IL157440A0 - Triazole derivatives and pharmaceutical compositions containing the same - Google Patents
Triazole derivatives and pharmaceutical compositions containing the sameInfo
- Publication number
- IL157440A0 IL157440A0 IL15744002A IL15744002A IL157440A0 IL 157440 A0 IL157440 A0 IL 157440A0 IL 15744002 A IL15744002 A IL 15744002A IL 15744002 A IL15744002 A IL 15744002A IL 157440 A0 IL157440 A0 IL 157440A0
- Authority
- IL
- Israel
- Prior art keywords
- same
- pharmaceutical compositions
- compositions containing
- triazole derivatives
- group
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229940042055 systemic antimycotics triazole derivative Drugs 0.000 title 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 230000000843 anti-fungal effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- -1 triazole compound Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
- C07F9/6518—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001046890 | 2001-02-22 | ||
| PCT/JP2002/001500 WO2002066465A1 (en) | 2001-02-22 | 2002-02-20 | Water-soluble triazole fungicide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL157440A0 true IL157440A0 (en) | 2004-03-28 |
Family
ID=18908429
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15744002A IL157440A0 (en) | 2001-02-22 | 2002-02-20 | Triazole derivatives and pharmaceutical compositions containing the same |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7230023B2 (cs) |
| EP (1) | EP1362856B1 (cs) |
| KR (1) | KR100851800B1 (cs) |
| CN (2) | CN100349569C (cs) |
| AT (1) | ATE407932T1 (cs) |
| AU (1) | AU2002234892C9 (cs) |
| BR (1) | BR0207534A (cs) |
| CA (1) | CA2439001C (cs) |
| CZ (1) | CZ20032218A3 (cs) |
| DE (1) | DE60228821D1 (cs) |
| ES (1) | ES2314028T3 (cs) |
| HU (1) | HUP0303249A3 (cs) |
| IL (1) | IL157440A0 (cs) |
| MX (1) | MXPA03007588A (cs) |
| NO (1) | NO326520B1 (cs) |
| NZ (1) | NZ527693A (cs) |
| PL (1) | PL363523A1 (cs) |
| PT (1) | PT1362856E (cs) |
| RU (1) | RU2276670C2 (cs) |
| SK (1) | SK10592003A3 (cs) |
| WO (1) | WO2002066465A1 (cs) |
| ZA (1) | ZA200306547B (cs) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200410948A (en) * | 2002-09-20 | 2004-07-01 | Sankyo Co | Water soluble triazole compounds |
| KR101189383B1 (ko) * | 2004-08-05 | 2012-10-10 | 스미또모 가가꾸 가부시키가이샤 | 할로겐 치환 벤젠디메탄올의 제조 방법 |
| KR100738228B1 (ko) | 2006-02-22 | 2007-07-12 | 한국화학연구원 | 아졸계 항균제 화합물 및 그의 제조방법 |
| TW200817424A (en) | 2006-08-04 | 2008-04-16 | Daiichi Sankyo Co Ltd | Benzylphenyl glucopyranoside derivatives |
| MX2009003673A (es) | 2006-10-04 | 2009-04-22 | Pfizer Prod Inc | Derivados de piridido[4,3-d]pirimidin-4(3h)-ona como antagonistas de los receptores de calcio. |
| WO2010019204A1 (en) * | 2008-08-12 | 2010-02-18 | Merck Sharp & Dohme Corp. | Antifungal agents |
| US8722727B2 (en) * | 2008-08-12 | 2014-05-13 | Seynix, Inc. | Antifungal agents |
| CN103508981A (zh) * | 2012-06-18 | 2014-01-15 | 北京美倍他药物研究有限公司 | 新的哌嗪衍生物及其医药用途 |
| CN107556294A (zh) * | 2016-06-30 | 2018-01-09 | 陕西合成药业股份有限公司 | 一种新型抗真菌感染药物及其制备方法和用途 |
| CN114761004A (zh) * | 2019-12-06 | 2022-07-15 | 细胞基因公司 | 用于制备2-(4-氯苯基)-n-((2-(2，6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2，2-二氟乙酰胺的方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2104065B (en) * | 1981-06-04 | 1985-11-06 | Ciba Geigy Ag | Heterocyclyl-substituted mandelic acid compounds and mandelonitriles and their use for combating microorganisms |
| CS228931B2 (cs) | 1981-06-06 | 1984-05-14 | Pfizer | Způsob výroby 2-(2,4-difluorfenyl)-l,3-bis(lH-l,2,4-triazol-l-yl)propan- -2-oiu |
| EP0069442B1 (en) | 1981-06-06 | 1985-02-20 | Pfizer Limited | Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them |
| JPS6214766A (ja) | 1985-07-11 | 1987-01-23 | Tokyu Foods:Kk | 肉そばの製造法 |
| RU2039050C1 (ru) * | 1989-09-26 | 1995-07-09 | Такеда Кемикал Индастриз ЛТД | Производные 1,2,4-триазола, оптически инертные или имеющие r- или s-конфигурацию c-2 и c-3 асимметричных центров, или их соли, обладающие фунгицидной активностью, и способ их получения |
| GB9002375D0 (en) | 1990-02-02 | 1990-04-04 | Pfizer Ltd | Triazole antifungal agents |
| CA2049802A1 (en) * | 1990-08-26 | 1992-02-27 | Sadao Oida | Anti-fungal triazole derivatives, their preparation and uses |
| EP0510700A3 (en) * | 1991-04-26 | 1992-12-16 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and use |
| JP3050982B2 (ja) | 1991-12-13 | 2000-06-12 | 富山化学工業株式会社 | 新規なトリアゾール誘導体およびその塩 |
| US5622944A (en) * | 1992-06-12 | 1997-04-22 | Affymax Technologies N.V. | Testosterone prodrugs for improved drug delivery |
| JPH05345768A (ja) | 1992-06-13 | 1993-12-27 | Nippon Nohyaku Co Ltd | 新規トリアゾール化合物及び該化合物を有効成分とする抗真菌剤 |
| TW297813B (cs) * | 1993-09-24 | 1997-02-11 | Takeda Pharm Industry Co Ltd | |
| NZ270418A (en) * | 1994-02-07 | 1997-09-22 | Eisai Co Ltd | Polycyclic triazole & imidazole derivatives, antifungal compositions |
| JP3635686B2 (ja) | 1994-08-10 | 2005-04-06 | エーザイ株式会社 | 抗真菌剤及びその製造方法 |
| AU1961695A (en) | 1994-03-12 | 1995-10-03 | Yuhan Corporation | Triazole compounds and processes for the preparation thereof |
| JP3056412B2 (ja) | 1995-02-17 | 2000-06-26 | 武田薬品工業株式会社 | アゾール化合物およびその用途 |
| ATE206410T1 (de) | 1995-04-06 | 2001-10-15 | Sankyo Co | Triazole als fungizide mittel. |
| ATE198593T1 (de) | 1995-08-02 | 2001-01-15 | Uriach & Cia Sa J | Pyrimidonderivate mit antifungaler wirkung |
| KR20000064644A (ko) | 1997-01-17 | 2000-11-06 | 믹에티취 알.지. | 진균 감염 치료제로서의 신규한 트리아졸 |
| JPH10279567A (ja) | 1997-02-04 | 1998-10-20 | Sankyo Co Ltd | トリアゾール誘導体 |
| JPH1180135A (ja) | 1997-07-08 | 1999-03-26 | Sankyo Co Ltd | 抗真菌トリアゾール化合物 |
| JP3638438B2 (ja) * | 1997-12-26 | 2005-04-13 | エスエス製薬株式会社 | トリアゾール誘導体またはその塩、その製造方法及び当該化合物を有効成分とする医薬 |
| AU2931399A (en) | 1998-03-06 | 1999-09-20 | F. Hoffmann-La Roche Ag | 3-(4-(4-cyanophenyl)thiazol-2-y))-1-(1h-1,2,4-triazol-1-yl) -butan-2-ol derivatives having antifungal activity |
| US6265584B1 (en) * | 1998-05-22 | 2001-07-24 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| AU1177200A (en) | 1998-11-10 | 2000-05-29 | Meiji Seika Kaisha Ltd. | Novel imidazo(5,1-B)thiazole derivatives and fungicides containing the same as the active ingredient |
| AU1915500A (en) * | 1998-11-20 | 2000-06-13 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| AU4934299A (en) | 1999-07-15 | 2001-02-05 | Kuhnil Pharm. Co., Ltd. | Novel water soluble-cyclosporine conjugated compounds |
| US6362172B2 (en) | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| EP1278755A2 (en) | 2000-03-07 | 2003-01-29 | Ranbaxy Laboratories, Limited | Azole compounds as therapeutic agents for fungal infections |
| TW591024B (en) * | 2000-03-27 | 2004-06-11 | Sankyo Lifetech Company Ltd | An amide type triazole compound having antifungal activity |
| JP2001342187A (ja) | 2000-03-27 | 2001-12-11 | Sankyo Co Ltd | アミド系トリアゾール化合物 |
| US6319933B1 (en) | 2000-04-17 | 2001-11-20 | Basilea Pharmaceutica Ag | Azole derivatives |
-
2002
- 2002-02-02 HU HU0303249A patent/HUP0303249A3/hu unknown
- 2002-02-20 RU RU2003125879/04A patent/RU2276670C2/ru not_active IP Right Cessation
- 2002-02-20 IL IL15744002A patent/IL157440A0/xx unknown
- 2002-02-20 SK SK1059-2003A patent/SK10592003A3/sk unknown
- 2002-02-20 CA CA2439001A patent/CA2439001C/en not_active Expired - Fee Related
- 2002-02-20 WO PCT/JP2002/001500 patent/WO2002066465A1/ja not_active Ceased
- 2002-02-20 PL PL02363523A patent/PL363523A1/xx not_active IP Right Cessation
- 2002-02-20 AU AU2002234892A patent/AU2002234892C9/en not_active Ceased
- 2002-02-20 PT PT02701569T patent/PT1362856E/pt unknown
- 2002-02-20 CN CNB2005100916023A patent/CN100349569C/zh not_active Expired - Fee Related
- 2002-02-20 CN CNB028084713A patent/CN100430390C/zh not_active Expired - Fee Related
- 2002-02-20 CZ CZ20032218A patent/CZ20032218A3/cs unknown
- 2002-02-20 ES ES02701569T patent/ES2314028T3/es not_active Expired - Lifetime
- 2002-02-20 AT AT02701569T patent/ATE407932T1/de not_active IP Right Cessation
- 2002-02-20 DE DE60228821T patent/DE60228821D1/de not_active Expired - Lifetime
- 2002-02-20 EP EP02701569A patent/EP1362856B1/en not_active Expired - Lifetime
- 2002-02-20 BR BR0207534-2A patent/BR0207534A/pt not_active IP Right Cessation
- 2002-02-20 MX MXPA03007588A patent/MXPA03007588A/es active IP Right Grant
- 2002-02-20 KR KR1020037011103A patent/KR100851800B1/ko not_active Expired - Fee Related
- 2002-02-20 NZ NZ527693A patent/NZ527693A/en unknown
-
2003
- 2003-08-20 US US10/647,023 patent/US7230023B2/en not_active Expired - Fee Related
- 2003-08-21 NO NO20033723A patent/NO326520B1/no not_active IP Right Cessation
- 2003-08-21 ZA ZA200306547A patent/ZA200306547B/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MXPA04004674A (es) | Ligados de los receptors de los canabinodies. | |
| PL334915A1 (en) | Pyrrolidine derivatives exhibiting phospholipase a2 inhibiting activity | |
| IL150650A0 (en) | Piperidine derivatives and pharmaceutical compositions containing the same | |
| EP1382603A4 (en) | NITROGEN COMPOUND WITH CONDENSED RINGS HAVING A PYRAZOLYL GROUP AND AS A SUBSTITUTE, AND MEDICAL COMPOSITION COMPRISING SAME | |
| WO2001025227A3 (fr) | Derives de la quinolyl propyl piperidine et leur utilisation en tant que antibacteriens | |
| EP0630898A4 (en) | MEDICINE FOR THROMBOZYTOPENIA. | |
| ZA200108124B (en) | Pharmaceutical compounds. | |
| AU9281198A (en) | Benzofuran derivatives | |
| IL157440A0 (en) | Triazole derivatives and pharmaceutical compositions containing the same | |
| ID24846A (id) | Turunan-turunan bifenilamidina | |
| MXPA05006450A (es) | Nuevo derivado de 2,4-diamino-1,3,5-triazina. | |
| NO982873D0 (no) | 1-metylkarbapenemderivater | |
| EP1209151A4 (en) | PIPERID DERIVATIVES SUBSTITUTED IN 4-POSITION | |
| EP1152004A4 (en) | PHOSPHONIC ACID DERIVATIVES HAVING CARBOXYPEPTIDASE B INHIBITOR ACTIVITY | |
| EP1026162A4 (en) | ANTI-RHUMATISMAL AGENT | |
| FI952420A0 (fi) | Glukopyranosidibentsotiofeenit | |
| MY129094A (en) | Condensed polycyclic compounds | |
| WO2004048381A3 (en) | Pyrazoloazepine compounds as pharmaceutical agents | |
| IL151880A0 (en) | Triazole derivatives and pharmaceutical compositions containing the same | |
| SE0102809D0 (sv) | Novel compounds | |
| EP1557407A4 (en) | NEW ALPHA-CETOAMIDE DERIVATIVE AND USE THEREOF | |
| EP1118327A4 (en) | PREVENTIVE AND / OR THERAPEUTIC AGENTS FOR THE TREATMENT OF SINUSITIS. |