10-16 | 2004-05-06 | Richon Victoria M. | Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors |
AU2003219803B8 (en) * | 2002-02-15 | 2005-08-25 | Sloan-Kettering Institute For Cancer Research | Method of treating TRX mediated diseases |
US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
US20060276547A1 (en) * | 2002-03-04 | 2006-12-07 | Bacopoulos Nicholas G | Methods of treating cancer with HDAC inhibitors |
US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
EP1487426B1 (en) * | 2002-03-04 | 2012-08-22 | Sloan-kettering Institute For Cancer Research | Methods of inducing terminal differentiation |
US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
CN100566711C (zh) * | 2002-04-15 | 2009-12-09 | 斯隆-凯特林癌症研究院 | 治疗癌症的化合物及其用途 |
US20050222013A1 (en) * | 2003-01-16 | 2005-10-06 | Georgetown University | Methods for the use of inhibitors of histone deacetylase as synergistic agents in cancer therapy |
US8299126B2 (en) * | 2003-02-27 | 2012-10-30 | Leonard A. Cohen | Treatment of canine hemangiosarcoma with a histone deacetylase inhibitor |
US7375228B2 (en) * | 2003-03-17 | 2008-05-20 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
JP2006523693A (ja) * | 2003-04-01 | 2006-10-19 | メモリアル スローン−ケタリング キャンサー センター | ヒドロキサム酸化合物およびその使用方法 |
EP1644049B1 (en) | 2003-04-30 | 2007-09-26 | Ramot at Tel Aviv University Ltd. | Method and device for radiotherapy |
EP2238982B8 (en) | 2003-06-27 | 2013-01-16 | Astellas Pharma Inc. | Therapeutic agent for soft tissue sarcoma |
DK1663194T3 (da) * | 2003-08-26 | 2010-07-19 | Merck Hdac Res Llc | Anvendelse af SAHA til behandling af mesotheliom |
WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
US20050159470A1 (en) * | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
US7951780B2 (en) | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
US8771754B2 (en) * | 2004-09-17 | 2014-07-08 | Vanderbilt University | Use of GSK3 inhibitors in combination with radiation therapies |
JP5525689B2 (ja) * | 2004-11-02 | 2014-06-18 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ アズ リプレゼンティッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 過剰増殖性障害を処置するための組成物および方法 |
JP2008524246A (ja) * | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
NZ599464A (en) | 2005-02-03 | 2014-03-28 | Topotarget Uk Ltd | Combination therapies using hdac inhibitors |
NZ548087A (en) * | 2005-04-29 | 2010-10-29 | Tomizo Yamamoto | Rubber or resin foam containing zirconium or germanium |
JP2008540574A (ja) * | 2005-05-11 | 2008-11-20 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
JP5108750B2 (ja) | 2005-05-13 | 2012-12-26 | トポターゲット ユーケー リミテッド | Hdac阻害剤の医薬製剤 |
TWI365068B (en) * | 2005-05-20 | 2012-06-01 | Merck Sharp & Dohme | Formulations of suberoylanilide hydroxamic acid and methods for producing same |
CN101263121A (zh) * | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
US20080292616A1 (en) * | 2005-08-19 | 2008-11-27 | Government Of The United Of America, Represented By The Secretary, Department Of Health And.... | Topical Formulations of Histone Deacetylase Inhibitors and Methods Using the Same |
RU2436572C2 (ru) * | 2005-10-24 | 2011-12-20 | Новартис Аг | Комбинация ингибиторов гистондеацетилазы и излучения |
JP2009514889A (ja) * | 2005-11-04 | 2009-04-09 | メルク エンド カムパニー インコーポレーテッド | 癌を治療するためにsaha及びボルテゾミブを用いる方法 |
CA2622136A1 (en) * | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Methods of using saha and erlotinib for treating cancer |
WO2007054719A2 (en) | 2005-11-10 | 2007-05-18 | Topotarget Uk Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
EP1965824A4 (en) * | 2005-11-18 | 2011-10-19 | Gloucester Pharmaceuticals Inc | METABOLITENE DERIVATIVES OF HDAC INHIBITOR FK228 |
JP2009525955A (ja) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
US20100137239A1 (en) | 2006-04-24 | 2010-06-03 | Gloucester Pharmaceuticals | Gemcitabine combination therapy |
WO2007146730A2 (en) | 2006-06-08 | 2007-12-21 | Gloucester Pharmaceuticals | Deacetylase inhibitor therapy |
MX2009003405A (es) * | 2006-09-28 | 2009-04-09 | Merck & Co Inc | Composiciones farmaceuticas de inhibidores de la histona desacetilasa y compuestos quelantes de metal, y complejos de quelato de metal-inhibidor de histona desacetilasa. |
EP2086323A4 (en) * | 2006-11-03 | 2010-01-06 | Univ Maryland | METHOD OF USE OF SAHA AND BORTEZOMIB FOR THE TREATMENT OF MULTIPLE MYELOMA |
BRPI0720734A2 (pt) * | 2006-12-29 | 2014-01-07 | Gloucester Pharmaceuticals Inc | Preparação da romidepsina |
CN101801994A (zh) | 2006-12-29 | 2010-08-11 | 格洛斯特制药公司 | 制备Romidepsin |
MX2010003230A (es) * | 2007-09-25 | 2010-04-07 | Topotarget Uk Ltd | Metodos para la sintesis de ciertos compuestos de acido hidroxamico. |
US20110053991A1 (en) * | 2007-11-19 | 2011-03-03 | Gore Lia | Treatment of Histone Deacetylase Mediated Disorders |
ES2536208T3 (es) * | 2008-03-07 | 2015-05-21 | Onxeo Dk, Branch Of Onxeo S.A., France | Métodos de tratamiento que emplean infusión continua prolongada de Belinostat |
US20100015042A1 (en) * | 2008-07-03 | 2010-01-21 | Ramot At Tel Aviv University Ltd. | Combine radiation therapy and chemotherapy for treating cancer |
GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
WO2011053700A1 (en) | 2009-10-28 | 2011-05-05 | Henry Ford Health System | Methods to mitigate injury from radiation exposure |
RU2627588C2 (ru) | 2010-03-08 | 2017-08-09 | Спектрум Фармасьютикалз, Инк. | Способы лечения рака с применением ингибитора аутофагии на основе тиоксантона |
US20120190817A2 (en) | 2010-07-12 | 2012-07-26 | Celgene Corporation | Romidepsin solid forms and uses thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
UY34295A (es) * | 2011-09-08 | 2013-04-30 | Servier Lab | Nuevo esquema de administración de la n-hidroxi -4- {2-[3- (n,ndimetilaminometil)benzofuran -2- ilcarbonilamino]etoxi}benzamida |
RU2478374C1 (ru) * | 2012-02-06 | 2013-04-10 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Минздравсоцразвития России | Способ внутриполостной терапии при лечении больных с метастазами рака во влагалище |
US8836679B2 (en) * | 2012-08-06 | 2014-09-16 | Au Optronics Corporation | Display with multiplexer feed-through compensation and methods of driving same |
AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
CN103159646B (zh) * | 2013-03-19 | 2014-10-22 | 广东药学院 | 一种异羟肟酸类化合物及其制备方法和应用 |
CN111481551B (zh) * | 2013-04-09 | 2023-06-09 | 伊利诺伊大学董事会 | 肿瘤选择性联合疗法 |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
WO2016118730A1 (en) | 2015-01-23 | 2016-07-28 | Temple University-Of The Commonwealth System Of Higher Education | Use of short chain fatty acids in cancer prevention |
CN104788391B (zh) * | 2015-04-21 | 2017-03-08 | 中国医学科学院医药生物技术研究所 | 肉桂酰中性红酰胺(ca‑pz)及其制备与应用 |
AU2017221268B2 (en) * | 2016-02-15 | 2024-02-15 | Astrazeneca Ab | Methods comprising fixed intermittent dosing of cediranib |
US11065217B2 (en) | 2017-01-27 | 2021-07-20 | Temple University—Of the Commonwealth System of Higher Education | Use of short chain fatty acids for the treatment and prevention of diseases and disorders |
KR102560243B1 (ko) | 2017-05-11 | 2023-07-27 | 알파 타우 메디컬 리미티드 | 근접치료 디바이스용 폴리머 코팅 |
AU2019247818B2 (en) | 2018-04-02 | 2021-10-14 | Alpha Tau Medical Ltd. | Controlled release of radionuclides |
EP3873598A4 (en) * | 2018-11-01 | 2022-07-20 | Alpha Tau Medical Ltd. | INTRATUMORAL ALPHA-EMITTING RADIATION AND ACTIVATION OF CYTOPLASMIC SENSORS FOR AN INTRACELLULAR PATHOGEN |
US11654300B2 (en) | 2020-01-28 | 2023-05-23 | Reflexion Medical, Inc. | Joint optimization of radionuclide and external beam radiotherapy |
EP4213826A1 (en) * | 2020-09-15 | 2023-07-26 | Oncoinvent AS | Preparations of radium-224 and progenies for use in radionuclide therapy in combination with dna repair inhibitors |
WO2022130195A1 (en) | 2020-12-16 | 2022-06-23 | Alpha Tau Medical Ltd. | Diffusing alpha-emitters radiation therapy with enhanced beta treatment |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61176523A (ja) * | 1985-01-30 | 1986-08-08 | Teruhiko Beppu | 制癌剤 |
US5330744A (en) * | 1988-11-14 | 1994-07-19 | Sloan-Kettering Institute For Cancer Research | Method for increasing sensitivity to chemically induced terminal differentiation |
US5175191A (en) * | 1988-11-14 | 1992-12-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5608108A (en) * | 1988-11-14 | 1997-03-04 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5055608A (en) * | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
US5700811A (en) * | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
USRE38506E1 (en) * | 1991-10-04 | 2004-04-20 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5635532A (en) * | 1991-10-21 | 1997-06-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Compositions and methods for therapy and prevention of pathologies including cancer, AIDS and anemia |
US6043389A (en) * | 1997-03-11 | 2000-03-28 | Mor Research Applications, Ltd. | Hydroxy and ether-containing oxyalkylene esters and uses thereof |
US6231880B1 (en) * | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
AUPO721997A0 (en) * | 1997-06-06 | 1997-07-03 | Queensland Institute Of Medical Research, The | Anticancer compounds |
US6262116B1 (en) * | 1998-01-23 | 2001-07-17 | Sloan-Kettering Institute For Cancer Research | Transcription therapy for cancers |
ES2185378T3 (es) * | 1998-09-25 | 2003-04-16 | Warner Lambert Co | Quimioterapia de cancer con acetildinalina en combinacion con gemcitabina, capecitabina o cisplatina. |
CZ20011342A3 (cs) * | 1998-10-13 | 2001-09-12 | Fujisawa Pharmaceutical Co., Ltd. | Cyklické tetrapeptidy |
EA007649B1 (ru) * | 1999-09-08 | 2006-12-29 | Слоан-Кеттеринг Инститьют Фор Кэнсер Рисёч | Ингибиторы гистондеацетилазы, вызывающие дифференцировку клеток, и их применение |
ATE392210T1 (de) * | 1999-10-07 | 2008-05-15 | Aguilar Cordova Carlos Estuard | Methoden zur behandlung von festen tumoren und metastasen mit gentherapie |
WO2001038322A1 (en) * | 1999-11-23 | 2001-05-31 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US6544957B2 (en) * | 2000-01-04 | 2003-04-08 | The Johns Hopkins University | Methods and reagents for facilitating transcription |
AU2001298014A1 (en) * | 2000-03-24 | 2003-01-29 | Methylgene, Inc. | Inhibition of specific histone deacetylase isoforms |
ES2277923T3 (es) * | 2000-07-06 | 2007-08-01 | Sumitomo Chemical Company, Limited | Insecticidas. |
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WO2002022133A1 (en) * | 2000-09-12 | 2002-03-21 | Virginia Commonwealth University | Promotion of adoptosis in cancer cells by co-administration of cyclin dependent kinase inhibitors and cellular differentiation agents |
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US20020103192A1 (en) * | 2000-10-26 | 2002-08-01 | Curtin Michael L. | Inhibitors of histone deacetylase |
AU2002243231A1 (en) * | 2000-11-21 | 2002-07-24 | Wake Forest University | Method of treating autoimmune diseases |
AR035659A1 (es) * | 2000-12-07 | 2004-06-23 | Hoffmann La Roche | Hidroxiamidas de acido (1-oxo-1,2,3,4-tetrahidro-naftalen-2-il)-alcanoico, proceso para la manufactura de estos compuestos, composiciones farmaceuticas que contienen dichos compuestos y los usos de los mismos |
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US20020183388A1 (en) * | 2001-02-01 | 2002-12-05 | Gudas Lorraine J. | Use of retinoids plus histone deacetylase inhibitors to inhibit the growth of solid tumors |
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US20040142859A1 (en) * | 2002-05-02 | 2004-07-22 | Steffan Joan S. | Method for treating neurodegenerative, psychiatric, and other disorders with deacetylase inhibitors |
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US20040087657A1 (en) * | 2001-10-16 | 2004-05-06 | Richon Victoria M. | Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors |
US20040132643A1 (en) * | 2002-01-09 | 2004-07-08 | Fojo Antonio Tito | Histone deacelylase inhibitors in diagnosis and treatment of thyroid neoplasms |
AU2003219803B8 (en) * | 2002-02-15 | 2005-08-25 | Sloan-Kettering Institute For Cancer Research | Method of treating TRX mediated diseases |
EP1487426B1 (en) * | 2002-03-04 | 2012-08-22 | Sloan-kettering Institute For Cancer Research | Methods of inducing terminal differentiation |
US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
US20060276547A1 (en) * | 2002-03-04 | 2006-12-07 | Bacopoulos Nicholas G | Methods of treating cancer with HDAC inhibitors |
AU2003226014A1 (en) * | 2002-03-28 | 2003-10-13 | Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and alzheimer's disease |
CN100566711C (zh) * | 2002-04-15 | 2009-12-09 | 斯隆-凯特林癌症研究院 | 治疗癌症的化合物及其用途 |
JP2006523693A (ja) * | 2003-04-01 | 2006-10-19 | メモリアル スローン−ケタリング キャンサー センター | ヒドロキサム酸化合物およびその使用方法 |
DK1663194T3 (da) * | 2003-08-26 | 2010-07-19 | Merck Hdac Res Llc | Anvendelse af SAHA til behandling af mesotheliom |
CN1964714B (zh) * | 2003-08-29 | 2011-09-28 | Hdac默克研究有限责任公司 | 辛二酰苯胺异羟肟酸和吉西他滨在制备用于治疗癌症的药物中的用途 |
-
2003
- 2003-04-15 CN CNB038138492A patent/CN100566711C/zh not_active Expired - Fee Related
- 2003-04-15 US US10/413,422 patent/US20040018968A1/en not_active Abandoned
- 2003-04-15 MX MXPA04010199A patent/MXPA04010199A/es active IP Right Grant
- 2003-04-15 BR BR0309280-1A patent/BR0309280A/pt not_active IP Right Cessation
- 2003-04-15 WO PCT/US2003/011812 patent/WO2003088954A1/en active IP Right Grant
- 2003-04-15 CA CA002482508A patent/CA2482508A1/en not_active Abandoned
- 2003-04-15 EP EP03747011A patent/EP1501489A4/en not_active Withdrawn
- 2003-04-15 IL IL16459903A patent/IL164599A0/xx unknown
- 2003-04-15 AU AU2003226408A patent/AU2003226408B2/en not_active Ceased
- 2003-04-15 JP JP2003585706A patent/JP2005530734A/ja not_active Withdrawn
-
2004
- 2004-11-15 EC EC2004005430A patent/ECSP045430A/es unknown
-
2006
- 2006-06-07 HK HK06106520A patent/HK1086488A1/xx not_active IP Right Cessation
-
2008
- 2008-10-08 US US12/287,490 patent/US20090054720A1/en not_active Abandoned
-
2009
- 2009-02-25 JP JP2009043108A patent/JP2009114207A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ECSP045430A (es) | 2005-05-30 |
WO2003088954A1 (en) | 2003-10-30 |
CN1728991A (zh) | 2006-02-01 |
JP2009114207A (ja) | 2009-05-28 |
EP1501489A4 (en) | 2007-11-21 |
CN100566711C (zh) | 2009-12-09 |
HK1086488A1 (en) | 2006-09-22 |
BR0309280A (pt) | 2005-02-22 |
JP2005530734A (ja) | 2005-10-13 |
MXPA04010199A (es) | 2005-07-05 |
AU2003226408B2 (en) | 2007-06-14 |
EP1501489A1 (en) | 2005-02-02 |
AU2003226408A1 (en) | 2003-11-03 |
CA2482508A1 (en) | 2003-10-30 |
US20040018968A1 (en) | 2004-01-29 |
US20090054720A1 (en) | 2009-02-26 |
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