ZA200307588B - Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides. - Google Patents

Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides.

Info

Publication number
ZA200307588B
ZA200307588B ZA200307588A ZA200307588A ZA200307588B ZA 200307588 B ZA200307588 B ZA 200307588B ZA 200307588 A ZA200307588 A ZA 200307588A ZA 200307588 A ZA200307588 A ZA 200307588A ZA 200307588 B ZA200307588 B ZA 200307588B
Authority
ZA
South Africa
Prior art keywords
beta
halo
preparation
arabinofuranosyl
arabinofuranosyl nucleosides
Prior art date
Application number
ZA200307588A
Other languages
English (en)
Inventor
Marcos Sznaidman
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of ZA200307588B publication Critical patent/ZA200307588B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
ZA200307588A 2001-03-30 2003-09-29 Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides. ZA200307588B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28030701P 2001-03-30 2001-03-30

Publications (1)

Publication Number Publication Date
ZA200307588B true ZA200307588B (en) 2004-06-30

Family

ID=23072521

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200307588A ZA200307588B (en) 2001-03-30 2003-09-29 Process for the preparation of 2'-Halo-beta-L-arabinofuranosyl nucleosides.

Country Status (17)

Country Link
US (2) US6870048B2 (xx)
EP (1) EP1373288B1 (xx)
JP (1) JP4430307B2 (xx)
KR (1) KR100910791B1 (xx)
CN (2) CN1330660C (xx)
AT (1) ATE298759T1 (xx)
AU (1) AU2002303187C1 (xx)
BR (1) BR0208517A (xx)
CA (1) CA2442979C (xx)
DE (1) DE60204859T2 (xx)
ES (1) ES2243726T3 (xx)
HK (1) HK1117169A1 (xx)
IL (2) IL158185A0 (xx)
MX (1) MXPA03008870A (xx)
NZ (1) NZ528575A (xx)
WO (1) WO2002079213A1 (xx)
ZA (1) ZA200307588B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158185A0 (en) * 2001-03-30 2004-03-28 Triangle Pharmaceuticals Inc PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
JP2006265156A (ja) * 2005-03-23 2006-10-05 Ajinomoto Co Inc ２−デオキシ−ｌ−リボフラノシルクロリド化合物の製造方法
WO2008022469A1 (en) * 2006-08-23 2008-02-28 Mcgill University 2'-DEOXY-2'-FLUORO-β-D-ARABINONUCLEOSIDE 5'-TRIPHOSPHATES AND THEIR USE IN ENZYMATIC NUCLEIC ACID SYNTHESIS
CN101469012B (zh) * 2007-12-26 2013-03-27 杭州容立医药科技有限公司 2-氨基-6-甲氧基-9-(β-D-阿拉伯糖基)-9H-嘌呤的合成方法
US9790252B2 (en) 2009-07-01 2017-10-17 Cornell University 2-fluorinated riboses and arabinoses and methods of use and synthesis
CN102060899B (zh) * 2010-12-27 2012-07-25 江苏奥赛康药业股份有限公司 一种奈拉滨N-9位α型异构体、其制备方法及其应用
CN102344427B (zh) * 2011-08-10 2013-07-31 济南圣泉集团股份有限公司 一种烯糖的合成方法
CN102863479B (zh) * 2011-11-04 2015-06-17 济南圣泉唐和唐生物科技有限公司 一种制备全乙酰溴代-l-阿拉伯糖的方法
CN103694279B (zh) * 2013-12-23 2015-12-02 江西苏克尔新材料有限公司 一种制备2-脱氧-l-核糖的方法
CN105732732B (zh) * 2016-04-14 2018-04-06 四川理工学院 一种制备2‑脱氧‑d‑核糖的方法
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008384A (en) * 1988-07-12 1991-04-16 Pfizer Inc. Process for the production of O.sup. 2,2'-anhydro-1-(β-D-arabinofuranosyl)thymine
US5587362A (en) 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
CN1039121C (zh) * 1994-10-18 1998-07-15 北京医科大学药学院 具有嘧啶或嘌呤取代基的氢化呋喃衍生物及其制法
US5808040A (en) 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
TW434252B (en) * 1997-07-23 2001-05-16 Univ Georgia Res Found Process for the preparation of 2'-fluoro-5-methyl-β-L-arabino-furanosyluridine
IL158185A0 (en) * 2001-03-30 2004-03-28 Triangle Pharmaceuticals Inc PROCESS FOR THE PREPARATION OF 2'-HALO-&beta -L-ARABINOFURANOSYL NUCLEOSIDES

Also Published As

Publication number Publication date
CN101117346B (zh) 2012-12-12
IL158185A (en) 2009-09-22
EP1373288B1 (en) 2005-06-29
CN1571792A (zh) 2005-01-26
KR20030092037A (ko) 2003-12-03
US6870048B2 (en) 2005-03-22
US7291726B2 (en) 2007-11-06
CA2442979C (en) 2010-02-16
JP4430307B2 (ja) 2010-03-10
CA2442979A1 (en) 2002-10-10
CN101117346A (zh) 2008-02-06
KR100910791B1 (ko) 2009-08-04
DE60204859T2 (de) 2006-04-27
US20050187384A1 (en) 2005-08-25
DE60204859D1 (de) 2005-08-04
MXPA03008870A (es) 2004-01-29
HK1117169A1 (xx) 2009-01-09
JP2004526743A (ja) 2004-09-02
US20030060622A1 (en) 2003-03-27
BR0208517A (pt) 2005-02-01
CN1330660C (zh) 2007-08-08
AU2002303187C1 (en) 2008-06-12
IL158185A0 (en) 2004-03-28
AU2002303187B8 (en) 2002-10-15
EP1373288A1 (en) 2004-01-02
ATE298759T1 (de) 2005-07-15
ES2243726T3 (es) 2005-12-01
AU2002303187B2 (en) 2007-11-08
NZ528575A (en) 2006-04-28
WO2002079213A1 (en) 2002-10-10

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