NO20032827L - Fremgangsmate for fremstilling av det anticholinerge middel tiotropiumbromid - Google Patents

Fremgangsmate for fremstilling av det anticholinerge middel tiotropiumbromid

Info

Publication number
NO20032827L
NO20032827L NO20032827A NO20032827A NO20032827L NO 20032827 L NO20032827 L NO 20032827L NO 20032827 A NO20032827 A NO 20032827A NO 20032827 A NO20032827 A NO 20032827A NO 20032827 L NO20032827 L NO 20032827L
Authority
NO
Norway
Prior art keywords
anticholinergic
preparing
thiotropium bromide
thiotropium
bromide
Prior art date
Application number
NO20032827A
Other languages
English (en)
Other versions
NO327739B1 (no
NO20032827D0 (no
Inventor
Rolf Banholzer
Wolfgang Broeder
Manfred Graulich
Sven Luettke
Andreas Mathes
Helmut Meissner
Peter Specht
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20032827(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of NO20032827L publication Critical patent/NO20032827L/no
Publication of NO20032827D0 publication Critical patent/NO20032827D0/no
Publication of NO327739B1 publication Critical patent/NO327739B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20032827A 2000-12-22 2003-06-20 Fremgangsmate for fremstilling av tiotropiumbromid NO327739B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums
PCT/EP2001/014566 WO2002051840A1 (de) 2000-12-22 2001-12-12 Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Publications (3)

Publication Number Publication Date
NO20032827L true NO20032827L (no) 2003-06-20
NO20032827D0 NO20032827D0 (no) 2003-06-20
NO327739B1 NO327739B1 (no) 2009-09-14

Family

ID=7668836

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20032827A NO327739B1 (no) 2000-12-22 2003-06-20 Fremgangsmate for fremstilling av tiotropiumbromid

Country Status (42)

Country Link
US (1) US6486321B2 (no)
EP (2) EP1426373B1 (no)
JP (1) JP4198991B2 (no)
KR (1) KR100853109B1 (no)
CN (2) CN1244581C (no)
AR (1) AR033599A1 (no)
AT (2) ATE337314T1 (no)
AU (1) AU2002229650B2 (no)
BG (1) BG66373B1 (no)
BR (1) BRPI0116444B8 (no)
CA (1) CA2433518C (no)
CY (1) CY1105210T1 (no)
CZ (1) CZ294958B6 (no)
DE (3) DE10064816A1 (no)
DK (2) DK1426373T3 (no)
EA (1) EA005533B1 (no)
EC (1) ECSP034652A (no)
EE (1) EE04495B1 (no)
EG (1) EG23914A (no)
ES (2) ES2221658T3 (no)
HK (2) HK1060570A1 (no)
HR (1) HRP20030502B1 (no)
HU (1) HU230320B1 (no)
IL (2) IL156351A0 (no)
ME (1) MEP40608A (no)
MX (1) MXPA03005426A (no)
MY (1) MY129525A (no)
NO (1) NO327739B1 (no)
NZ (1) NZ527066A (no)
PE (1) PE20020755A1 (no)
PL (1) PL202478B1 (no)
PT (2) PT1345936E (no)
RS (1) RS50271B (no)
SA (1) SA01220589B1 (no)
SI (1) SI1345936T1 (no)
SK (1) SK287318B6 (no)
TR (1) TR200401127T4 (no)
TW (1) TWI234564B (no)
UA (1) UA74409C2 (no)
UY (1) UY27079A1 (no)
WO (1) WO2002051840A1 (no)
ZA (1) ZA200304707B (no)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
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BR0107304A (pt) * 2000-10-12 2002-08-13 Boehringer Ingelheim Pharma Pó para inalação contendo tiotrópio
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
US6852728B2 (en) * 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
EE05316B1 (et) * 2001-06-22 2010-08-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Kristalliline antikolinergikum, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
AU2003221531B2 (en) * 2002-04-04 2008-10-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations suitable for inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
EP2083007B1 (de) * 2003-11-03 2013-04-24 Boehringer Ingelheim International Gmbh Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
CN101407514B (zh) * 2003-11-03 2013-05-29 贝林格尔.英格海姆国际有限公司 噻托铵盐、包含噻托铵盐的药物制剂及其用途
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
EP1879888A2 (en) * 2005-05-02 2008-01-23 Boehringer Ingelheim International GmbH Crystalline forms of tiotropium bromide
DK1881980T3 (da) 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
BRPI0611763A2 (pt) * 2005-06-15 2010-09-28 Boehringer Ingelheim Int processo para a preparação de sais de tiotrópio, sais de tiotrópio como tais e composições farmacêuticas dos mesmos
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
CN1316245C (zh) * 2005-07-28 2007-05-16 山东齐都药业有限公司 托烷司琼合成中残留中间体托品醇的检测方法
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
CN102731494A (zh) * 2005-12-19 2012-10-17 西科尔公司 噻托溴铵的新形式及其制备方法
WO2007075838A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Pure and stable tiotropium bromide
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
CN100410254C (zh) * 2006-03-07 2008-08-13 南昌弘益科技有限公司 噻托溴铵无水物制备方法
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1882691A1 (en) * 2006-07-26 2008-01-30 CHIESI FARMACEUTICI S.p.A. Quinuclidine derivatives as M3 antagonists
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
WO2009087419A1 (en) * 2008-01-10 2009-07-16 Generics [Uk] Limited Novel process for the preparation of scopine esters
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
AU2010280497B2 (en) 2009-08-07 2015-10-22 Generics [Uk] Limited Anhydrate of tiotropium bromide
CN101768158B (zh) * 2010-01-04 2013-05-29 南昌弘益科技有限公司 噻托溴铵无水物及其制备方法
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
RS55996B1 (sr) * 2011-12-22 2017-09-29 Cerbios-Pharma S A Kontinuirani postupak za alkilaciju cikličnih tercijarnih amina
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
JP6473738B2 (ja) 2013-04-01 2019-02-20 パルマトリックス，インコーポレイテッド チオトロピウム乾燥粉末
WO2018055642A1 (en) * 2016-09-23 2018-03-29 Gbr Laboratories Pvt. Ltd. A process for preparing tiotropium bromide and intermediates thereof
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法

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US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions

Also Published As

Publication number Publication date
ECSP034652A (es) 2003-07-25
HUP0301457A2 (hu) 2003-10-28
DK1426373T3 (da) 2006-12-18
MEP40608A (en) 2011-02-10
MXPA03005426A (es) 2005-04-20
EP1345936A1 (de) 2003-09-24
US20020133010A1 (en) 2002-09-19
HK1060570A1 (en) 2004-08-13
ES2271722T3 (es) 2007-04-16
JP2004525099A (ja) 2004-08-19
BRPI0116444B8 (pt) 2021-05-25
EP1426373A1 (de) 2004-06-09
TWI234564B (en) 2005-06-21
HRP20030502B1 (en) 2011-09-30
MY129525A (en) 2007-04-30
UA74409C2 (uk) 2005-12-15
UY27079A1 (es) 2002-07-31
TR200401127T4 (tr) 2004-07-21
CA2433518C (en) 2007-03-20
CZ294958B6 (cs) 2005-04-13
HRP20030502A2 (en) 2005-04-30
BG107910A (bg) 2004-02-27
CN1244581C (zh) 2006-03-08
HUP0301457A3 (en) 2006-05-29
SA01220589B1 (ar) 2006-10-31
CN100393719C (zh) 2008-06-11
KR100853109B1 (ko) 2008-08-21
HU230320B1 (hu) 2016-01-28
EE200300309A (et) 2003-10-15
CZ20031685A3 (cs) 2003-10-15
IL156351A (en) 2011-09-27
ATE266661T1 (de) 2004-05-15
EG23914A (en) 2007-12-30
PT1345936E (pt) 2004-09-30
KR20030062439A (ko) 2003-07-25
EA005533B1 (ru) 2005-04-28
EP1345936B1 (de) 2004-05-12
SI1345936T1 (en) 2004-08-31
PT1426373E (pt) 2006-11-30
CY1105210T1 (el) 2010-03-03
CA2433518A1 (en) 2002-07-04
WO2002051840A1 (de) 2002-07-04
AU2002229650B2 (en) 2006-12-21
CN1481383A (zh) 2004-03-10
EP1426373B1 (de) 2006-08-23
HK1096683A1 (en) 2007-06-08
DE10064816A1 (de) 2002-06-27
EE04495B1 (et) 2005-06-15
RS50271B (sr) 2009-07-15
SK287318B6 (sk) 2010-07-07
ATE337314T1 (de) 2006-09-15
CN1840529A (zh) 2006-10-04
YU50903A (sh) 2006-05-25
AR033599A1 (es) 2003-12-26
EA200300666A1 (ru) 2003-12-25
PE20020755A1 (es) 2002-09-24
BR0116444A (pt) 2003-12-23
PL202478B1 (pl) 2009-06-30
DE50102299D1 (de) 2004-06-17
NZ527066A (en) 2004-12-24
SK9352003A3 (en) 2003-10-07
IL156351A0 (en) 2004-01-04
ES2221658T3 (es) 2005-01-01
BG66373B1 (bg) 2013-10-31
BRPI0116444B1 (pt) 2015-09-01
JP4198991B2 (ja) 2008-12-17
US6486321B2 (en) 2002-11-26
DK1345936T3 (da) 2004-07-19
PL361837A1 (en) 2004-10-04
DE50110835D1 (de) 2006-10-05
NO327739B1 (no) 2009-09-14
NO20032827D0 (no) 2003-06-20
ZA200304707B (en) 2004-04-20

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