CY1106259T1 - Συνδυασμενη θepαπεια που πepιλαμβανει zd6474 κι ενα ταξανιο - Google Patents

Συνδυασμενη θepαπεια που πepιλαμβανει zd6474 κι ενα ταξανιο

Info

Publication number
CY1106259T1
CY1106259T1 CY20061101619T CY061101619T CY1106259T1 CY 1106259 T1 CY1106259 T1 CY 1106259T1 CY 20061101619 T CY20061101619 T CY 20061101619T CY 061101619 T CY061101619 T CY 061101619T CY 1106259 T1 CY1106259 T1 CY 1106259T1
Authority
CY
Cyprus
Prior art keywords
taxane
class
warm
human
producing
Prior art date
Application number
CY20061101619T
Other languages
English (en)
Inventor
Stephen Robert Wedge
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1106259T1 publication Critical patent/CY1106259T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία μέθοδο για την παραγωγή ενός αντιαγγειογόνου αποτελέσματος και/ή τη μείωση της αγγειακής διαπερατότητας σ' ένα θερμόαιμο ζώο όπως ο άνθρωπος, ιδιαίτερα σε μία μέθοδο για την αντιμετώπιση ενός καρκίνου που συμπεριλαμβάνει ένα συμπαγή όγκο, η οποία περιλαμβάνει τη χορήγηση ZD6474 σε συνδυασμό μ' ένα ταξάνιο• σε μία φαρμακευτική σύνθεση που περιέχει ZD6474 κι ένα ταξάνιο• σ' ένα συνδυασμένο προϊόν που περιέχει ZD6474 κι ένα ταξάνιο για χρήση σε μία μέθοδο θεραπευτικής αγωγής σε σώμα ανθρώπου ή ζώου• σ' ένα κιτ που περιλαμβάνει ZD6474 κι ένα ταξάνιο˙ στη χρήση του ZD6474 κι ενός ταξανίου στην παρασκευή ενός φαρμάκου για χρήση στην παραγωγή ενός αντιαγγειογόνου αποτελέσματος και/ή τη μείωση της αγγειακής διαπερατότητας σ' ένα θερμόαιμο ζώο όπως ο άνθρωπος που προαιρετικά μπορεί να υποβάλλεται σε ιονίζουσα ακτινοβολία.
CY20061101619T 2001-11-08 2006-11-09 Συνδυασμενη θepαπεια που πepιλαμβανει zd6474 κι ενα ταξανιο CY1106259T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0126879.6A GB0126879D0 (en) 2001-11-08 2001-11-08 Combination therapy
PCT/GB2002/005021 WO2003039551A1 (en) 2001-11-08 2002-11-06 Combination therapy comprising zd6474 and a taxane

Publications (1)

Publication Number Publication Date
CY1106259T1 true CY1106259T1 (el) 2011-06-08

Family

ID=9925430

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101619T CY1106259T1 (el) 2001-11-08 2006-11-09 Συνδυασμενη θepαπεια που πepιλαμβανει zd6474 κι ενα ταξανιο

Country Status (23)

Country Link
US (2) US20050043395A1 (el)
EP (1) EP1446124B1 (el)
JP (1) JP4694127B2 (el)
KR (1) KR100959607B1 (el)
CN (1) CN1298328C (el)
AR (1) AR037346A1 (el)
AT (1) ATE335488T1 (el)
AU (1) AU2002337382B2 (el)
BR (1) BR0213906A (el)
CA (1) CA2464758C (el)
CY (1) CY1106259T1 (el)
DE (1) DE60213845T2 (el)
DK (1) DK1446124T3 (el)
ES (1) ES2269769T3 (el)
GB (1) GB0126879D0 (el)
HK (1) HK1068546A1 (el)
IL (2) IL161744A0 (el)
MX (1) MXPA04004355A (el)
NO (1) NO328048B1 (el)
NZ (1) NZ532525A (el)
PT (1) PT1446124E (el)
WO (1) WO2003039551A1 (el)
ZA (1) ZA200403455B (el)

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KR100881105B1 (ko) 1999-11-05 2009-02-02 아스트라제네카 아베 Ｖｅｇｆ 억제제로서의 퀴나졸린 유도체
GB0008269D0 (en) 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
DE60121931T2 (de) * 2000-04-07 2007-03-01 Astrazeneca Ab Chinazolinverbindungen
BR0307151A (pt) 2002-02-01 2004-12-07 Astrazeneca Ab Composto ou um sal do mesmo, processo para a preparação do mesmo, composição farmacêutica, uso do composto ou de um seu sal, método para produzir um efeito antiangiogênico e/ou redutor da permeabilidade vascular em um animal de sangue quente, como um ser humano, que necessita de um tratamento do tipo referido, e, processos para a preparação de 5-bromo-7- azaindol, e para a produção de 5-metóxi-7-azaindol
TWI324597B (en) * 2002-03-28 2010-05-11 Astrazeneca Ab Quinazoline derivatives
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
SI1562955T1 (sl) 2002-11-04 2008-06-30 Astrazeneca Ab Derivati kinazolina kot inhibitorji Src-triozin kinaze
US20060142316A1 (en) * 2003-02-13 2006-06-29 Wedge Stephen R Combination therapy
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
DE602004028834D1 (de) * 2003-07-10 2010-10-07 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
AU2004291037A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0406445D0 (en) * 2004-03-23 2004-04-28 Astrazeneca Ab Combination therapy
EP1765313A2 (en) * 2004-06-24 2007-03-28 Novartis Vaccines and Diagnostics, Inc. Compounds for immunopotentiation
JP2008514577A (ja) * 2004-09-27 2008-05-08 アストラゼネカ アクチボラグ Ｚｄ６４７４及びイマチニブを含んでなる組合せ
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
GB0519879D0 (en) 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
AU2006328189B2 (en) * 2005-12-22 2010-01-21 Astrazeneca Ab Combination of ZD6474 and pemetrexed
CA2652926A1 (en) * 2006-05-26 2007-12-06 Bayer Healthcare Llc Drug combinations with substituted diaryl ureas for the treatment of cancer
CN101553253A (zh) * 2006-09-29 2009-10-07 阿斯利康(瑞典)有限公司 用于癌症治疗的zd6474和贝伐单抗的组合
US20080190689A1 (en) * 2007-02-12 2008-08-14 Ballard Ebbin C Inserts for engine exhaust systems
ES2444128T3 (es) 2008-05-13 2014-02-24 Astrazeneca Ab Nueva SAL-554
WO2010061208A2 (en) * 2008-11-03 2010-06-03 Astrazeneca Ab Therapeutic treatment 555
CN106397401B (zh) * 2016-08-30 2018-11-13 山东罗欣药业集团股份有限公司 一种抗癌药物的晶体化合物及其制备方法
CN106478598B (zh) * 2016-08-30 2018-11-13 山东罗欣药业集团股份有限公司 一种凡德他尼水合物晶体及其制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5565478A (en) * 1994-03-14 1996-10-15 The United States Of America As Represented By The Department Of Health & Human Services Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs
DE69722793T2 (de) * 1996-04-26 2004-05-19 Genaera Corp. Squalamin in kombination mit anderen antikrebs-mittelen zur behandlung von tumoren
GB9718972D0 (en) * 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
CA2362937C (en) * 1999-02-24 2011-03-22 The Uab Research Foundation Taxane derivatives for targeted therapy of cancer
ES2223705T3 (es) * 1999-04-28 2005-03-01 Board Of Regents, The University Of Texas System Composiciones y metodos para el tratamiento de cancer mediante inhibi cion selectiva del vegf.
KR100881105B1 (ko) * 1999-11-05 2009-02-02 아스트라제네카 아베 Ｖｅｇｆ 억제제로서의 퀴나졸린 유도체
TWI310684B (en) * 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
AU2003249000B2 (en) * 2002-08-09 2007-04-05 Astrazeneca Ab Combination of ZD6474, an inhibitor of the vasuclar endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
US20060142316A1 (en) * 2003-02-13 2006-06-29 Wedge Stephen R Combination therapy
DE602004028834D1 (de) * 2003-07-10 2010-10-07 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
JP2008514577A (ja) * 2004-09-27 2008-05-08 アストラゼネカ アクチボラグ Ｚｄ６４７４及びイマチニブを含んでなる組合せ
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
AU2006328189B2 (en) * 2005-12-22 2010-01-21 Astrazeneca Ab Combination of ZD6474 and pemetrexed
CN101553253A (zh) * 2006-09-29 2009-10-07 阿斯利康(瑞典)有限公司 用于癌症治疗的zd6474和贝伐单抗的组合

Also Published As

Publication number Publication date
CN1298328C (zh) 2007-02-07
NZ532525A (en) 2006-11-30
DE60213845T2 (de) 2007-03-29
AR037346A1 (es) 2004-11-03
JP4694127B2 (ja) 2011-06-08
DK1446124T3 (da) 2006-11-13
KR20050043779A (ko) 2005-05-11
KR100959607B1 (ko) 2010-05-27
ATE335488T1 (de) 2006-09-15
US20120252827A1 (en) 2012-10-04
US20050043395A1 (en) 2005-02-24
MXPA04004355A (es) 2004-08-11
EP1446124A1 (en) 2004-08-18
GB0126879D0 (en) 2002-01-02
CN1612738A (zh) 2005-05-04
IL161744A0 (en) 2005-11-20
AU2002337382B2 (en) 2008-06-12
IL161744A (en) 2012-01-31
DE60213845D1 (de) 2006-09-21
NO328048B1 (no) 2009-11-16
PT1446124E (pt) 2006-12-29
ZA200403455B (en) 2005-08-29
NO20042365L (no) 2004-06-07
HK1068546A1 (en) 2005-04-29
ES2269769T3 (es) 2007-04-01
CA2464758C (en) 2010-09-28
WO2003039551A1 (en) 2003-05-15
JP2005511597A (ja) 2005-04-28
EP1446124B1 (en) 2006-08-09
BR0213906A (pt) 2004-08-31
CA2464758A1 (en) 2003-05-15

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