CY1111565T1 - Θεραπεια συνδυασμου του zd6474 με 5-fu και/ή cpt-11 - Google Patents

Θεραπεια συνδυασμου του zd6474 με 5-fu και/ή cpt-11

Info

Publication number
CY1111565T1
CY1111565T1 CY20111100565T CY111100565T CY1111565T1 CY 1111565 T1 CY1111565 T1 CY 1111565T1 CY 20111100565 T CY20111100565 T CY 20111100565T CY 111100565 T CY111100565 T CY 111100565T CY 1111565 T1 CY1111565 T1 CY 1111565T1
Authority
CY
Cyprus
Prior art keywords
cpt
combination
combination treatment
cancer
treatment
Prior art date
Application number
CY20111100565T
Other languages
English (en)
Inventor
Stephen Robert Wedge
Anderson Joseph Ryan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0303289A external-priority patent/GB0303289D0/en
Priority claimed from GB0314100A external-priority patent/GB0314100D0/en
Priority claimed from GB0316184A external-priority patent/GB0316184D0/en
Priority claimed from GB0318311A external-priority patent/GB0318311D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CY1111565T1 publication Critical patent/CY1111565T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)

Abstract

Η παρούσα εφεύρεση αναφέρεται σε μία μέθοδο για την παραγωγή μίας αντιαγγειογενετικής επίδρασης και/ή επίδρασης μείωσης της αγγειακής διαπερατότητας σε ένα θερμόαιμο ζώο όπως είναι ένας άνθρωπος, που προαιρετικά υποβάλλεται σε θεραπεία με ιονίζουσα ακτινοβολία, ειδικότερα σε μία μέθοδο για τη θεραπευτική αντιμετώπιση ενός καρκίνου, ειδικότερα ενός καρκίνου που συμπεριλαμβάνει έναν συμπαγή όγκο, η οποία περιλαμβάνει μία από τις εξής: τη χορήγηση του ZD6474 σε συνδυασμό με την 5-FU ˙ τη χορήγηση του ZD6474 σε συνδυασμό με την CPT-11 ˙ και τη χορήγηση του ZD6474 σε συνδυασμό με την 5-FU και την CPT-11 ˙ σε μία φαρμακευτική σύνθεση που περιλαμβάνει ένα από τα εξής: ZD6474 και 5-FU ˙ ZD6474 και CPT-11 ˙ και ZD6474 και 5-FU και CPT-11 ˙ σε ένα προϊόν συνδυασμού που περιέχει ένα από τα εξής: ZD6474 και 5-FU ˙ ZD6474 και CPT-11 ˙ και ZD6474 και 5-FU και CPT-11, για χρήση, με θεραπεία, σε μία μέθοδο θεραπευτικής αντιμετώπισης σε σώμα ανθρώπου ή ζώου ˙ σε ένα κιτ που περιλαμβάνει ένα από τα εξής: ZD6474 και 5-FU ˙ ZD6474 και CPT-11 ˙ και ZD6474 και 5-FU και CPT-11 ˙ στη χρήση ενός από τα εξής: ZD6474 και 5-FU ˙ ZD6474 και CPT-11 ˙ και ZD6474 και 5-FU και CPT-11, στην παρασκευή ενός φαρμάκου για χρήση στην παραγωγή ενός αντιαγγειογενετικού αποτελέσματος και/ή ενός αποτελέσματος μείωσης της αγγειακής διαπερατότητας σε ένα θερμόαιμο ζώο όπως είναι ένας άνθρωπος, που προαιρετικά υποβάλλεται σε θεραπεία με ιονίζουσα ακτινοβολία.
CY20111100565T 2003-02-13 2011-06-15 Θεραπεια συνδυασμου του zd6474 με 5-fu και/ή cpt-11 CY1111565T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0303289A GB0303289D0 (en) 2003-02-13 2003-02-13 Combination therapy
GB0314100A GB0314100D0 (en) 2003-06-18 2003-06-18 Combination therapy
GB0316184A GB0316184D0 (en) 2003-07-10 2003-07-10 Combination therapy
GB0318311A GB0318311D0 (en) 2003-08-05 2003-08-05 Combination therapy
EP04710081A EP1592423B1 (en) 2003-02-13 2004-02-11 Combination therapy of zd6474 with 5-fu and/or cpt-11

Publications (1)

Publication Number Publication Date
CY1111565T1 true CY1111565T1 (el) 2015-10-07

Family

ID=32872851

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111100565T CY1111565T1 (el) 2003-02-13 2011-06-15 Θεραπεια συνδυασμου του zd6474 με 5-fu και/ή cpt-11

Country Status (18)

Country Link
US (4) US20060142316A1 (el)
EP (1) EP1592423B1 (el)
JP (3) JP2006517575A (el)
KR (2) KR20110006699A (el)
AT (1) ATE506062T1 (el)
AU (1) AU2004212255B2 (el)
CA (1) CA2514227C (el)
CY (1) CY1111565T1 (el)
DE (1) DE602004032310D1 (el)
DK (1) DK1592423T3 (el)
HK (1) HK1084032A1 (el)
IL (1) IL169702A (el)
MX (1) MXPA05008583A (el)
NO (1) NO331486B1 (el)
NZ (1) NZ541297A (el)
PT (1) PT1592423E (el)
SI (1) SI1592423T1 (el)
WO (1) WO2004071397A2 (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72946C2 (uk) 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
GB0008269D0 (en) 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
RU2350618C2 (ru) 2002-11-04 2009-03-27 Астразенека Аб ПРОИЗВОДНЫЕ ХИНАЗОЛИНА В КАЧЕСТВЕ ИНГИБИТОРОВ Src ТИРОЗИНКИНАЗЫ
JP2006517575A (ja) * 2003-02-13 2006-07-27 アストラゼネカ アクチボラグ 組合せ療法
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
DE602004028834D1 (de) * 2003-07-10 2010-10-07 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
WO2005117980A1 (en) * 2004-06-04 2005-12-15 Pfizer Products Inc. Method for treating abnormal cell growth
BRPI0516052A (pt) * 2004-09-27 2008-08-19 Astrazeneca Ab uso de zd6474 ou de um sal farmaceuticamente aceitável do mesmo e de imatinib, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou de redução da permeabilidade vascular em um animal de sangue quente
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
GB0519879D0 (en) 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
JP5167144B2 (ja) * 2005-12-22 2013-03-21 アストラゼネカ アクチボラグ 併用療法
WO2008037996A1 (en) * 2006-09-29 2008-04-03 Astrazeneca Ab Combination of zd6474 and bevacizumab for cancer therapy

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72946C2 (uk) * 1999-11-05 2005-05-16 Астразенека Аб Похідні хіназоліну як інгібітори васкулярного ендотеліального фактора росту (vegf)
GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
CA2495487A1 (en) * 2002-08-09 2004-02-19 Astrazeneca Ab Combination of zd6474, an inhibitor of the vascular endothelial growth factor receptor, with radiotherapy in the treatment of cancer
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
JP2006517575A (ja) * 2003-02-13 2006-07-27 アストラゼネカ アクチボラグ 組合せ療法
DE602004028834D1 (de) * 2003-07-10 2010-10-07 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
BRPI0516052A (pt) * 2004-09-27 2008-08-19 Astrazeneca Ab uso de zd6474 ou de um sal farmaceuticamente aceitável do mesmo e de imatinib, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou de redução da permeabilidade vascular em um animal de sangue quente
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
JP4834985B2 (ja) * 2004-12-10 2011-12-14 日産自動車株式会社 組電池の容量調整装置
JP5167144B2 (ja) * 2005-12-22 2013-03-21 アストラゼネカ アクチボラグ 併用療法
WO2008037996A1 (en) * 2006-09-29 2008-04-03 Astrazeneca Ab Combination of zd6474 and bevacizumab for cancer therapy

Also Published As

Publication number Publication date
KR20110006699A (ko) 2011-01-20
JP2011016853A (ja) 2011-01-27
MXPA05008583A (es) 2005-11-04
CA2514227A1 (en) 2004-08-26
PT1592423E (pt) 2011-06-16
DK1592423T3 (da) 2011-06-27
NO331486B1 (no) 2012-01-16
AU2004212255A1 (en) 2004-08-26
NO20053649D0 (no) 2005-07-27
JP2006517575A (ja) 2006-07-27
KR20050100683A (ko) 2005-10-19
JP5563950B2 (ja) 2014-07-30
HK1084032A1 (en) 2006-07-21
EP1592423B1 (en) 2011-04-20
IL169702A (en) 2014-05-28
EP1592423A2 (en) 2005-11-09
WO2004071397A2 (en) 2004-08-26
NO20053649L (no) 2005-09-12
US20110086870A1 (en) 2011-04-14
CA2514227C (en) 2011-08-09
WO2004071397A3 (en) 2004-10-14
US20100130520A1 (en) 2010-05-27
SI1592423T1 (sl) 2011-07-29
ATE506062T1 (de) 2011-05-15
IL169702A0 (en) 2007-07-04
US20120252826A1 (en) 2012-10-04
AU2004212255B2 (en) 2007-07-05
US20060142316A1 (en) 2006-06-29
DE602004032310D1 (de) 2011-06-01
JP2014065750A (ja) 2014-04-17
NZ541297A (en) 2008-03-28

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