ATE196912T1 - Propargylethoxyamino nucleotide - Google Patents

Propargylethoxyamino nucleotide

Info

Publication number
ATE196912T1
ATE196912T1 AT97937953T AT97937953T ATE196912T1 AT E196912 T1 ATE196912 T1 AT E196912T1 AT 97937953 T AT97937953 T AT 97937953T AT 97937953 T AT97937953 T AT 97937953T AT E196912 T1 ATE196912 T1 AT E196912T1
Authority
AT
Austria
Prior art keywords
sub
propargylethoxyamino
nucleosides
nucleotides
propargylethoxyamino nucleotides
Prior art date
Application number
AT97937953T
Other languages
English (en)
Inventor
Shaheer H Khan
Steven M Menchen
Barnett B Rosenblum
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Application granted granted Critical
Publication of ATE196912T1 publication Critical patent/ATE196912T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT97937953T 1996-08-13 1997-08-13 Propargylethoxyamino nucleotide ATE196912T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/696,808 US5821356A (en) 1996-08-12 1996-08-13 Propargylethoxyamino nucleotides
PCT/US1997/011553 WO1998006732A1 (en) 1996-08-13 1997-08-13 Propargylethoxyamino nucleotides

Publications (1)

Publication Number Publication Date
ATE196912T1 true ATE196912T1 (de) 2000-10-15

Family

ID=24798636

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97937953T ATE196912T1 (de) 1996-08-13 1997-08-13 Propargylethoxyamino nucleotide

Country Status (8)

Country Link
US (5) US5821356A (de)
EP (1) EP0915901B1 (de)
JP (1) JP3486660B2 (de)
AT (1) ATE196912T1 (de)
AU (1) AU703281B2 (de)
CA (1) CA2230059C (de)
DE (1) DE69703298T2 (de)
WO (1) WO1998006732A1 (de)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides
DE69806003T2 (de) 1997-03-12 2003-01-30 Pe Corp. (Ny), Foster City Dna polymerasen, die verbesserte fähigkeiten zum einbau markierter nukleotide besitzen
US5770716A (en) * 1997-04-10 1998-06-23 The Perkin-Elmer Corporation Substituted propargylethoxyamido nucleosides, oligonucleotides and methods for using same
JP3489991B2 (ja) * 1997-07-07 2004-01-26 理化学研究所 ３’−デオキシリボヌクレオチド誘導体
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
US8445664B2 (en) 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US6046039A (en) * 1998-08-19 2000-04-04 Battelle Memorial Institute Methods for producing partially digested restriction DNA fragments and for producing a partially modified PCR product
US7135284B1 (en) * 1999-02-05 2006-11-14 Integrated Dna Technologies, Inc. Primer extension methods for production of high specific activity nucleic acid probes
US6716994B1 (en) * 2000-01-04 2004-04-06 Applera Corporation Mobility-Modifying Cyanine Dyes
US6221604B1 (en) 2000-02-07 2001-04-24 Pe Corporation Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
US6664079B2 (en) 2000-10-06 2003-12-16 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
US6811979B2 (en) * 2000-10-11 2004-11-02 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
JP4787405B2 (ja) * 2000-12-26 2011-10-05 独立行政法人理化学研究所 修飾ヌクレオチド
EP1401850A1 (de) * 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US20030082547A1 (en) 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
US20050042629A1 (en) 2002-09-13 2005-02-24 Applera Corporation Thermus scotoductus nucleic acid polymerases
US7052877B2 (en) 2001-11-30 2006-05-30 Applera Corporation Thermus brockianus nucleic acid polymerases
GB0129012D0 (en) 2001-12-04 2002-01-23 Solexa Ltd Labelled nucleotides
US7057026B2 (en) * 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt-MFD GmbH & Co. KG, 41812 Erkelenz Festwalzgerät einer Festwalzmaschine für Kurbelwellen
IL163822A0 (en) * 2002-03-15 2005-12-18 Nuevolution As An improved method for synthesising templated molecules
WO2003078627A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of functional entity transfer to nucleophil
AU2003247266A1 (en) * 2002-08-01 2004-02-23 Nuevolution A/S Multi-step synthesis of templated molecules
US11008359B2 (en) 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
AU2003259350A1 (en) * 2002-08-23 2004-03-11 Solexa Limited Modified nucleotides for polynucleotide sequencing
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
AU2003266932B2 (en) * 2002-09-27 2009-04-09 Mpm-Holding Aps Spatially encoded polymer matrix
US7407747B2 (en) * 2002-10-15 2008-08-05 Applera Corporation Method for drying dye-terminator sequencing reagents
PT1558744E (pt) 2002-10-30 2011-09-22 Nuevolution As Codificação enzimática
WO2004056994A2 (en) 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
DE602004023960D1 (de) 2003-09-18 2009-12-17 Nuevolution As Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen
US7998706B2 (en) * 2003-12-23 2011-08-16 Applied Biosystems, Llc Propargyl substituted nucleoside compounds and methods
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US9574189B2 (en) * 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries
WO2008027162A2 (en) * 2006-08-28 2008-03-06 The Trustees Of The University Of Pennsylvania 129xe biosensors and their use
US8399188B2 (en) 2006-09-28 2013-03-19 Illumina, Inc. Compositions and methods for nucleotide sequencing
US7883869B2 (en) 2006-12-01 2011-02-08 The Trustees Of Columbia University In The City Of New York Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
EP3431615A3 (de) 2007-10-19 2019-02-20 The Trustees of Columbia University in the City of New York Dna-sequenzierung mit nichtfluoreszierenden, reversiblen nukleotidterminatoren und spaltbaren, etikettmodifizierten nukleotidterminatoren
WO2009051807A1 (en) 2007-10-19 2009-04-23 The Trustees Of Columbia University In The City Of New York Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis
ES2713873T3 (es) 2010-04-16 2019-05-24 Nuevolution As Complejos bifuncionales y métodos para hacer y utilizar tales complejos
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
CN105377869B (zh) 2013-03-15 2018-07-10 伊鲁米纳剑桥有限公司 修饰的核苷或核苷酸
US10648026B2 (en) 2013-03-15 2020-05-12 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
CN104650170B (zh) * 2013-11-20 2017-07-07 上海毕欧桥生物科技有限公司 荧光染料修饰的核苷酸及类似物的固相合成方法
BR112021012146A2 (pt) 2018-12-20 2021-08-31 Life Technologies Corporation Corante de rodamina modificado e uso do mesmo em ensaios biológicos
BR112021012154A2 (pt) 2018-12-20 2021-09-08 Life Technologies Corporation Corante de rodamina assimétrica e uso da mesma em ensaios biológicos

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207988A1 (es) * 1974-07-16 1976-11-22 Ciba Geigy Ag Complejos de cobre niquel cromo y cobalto de colorantes azoicos y azometinicos y procedimiento para su obtencion
US5171534A (en) * 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
US5047519A (en) * 1986-07-02 1991-09-10 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US5151507A (en) * 1986-07-02 1992-09-29 E. I. Du Pont De Nemours And Company Alkynylamino-nucleotides
US4879214A (en) * 1988-11-15 1989-11-07 E. I. Du Pont De Nemours And Company Differentiation of nucleic acid segments on the basis of nucleotide differences
US5366860A (en) * 1989-09-29 1994-11-22 Applied Biosystems, Inc. Spectrally resolvable rhodamine dyes for nucleic acid sequence determination
US5188934A (en) * 1989-11-14 1993-02-23 Applied Biosystems, Inc. 4,7-dichlorofluorescein dyes as molecular probes
WO1993024511A1 (en) * 1992-05-29 1993-12-09 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
WO1994017092A1 (en) * 1993-01-26 1994-08-04 Microprobe Corporation Bifunctional crosslinking oligonucleotides adapted for linking to a desired gene sequence of invading organism or cell
AU1436995A (en) * 1993-12-30 1995-07-17 Chemgenes Corporation Synthesis of propargyl modified nucleosides and phosphoramidites and their incorporation into defined sequence oligonucleotides
DE901494T1 (de) 1995-09-11 1999-10-21 Corning Inc., Corning Photochrome spiroxazine mit einem asymmetrischen monozylklischen substituenten, zusammensetzungen und produkte die diese enthalten
US5912340A (en) 1995-10-04 1999-06-15 Epoch Pharmaceuticals, Inc. Selective binding complementary oligonucleotides
US5821356A (en) * 1996-08-12 1998-10-13 The Perkin Elmer Corporation Propargylethoxyamino nucleotides

Also Published As

Publication number Publication date
US20060286561A1 (en) 2006-12-21
EP0915901B1 (de) 2000-10-11
US6248568B1 (en) 2001-06-19
US6504024B2 (en) 2003-01-07
JPH11513044A (ja) 1999-11-09
DE69703298D1 (de) 2000-11-16
US7019128B2 (en) 2006-03-28
US20030148470A1 (en) 2003-08-07
US5821356A (en) 1998-10-13
CA2230059A1 (en) 1998-02-19
AU4039097A (en) 1998-03-06
EP0915901A1 (de) 1999-05-19
CA2230059C (en) 2002-05-07
JP3486660B2 (ja) 2004-01-13
AU703281B2 (en) 1999-03-25
WO1998006732A1 (en) 1998-02-19
US20020045180A1 (en) 2002-04-18
DE69703298T2 (de) 2001-04-26

Similar Documents

Publication Publication Date Title
ATE196912T1 (de) Propargylethoxyamino nucleotide
DE60144479D1 (de)
ATE373671T1 (de) Aminooxy-modifizierte oligonukleotide
ATE277068T1 (de) 2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind
CA2167361A1 (en) 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides
EP1121371B8 (de) Einen starren linker enthaltende nukleotide
AU6589094A (en) 7-deazapurine modified oligonucleotides
AU6249501A (en) Nucleotide analogues comprising a reporter moiety and a polymerase enzyme blocking moiety
WO2000030629A3 (en) Method of promoting cervical and vaginal secretions
ID25613A (id) Metode untuk menghasilkan purin nukleosida melalui fermentasi
CA2215190A1 (en) Aryl-ester phosphoramidate derivatives of nucleosides
NO974077D0 (no) Fremgangsmåte for fremstilling av 2'-O-substituerte pyrimidiner og oligomeriske forbindelser derav
PT1280813E (pt) Analogos de nucleosidos de pirimidina antivirais
DE69308908D1 (de) Verfahren zur Herstellung von Cytidin-Diphosphat-Cholin
FR05C0032I2 (fr) Analogues de nucleotides
WO1999023104A3 (en) Antitumour uridine analogues
IL136895A0 (en) Novel pharmaceutical compositions of uridine triphosphate
WO1997046569A3 (en) 2'-substituted nucleosides and oligonucleotide derivatives
AU9355698A (en) Novel nucleoside or nucleotide fluorescent conjugates, preparation method and uses
WO2000061594A3 (de) Nucleosid-derivate mit photolabilen schutzgruppen
AU2002305073A1 (en) Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
HK1049944A1 (zh) L-核苷、l-核苷酸及其类似物的组合物和治疗方法
WO2000039143A3 (en) Antiviral nucleoside analogues
NO891835L (no) Prodrug-former av 2',3'-didehydro-2',3'-dideoksy-nukleosider.
AU5497396A (en) Process for the synthesis of nucleoside analogues

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties