IL157366A0 - A cell therapy method for the treatment of tumors - Google Patents
A cell therapy method for the treatment of tumorsInfo
- Publication number
- IL157366A0 IL157366A0 IL15736602A IL15736602A IL157366A0 IL 157366 A0 IL157366 A0 IL 157366A0 IL 15736602 A IL15736602 A IL 15736602A IL 15736602 A IL15736602 A IL 15736602A IL 157366 A0 IL157366 A0 IL 157366A0
- Authority
- IL
- Israel
- Prior art keywords
- cells
- specific
- antigen
- stimulate
- responses
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002659 cell therapy Methods 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 4
- 102000036639 antigens Human genes 0.000 abstract 4
- 108091007433 antigens Proteins 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 239000012636 effector Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 abstract 1
- 241000255581 Drosophila <fruit fly, genus> Species 0.000 abstract 1
- 241000255601 Drosophila melanogaster Species 0.000 abstract 1
- 230000005867 T cell response Effects 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 208000007654 attenuated familial adenomatous polyposis Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000001010 compromised effect Effects 0.000 abstract 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 1
- 230000003292 diminished effect Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002934 lysing effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46449—Melanoma antigens
- A61K39/464491—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0601—Invertebrate cells or tissues, e.g. insect cells; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55533—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
- A61K2039/55527—Interleukins
- A61K2039/55538—IL-12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27025201P | 2001-02-20 | 2001-02-20 | |
PCT/US2002/005748 WO2002065992A2 (fr) | 2001-02-20 | 2002-02-19 | Methode therapeutique cellulaire utilisee dans le traitement des tumeurs |
Publications (1)
Publication Number | Publication Date |
---|---|
IL157366A0 true IL157366A0 (en) | 2004-02-19 |
Family
ID=23030546
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15736602A IL157366A0 (en) | 2001-02-20 | 2002-02-19 | A cell therapy method for the treatment of tumors |
IL157366A IL157366A (en) | 2001-02-20 | 2003-08-12 | A method for preparing a CD8 + cell proliferation suitable for cancer treatment |
IL219223A IL219223B (en) | 2001-02-20 | 2012-04-17 | Non-naturally occurring antigen-presenting cells derived from Drosophila melanogaster for use in the preparation of CD8+ cell suspensions and methods for their production |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL157366A IL157366A (en) | 2001-02-20 | 2003-08-12 | A method for preparing a CD8 + cell proliferation suitable for cancer treatment |
IL219223A IL219223B (en) | 2001-02-20 | 2012-04-17 | Non-naturally occurring antigen-presenting cells derived from Drosophila melanogaster for use in the preparation of CD8+ cell suspensions and methods for their production |
Country Status (22)
Country | Link |
---|---|
US (2) | US20030077248A1 (fr) |
EP (3) | EP2848255B1 (fr) |
JP (3) | JP2006510567A (fr) |
KR (2) | KR100971266B1 (fr) |
CN (1) | CN1571834B (fr) |
AT (1) | ATE396691T1 (fr) |
BR (1) | BR0207399A (fr) |
CA (2) | CA2698079C (fr) |
DE (1) | DE60226853D1 (fr) |
DK (1) | DK2016930T3 (fr) |
EA (1) | EA013944B1 (fr) |
ES (2) | ES2643582T3 (fr) |
HK (2) | HK1058485A1 (fr) |
HU (1) | HUP0402656A3 (fr) |
IL (3) | IL157366A0 (fr) |
MX (1) | MXPA03007503A (fr) |
NO (1) | NO334885B1 (fr) |
NZ (1) | NZ527683A (fr) |
PL (1) | PL206976B1 (fr) |
PT (1) | PT1377251E (fr) |
WO (1) | WO2002065992A2 (fr) |
ZA (1) | ZA200307327B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7973137B1 (en) | 1996-03-28 | 2011-07-05 | Johns Hopkins University | Cell compositions comprising molecular complexes that modify immune responses |
US20040071671A1 (en) * | 2001-02-20 | 2004-04-15 | Leturcq Didier J. | Cell therapy method for the treatment of tumors |
US20030077248A1 (en) | 2001-02-20 | 2003-04-24 | Ann Moriarty | Cell therapy method for the treatment of tumors |
SI2371854T1 (sl) * | 2001-03-09 | 2014-09-30 | Board Of Regents, The University Of Texas System Office Of The General Counsel | Induciranje imunosti tumorja z variantami beljakovine, ki se veĺ˝e na folat |
US8802618B2 (en) * | 2002-03-08 | 2014-08-12 | Board Of Regents, The University Of Texas System | Controlled modulation of amino acid side chain length of peptide antigens |
CA2800113C (fr) * | 2002-07-12 | 2015-02-03 | The Johns Hopkins University | Reactifs et procedes permettant d'impliquer des recepteurs clonotypiques de lymphocytes uniques |
CA2505379A1 (fr) * | 2002-11-07 | 2004-05-21 | Johnson & Johnson Research Pty Limited | Moyens de production et d'utilisation d'une population de lymphocytes t cytotoxiques specifiques d'une maladie |
JP4609855B2 (ja) * | 2003-06-16 | 2011-01-12 | 国立大学法人九州大学 | ヒト由来免疫担当細胞の製造方法 |
JP2005139118A (ja) * | 2003-11-07 | 2005-06-02 | Ortho Mcneil Pharmaceut Inc | 腫瘍の治療のための細胞治療方法 |
US20100094560A1 (en) * | 2006-08-15 | 2010-04-15 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
WO2008039874A2 (fr) | 2006-09-26 | 2008-04-03 | Cedars-Sinai Medical Center | Vaccins comprenant des antigènes de cellules souches cancéreuses et procédés |
CA2700579A1 (fr) * | 2006-09-28 | 2008-04-03 | Cedars-Sinai Medical Center | Vaccins contre le cancer et methodes de vaccination |
BRPI0720342A2 (pt) | 2006-10-04 | 2018-09-18 | Janssen Pharmaceutica N.V. | preparado de células apresentadoras de antígenos artificiais e seu uso em terapias celulares. |
PL2328923T3 (pl) | 2008-09-02 | 2016-06-30 | Cedars Sinai Medical Center | Epitopy CD133 |
JP2010235611A (ja) * | 2010-05-10 | 2010-10-21 | Ortho Mcneil Pharmaceut Inc | 腫瘍の治療のための細胞治療方法 |
US9029502B2 (en) | 2010-12-20 | 2015-05-12 | The Regents Of The University Of Michigan | Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction |
US20140234351A1 (en) | 2013-02-14 | 2014-08-21 | Immunocellular Therapeutics, Ltd. | Cancer vaccines and vaccination methods |
CN103667189B (zh) * | 2013-09-24 | 2015-10-28 | 上海宇研生物技术有限公司 | 用于治疗肺癌的cd8毒性t淋巴细胞及其制备方法 |
AU2015317712B2 (en) * | 2014-09-17 | 2019-01-17 | The Johns Hopkins University | Reagents and methods for identifying, enriching, and/or expanding antigen-specific T cells |
US9993538B2 (en) | 2015-05-29 | 2018-06-12 | Galena Biopharma, Inc. | Peptide vaccine therapy for treatment of FRα-expressing tumors |
WO2017210255A1 (fr) | 2016-05-31 | 2017-12-07 | Galena Biopharma, Inc. | Thérapie vaccinale pour le traitement du cancer de l'endomètre et de l'ovaire |
WO2017216768A1 (fr) | 2016-06-16 | 2017-12-21 | Association For The Advancement Of Tissue Engineering And Cell Based Technologies And Therapies - A4Tec | Antigène artificiel dérivé d'un dendrimère, procédés associés et utilisations |
EP3493836A4 (fr) * | 2016-08-02 | 2020-03-04 | Nantcell, Inc. | Transfection de cellules dendritiques et procédés associés |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4530901A (en) | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
US4401756A (en) | 1981-04-14 | 1983-08-30 | Immunex Corporation | Process for preparing human interleukin 2 |
US4473642A (en) | 1981-04-29 | 1984-09-25 | Immunex Corporation | Constitutive production of interleukin 2 by a T cell hybridoma |
US4407945A (en) | 1981-04-29 | 1983-10-04 | Immunex Corporation | Constitutive production of interleukin 2 by a T cell hybridoma |
US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
US4992367A (en) | 1986-05-12 | 1991-02-12 | Hoffmann-La Roche Inc. | Enhanced expression of human interleukin-2 in mammalian cells |
US5229115A (en) | 1990-07-26 | 1993-07-20 | Immunex Corporation | Adoptive immunotherapy with interleukin-7 |
US5637483A (en) | 1991-10-04 | 1997-06-10 | Whitehead Institute For Biomedical Research | Irradiated tumor cell vaccine engineered to express GM-CSF |
US5583031A (en) | 1992-02-06 | 1996-12-10 | President And Fellows Of Harvard College | Empty major histocompatibility class II heterodimers |
US5314813A (en) * | 1992-02-19 | 1994-05-24 | Scripps Research Institute | Drosophila cell lines expressing genes encoding MHC class I antigens and B2-microglobulin and capable of assembling empty complexes and methods of making said cell lines |
CA2069541C (fr) | 1992-05-26 | 2005-02-01 | Cornelis J. M. Melief | Induction d'une reponse chez des lymphocytes t specifiques de l'antigene |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US5662907A (en) * | 1992-08-07 | 1997-09-02 | Cytel Corporation | Induction of anti-tumor cytotoxic T lymphocytes in humans using synthetic peptide epitopes |
US5487974A (en) | 1992-12-22 | 1996-01-30 | Ludwig Institute For Cancer-Research | Method for detecting complexes containing human leukocyte antigen A2 (HLA-A2) molecules and a tyrosinase drived peptide on abnormal cells |
US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
US5820866A (en) | 1994-03-04 | 1998-10-13 | National Jewish Center For Immunology And Respiratory Medicine | Product and process for T cell regulation |
US5585461A (en) * | 1994-03-24 | 1996-12-17 | Ludwig Institute For Cancer Research | Isolated, MAGE-3 derived peptides which complex with HLA-A2 molecules and uses thereof |
US5874560A (en) | 1994-04-22 | 1999-02-23 | The United States Of America As Represented By The Department Of Health And Human Services | Melanoma antigens and their use in diagnostic and therapeutic methods |
US6017719A (en) | 1994-06-14 | 2000-01-25 | Nexell Therapeutics, Inc. | Positive and positive/negative cell selection mediated by peptide release |
US5595881A (en) | 1994-08-09 | 1997-01-21 | Anergen, Inc. | Method for the detection of antigen presenting cells |
US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
US5843648A (en) * | 1995-01-10 | 1998-12-01 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | P15 and tyrosinase melanoma antigens and their use in diagnostic and therapeutic methods |
US5645837A (en) | 1995-01-17 | 1997-07-08 | Thomas Jefferson University | Peptides that inhibit T cell activation and methods of using the same |
ES2201177T3 (es) | 1995-03-08 | 2004-03-16 | The Scripps Research Institute | Sistema de presentacion de antigenos y activacion de celulas-t. |
US5759783A (en) | 1995-03-14 | 1998-06-02 | Ludwig Institute For Cancer Research | Method of screening for cancer by detecting messenger RNA for a MAGE-XP gene |
US5587289A (en) | 1995-03-14 | 1996-12-24 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules which are members of the MAGE-Xp family and uses thereof |
US5695760A (en) | 1995-04-24 | 1997-12-09 | Boehringer Inglehiem Pharmaceuticals, Inc. | Modified anti-ICAM-1 antibodies and their use in the treatment of inflammation |
US5985270A (en) | 1995-09-13 | 1999-11-16 | Fordham University | Adoptive immunotherapy using macrophages sensitized with heat shock protein-epitope complexes |
IL125884A0 (en) | 1996-03-04 | 1999-04-11 | Targeted Genetics Corp | Modified rapid expansion methods ("modified-rem") for in vitro propagation of t lymphocytes |
WO1997046256A1 (fr) * | 1996-05-23 | 1997-12-11 | The Scripps Research Institute | Systemes de presentation d'antigenes de la classe ii du cmh et procedes d'activation des lymphocytes t a cd4?+¿ |
CA2318987A1 (fr) * | 1998-01-26 | 1999-07-29 | Genzyme Corporation | Hybrides de cellules effectrices immunes |
WO1999054345A1 (fr) | 1998-04-21 | 1999-10-28 | Thomas Jefferson University | Antagonistes de cd8 |
US6140050A (en) * | 1998-06-26 | 2000-10-31 | Ludwig Institute For Cancer Research | Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith |
US6913749B2 (en) | 1998-11-02 | 2005-07-05 | Resistentia Pharmaceuticals Ab | Immunogenic polypeptides for inducing anti-self IgE responses |
DK1179176T3 (da) | 1999-04-16 | 2006-08-07 | Ortho Mcneil Pharm Inc | Fremgangsmåde til detektion af antigenspecifikke T-celler |
JP2001089389A (ja) | 1999-07-22 | 2001-04-03 | Sumitomo Pharmaceut Co Ltd | 抗原特異的t細胞の誘導剤 |
EP1257565A4 (fr) * | 2000-02-01 | 2005-04-06 | Austin Research Inst | Antigenes derives de mucine-1 et leur utilisation en immunotherapie |
AU3823601A (en) * | 2000-02-11 | 2001-08-20 | Dana Farber Cancer Inst Inc | Cytotoxic t lymphocytes activated by dendritic cell hybrids |
EP1299523B1 (fr) * | 2000-07-10 | 2008-12-24 | Eppendorf Ag | Procede pour la modification de cellules biologiques |
US20030077248A1 (en) | 2001-02-20 | 2003-04-24 | Ann Moriarty | Cell therapy method for the treatment of tumors |
-
2002
- 2002-02-19 US US10/080,013 patent/US20030077248A1/en not_active Abandoned
- 2002-02-19 PL PL369971A patent/PL206976B1/pl unknown
- 2002-02-19 WO PCT/US2002/005748 patent/WO2002065992A2/fr active Application Filing
- 2002-02-19 EP EP14187466.9A patent/EP2848255B1/fr not_active Expired - Lifetime
- 2002-02-19 MX MXPA03007503A patent/MXPA03007503A/es active IP Right Grant
- 2002-02-19 ES ES14187466.9T patent/ES2643582T3/es not_active Expired - Lifetime
- 2002-02-19 NZ NZ527683A patent/NZ527683A/en not_active IP Right Cessation
- 2002-02-19 DE DE60226853T patent/DE60226853D1/de not_active Expired - Lifetime
- 2002-02-19 JP JP2002565553A patent/JP2006510567A/ja not_active Withdrawn
- 2002-02-19 BR BR0207399-4A patent/BR0207399A/pt not_active Application Discontinuation
- 2002-02-19 KR KR1020097010449A patent/KR100971266B1/ko not_active IP Right Cessation
- 2002-02-19 DK DK08009460.0T patent/DK2016930T3/en active
- 2002-02-19 EP EP02742493A patent/EP1377251B1/fr not_active Expired - Lifetime
- 2002-02-19 IL IL15736602A patent/IL157366A0/xx unknown
- 2002-02-19 CA CA2698079A patent/CA2698079C/fr not_active Expired - Fee Related
- 2002-02-19 AT AT02742493T patent/ATE396691T1/de not_active IP Right Cessation
- 2002-02-19 KR KR1020037010894A patent/KR100962544B1/ko active IP Right Grant
- 2002-02-19 CA CA2438754A patent/CA2438754C/fr not_active Expired - Fee Related
- 2002-02-19 PT PT02742493T patent/PT1377251E/pt unknown
- 2002-02-19 HU HU0402656A patent/HUP0402656A3/hu unknown
- 2002-02-19 ES ES02742493T patent/ES2306771T3/es not_active Expired - Lifetime
- 2002-02-19 EP EP08009460.0A patent/EP2016930B1/fr not_active Expired - Lifetime
- 2002-02-19 CN CN028082966A patent/CN1571834B/zh not_active Expired - Fee Related
- 2002-02-19 EA EA200300815A patent/EA013944B1/ru not_active IP Right Cessation
-
2003
- 2003-08-12 IL IL157366A patent/IL157366A/en not_active IP Right Cessation
- 2003-08-19 NO NO20033674A patent/NO334885B1/no not_active IP Right Cessation
- 2003-09-18 ZA ZA2003/07327A patent/ZA200307327B/en unknown
-
2004
- 2004-02-25 HK HK04101353A patent/HK1058485A1/xx not_active IP Right Cessation
-
2008
- 2008-01-16 US US12/014,863 patent/US9222071B2/en not_active Expired - Fee Related
-
2010
- 2010-03-11 JP JP2010054732A patent/JP2010222352A/ja active Pending
-
2012
- 2012-02-02 JP JP2012020842A patent/JP5634415B2/ja not_active Expired - Fee Related
- 2012-04-17 IL IL219223A patent/IL219223B/en not_active IP Right Cessation
-
2015
- 2015-09-18 HK HK15109174.2A patent/HK1208376A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL219223A0 (en) | A cell therapy method for the treatment of tumors | |
EP1470821A3 (fr) | Méthode de thérapie cellulaire pour le traitement des tumeurs | |
Vatakis et al. | Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells | |
Nanda et al. | Induction of anti-self-immunity to cure cancer | |
Ji et al. | Improvement of DC vaccine with ALA-PDT induced immunogenic apoptotic cells for skin squamous cell carcinoma | |
Chattopadhyay et al. | Regulatory T cells and tumor immunity | |
Mukherji | Immunology of melanoma | |
Wennhold et al. | CD40-activated B cells induce anti-tumor immunity in vivo | |
ATE491465T1 (de) | Verfahren zur gewinnung aktivierter t-zellen und mit antigen-inkubierten antigen-präsentierender zellen | |
Chatenoud | Natural and induced T CD4+ CD25+ FOXP3+ regulatory T cells | |
CY1110235T1 (el) | Χρηση αλλογενετικων κυτταρικων γραμμων για τη φορτωση κυτταρων που εμφανιζουν αντιγονο για την προκληση ή εξαλειψη ανοσολογικων απαντησεων | |
Dietrich et al. | T-cell immunotherapy for malignant glioma: toward a combined approach | |
Laumbacher et al. | Activated monocytes prime naïve T cells against autologous cancer: vigorous cancer destruction in vitro and in vivo | |
CN106279392B (zh) | 肿瘤相关抗原XAGE-1b短肽及其应用 | |
Crowley et al. | Human xenograft-nude mouse model of adoptive immunotherapy with human melanoma-specific cytotoxic T-cells | |
Yamaguchi et al. | Dendritic cell-based vaccines suppress metastatic liver tumor via activation of local innate and acquired immunity | |
Sioud | Does our current understanding of immune tolerance, autoimmunity, and immunosuppressive mechanisms facilitate the design of efficient cancer vaccines? | |
Mortara et al. | Irradiated CIITA-positive mammary adenocarcinoma cells act as a potent anti-tumor-preventive vaccine by inducing tumor-specific CD4+ T cell priming and CD8+ T cell effector functions | |
Dominguez et al. | Implications of aging and self-tolerance on the generation of immune and antitumor immune responses | |
Gritzapis et al. | Ontak reduces the immunosuppressive tumor environment and enhances successful therapeutic vaccination in HER-2/neu-tolerant mice | |
Jang et al. | Simultaneous expression of allogenic class II MHC and B7. 1 (CD80) molecules in A20 B-lymphoma cell line enhances tumor immunogenicity | |
Pancholi et al. | An approach to isolating T cell lines that react to antigens presented on the surface of dendritic cells | |
Palermo et al. | Transfer of efficient anti-melanocyte T cells from vitiligo donors to melanoma patients as a novel immunotherapeutical strategy | |
Cheng et al. | Induction of tumor-specific T cell response by cognating tumor cells with foreign antigen-primed Th cells. | |
Ziegler et al. | The liver and immunoregulation of neuroblastoma growth |