IL156351A0 - Method for producing the anticholinergic agent tiotropium bromide - Google Patents

Method for producing the anticholinergic agent tiotropium bromide

Info

Publication number
IL156351A0
IL156351A0 IL15635101A IL15635101A IL156351A0 IL 156351 A0 IL156351 A0 IL 156351A0 IL 15635101 A IL15635101 A IL 15635101A IL 15635101 A IL15635101 A IL 15635101A IL 156351 A0 IL156351 A0 IL 156351A0
Authority
IL
Israel
Prior art keywords
producing
tiotropium bromide
anticholinergic agent
agent tiotropium
anticholinergic
Prior art date
Application number
IL15635101A
Other languages
English (en)
Original Assignee
Boehringer Engelheim Pharma Gm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL156351(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Engelheim Pharma Gm filed Critical Boehringer Engelheim Pharma Gm
Publication of IL156351A0 publication Critical patent/IL156351A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL15635101A 2000-12-22 2001-12-12 Method for producing the anticholinergic agent tiotropium bromide IL156351A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums
PCT/EP2001/014566 WO2002051840A1 (de) 2000-12-22 2001-12-12 Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Publications (1)

Publication Number Publication Date
IL156351A0 true IL156351A0 (en) 2004-01-04

Family

ID=7668836

Family Applications (2)

Application Number Title Priority Date Filing Date
IL15635101A IL156351A0 (en) 2000-12-22 2001-12-12 Method for producing the anticholinergic agent tiotropium bromide
IL156351A IL156351A (en) 2000-12-22 2003-06-09 Method of producing the anticholinergic preparation tiotropium bromide

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL156351A IL156351A (en) 2000-12-22 2003-06-09 Method of producing the anticholinergic preparation tiotropium bromide

Country Status (42)

Country Link
US (1) US6486321B2 (zh)
EP (2) EP1426373B1 (zh)
JP (1) JP4198991B2 (zh)
KR (1) KR100853109B1 (zh)
CN (2) CN1244581C (zh)
AR (1) AR033599A1 (zh)
AT (2) ATE337314T1 (zh)
AU (1) AU2002229650B2 (zh)
BG (1) BG66373B1 (zh)
BR (1) BRPI0116444B8 (zh)
CA (1) CA2433518C (zh)
CY (1) CY1105210T1 (zh)
CZ (1) CZ294958B6 (zh)
DE (3) DE10064816A1 (zh)
DK (2) DK1426373T3 (zh)
EA (1) EA005533B1 (zh)
EC (1) ECSP034652A (zh)
EE (1) EE04495B1 (zh)
EG (1) EG23914A (zh)
ES (2) ES2221658T3 (zh)
HK (2) HK1060570A1 (zh)
HR (1) HRP20030502B1 (zh)
HU (1) HU230320B1 (zh)
IL (2) IL156351A0 (zh)
ME (1) MEP40608A (zh)
MX (1) MXPA03005426A (zh)
MY (1) MY129525A (zh)
NO (1) NO327739B1 (zh)
NZ (1) NZ527066A (zh)
PE (1) PE20020755A1 (zh)
PL (1) PL202478B1 (zh)
PT (2) PT1426373E (zh)
RS (1) RS50271B (zh)
SA (1) SA01220589B1 (zh)
SI (1) SI1345936T1 (zh)
SK (1) SK287318B6 (zh)
TR (1) TR200401127T4 (zh)
TW (1) TWI234564B (zh)
UA (1) UA74409C2 (zh)
UY (1) UY27079A1 (zh)
WO (1) WO2002051840A1 (zh)
ZA (1) ZA200304707B (zh)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
SI1292281T1 (en) * 2000-10-12 2004-12-31 Boehringer Ingelheim Pharma Novel tiotropium-containing inhalation powder
US6706726B2 (en) 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US6852728B2 (en) 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020137764A1 (en) 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
HUP0400333A3 (en) * 2001-06-22 2012-10-29 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of pharmaceutical composition
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
MXPA04009583A (es) * 2002-04-04 2005-01-11 Boehringer Ingelheim Pharma Nuevas formulaciones en polvo adecuadas para inhalacion.
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
WO2005042528A1 (de) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Neue tiotropiumsalze, verfahren zu deren herstellung sowie diese enthaltende arzneimittelformulierungen
JP5165244B2 (ja) 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング チオトロピウム塩の製法、チオトロピウム塩及びそれを含有する医薬組成物
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
BRPI0611091A2 (pt) * 2005-05-02 2010-08-03 Boehringer Ingelheim Int formas cristalinas de brometo de tiotrópico
NZ563596A (en) * 2005-05-02 2011-01-28 Boehringer Ingelheim Int Crystalline form of tiotropium bromide anhydrate
BRPI0611763A2 (pt) * 2005-06-15 2010-09-28 Boehringer Ingelheim Int processo para a preparação de sais de tiotrópio, sais de tiotrópio como tais e composições farmacêuticas dos mesmos
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
CN1316245C (zh) * 2005-07-28 2007-05-16 山东齐都药业有限公司 托烷司琼合成中残留中间体托品醇的检测方法
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
US8163913B2 (en) * 2005-12-19 2012-04-24 Sicor Inc. Forms of tiotropium bromide and processes for preparation thereof
JP2008530251A (ja) * 2005-12-19 2008-08-07 シコール インコーポレイティド 純粋且つ安定な臭化チオトロピウム
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100410254C (zh) * 2006-03-07 2008-08-13 南昌弘益科技有限公司 噻托溴铵无水物制备方法
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1882691A1 (en) * 2006-07-26 2008-01-30 CHIESI FARMACEUTICI S.p.A. Quinuclidine derivatives as M3 antagonists
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
CA2710523C (en) * 2008-01-10 2014-11-18 Generics [Uk] Limited Process for the preparation of scopine esters
AU2010280497B2 (en) 2009-08-07 2015-10-22 Generics [Uk] Limited Anhydrate of tiotropium bromide
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN101768158B (zh) * 2010-01-04 2013-05-29 南昌弘益科技有限公司 噻托溴铵无水物及其制备方法
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
HUE034540T2 (en) * 2011-12-22 2018-02-28 Cerbios Pharma Sa A continuous process for alkylating cyclic tertiary amines
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
CN105324106A (zh) 2013-04-01 2016-02-10 普马特里克斯营业公司 噻托铵干粉
WO2018055642A1 (en) * 2016-09-23 2018-03-29 Gbr Laboratories Pvt. Ltd. A process for preparing tiotropium bromide and intermediates thereof
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法

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US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions

Also Published As

Publication number Publication date
JP4198991B2 (ja) 2008-12-17
PE20020755A1 (es) 2002-09-24
US20020133010A1 (en) 2002-09-19
NO20032827D0 (no) 2003-06-20
TR200401127T4 (tr) 2004-07-21
CN1244581C (zh) 2006-03-08
US6486321B2 (en) 2002-11-26
CN1840529A (zh) 2006-10-04
JP2004525099A (ja) 2004-08-19
BRPI0116444B1 (pt) 2015-09-01
EA200300666A1 (ru) 2003-12-25
HK1060570A1 (en) 2004-08-13
PT1345936E (pt) 2004-09-30
CZ294958B6 (cs) 2005-04-13
HRP20030502B1 (en) 2011-09-30
YU50903A (sh) 2006-05-25
BG107910A (bg) 2004-02-27
EP1426373A1 (de) 2004-06-09
CN1481383A (zh) 2004-03-10
SA01220589B1 (ar) 2006-10-31
ATE337314T1 (de) 2006-09-15
ES2271722T3 (es) 2007-04-16
HUP0301457A3 (en) 2006-05-29
KR20030062439A (ko) 2003-07-25
DE50110835D1 (de) 2006-10-05
HRP20030502A2 (en) 2005-04-30
BRPI0116444B8 (pt) 2021-05-25
DE50102299D1 (de) 2004-06-17
CA2433518C (en) 2007-03-20
AR033599A1 (es) 2003-12-26
HUP0301457A2 (hu) 2003-10-28
HK1096683A1 (en) 2007-06-08
ECSP034652A (es) 2003-07-25
DK1426373T3 (da) 2006-12-18
SK9352003A3 (en) 2003-10-07
EP1345936A1 (de) 2003-09-24
RS50271B (sr) 2009-07-15
KR100853109B1 (ko) 2008-08-21
BR0116444A (pt) 2003-12-23
CN100393719C (zh) 2008-06-11
DE10064816A1 (de) 2002-06-27
EP1345936B1 (de) 2004-05-12
ES2221658T3 (es) 2005-01-01
BG66373B1 (bg) 2013-10-31
NO327739B1 (no) 2009-09-14
MEP40608A (en) 2011-02-10
EE200300309A (et) 2003-10-15
CZ20031685A3 (cs) 2003-10-15
NZ527066A (en) 2004-12-24
HU230320B1 (hu) 2016-01-28
PL361837A1 (en) 2004-10-04
EE04495B1 (et) 2005-06-15
SI1345936T1 (en) 2004-08-31
WO2002051840A1 (de) 2002-07-04
TWI234564B (en) 2005-06-21
CA2433518A1 (en) 2002-07-04
ATE266661T1 (de) 2004-05-15
DK1345936T3 (da) 2004-07-19
MXPA03005426A (es) 2005-04-20
MY129525A (en) 2007-04-30
NO20032827L (no) 2003-06-20
SK287318B6 (sk) 2010-07-07
EA005533B1 (ru) 2005-04-28
ZA200304707B (en) 2004-04-20
PL202478B1 (pl) 2009-06-30
IL156351A (en) 2011-09-27
UA74409C2 (uk) 2005-12-15
EP1426373B1 (de) 2006-08-23
CY1105210T1 (el) 2010-03-03
PT1426373E (pt) 2006-11-30
AU2002229650B2 (en) 2006-12-21
UY27079A1 (es) 2002-07-31
EG23914A (en) 2007-12-30

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