AR037346A1 - Terapia de combinacion - Google Patents
Terapia de combinacionInfo
- Publication number
- AR037346A1 AR037346A1 ARP020104292A ARP020104292A AR037346A1 AR 037346 A1 AR037346 A1 AR 037346A1 AR P020104292 A ARP020104292 A AR P020104292A AR P020104292 A ARP020104292 A AR P020104292A AR 037346 A1 AR037346 A1 AR 037346A1
- Authority
- AR
- Argentina
- Prior art keywords
- taxane
- human
- methoxy
- warm
- treating
- Prior art date
Links
- 238000002648 combination therapy Methods 0.000 title 1
- UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 abstract 6
- 229940123237 Taxane Drugs 0.000 abstract 5
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 5
- 241001465754 Metazoa Species 0.000 abstract 3
- 238000004519 manufacturing process Methods 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 230000001772 anti-angiogenic effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000008728 vascular permeability Effects 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000013066 combination product Substances 0.000 abstract 1
- 229940127555 combination product Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000005865 ionizing radiation Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un método para producir un efecto antiangiogénico y/o reducir la permeabilidad vascular en un animal de sangre caliente, tal como un humano, particularmente un método para el tratamiento de un cáncer, que involucra un tumor sólido, que comprende la administración de 4-(4-bromo-2-fluoroanilino)-6-metoxi-7-(1-metilpiperidin-4-il-metoxi)quinazolin ZD6474 en combinación con un taxano; con una composición farmacéutica que comprende ZD6474 y un taxano; con un producto de combinación que comprende ZD6474 y un taxano para usar en un método de tratamiento de un cuerpo humano o animal por terapia; con un conjunto de elementos (kit) que comprende ZD6474 y un taxano; con el uso de ZD6474 y un taxano, en la fabricación de un medicamento para usar en la producción de un efecto antiangiogénico y/o la reducción de la permeabilidad vascular en un animal de sangre caliente, tal como un humano, que está siendo tratado opcionalmente con radiación ionizante.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0126879.6A GB0126879D0 (en) | 2001-11-08 | 2001-11-08 | Combination therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
AR037346A1 true AR037346A1 (es) | 2004-11-03 |
Family
ID=9925430
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP020104292A AR037346A1 (es) | 2001-11-08 | 2002-11-08 | Terapia de combinacion |
Country Status (23)
Country | Link |
---|---|
US (2) | US20050043395A1 (es) |
EP (1) | EP1446124B1 (es) |
JP (1) | JP4694127B2 (es) |
KR (1) | KR100959607B1 (es) |
CN (1) | CN1298328C (es) |
AR (1) | AR037346A1 (es) |
AT (1) | ATE335488T1 (es) |
AU (1) | AU2002337382B2 (es) |
BR (1) | BR0213906A (es) |
CA (1) | CA2464758C (es) |
CY (1) | CY1106259T1 (es) |
DE (1) | DE60213845T2 (es) |
DK (1) | DK1446124T3 (es) |
ES (1) | ES2269769T3 (es) |
GB (1) | GB0126879D0 (es) |
HK (1) | HK1068546A1 (es) |
IL (2) | IL161744A0 (es) |
MX (1) | MXPA04004355A (es) |
NO (1) | NO328048B1 (es) |
NZ (1) | NZ532525A (es) |
PT (1) | PT1446124E (es) |
WO (1) | WO2003039551A1 (es) |
ZA (1) | ZA200403455B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ518028A (en) | 1999-11-05 | 2004-03-26 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
SI1274692T1 (sl) * | 2000-04-07 | 2006-12-31 | Astrazeneca Ab | Kinazolinske spojine |
RU2362774C1 (ru) * | 2002-02-01 | 2009-07-27 | Астразенека Аб | Хиназолиновые соединения |
TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
JP4593464B2 (ja) | 2002-11-04 | 2010-12-08 | アストラゼネカ アクチボラグ | Srcチロシンキナーゼ阻害剤としてのキナゾリン誘導体 |
AU2004212255B2 (en) * | 2003-02-13 | 2007-07-05 | Astrazeneca Ab | Combination therapy of ZD6474 with 5-FU or/and CPT-11 |
GB0310401D0 (en) * | 2003-05-07 | 2003-06-11 | Astrazeneca Ab | Therapeutic agent |
NZ544458A (en) * | 2003-07-10 | 2009-04-30 | Astrazeneca Ab | Use of the quinazoline derivative ZD6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
CN1897949A (zh) * | 2003-11-14 | 2007-01-17 | 马尔药品公司 | 包含使用et-743和紫杉醇来治疗癌症的联合疗法 |
GB0406445D0 (en) * | 2004-03-23 | 2004-04-28 | Astrazeneca Ab | Combination therapy |
WO2006002422A2 (en) * | 2004-06-24 | 2006-01-05 | Novartis Vaccines And Diagnostics Inc. | Compounds for immunopotentiation |
BRPI0516052A (pt) * | 2004-09-27 | 2008-08-19 | Astrazeneca Ab | uso de zd6474 ou de um sal farmaceuticamente aceitável do mesmo e de imatinib, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou de redução da permeabilidade vascular em um animal de sangue quente |
GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
GB0519879D0 (en) | 2005-09-30 | 2005-11-09 | Astrazeneca Ab | Chemical process |
BRPI0620140A2 (pt) * | 2005-12-22 | 2011-11-01 | Astrazeneca Ab | uso de zd6474 ou de um sal farmaceuticamente aceitável do mesmo e pemetrexed, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular |
MX2008014953A (es) * | 2006-05-26 | 2009-03-05 | Bayer Healthcare Llc | Combinaciones de medicamentos con diarilureas sustituidas para el tratamiento de cancer. |
WO2008037996A1 (en) * | 2006-09-29 | 2008-04-03 | Astrazeneca Ab | Combination of zd6474 and bevacizumab for cancer therapy |
US20080190689A1 (en) * | 2007-02-12 | 2008-08-14 | Ballard Ebbin C | Inserts for engine exhaust systems |
WO2009138781A1 (en) | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy}quinazoline |
WO2010061208A2 (en) * | 2008-11-03 | 2010-06-03 | Astrazeneca Ab | Therapeutic treatment 555 |
CN106478598B (zh) * | 2016-08-30 | 2018-11-13 | 山东罗欣药业集团股份有限公司 | 一种凡德他尼水合物晶体及其制备方法 |
CN106397401B (zh) * | 2016-08-30 | 2018-11-13 | 山东罗欣药业集团股份有限公司 | 一种抗癌药物的晶体化合物及其制备方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5565478A (en) * | 1994-03-14 | 1996-10-15 | The United States Of America As Represented By The Department Of Health & Human Services | Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs |
DK0910382T3 (da) * | 1996-04-26 | 2003-10-06 | Genaera Corp | Squalamin i kombination med andre anticancermidler til behandling af tumorer |
GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
GB9727524D0 (en) * | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Synergistic antitumor composition containing a biologically active ureido compound |
US6191290B1 (en) * | 1999-02-24 | 2001-02-20 | Uab Research Foundation | Taxane derivatives for targeted therapy of cancer |
JP4926320B2 (ja) * | 1999-04-28 | 2012-05-09 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | Vegfの選択的阻害による癌処置のための組成物および方法 |
NZ518028A (en) * | 1999-11-05 | 2004-03-26 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
TWI310684B (en) * | 2000-03-27 | 2009-06-11 | Bristol Myers Squibb Co | Synergistic pharmaceutical kits for treating cancer |
GB0008269D0 (en) * | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
CA2495487A1 (en) * | 2002-08-09 | 2004-02-19 | Astrazeneca Ab | Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer |
GB0218526D0 (en) * | 2002-08-09 | 2002-09-18 | Astrazeneca Ab | Combination therapy |
GB0223380D0 (en) * | 2002-10-09 | 2002-11-13 | Astrazeneca Ab | Combination therapy |
AU2004212255B2 (en) * | 2003-02-13 | 2007-07-05 | Astrazeneca Ab | Combination therapy of ZD6474 with 5-FU or/and CPT-11 |
NZ544458A (en) * | 2003-07-10 | 2009-04-30 | Astrazeneca Ab | Use of the quinazoline derivative ZD6474 combined with platinum compounds and optionally ionising radiation in the treatment of diseases associated with angiogenesis and/or increased vascular permeability |
BRPI0516052A (pt) * | 2004-09-27 | 2008-08-19 | Astrazeneca Ab | uso de zd6474 ou de um sal farmaceuticamente aceitável do mesmo e de imatinib, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou de redução da permeabilidade vascular em um animal de sangue quente |
GB0424339D0 (en) * | 2004-11-03 | 2004-12-08 | Astrazeneca Ab | Combination therapy |
BRPI0620140A2 (pt) * | 2005-12-22 | 2011-11-01 | Astrazeneca Ab | uso de zd6474 ou de um sal farmaceuticamente aceitável do mesmo e pemetrexed, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou redutor da permeabilidade vascular |
WO2008037996A1 (en) * | 2006-09-29 | 2008-04-03 | Astrazeneca Ab | Combination of zd6474 and bevacizumab for cancer therapy |
-
2001
- 2001-11-08 GB GBGB0126879.6A patent/GB0126879D0/en not_active Ceased
-
2002
- 2002-11-06 NZ NZ532525A patent/NZ532525A/en not_active IP Right Cessation
- 2002-11-06 DK DK02772624T patent/DK1446124T3/da active
- 2002-11-06 CN CNB028267958A patent/CN1298328C/zh not_active Expired - Fee Related
- 2002-11-06 AT AT02772624T patent/ATE335488T1/de active
- 2002-11-06 EP EP02772624A patent/EP1446124B1/en not_active Expired - Lifetime
- 2002-11-06 US US10/494,704 patent/US20050043395A1/en not_active Abandoned
- 2002-11-06 PT PT02772624T patent/PT1446124E/pt unknown
- 2002-11-06 MX MXPA04004355A patent/MXPA04004355A/es active IP Right Grant
- 2002-11-06 KR KR1020047007020A patent/KR100959607B1/ko not_active IP Right Cessation
- 2002-11-06 DE DE60213845T patent/DE60213845T2/de not_active Expired - Lifetime
- 2002-11-06 AU AU2002337382A patent/AU2002337382B2/en not_active Ceased
- 2002-11-06 WO PCT/GB2002/005021 patent/WO2003039551A1/en active IP Right Grant
- 2002-11-06 CA CA2464758A patent/CA2464758C/en not_active Expired - Fee Related
- 2002-11-06 JP JP2003541842A patent/JP4694127B2/ja not_active Expired - Fee Related
- 2002-11-06 IL IL16174402A patent/IL161744A0/xx unknown
- 2002-11-06 BR BR0213906-5A patent/BR0213906A/pt not_active IP Right Cessation
- 2002-11-06 ES ES02772624T patent/ES2269769T3/es not_active Expired - Lifetime
- 2002-11-08 AR ARP020104292A patent/AR037346A1/es not_active Application Discontinuation
-
2004
- 2004-05-03 IL IL161744A patent/IL161744A/en not_active IP Right Cessation
- 2004-05-06 ZA ZA200403455A patent/ZA200403455B/en unknown
- 2004-06-07 NO NO20042365A patent/NO328048B1/no not_active IP Right Cessation
-
2005
- 2005-02-03 HK HK05100883A patent/HK1068546A1/xx not_active IP Right Cessation
-
2006
- 2006-11-09 CY CY20061101619T patent/CY1106259T1/el unknown
-
2011
- 2011-11-07 US US13/290,730 patent/US20120252827A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1612738A (zh) | 2005-05-04 |
NO328048B1 (no) | 2009-11-16 |
PT1446124E (pt) | 2006-12-29 |
US20120252827A1 (en) | 2012-10-04 |
NO20042365L (no) | 2004-06-07 |
IL161744A (en) | 2012-01-31 |
IL161744A0 (en) | 2005-11-20 |
HK1068546A1 (en) | 2005-04-29 |
EP1446124A1 (en) | 2004-08-18 |
GB0126879D0 (en) | 2002-01-02 |
US20050043395A1 (en) | 2005-02-24 |
BR0213906A (pt) | 2004-08-31 |
JP4694127B2 (ja) | 2011-06-08 |
CN1298328C (zh) | 2007-02-07 |
ES2269769T3 (es) | 2007-04-01 |
ATE335488T1 (de) | 2006-09-15 |
KR20050043779A (ko) | 2005-05-11 |
CY1106259T1 (el) | 2011-06-08 |
NZ532525A (en) | 2006-11-30 |
KR100959607B1 (ko) | 2010-05-27 |
WO2003039551A1 (en) | 2003-05-15 |
DE60213845D1 (de) | 2006-09-21 |
CA2464758C (en) | 2010-09-28 |
MXPA04004355A (es) | 2004-08-11 |
ZA200403455B (en) | 2005-08-29 |
AU2002337382B2 (en) | 2008-06-12 |
CA2464758A1 (en) | 2003-05-15 |
DK1446124T3 (da) | 2006-11-13 |
DE60213845T2 (de) | 2007-03-29 |
EP1446124B1 (en) | 2006-08-09 |
JP2005511597A (ja) | 2005-04-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |