ECSP045430A - Terapia de combinación para el tratamiento de cancer - Google Patents
Terapia de combinación para el tratamiento de cancerInfo
- Publication number
- ECSP045430A ECSP045430A EC2004005430A ECSP045430A ECSP045430A EC SP045430 A ECSP045430 A EC SP045430A EC 2004005430 A EC2004005430 A EC 2004005430A EC SP045430 A ECSP045430 A EC SP045430A EC SP045430 A ECSP045430 A EC SP045430A
- Authority
- EC
- Ecuador
- Prior art keywords
- combination therapy
- cancer treatment
- amount
- patient
- need
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
La presente invención se relaciona con un método para el tratamiento de cáncer en un paciente necesitado de ello. El método comprende administrar a un paciente necesitado de ello una primer cantidad de un inhibidor de histona deacetilaza en un primer procedimiento de tratamiento, y una segunda cantidad o dosis de radiación en un segundo procedimiento de tratamiento. El primer y segundo tratamiento juntos comprenden una cantidad terapéuticamente efectiva. La combinación del inhibidor HDAC y la terapia de radiación es terapéuticamente sinergística.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37303302P | 2002-04-15 | 2002-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
ECSP045430A true ECSP045430A (es) | 2005-05-30 |
Family
ID=29250948
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EC2004005430A ECSP045430A (es) | 2002-04-15 | 2004-11-15 | Terapia de combinación para el tratamiento de cancer |
Country Status (12)
Country | Link |
---|---|
US (2) | US20040018968A1 (es) |
EP (1) | EP1501489A4 (es) |
JP (2) | JP2005530734A (es) |
CN (1) | CN100566711C (es) |
AU (1) | AU2003226408B2 (es) |
BR (1) | BR0309280A (es) |
CA (1) | CA2482508A1 (es) |
EC (1) | ECSP045430A (es) |
HK (1) | HK1086488A1 (es) |
IL (1) | IL164599A0 (es) |
MX (1) | MXPA04010199A (es) |
WO (1) | WO2003088954A1 (es) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001018171A2 (en) * | 1999-09-08 | 2001-03-15 | Sloan-Kettering Institute For Cancer Research | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
AU2002340253C1 (en) * | 2001-10-16 | 2011-03-31 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases and cancer of the brain |
JP2005525345A (ja) * | 2002-02-15 | 2005-08-25 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Trx媒介性疾患を処置する方法 |
US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
US20060276547A1 (en) * | 2002-03-04 | 2006-12-07 | Bacopoulos Nicholas G | Methods of treating cancer with HDAC inhibitors |
US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
EP2082737B1 (en) * | 2002-03-04 | 2014-12-31 | Merck HDAC Research, LLC | Methods of inducing terminal differentiation |
MXPA04010199A (es) * | 2002-04-15 | 2005-07-05 | Sloan Kettering Inst Cancer | Terapia en combinacion para el tratamiento de cancer. |
WO2004064727A2 (en) * | 2003-01-16 | 2004-08-05 | Georgetown University | Method of cancer treatment using hdac inhibitors |
WO2004075859A2 (en) * | 2003-02-27 | 2004-09-10 | Institute For Cancer Prevention | Treatment of canine hemangiosarcoma with a histone deacetylase inhibitor |
WO2004082638A2 (en) * | 2003-03-17 | 2004-09-30 | Syrrx, Inc. | Histone deacetylase inhibitors |
CN1839121A (zh) | 2003-04-01 | 2006-09-27 | 斯隆-凯特林癌症研究所 | 异羟肟酸化合物及其使用方法 |
EP1644049B1 (en) | 2003-04-30 | 2007-09-26 | Ramot at Tel Aviv University Ltd. | Method and device for radiotherapy |
EP2238982B8 (en) | 2003-06-27 | 2013-01-16 | Astellas Pharma Inc. | Therapeutic agent for soft tissue sarcoma |
EP1663194B1 (en) * | 2003-08-26 | 2010-03-31 | Merck HDAC Research, LLC | Use of SAHA for treating mesothelioma |
US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
US20050159470A1 (en) * | 2003-12-19 | 2005-07-21 | Syrrx, Inc. | Histone deacetylase inhibitors |
US7951780B2 (en) | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
WO2006034207A2 (en) * | 2004-09-17 | 2006-03-30 | Vanderbilt University | Use of gsk3 inhibitors in combination with radiation therapies |
WO2006050270A2 (en) * | 2004-11-02 | 2006-05-11 | The Government Of The United States Of America As Represented By The Secretary Department Of Health & Human Services | Compositions and methods for treating hyperproliferative disorders |
US7642275B2 (en) * | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
EP2500063A1 (en) | 2005-02-03 | 2012-09-19 | TopoTarget UK Limited | Combination therapy using HDAC inhibitors and melphalan for treating cancer |
NZ548087A (en) * | 2005-04-29 | 2010-10-29 | Tomizo Yamamoto | Rubber or resin foam containing zirconium or germanium |
WO2006122319A2 (en) * | 2005-05-11 | 2006-11-16 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
ES2540204T3 (es) | 2005-05-13 | 2015-07-09 | Topotarget Uk Limited | Formulaciones farmacéuticas de inhibidores de la HDAC |
TWI415603B (zh) * | 2005-05-20 | 2013-11-21 | Merck Sharp & Dohme | 1,8-辛二醯基苯胺羥胺酸(suberoylanilide hydroxamic acid)之調配物及其製配方法 |
ZA200800901B (en) | 2005-07-14 | 2010-05-26 | Takeda San Diego Inc | Histone deacetylase inhibitors |
US20080292616A1 (en) * | 2005-08-19 | 2008-11-27 | Government Of The United Of America, Represented By The Secretary, Department Of Health And.... | Topical Formulations of Histone Deacetylase Inhibitors and Methods Using the Same |
KR20080064988A (ko) * | 2005-10-24 | 2008-07-10 | 노파르티스 아게 | 히스톤 데아세틸라제 억제제 및 방사선의 조합 |
EP1942907A2 (en) * | 2005-11-04 | 2008-07-16 | Merck and Co., Inc. | Methods of using saha and erlotinib for treating cancer |
WO2007056135A1 (en) * | 2005-11-04 | 2007-05-18 | Merck & Co., Inc. | Method of treating cancers with saha and pemetrexed |
EP1957056A2 (en) * | 2005-11-10 | 2008-08-20 | TopoTarget UK Limited | Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer alone or in combination with chemotherapeutic agent |
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JP2009525955A (ja) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
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AU2007300532A1 (en) * | 2006-09-28 | 2008-04-03 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions of HDAC inhibitors and chelatable metal compounds, and metal-HDAC inhibitor chelate complexes |
WO2008057456A2 (en) * | 2006-11-03 | 2008-05-15 | University Of Maryland, Baltimore | Methods of using saha and bortezomib for treating multiple myeloma |
AU2007342028B2 (en) | 2006-12-29 | 2013-06-13 | Celgene Corporation | Purifiction of romidepsin |
AU2007342030B2 (en) * | 2006-12-29 | 2013-08-15 | Celgene Corporation | Romidepsin-based treatments for cancer |
JP2010540426A (ja) * | 2007-09-25 | 2010-12-24 | トポターゲット ユーケー リミテッド | 特定のヒドロキサム酸化合物の合成方法 |
WO2009067543A2 (en) * | 2007-11-19 | 2009-05-28 | The Regents Of The University Of Colorado | Treatment of histone deacetylase mediated disorders |
CN102083428A (zh) * | 2008-03-07 | 2011-06-01 | 顶标公司 | 采用长时间连续输液Belinostat进行治疗的方法 |
US20100015042A1 (en) * | 2008-07-03 | 2010-01-21 | Ramot At Tel Aviv University Ltd. | Combine radiation therapy and chemotherapy for treating cancer |
GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
WO2011053700A1 (en) | 2009-10-28 | 2011-05-05 | Henry Ford Health System | Methods to mitigate injury from radiation exposure |
RU2627588C2 (ru) * | 2010-03-08 | 2017-08-09 | Спектрум Фармасьютикалз, Инк. | Способы лечения рака с применением ингибитора аутофагии на основе тиоксантона |
CA2804795A1 (en) | 2010-07-12 | 2012-01-19 | Nicholas Vrolijk | Romidepsin solid forms and uses thereof |
US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
UY34295A (es) * | 2011-09-08 | 2013-04-30 | Servier Lab | Nuevo esquema de administración de la n-hidroxi -4- {2-[3- (n,ndimetilaminometil)benzofuran -2- ilcarbonilamino]etoxi}benzamida |
RU2478374C1 (ru) * | 2012-02-06 | 2013-04-10 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Минздравсоцразвития России | Способ внутриполостной терапии при лечении больных с метастазами рака во влагалище |
US8836679B2 (en) * | 2012-08-06 | 2014-09-16 | Au Optronics Corporation | Display with multiplexer feed-through compensation and methods of driving same |
AU2013202506B2 (en) | 2012-09-07 | 2015-06-18 | Celgene Corporation | Resistance biomarkers for hdac inhibitors |
AU2013202507B9 (en) | 2012-11-14 | 2015-08-13 | Celgene Corporation | Inhibition of drug resistant cancer cells |
CN103159646B (zh) * | 2013-03-19 | 2014-10-22 | 广东药学院 | 一种异羟肟酸类化合物及其制备方法和应用 |
PL2984184T3 (pl) * | 2013-04-09 | 2021-06-14 | The Board Of Trustees Of The University Of Illinois | Stosowanie DNQ lub DNQ-87 w połączeniu z inhibitorem PARP1 do leczenia nowotworu |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
RU2017127597A (ru) | 2015-01-23 | 2019-02-25 | Темпл Юнивёрсити-Оф Дзе Коммонвелс Систем Оф Хайе Эдьюкейшен | Применение короткоцепочечных жирных кислот для профилактики рака |
CN104788391B (zh) * | 2015-04-21 | 2017-03-08 | 中国医学科学院医药生物技术研究所 | 肉桂酰中性红酰胺(ca‑pz)及其制备与应用 |
EP4071174A1 (en) * | 2016-02-15 | 2022-10-12 | AstraZeneca AB | Methods comprising fixed intermittent dosing of cediranib |
US11065217B2 (en) | 2017-01-27 | 2021-07-20 | Temple University—Of the Commonwealth System of Higher Education | Use of short chain fatty acids for the treatment and prevention of diseases and disorders |
RU2763750C2 (ru) | 2017-05-11 | 2022-01-10 | Альфа Тау Медикал Лтд. | Полимерные покрытия для брахитерапевтических устройств |
CA3094785A1 (en) | 2018-04-02 | 2019-10-10 | Alpha Tau Medical Ltd. | Controlled release of radionuclides |
US20210379096A1 (en) * | 2018-11-01 | 2021-12-09 | Alpha Tau Medical Ltd. | Intratumoral Alpha-Emitter Radiation and Activation of Cytoplasmatic Sensors for Intracellular Pathogen |
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MX2023002800A (es) * | 2020-09-15 | 2023-04-21 | Oncoinvent As | Preparaciones de radio-224 y su progenie para uso en terapia con radionúclidos en combinación con inhibidores de reparación del adn. |
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JPS61176523A (ja) * | 1985-01-30 | 1986-08-08 | Teruhiko Beppu | 制癌剤 |
US5055608A (en) * | 1988-11-14 | 1991-10-08 | Sloan-Kettering Institute For Cancer Research | Novel potent inducers of thermal differentiation and method of use thereof |
US5330744A (en) * | 1988-11-14 | 1994-07-19 | Sloan-Kettering Institute For Cancer Research | Method for increasing sensitivity to chemically induced terminal differentiation |
US5175191A (en) * | 1988-11-14 | 1992-12-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
US5608108A (en) * | 1988-11-14 | 1997-03-04 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5700811A (en) * | 1991-10-04 | 1997-12-23 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and method of use thereof |
US5369108A (en) * | 1991-10-04 | 1994-11-29 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
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PL348673A1 (en) * | 1998-09-25 | 2002-06-03 | Warner Lambert Co | Chemotherapy of cancer with acetyldinaline in combination with gemcitabine, capecitabine or cisplatin |
BR9914779A (pt) * | 1998-10-13 | 2001-07-03 | Fujisawa Pharmaceutical Co | Composto wf27082, processo para sua produção, composição farmacêutica contendo o mesmo, cepa de fundos pertencente ao gênero acremonium, composto tendo atividade inibidora de desacetilase de histona, processo para sua produção, seu método e uso |
WO2001018171A2 (en) * | 1999-09-08 | 2001-03-15 | Sloan-Kettering Institute For Cancer Research | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
ATE392210T1 (de) * | 1999-10-07 | 2008-05-15 | Aguilar Cordova Carlos Estuard | Methoden zur behandlung von festen tumoren und metastasen mit gentherapie |
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US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
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US20040077591A1 (en) * | 2002-03-28 | 2004-04-22 | The Brigham And Women's Hospital, Inc. | Histone deacetylase inhibitors for the treatment of multiple sclerosis, amyotrophic lateral sclerosis and Alzheimer's Disease |
MXPA04010199A (es) * | 2002-04-15 | 2005-07-05 | Sloan Kettering Inst Cancer | Terapia en combinacion para el tratamiento de cancer. |
CA2506504A1 (en) * | 2002-11-20 | 2004-06-03 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
CN1839121A (zh) * | 2003-04-01 | 2006-09-27 | 斯隆-凯特林癌症研究所 | 异羟肟酸化合物及其使用方法 |
EP1663194B1 (en) * | 2003-08-26 | 2010-03-31 | Merck HDAC Research, LLC | Use of SAHA for treating mesothelioma |
WO2005023179A2 (en) * | 2003-08-29 | 2005-03-17 | Aton Pharma, Inc. | Combination methods of treating cancer |
-
2003
- 2003-04-15 MX MXPA04010199A patent/MXPA04010199A/es active IP Right Grant
- 2003-04-15 BR BR0309280-1A patent/BR0309280A/pt not_active IP Right Cessation
- 2003-04-15 IL IL16459903A patent/IL164599A0/xx unknown
- 2003-04-15 WO PCT/US2003/011812 patent/WO2003088954A1/en active IP Right Grant
- 2003-04-15 JP JP2003585706A patent/JP2005530734A/ja not_active Withdrawn
- 2003-04-15 US US10/413,422 patent/US20040018968A1/en not_active Abandoned
- 2003-04-15 EP EP03747011A patent/EP1501489A4/en not_active Withdrawn
- 2003-04-15 CA CA002482508A patent/CA2482508A1/en not_active Abandoned
- 2003-04-15 AU AU2003226408A patent/AU2003226408B2/en not_active Ceased
- 2003-04-15 CN CNB038138492A patent/CN100566711C/zh not_active Expired - Fee Related
-
2004
- 2004-11-15 EC EC2004005430A patent/ECSP045430A/es unknown
-
2006
- 2006-06-07 HK HK06106520A patent/HK1086488A1/xx not_active IP Right Cessation
-
2008
- 2008-10-08 US US12/287,490 patent/US20090054720A1/en not_active Abandoned
-
2009
- 2009-02-25 JP JP2009043108A patent/JP2009114207A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
US20090054720A1 (en) | 2009-02-26 |
CN100566711C (zh) | 2009-12-09 |
HK1086488A1 (en) | 2006-09-22 |
MXPA04010199A (es) | 2005-07-05 |
AU2003226408B2 (en) | 2007-06-14 |
CN1728991A (zh) | 2006-02-01 |
EP1501489A4 (en) | 2007-11-21 |
IL164599A0 (en) | 2005-12-18 |
CA2482508A1 (en) | 2003-10-30 |
AU2003226408A1 (en) | 2003-11-03 |
BR0309280A (pt) | 2005-02-22 |
WO2003088954A1 (en) | 2003-10-30 |
JP2005530734A (ja) | 2005-10-13 |
JP2009114207A (ja) | 2009-05-28 |
EP1501489A1 (en) | 2005-02-02 |
US20040018968A1 (en) | 2004-01-29 |
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