ES2306771T3 - Un metodo de terapia celular para tratamiento de tumores. - Google Patents

Un metodo de terapia celular para tratamiento de tumores. Download PDF

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Publication number
ES2306771T3
ES2306771T3 ES02742493T ES02742493T ES2306771T3 ES 2306771 T3 ES2306771 T3 ES 2306771T3 ES 02742493 T ES02742493 T ES 02742493T ES 02742493 T ES02742493 T ES 02742493T ES 2306771 T3 ES2306771 T3 ES 2306771T3
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Spain
Prior art keywords
peripheral blood
cells
blood monocytes
nnapc
approximately
Prior art date
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Expired - Lifetime
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ES02742493T
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English (en)
Inventor
Juli Degraw
Ann Moriarty
Didier J Leturcq
Michael R Jackson
Per A Peterson
Marja Heiskala
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Janssen Pharmaceuticals Inc
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Ortho McNeil Pharmaceutical Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/46449—Melanoma antigens
    • A61K39/464491—Melan-A/MART
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0601—Invertebrate cells or tissues, e.g. insect cells; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5156—Animal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A61K2039/55533—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins
    • A61K2039/55538—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/50—Cell markers; Cell surface determinants
    • C12N2501/515—CD3, T-cell receptor complex
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/99—Coculture with; Conditioned medium produced by genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2510/00—Genetically modified cells

Abstract

Un método para preparar una suspensión CD8 + para su uso en el tratamiento de un sujeto con cáncer que comprende: a. preparar una línea celular presentadora de antígenos no natural (nnAPC), donde dicha nnAPC presenta de cuatro a diez moléculas peptídicas diferentes asociadas con dicho cáncer simultáneamente donde dichas moléculas peptídicas tienen cada una aproximadamente de seis a doce aminoácidos de longitud; b. estimular las células CD8 + cosechadas a partir de dicho sujeto o donante adecuado con dicha línea celular nnAPC; c. añadir dichas células CD8 + a un medio que contiene una citoquina, seleccionada del grupo que consiste en IL-2, IL-7 o medio de crecimiento acondicionado (CGM), donde dichas citoquinas se pueden utilizar individualmente o combinadas; d. mezclar monocitos de sangre periférica no suspendidos, o alternativamente, monocitos de sangre periférica empobrecidos en CD8 recogidos de dicho sujeto o donante adecuado con aproximadamente 1 a 50 mug/ml de uno de dichos péptidos que dicha nnAPC presenta simultáneamente; e. irradiar dicha suspensión de monocitos de sangre periférica con una dosis suficiente de radiación gamma necesaria para evitar la proliferación de estas células en la suspensión, excepto los monocitos de sangre periférica deseados; f. aislar los monocitos de sangre periférica adherentes; g. cargar dichos monocitos de sangre periférica adherentes con aproximadamente 1 mg/ml a 50 mug/ml de cada uno de los péptidos mencionados; y h. combinar dichas células CD8 + con dichos monocitos de sangre periférica adherentes en una proporción de aproximadamente diez células CD8 + por monocito de sangre de periférica.
ES02742493T 2001-02-20 2002-02-19 Un metodo de terapia celular para tratamiento de tumores. Expired - Lifetime ES2306771T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27025201P 2001-02-20 2001-02-20

Publications (1)

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ES2306771T3 true ES2306771T3 (es) 2008-11-16

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ID=23030546

Family Applications (2)

Application Number Title Priority Date Filing Date
ES02742493T Expired - Lifetime ES2306771T3 (es) 2001-02-20 2002-02-19 Un metodo de terapia celular para tratamiento de tumores.
ES14187466.9T Expired - Lifetime ES2643582T3 (es) 2001-02-20 2002-02-19 Antígeno de Drosophila artificial que presenta célula para preparar suspensión de células CD8 para su uso en el tratamiento del cáncer

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ES14187466.9T Expired - Lifetime ES2643582T3 (es) 2001-02-20 2002-02-19 Antígeno de Drosophila artificial que presenta célula para preparar suspensión de células CD8 para su uso en el tratamiento del cáncer

Country Status (22)

Country Link
US (2) US20030077248A1 (es)
EP (3) EP2848255B1 (es)
JP (3) JP2006510567A (es)
KR (2) KR100971266B1 (es)
CN (1) CN1571834B (es)
AT (1) ATE396691T1 (es)
BR (1) BR0207399A (es)
CA (2) CA2438754C (es)
DE (1) DE60226853D1 (es)
DK (1) DK2016930T3 (es)
EA (1) EA013944B1 (es)
ES (2) ES2306771T3 (es)
HK (2) HK1058485A1 (es)
HU (1) HUP0402656A3 (es)
IL (3) IL157366A0 (es)
MX (1) MXPA03007503A (es)
NO (1) NO334885B1 (es)
NZ (1) NZ527683A (es)
PL (1) PL206976B1 (es)
PT (1) PT1377251E (es)
WO (1) WO2002065992A2 (es)
ZA (1) ZA200307327B (es)

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Publication number Publication date
NO334885B1 (no) 2014-06-30
CA2698079A1 (en) 2002-08-29
JP2006510567A (ja) 2006-03-30
JP2012097117A (ja) 2012-05-24
ES2643582T3 (es) 2017-11-23
WO2002065992A2 (en) 2002-08-29
EA013944B1 (ru) 2010-08-30
EP2016930A2 (en) 2009-01-21
IL219223B (en) 2018-05-31
IL157366A0 (en) 2004-02-19
NZ527683A (en) 2006-06-30
EP1377251B1 (en) 2008-05-28
DK2016930T3 (en) 2014-12-08
ZA200307327B (en) 2005-03-30
CN1571834B (zh) 2013-03-20
HUP0402656A2 (hu) 2005-03-29
NO20033674D0 (no) 2003-08-19
EP2016930B1 (en) 2014-10-15
PL206976B1 (pl) 2010-10-29
JP5634415B2 (ja) 2014-12-03
HK1208376A1 (en) 2016-03-04
US20030077248A1 (en) 2003-04-24
HUP0402656A3 (en) 2012-03-28
CA2438754C (en) 2014-10-07
PT1377251E (pt) 2008-08-05
BR0207399A (pt) 2004-10-26
EP2848255A1 (en) 2015-03-18
CA2698079C (en) 2015-01-13
US20090305418A1 (en) 2009-12-10
KR100971266B1 (ko) 2010-07-20
KR20030077029A (ko) 2003-09-29
KR20090061081A (ko) 2009-06-15
US9222071B2 (en) 2015-12-29
EA200300815A1 (ru) 2004-06-24
CN1571834A (zh) 2005-01-26
HK1058485A1 (en) 2004-05-21
EP2016930A3 (en) 2009-09-02
NO20033674L (no) 2003-10-17
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EP1377251A4 (en) 2006-01-11
MXPA03007503A (es) 2004-10-15
KR100962544B1 (ko) 2010-06-14
WO2002065992A3 (en) 2003-02-13
DE60226853D1 (de) 2008-07-10
ATE396691T1 (de) 2008-06-15
PL369971A1 (en) 2005-05-02
CA2438754A1 (en) 2002-08-29
EP2848255B1 (en) 2017-08-23
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