BR0208517A - Processo para a preparação de nucleosìdeos de 2'-halo-sg(b) l-arabinofuranosila - Google Patents

Processo para a preparação de nucleosìdeos de 2'-halo-sg(b) l-arabinofuranosila

Info

Publication number
BR0208517A
BR0208517A BR0208517-8A BR0208517A BR0208517A BR 0208517 A BR0208517 A BR 0208517A BR 0208517 A BR0208517 A BR 0208517A BR 0208517 A BR0208517 A BR 0208517A
Authority
BR
Brazil
Prior art keywords
halo
preparation
arabinofuranosyl
deoxy
beta
Prior art date
Application number
BR0208517-8A
Other languages
English (en)
Inventor
Marcos Sznaidman
Original Assignee
Triangle Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Triangle Pharmaceuticals Inc filed Critical Triangle Pharmaceuticals Inc
Publication of BR0208517A publication Critical patent/BR0208517A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE NUCLEOSìDEOS DE 2<39>-HALO-SG(B) L-ARABINOFURANOSILA". A presente invenção é direcionada ao processo para a preparação de nucleosídeo de 2<39>-deóxi-2<39>-halo-<225>-L-arabinofuranosila, e em particular, timina (L-FMAU) de 2<39>deóxi-2<39>-fluoro-<225>-L-arabinofuranosila a partir de Larabinose; que é comercialmente disponível e menos cara do que L-ribose ou L-xilose em dez etapas. Todos os reagentes e materiais de partida não são caros e nenhum equipamento especial é requerido para realizar as reações.
BR0208517-8A 2001-03-30 2002-03-29 Processo para a preparação de nucleosìdeos de 2'-halo-sg(b) l-arabinofuranosila BR0208517A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28030701P 2001-03-30 2001-03-30
PCT/US2002/009848 WO2002079213A1 (en) 2001-03-30 2002-03-29 Process for the preparation of 2'-halo-$g(b)-l-arabinofuranosyl nucleosides

Publications (1)

Publication Number Publication Date
BR0208517A true BR0208517A (pt) 2005-02-01

Family

ID=23072521

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0208517-8A BR0208517A (pt) 2001-03-30 2002-03-29 Processo para a preparação de nucleosìdeos de 2'-halo-sg(b) l-arabinofuranosila

Country Status (17)

Country Link
US (2) US6870048B2 (pt)
EP (1) EP1373288B1 (pt)
JP (1) JP4430307B2 (pt)
KR (1) KR100910791B1 (pt)
CN (2) CN101117346B (pt)
AT (1) ATE298759T1 (pt)
AU (1) AU2002303187C1 (pt)
BR (1) BR0208517A (pt)
CA (1) CA2442979C (pt)
DE (1) DE60204859T2 (pt)
ES (1) ES2243726T3 (pt)
HK (1) HK1117169A1 (pt)
IL (2) IL158185A0 (pt)
MX (1) MXPA03008870A (pt)
NZ (1) NZ528575A (pt)
WO (1) WO2002079213A1 (pt)
ZA (1) ZA200307588B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101117346B (zh) * 2001-03-30 2012-12-12 富光药品株式会社 2'-卤代-β-L-阿拉伯呋喃糖基核苷的制备方法
KR20040094692A (ko) * 2002-02-14 2004-11-10 파마셋, 리미티드 변형된 불소화 뉴클레오사이드 유사체
JP2006265156A (ja) * 2005-03-23 2006-10-05 Ajinomoto Co Inc ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
WO2008022469A1 (en) * 2006-08-23 2008-02-28 Mcgill University 2'-DEOXY-2'-FLUORO-β-D-ARABINONUCLEOSIDE 5'-TRIPHOSPHATES AND THEIR USE IN ENZYMATIC NUCLEIC ACID SYNTHESIS
CN101469012B (zh) * 2007-12-26 2013-03-27 杭州容立医药科技有限公司 2-氨基-6-甲氧基-9-(β-D-阿拉伯糖基)-9H-嘌呤的合成方法
WO2011003018A2 (en) * 2009-07-01 2011-01-06 Cornell University Halogenated 2-deoxy-lactones, 2'-deoxy--nucleosides, and derivatives thereof
CN102060899B (zh) * 2010-12-27 2012-07-25 江苏奥赛康药业股份有限公司 一种奈拉滨N-9位α型异构体、其制备方法及其应用
CN102344427B (zh) * 2011-08-10 2013-07-31 济南圣泉集团股份有限公司 一种烯糖的合成方法
CN102863479B (zh) * 2011-11-04 2015-06-17 济南圣泉唐和唐生物科技有限公司 一种制备全乙酰溴代-l-阿拉伯糖的方法
CN103694279B (zh) * 2013-12-23 2015-12-02 江西苏克尔新材料有限公司 一种制备2-脱氧-l-核糖的方法
CN105732732B (zh) * 2016-04-14 2018-04-06 四川理工学院 一种制备2‑脱氧‑d‑核糖的方法
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008384A (en) * 1988-07-12 1991-04-16 Pfizer Inc. Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
CN1039121C (zh) * 1994-10-18 1998-07-15 北京医科大学药学院 具有嘧啶或嘌呤取代基的氢化呋喃衍生物及其制法
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) * 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
CN101117346B (zh) * 2001-03-30 2012-12-12 富光药品株式会社 2'-卤代-β-L-阿拉伯呋喃糖基核苷的制备方法

Also Published As

Publication number Publication date
IL158185A (en) 2009-09-22
DE60204859D1 (de) 2005-08-04
DE60204859T2 (de) 2006-04-27
CN1330660C (zh) 2007-08-08
WO2002079213A1 (en) 2002-10-10
US20050187384A1 (en) 2005-08-25
EP1373288B1 (en) 2005-06-29
CN101117346B (zh) 2012-12-12
ES2243726T3 (es) 2005-12-01
AU2002303187B2 (en) 2007-11-08
ATE298759T1 (de) 2005-07-15
US20030060622A1 (en) 2003-03-27
IL158185A0 (en) 2004-03-28
CN101117346A (zh) 2008-02-06
EP1373288A1 (en) 2004-01-02
KR20030092037A (ko) 2003-12-03
JP2004526743A (ja) 2004-09-02
JP4430307B2 (ja) 2010-03-10
CA2442979A1 (en) 2002-10-10
MXPA03008870A (es) 2004-01-29
HK1117169A1 (pt) 2009-01-09
NZ528575A (en) 2006-04-28
KR100910791B1 (ko) 2009-08-04
AU2002303187C1 (en) 2008-06-12
US6870048B2 (en) 2005-03-22
ZA200307588B (en) 2004-06-30
CN1571792A (zh) 2005-01-26
US7291726B2 (en) 2007-11-06
CA2442979C (en) 2010-02-16
AU2002303187B8 (en) 2002-10-15

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: GILEAD SCIENCES, INC. (US)

Free format text: TRANSFERIDO DE: TRIANGLE PHARMACEUTICALS, INC.

B25A Requested transfer of rights approved

Owner name: BUKWANG PHARMACEUTICAL CO., LTD. (KR)

Free format text: TRANSFERIDO DE: GILEAD SCIENCES, INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 14A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2384 DE 13-09-2016 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.