ATE506062T1 - Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11 - Google Patents

Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11

Info

Publication number
ATE506062T1
ATE506062T1 AT04710081T AT04710081T ATE506062T1 AT E506062 T1 ATE506062 T1 AT E506062T1 AT 04710081 T AT04710081 T AT 04710081T AT 04710081 T AT04710081 T AT 04710081T AT E506062 T1 ATE506062 T1 AT E506062T1
Authority
AT
Austria
Prior art keywords
cpt
combination
combination therapy
cancer
antiangiogenic
Prior art date
Application number
AT04710081T
Other languages
English (en)
Inventor
Stephen Robert Wedge
Anderson Joseph Ryan
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0303289A external-priority patent/GB0303289D0/en
Priority claimed from GB0314100A external-priority patent/GB0314100D0/en
Priority claimed from GB0316184A external-priority patent/GB0316184D0/en
Priority claimed from GB0318311A external-priority patent/GB0318311D0/en
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE506062T1 publication Critical patent/ATE506062T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04710081T 2003-02-13 2004-02-11 Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11 ATE506062T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0303289A GB0303289D0 (en) 2003-02-13 2003-02-13 Combination therapy
GB0314100A GB0314100D0 (en) 2003-06-18 2003-06-18 Combination therapy
GB0316184A GB0316184D0 (en) 2003-07-10 2003-07-10 Combination therapy
GB0318311A GB0318311D0 (en) 2003-08-05 2003-08-05 Combination therapy
PCT/GB2004/000550 WO2004071397A2 (en) 2003-02-13 2004-02-11 Combination therapy of zd6474 with 5-fu or/and cpt-11

Publications (1)

Publication Number Publication Date
ATE506062T1 true ATE506062T1 (de) 2011-05-15

Family

ID=32872851

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04710081T ATE506062T1 (de) 2003-02-13 2004-02-11 Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11

Country Status (18)

Country Link
US (4) US20060142316A1 (de)
EP (1) EP1592423B1 (de)
JP (3) JP2006517575A (de)
KR (2) KR20050100683A (de)
AT (1) ATE506062T1 (de)
AU (1) AU2004212255B2 (de)
CA (1) CA2514227C (de)
CY (1) CY1111565T1 (de)
DE (1) DE602004032310D1 (de)
DK (1) DK1592423T3 (de)
HK (1) HK1084032A1 (de)
IL (1) IL169702A (de)
MX (1) MXPA05008583A (de)
NO (1) NO331486B1 (de)
NZ (1) NZ541297A (de)
PT (1) PT1592423E (de)
SI (1) SI1592423T1 (de)
WO (1) WO2004071397A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1244647E (pt) * 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
JP4593464B2 (ja) 2002-11-04 2010-12-08 アストラゼネカ アクチボラグ Ｓｒｃチロシンキナーゼ阻害剤としてのキナゾリン誘導体
DE602004032310D1 (de) * 2003-02-13 2011-06-01 Astrazeneca Ab Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11
GB0310401D0 (en) * 2003-05-07 2003-06-11 Astrazeneca Ab Therapeutic agent
ATE478671T1 (de) * 2003-07-10 2010-09-15 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
MXPA06014021A (es) * 2004-06-04 2007-02-08 Pfizer Prod Inc Procedimiento para tratar crecimiento celular anormal.
JP2008514577A (ja) * 2004-09-27 2008-05-08 アストラゼネカ アクチボラグ Ｚｄ６４７４及びイマチニブを含んでなる組合せ
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
GB0519879D0 (en) 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
WO2007071958A2 (en) * 2005-12-22 2007-06-28 Astrazeneca Ab Combination of zd6474 and pemetrexed
EP2066353B1 (de) * 2006-09-29 2013-01-02 AstraZeneca AB Kombination von zd6474 und bevacizumab für die krebstherapie

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1244647E (pt) * 1999-11-05 2006-10-31 Astrazeneca Ab Derivados de quinazolina como inibidores de vegf
GB0008269D0 (en) * 2000-04-05 2000-05-24 Astrazeneca Ab Combination chemotherapy
GB0126879D0 (en) * 2001-11-08 2002-01-02 Astrazeneca Ab Combination therapy
CN1313094C (zh) * 2002-08-09 2007-05-02 阿斯利康(瑞典)有限公司 Zd6474在制备在用电离辐射治疗的人体中治疗癌症的药物的用途
GB0218526D0 (en) * 2002-08-09 2002-09-18 Astrazeneca Ab Combination therapy
GB0223380D0 (en) * 2002-10-09 2002-11-13 Astrazeneca Ab Combination therapy
DE602004032310D1 (de) * 2003-02-13 2011-06-01 Astrazeneca Ab Kombinationstherapie von zd6474 mit 5-fu oder/und cpt-11
ATE478671T1 (de) * 2003-07-10 2010-09-15 Astrazeneca Ab Verwendung des chinazolin-derivats zd6474 in kombination mit platinverbindungen und optional ionisierender strahlung bei der behandlung von erkrankungen im zusammenhang mit angiogenese und/oder erhöhter gefässpermeabilität
JP2008514577A (ja) * 2004-09-27 2008-05-08 アストラゼネカ アクチボラグ Ｚｄ６４７４及びイマチニブを含んでなる組合せ
GB0424339D0 (en) * 2004-11-03 2004-12-08 Astrazeneca Ab Combination therapy
JP4834985B2 (ja) * 2004-12-10 2011-12-14 日産自動車株式会社 組電池の容量調整装置
WO2007071958A2 (en) * 2005-12-22 2007-06-28 Astrazeneca Ab Combination of zd6474 and pemetrexed
EP2066353B1 (de) * 2006-09-29 2013-01-02 AstraZeneca AB Kombination von zd6474 und bevacizumab für die krebstherapie

Also Published As

Publication number Publication date
EP1592423B1 (de) 2011-04-20
MXPA05008583A (es) 2005-11-04
CA2514227A1 (en) 2004-08-26
JP2011016853A (ja) 2011-01-27
US20100130520A1 (en) 2010-05-27
KR20110006699A (ko) 2011-01-20
US20120252826A1 (en) 2012-10-04
AU2004212255B2 (en) 2007-07-05
NO20053649L (no) 2005-09-12
JP5563950B2 (ja) 2014-07-30
EP1592423A2 (de) 2005-11-09
CA2514227C (en) 2011-08-09
NO20053649D0 (no) 2005-07-27
DK1592423T3 (da) 2011-06-27
DE602004032310D1 (de) 2011-06-01
HK1084032A1 (en) 2006-07-21
IL169702A (en) 2014-05-28
US20060142316A1 (en) 2006-06-29
CY1111565T1 (el) 2015-10-07
NZ541297A (en) 2008-03-28
US20110086870A1 (en) 2011-04-14
WO2004071397A2 (en) 2004-08-26
KR20050100683A (ko) 2005-10-19
WO2004071397A3 (en) 2004-10-14
AU2004212255A1 (en) 2004-08-26
PT1592423E (pt) 2011-06-16
JP2014065750A (ja) 2014-04-17
SI1592423T1 (sl) 2011-07-29
IL169702A0 (en) 2007-07-04
JP2006517575A (ja) 2006-07-27
NO331486B1 (no) 2012-01-16

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