BR0116444A - Processo para a preparação de brometo de tiotrópio anticolinérgico - Google Patents

Processo para a preparação de brometo de tiotrópio anticolinérgico

Info

Publication number
BR0116444A
BR0116444A BR0116444-9A BR0116444A BR0116444A BR 0116444 A BR0116444 A BR 0116444A BR 0116444 A BR0116444 A BR 0116444A BR 0116444 A BR0116444 A BR 0116444A
Authority
BR
Brazil
Prior art keywords
preparation
tiotropium bromide
anticholinergic
anticholinergic tiotropium
bromide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BR0116444-9A
Other languages
English (en)
Other versions
BRPI0116444B1 (pt
BRPI0116444B8 (pt
Inventor
Rolf Bahnholzer
Manfred Graulich
Sven Luettke
Andreas Mathes
Helmut Meissner
Peter Specht
Wolfgang Broeder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0116444(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BR0116444A publication Critical patent/BR0116444A/pt
Publication of BRPI0116444B1 publication Critical patent/BRPI0116444B1/pt
Publication of BRPI0116444B8 publication Critical patent/BRPI0116444B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE BROMETO DE TIOTRóPIO ANTICOLINéRGICO". A invenção refere-se a um novo processo para a preparação de brometo de (l<244>2, <225>,4 <225>,a7 <225>,7-[hidroxidl-2-tienilacetil)óxi]-9,9-dimetil-3-oxa9-azoniatricicio[ 3.3.1 .0^ 2,4^ ]nonano.
BRPI0116444A 2000-12-22 2001-12-12 processo para a preparação de brometo de tiotrópio anticolinérgico, bem como uso de éster de tropenol como material de partida BRPI0116444B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums
PCT/EP2001/014566 WO2002051840A1 (de) 2000-12-22 2001-12-12 Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Publications (3)

Publication Number Publication Date
BR0116444A true BR0116444A (pt) 2003-12-23
BRPI0116444B1 BRPI0116444B1 (pt) 2015-09-01
BRPI0116444B8 BRPI0116444B8 (pt) 2021-05-25

Family

ID=7668836

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0116444A BRPI0116444B8 (pt) 2000-12-22 2001-12-12 processo para a preparação de brometo de tiotrópio anticolinérgico, bem como uso de éster de tropenol como material de partida

Country Status (42)

Country Link
US (1) US6486321B2 (pt)
EP (2) EP1426373B1 (pt)
JP (1) JP4198991B2 (pt)
KR (1) KR100853109B1 (pt)
CN (2) CN1244581C (pt)
AR (1) AR033599A1 (pt)
AT (2) ATE337314T1 (pt)
AU (1) AU2002229650B2 (pt)
BG (1) BG66373B1 (pt)
BR (1) BRPI0116444B8 (pt)
CA (1) CA2433518C (pt)
CY (1) CY1105210T1 (pt)
CZ (1) CZ294958B6 (pt)
DE (3) DE10064816A1 (pt)
DK (2) DK1426373T3 (pt)
EA (1) EA005533B1 (pt)
EC (1) ECSP034652A (pt)
EE (1) EE04495B1 (pt)
EG (1) EG23914A (pt)
ES (2) ES2271722T3 (pt)
HK (2) HK1060570A1 (pt)
HR (1) HRP20030502B1 (pt)
HU (1) HU230320B1 (pt)
IL (2) IL156351A0 (pt)
ME (1) MEP40608A (pt)
MX (1) MXPA03005426A (pt)
MY (1) MY129525A (pt)
NO (1) NO327739B1 (pt)
NZ (1) NZ527066A (pt)
PE (1) PE20020755A1 (pt)
PL (1) PL202478B1 (pt)
PT (2) PT1345936E (pt)
RS (1) RS50271B (pt)
SA (1) SA01220589B1 (pt)
SI (1) SI1345936T1 (pt)
SK (1) SK287318B6 (pt)
TR (1) TR200401127T4 (pt)
TW (1) TWI234564B (pt)
UA (1) UA74409C2 (pt)
UY (1) UY27079A1 (pt)
WO (1) WO2002051840A1 (pt)
ZA (1) ZA200304707B (pt)

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US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US6852728B2 (en) * 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
KR100971616B1 (ko) * 2001-06-22 2010-07-22 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 결정질 항콜린제, 이의 제조방법 및 이를 포함하는 약제학적 조성물
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DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
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US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
BR0308984A (pt) * 2002-04-04 2005-02-09 Boehringer Ingelheim Pharma Formulações em pó adequadas para inalação
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
WO2005042526A1 (de) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend
CN1875020B (zh) * 2003-11-03 2010-04-28 贝林格尔.英格海姆国际有限公司 新颖的噻托铵盐,其制备方法及其药物制剂
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RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
CA2611902C (en) * 2005-06-15 2013-08-27 Boehringer Ingelheim International Gmbh Tiotropium salts, compositions thereof, and processes for preparing same via tiotropium bicarbonate reacted with an acid
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
CN1316245C (zh) * 2005-07-28 2007-05-16 山东齐都药业有限公司 托烷司琼合成中残留中间体托品醇的检测方法
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DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
JP2008530251A (ja) * 2005-12-19 2008-08-07 シコール インコーポレイティド 純粋且つ安定な臭化チオトロピウム
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WO2009087419A1 (en) * 2008-01-10 2009-07-16 Generics [Uk] Limited Novel process for the preparation of scopine esters
CN102639531B (zh) 2009-08-07 2016-01-20 基因里克斯(英国)有限公司 噻托溴铵的无水合物
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
CN101768158B (zh) * 2010-01-04 2013-05-29 南昌弘益科技有限公司 噻托溴铵无水物及其制备方法
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
SI2607351T1 (sl) * 2011-12-22 2017-07-31 Cerbios-Pharma S.A. Neprekinjen proces za alkiliranje cikličnih terciarnih aminov
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KR20150135328A (ko) 2013-04-01 2015-12-02 풀매트릭스 인코퍼레이티드 티오트로피움 건조 분말
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WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate
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Also Published As

Publication number Publication date
ZA200304707B (en) 2004-04-20
EP1345936B1 (de) 2004-05-12
BRPI0116444B1 (pt) 2015-09-01
NO20032827L (no) 2003-06-20
SK287318B6 (sk) 2010-07-07
CZ294958B6 (cs) 2005-04-13
DE50102299D1 (de) 2004-06-17
NO327739B1 (no) 2009-09-14
PE20020755A1 (es) 2002-09-24
MEP40608A (en) 2011-02-10
ES2271722T3 (es) 2007-04-16
CN100393719C (zh) 2008-06-11
TR200401127T4 (tr) 2004-07-21
DE10064816A1 (de) 2002-06-27
WO2002051840A1 (de) 2002-07-04
UY27079A1 (es) 2002-07-31
EP1426373B1 (de) 2006-08-23
IL156351A0 (en) 2004-01-04
SK9352003A3 (en) 2003-10-07
MY129525A (en) 2007-04-30
DK1345936T3 (da) 2004-07-19
KR100853109B1 (ko) 2008-08-21
HRP20030502B1 (en) 2011-09-30
BRPI0116444B8 (pt) 2021-05-25
EE04495B1 (et) 2005-06-15
HUP0301457A2 (hu) 2003-10-28
IL156351A (en) 2011-09-27
AR033599A1 (es) 2003-12-26
CY1105210T1 (el) 2010-03-03
CA2433518A1 (en) 2002-07-04
RS50271B (sr) 2009-07-15
ES2221658T3 (es) 2005-01-01
CN1244581C (zh) 2006-03-08
SA01220589B1 (ar) 2006-10-31
EA200300666A1 (ru) 2003-12-25
CA2433518C (en) 2007-03-20
EP1426373A1 (de) 2004-06-09
HK1060570A1 (en) 2004-08-13
EG23914A (en) 2007-12-30
CZ20031685A3 (cs) 2003-10-15
TWI234564B (en) 2005-06-21
YU50903A (sh) 2006-05-25
ECSP034652A (es) 2003-07-25
US20020133010A1 (en) 2002-09-19
KR20030062439A (ko) 2003-07-25
EE200300309A (et) 2003-10-15
AU2002229650B2 (en) 2006-12-21
BG107910A (bg) 2004-02-27
JP2004525099A (ja) 2004-08-19
NO20032827D0 (no) 2003-06-20
PT1426373E (pt) 2006-11-30
UA74409C2 (uk) 2005-12-15
ATE266661T1 (de) 2004-05-15
EP1345936A1 (de) 2003-09-24
DK1426373T3 (da) 2006-12-18
NZ527066A (en) 2004-12-24
CN1481383A (zh) 2004-03-10
SI1345936T1 (en) 2004-08-31
HK1096683A1 (en) 2007-06-08
US6486321B2 (en) 2002-11-26
MXPA03005426A (es) 2005-04-20
PL361837A1 (en) 2004-10-04
EA005533B1 (ru) 2005-04-28
PT1345936E (pt) 2004-09-30
BG66373B1 (bg) 2013-10-31
HRP20030502A2 (en) 2005-04-30
PL202478B1 (pl) 2009-06-30
CN1840529A (zh) 2006-10-04
ATE337314T1 (de) 2006-09-15
DE50110835D1 (de) 2006-10-05
HU230320B1 (hu) 2016-01-28
JP4198991B2 (ja) 2008-12-17
HUP0301457A3 (en) 2006-05-29

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