EP1408946A4 - Histone deacetylase inhibitors - Google Patents
Histone deacetylase inhibitorsInfo
- Publication number
- EP1408946A4 EP1408946A4 EP02719311A EP02719311A EP1408946A4 EP 1408946 A4 EP1408946 A4 EP 1408946A4 EP 02719311 A EP02719311 A EP 02719311A EP 02719311 A EP02719311 A EP 02719311A EP 1408946 A4 EP1408946 A4 EP 1408946A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- histone deacetylase
- deacetylase inhibitors
- inhibitors
- histone
- deacetylase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
- C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
- C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
- C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US812940 | 1985-12-23 | ||
US81294001A | 2001-03-27 | 2001-03-27 | |
US09/812,945 US7312247B2 (en) | 2001-03-27 | 2001-03-27 | Histone deacetylase inhibitors |
US812944 | 2001-03-27 | ||
US812945 | 2001-03-27 | ||
US09/812,944 US6495719B2 (en) | 2001-03-27 | 2001-03-27 | Histone deacetylase inhibitors |
US25947 | 2001-12-26 | ||
US10/025,947 US8026280B2 (en) | 2001-03-27 | 2001-12-26 | Histone deacetylase inhibitors |
PCT/US2002/008836 WO2002076941A2 (en) | 2001-03-27 | 2002-03-25 | Histone deacetylase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1408946A2 EP1408946A2 (en) | 2004-04-21 |
EP1408946A4 true EP1408946A4 (en) | 2004-06-09 |
Family
ID=27487458
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP02719311A Withdrawn EP1408946A4 (en) | 2001-03-27 | 2002-03-25 | Histone deacetylase inhibitors |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1408946A4 (en) |
AU (1) | AU2002250401A1 (en) |
CA (1) | CA2442366C (en) |
WO (1) | WO2002076941A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1291015A1 (en) | 2001-09-10 | 2003-03-12 | Lunamed AG | Dosage forms having prolonged active ingredient release |
CN100566711C (en) * | 2002-04-15 | 2009-12-09 | 斯隆-凯特林癌症研究院 | Chemical compound of treatment cancer and uses thereof |
GB0226855D0 (en) | 2002-11-18 | 2002-12-24 | Queen Mary & Westfield College | Histone deacetylase inhibitors |
AU2003291097A1 (en) | 2002-11-20 | 2004-06-15 | Errant Gene Therapeutics, Llc | Treatment of lung cells with histone deacetylase inhibitors |
WO2004076386A2 (en) | 2003-02-25 | 2004-09-10 | Topotarget Uk Limited | Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors |
US7842835B2 (en) | 2003-07-07 | 2010-11-30 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
AR050552A1 (en) * | 2004-09-02 | 2006-11-01 | Osi Pharm Inc | MERCAPTOAMIDS AS INHIBITORS OF HISTONA DEACETILASE |
WO2006029818A2 (en) * | 2004-09-16 | 2006-03-23 | Dsm Ip Assets B.V. | Cosmetic compositions containing an hydroxamic acid compound optionally in combination with a retinoid |
EP1904452A2 (en) | 2005-07-14 | 2008-04-02 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
GB0620823D0 (en) | 2006-10-19 | 2006-11-29 | Univ London | Histone deacetylase inhibitors |
JP2019189648A (en) * | 2019-07-08 | 2019-10-31 | 国立大学法人東京農工大学 | Cis-cinnamic acid analog and gravitropism regulator |
CN110523541B (en) * | 2019-09-04 | 2021-09-28 | 中南大学 | Alkyl thioether ether ethyl hydroximic acid medicament and preparation method and application thereof |
CN114805235B (en) * | 2022-05-09 | 2024-04-23 | 江苏中旗科技股份有限公司 | Synthetic preparation method of polysubstituted isoxazolidinone and intermediate thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3886278A (en) * | 1973-08-22 | 1975-05-27 | Mead Johnson & Co | Ammonium carboxylate sebum inhibition process |
JPS6054339A (en) * | 1983-09-05 | 1985-03-28 | Kuraray Co Ltd | Preparation of unsaturated carboxylic acid ester |
EP0405788A2 (en) * | 1989-06-29 | 1991-01-02 | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. | Di-tert-butyl(hydroxy)phenylthio substituted hydroxamic acid derivatives |
WO1998001423A1 (en) * | 1996-07-09 | 1998-01-15 | Smithkline Beecham S.P.A. | 5-indolyl-2,4-pentadienoic acid derivatives useful as inhibitors of bone resorption |
WO2000020370A1 (en) * | 1998-10-01 | 2000-04-13 | Allergan Sales, Inc. | 2, 4-pentadienoic acid derivatives having selective activity for retinoid x (rxr) receptors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6110955A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Metabolically stabilized oxyalkylene esters and uses thereof |
-
2002
- 2002-03-25 AU AU2002250401A patent/AU2002250401A1/en not_active Abandoned
- 2002-03-25 EP EP02719311A patent/EP1408946A4/en not_active Withdrawn
- 2002-03-25 WO PCT/US2002/008836 patent/WO2002076941A2/en not_active Application Discontinuation
- 2002-03-25 CA CA2442366A patent/CA2442366C/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3886278A (en) * | 1973-08-22 | 1975-05-27 | Mead Johnson & Co | Ammonium carboxylate sebum inhibition process |
JPS6054339A (en) * | 1983-09-05 | 1985-03-28 | Kuraray Co Ltd | Preparation of unsaturated carboxylic acid ester |
EP0405788A2 (en) * | 1989-06-29 | 1991-01-02 | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. | Di-tert-butyl(hydroxy)phenylthio substituted hydroxamic acid derivatives |
WO1998001423A1 (en) * | 1996-07-09 | 1998-01-15 | Smithkline Beecham S.P.A. | 5-indolyl-2,4-pentadienoic acid derivatives useful as inhibitors of bone resorption |
WO2000020370A1 (en) * | 1998-10-01 | 2000-04-13 | Allergan Sales, Inc. | 2, 4-pentadienoic acid derivatives having selective activity for retinoid x (rxr) receptors |
Non-Patent Citations (4)
Title |
---|
MANFRED JUNG ET AL: "Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 42, no. 22, 4 November 1999 (1999-11-04), pages 4669 - 4679, XP002144226, ISSN: 0022-2623 * |
PATENT ABSTRACTS OF JAPAN vol. 009, no. 184 (C - 294) 30 July 1985 (1985-07-30) * |
RICHON V M ET AL: "A CLASS OF HYBRID POLAR INDUCERS OF TRANSFORMED CELL DIFFERENTIATION INHIBITS HISTONE DEACETYLASES", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 6, 17 March 1998 (1998-03-17), pages 3003 - 3007, XP001120542, ISSN: 0027-8424 * |
SCHMIDT K ET AL: "INHIBITORS OF HISTONE DEACETYLASE SUPPRESS THE GROWTH OF MCF-7 BREAST CANCER CELLS", ARCHIV DER PHARMAZIE, VCH VERLAGSGESELLSCHAFT MBH, WEINHEIM, DE, vol. 332, no. 10, 1999, pages 353 - 357, XP000985303, ISSN: 0365-6233 * |
Also Published As
Publication number | Publication date |
---|---|
CA2442366A1 (en) | 2002-10-03 |
WO2002076941A3 (en) | 2004-02-12 |
AU2002250401A1 (en) | 2002-10-08 |
CA2442366C (en) | 2012-09-25 |
EP1408946A2 (en) | 2004-04-21 |
WO2002076941A2 (en) | 2002-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20031024 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK RO SI |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040427 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20041103 |