IL158185A0 - PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES - Google Patents
PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDESInfo
- Publication number
- IL158185A0 IL158185A0 IL15818502A IL15818502A IL158185A0 IL 158185 A0 IL158185 A0 IL 158185A0 IL 15818502 A IL15818502 A IL 15818502A IL 15818502 A IL15818502 A IL 15818502A IL 158185 A0 IL158185 A0 IL 158185A0
- Authority
- IL
- Israel
- Prior art keywords
- beta
- halo
- preparation
- arabinofuranosyl
- arabinofuranosyl nucleosides
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000002777 nucleoside Substances 0.000 title abstract 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 abstract 2
- SRBFZHDQGSBBOR-HWQSCIPKSA-N L-arabinopyranose Chemical compound O[C@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-HWQSCIPKSA-N 0.000 abstract 1
- RWQNBRDOKXIBIV-UHFFFAOYSA-N Thymine Natural products CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-MROZADKFSA-N aldehydo-L-ribose Chemical compound OC[C@H](O)[C@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-MROZADKFSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-WISUUJSJSA-N aldehydo-L-xylose Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WISUUJSJSA-N 0.000 abstract 1
- 229930195726 aldehydo-L-xylose Natural products 0.000 abstract 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- GBBJCSTXCAQSSJ-XQXXSGGOSA-N clevudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1[C@H](F)[C@@H](O)[C@H](CO)O1 GBBJCSTXCAQSSJ-XQXXSGGOSA-N 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 229940113082 thymine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28030701P | 2001-03-30 | 2001-03-30 | |
| PCT/US2002/009848 WO2002079213A1 (en) | 2001-03-30 | 2002-03-29 | Process for the preparation of 2'-halo-$g(b)-l-arabinofuranosyl nucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL158185A0 true IL158185A0 (en) | 2004-03-28 |
Family
ID=23072521
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15818502A IL158185A0 (en) | 2001-03-30 | 2002-03-29 | PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES |
| IL158185A IL158185A (en) | 2001-03-30 | 2003-09-30 | Process for the preparation of 2'-halo-beta-l-arabinofuranosyl nucleosides |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL158185A IL158185A (en) | 2001-03-30 | 2003-09-30 | Process for the preparation of 2'-halo-beta-l-arabinofuranosyl nucleosides |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6870048B2 (de) |
| EP (1) | EP1373288B1 (de) |
| JP (1) | JP4430307B2 (de) |
| KR (1) | KR100910791B1 (de) |
| CN (2) | CN1330660C (de) |
| AT (1) | ATE298759T1 (de) |
| AU (1) | AU2002303187C1 (de) |
| BR (1) | BR0208517A (de) |
| CA (1) | CA2442979C (de) |
| DE (1) | DE60204859T2 (de) |
| ES (1) | ES2243726T3 (de) |
| IL (2) | IL158185A0 (de) |
| MX (1) | MXPA03008870A (de) |
| NZ (1) | NZ528575A (de) |
| WO (1) | WO2002079213A1 (de) |
| ZA (1) | ZA200307588B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002079213A1 (en) * | 2001-03-30 | 2002-10-10 | Triangle Pharmaceuticals, Inc. | Process for the preparation of 2'-halo-$g(b)-l-arabinofuranosyl nucleosides |
| WO2003068162A2 (en) * | 2002-02-14 | 2003-08-21 | Pharmasset Ltd. | Modified fluorinated nucleoside analogues |
| JP2006265156A (ja) * | 2005-03-23 | 2006-10-05 | Ajinomoto Co Inc | ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法 |
| US20090298708A1 (en) * | 2006-08-23 | 2009-12-03 | Masad Damha J | 2'-deoxy-2'-fluoro-beta-d-arabinonucleoside 5'-triphosphates and their use in enzymatic nucleic acid synthesis |
| CN101469012B (zh) * | 2007-12-26 | 2013-03-27 | 杭州容立医药科技有限公司 | 2-氨基-6-甲氧基-9-(β-D-阿拉伯糖基)-9H-嘌呤的合成方法 |
| US9790252B2 (en) | 2009-07-01 | 2017-10-17 | Cornell University | 2-fluorinated riboses and arabinoses and methods of use and synthesis |
| CN102060899B (zh) * | 2010-12-27 | 2012-07-25 | 江苏奥赛康药业股份有限公司 | 一种奈拉滨N-9位α型异构体、其制备方法及其应用 |
| CN102344427B (zh) * | 2011-08-10 | 2013-07-31 | 济南圣泉集团股份有限公司 | 一种烯糖的合成方法 |
| CN102863479B (zh) * | 2011-11-04 | 2015-06-17 | 济南圣泉唐和唐生物科技有限公司 | 一种制备全乙酰溴代-l-阿拉伯糖的方法 |
| CN103694279B (zh) * | 2013-12-23 | 2015-12-02 | 江西苏克尔新材料有限公司 | 一种制备2-脱氧-l-核糖的方法 |
| CN105732732B (zh) * | 2016-04-14 | 2018-04-06 | 四川理工学院 | 一种制备2‑脱氧‑d‑核糖的方法 |
| WO2022008025A1 (en) * | 2020-07-05 | 2022-01-13 | Since & Technology Development Fund Authority | 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5008384A (en) * | 1988-07-12 | 1991-04-16 | Pfizer Inc. | Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine |
| US5587362A (en) * | 1994-01-28 | 1996-12-24 | Univ. Of Ga Research Foundation | L-nucleosides |
| CN1039121C (zh) * | 1994-10-18 | 1998-07-15 | 北京医科大学药学院 | 具有嘧啶或嘌呤取代基的氢化呋喃衍生物及其制法 |
| US5808040A (en) | 1995-01-30 | 1998-09-15 | Yale University | L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides |
| TW434252B (en) * | 1997-07-23 | 2001-05-16 | Univ Georgia Res Found | Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine |
| WO2002079213A1 (en) * | 2001-03-30 | 2002-10-10 | Triangle Pharmaceuticals, Inc. | Process for the preparation of 2'-halo-$g(b)-l-arabinofuranosyl nucleosides |
-
2002
- 2002-03-29 WO PCT/US2002/009848 patent/WO2002079213A1/en not_active Ceased
- 2002-03-29 CN CNB02810644XA patent/CN1330660C/zh not_active Expired - Lifetime
- 2002-03-29 CA CA2442979A patent/CA2442979C/en not_active Expired - Fee Related
- 2002-03-29 MX MXPA03008870A patent/MXPA03008870A/es active IP Right Grant
- 2002-03-29 NZ NZ528575A patent/NZ528575A/en not_active IP Right Cessation
- 2002-03-29 CN CN200710111954XA patent/CN101117346B/zh not_active Expired - Fee Related
- 2002-03-29 AT AT02731195T patent/ATE298759T1/de not_active IP Right Cessation
- 2002-03-29 ES ES02731195T patent/ES2243726T3/es not_active Expired - Lifetime
- 2002-03-29 IL IL15818502A patent/IL158185A0/xx unknown
- 2002-03-29 BR BR0208517-8A patent/BR0208517A/pt not_active IP Right Cessation
- 2002-03-29 DE DE60204859T patent/DE60204859T2/de not_active Expired - Lifetime
- 2002-03-29 EP EP02731195A patent/EP1373288B1/de not_active Expired - Lifetime
- 2002-03-29 KR KR1020037012772A patent/KR100910791B1/ko not_active Expired - Lifetime
- 2002-03-29 AU AU2002303187A patent/AU2002303187C1/en not_active Ceased
- 2002-03-29 JP JP2002577837A patent/JP4430307B2/ja not_active Expired - Fee Related
- 2002-03-29 US US10/112,403 patent/US6870048B2/en not_active Expired - Lifetime
-
2003
- 2003-09-29 ZA ZA200307588A patent/ZA200307588B/xx unknown
- 2003-09-30 IL IL158185A patent/IL158185A/en not_active IP Right Cessation
-
2005
- 2005-03-22 US US11/086,545 patent/US7291726B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NZ528575A (en) | 2006-04-28 |
| WO2002079213A1 (en) | 2002-10-10 |
| HK1117169A1 (en) | 2009-01-09 |
| US20030060622A1 (en) | 2003-03-27 |
| DE60204859T2 (de) | 2006-04-27 |
| KR100910791B1 (ko) | 2009-08-04 |
| US20050187384A1 (en) | 2005-08-25 |
| CN1571792A (zh) | 2005-01-26 |
| JP4430307B2 (ja) | 2010-03-10 |
| AU2002303187C1 (en) | 2008-06-12 |
| AU2002303187B8 (en) | 2002-10-15 |
| ZA200307588B (en) | 2004-06-30 |
| US7291726B2 (en) | 2007-11-06 |
| CN101117346A (zh) | 2008-02-06 |
| EP1373288A1 (de) | 2004-01-02 |
| CA2442979A1 (en) | 2002-10-10 |
| KR20030092037A (ko) | 2003-12-03 |
| CA2442979C (en) | 2010-02-16 |
| DE60204859D1 (de) | 2005-08-04 |
| AU2002303187B2 (en) | 2007-11-08 |
| JP2004526743A (ja) | 2004-09-02 |
| US6870048B2 (en) | 2005-03-22 |
| MXPA03008870A (es) | 2004-01-29 |
| ATE298759T1 (de) | 2005-07-15 |
| IL158185A (en) | 2009-09-22 |
| BR0208517A (pt) | 2005-02-01 |
| ES2243726T3 (es) | 2005-12-01 |
| CN1330660C (zh) | 2007-08-08 |
| EP1373288B1 (de) | 2005-06-29 |
| CN101117346B (zh) | 2012-12-12 |
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