DK1345936T3 - Fremgangsmåde til fremstilling af anticholinergikummet tiotropiumbromid - Google Patents

Fremgangsmåde til fremstilling af anticholinergikummet tiotropiumbromid

Info

Publication number
DK1345936T3
DK1345936T3 DK01990546T DK01990546T DK1345936T3 DK 1345936 T3 DK1345936 T3 DK 1345936T3 DK 01990546 T DK01990546 T DK 01990546T DK 01990546 T DK01990546 T DK 01990546T DK 1345936 T3 DK1345936 T3 DK 1345936T3
Authority
DK
Denmark
Prior art keywords
preparation
tiotropium bromide
anticholinergic
anticholinergic tiotropium
bromide
Prior art date
Application number
DK01990546T
Other languages
English (en)
Inventor
Rolf Banholzer
Manfred Graulich
Sven Luettke
Andreas Mathes
Helmut Meissner
Peter Specht
Wolfgang Broeder
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1345936(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Application granted granted Critical
Publication of DK1345936T3 publication Critical patent/DK1345936T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DK01990546T 2000-12-22 2001-12-12 Fremgangsmåde til fremstilling af anticholinergikummet tiotropiumbromid DK1345936T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums

Publications (1)

Publication Number Publication Date
DK1345936T3 true DK1345936T3 (da) 2004-07-19

Family

ID=7668836

Family Applications (2)

Application Number Title Priority Date Filing Date
DK01990546T DK1345936T3 (da) 2000-12-22 2001-12-12 Fremgangsmåde til fremstilling af anticholinergikummet tiotropiumbromid
DK04005241T DK1426373T3 (da) 2000-12-22 2001-12-12 Fremgangsmåde til fremstilling af en precursor for anticholinergikummet tiotropiumbromid

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK04005241T DK1426373T3 (da) 2000-12-22 2001-12-12 Fremgangsmåde til fremstilling af en precursor for anticholinergikummet tiotropiumbromid

Country Status (42)

Country Link
US (1) US6486321B2 (da)
EP (2) EP1426373B1 (da)
JP (1) JP4198991B2 (da)
KR (1) KR100853109B1 (da)
CN (2) CN100393719C (da)
AR (1) AR033599A1 (da)
AT (2) ATE337314T1 (da)
AU (1) AU2002229650B2 (da)
BG (1) BG66373B1 (da)
BR (1) BRPI0116444B8 (da)
CA (1) CA2433518C (da)
CY (1) CY1105210T1 (da)
CZ (1) CZ294958B6 (da)
DE (3) DE10064816A1 (da)
DK (2) DK1345936T3 (da)
EA (1) EA005533B1 (da)
EC (1) ECSP034652A (da)
EE (1) EE04495B1 (da)
EG (1) EG23914A (da)
ES (2) ES2271722T3 (da)
HK (2) HK1060570A1 (da)
HR (1) HRP20030502B1 (da)
HU (1) HU230320B1 (da)
IL (2) IL156351A0 (da)
ME (1) MEP40608A (da)
MX (1) MXPA03005426A (da)
MY (1) MY129525A (da)
NO (1) NO327739B1 (da)
NZ (1) NZ527066A (da)
PE (1) PE20020755A1 (da)
PL (1) PL202478B1 (da)
PT (2) PT1426373E (da)
RS (1) RS50271B (da)
SA (1) SA01220589B1 (da)
SI (1) SI1345936T1 (da)
SK (1) SK287318B6 (da)
TR (1) TR200401127T4 (da)
TW (1) TWI234564B (da)
UA (1) UA74409C2 (da)
UY (1) UY27079A1 (da)
WO (1) WO2002051840A1 (da)
ZA (1) ZA200304707B (da)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6908928B2 (en) 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
BR0107304A (pt) * 2000-10-12 2002-08-13 Boehringer Ingelheim Pharma Pó para inalação contendo tiotrópio
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US6852728B2 (en) 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
DK1401445T3 (da) * 2001-06-22 2006-11-27 Boehringer Ingelheim Pharma Krystallinsk anticholinergikum, fremgangsmåde til fremstilling af dette og anvendelse af dette til fremstilling af et lægemiddel
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
EP1494648B1 (en) * 2002-04-04 2006-09-20 Boehringer Ingelheim Pharma GmbH & Co.KG Powder formulations suitable for inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
JP5165245B2 (ja) * 2003-11-03 2013-03-21 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なチオトロピウム塩、その製造方法及びチオトロピウム塩を含有する医薬組成物
WO2005042526A1 (de) * 2003-11-03 2005-05-12 Boehringer Ingelheim International Gmbh Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
KR20080007656A (ko) * 2005-05-02 2008-01-22 베링거 인겔하임 인터내셔날 게엠베하 티오트로피움 브로마이드의 신규한 결정질 형태
CA2606549A1 (en) * 2005-05-02 2006-11-09 Boehringer Ingelheim International Gmbh Crystalline forms of tiotropium bromide
EP1896026B1 (en) * 2005-06-15 2013-10-09 Boehringer Ingelheim International GmbH Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
CN1316245C (zh) * 2005-07-28 2007-05-16 山东齐都药业有限公司 托烷司琼合成中残留中间体托品醇的检测方法
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
JP2008530251A (ja) * 2005-12-19 2008-08-07 シコール インコーポレイティド 純粋且つ安定な臭化チオトロピウム
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
ATE552256T1 (de) * 2005-12-19 2012-04-15 Sicor Inc Neuartige form von tiotropium-bromid und herstellungsverfahren dafür
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
CN100410254C (zh) * 2006-03-07 2008-08-13 南昌弘益科技有限公司 噻托溴铵无水物制备方法
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1882691A1 (en) * 2006-07-26 2008-01-30 CHIESI FARMACEUTICI S.p.A. Quinuclidine derivatives as M3 antagonists
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
CN105601628A (zh) * 2008-01-10 2016-05-25 基因里克斯(英国)有限公司 用于制备东莨菪醇酯的方法
WO2011015884A1 (en) * 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
NZ624602A (en) 2009-08-07 2015-11-27 Generics Uk Ltd Anhydrate of tiotropium bromide
CN101768158B (zh) * 2010-01-04 2013-05-29 南昌弘益科技有限公司 噻托溴铵无水物及其制备方法
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
LT2607351T (lt) * 2011-12-22 2017-06-12 Cerbios-Pharma S.A. Ciklinių tretinių aminų nepertraukiamo alkilinimo būdas
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
EP2981247B1 (en) 2013-04-01 2023-06-07 Pulmatrix Operating Company, Inc. Tiotropium dry powders
WO2018055642A1 (en) * 2016-09-23 2018-03-29 Gbr Laboratories Pvt. Ltd. A process for preparing tiotropium bromide and intermediates thereof
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions

Also Published As

Publication number Publication date
IL156351A0 (en) 2004-01-04
CY1105210T1 (el) 2010-03-03
CN1481383A (zh) 2004-03-10
PL202478B1 (pl) 2009-06-30
PE20020755A1 (es) 2002-09-24
SI1345936T1 (en) 2004-08-31
EP1426373B1 (de) 2006-08-23
BRPI0116444B1 (pt) 2015-09-01
NO327739B1 (no) 2009-09-14
US6486321B2 (en) 2002-11-26
EA200300666A1 (ru) 2003-12-25
PT1345936E (pt) 2004-09-30
CZ294958B6 (cs) 2005-04-13
UA74409C2 (uk) 2005-12-15
HRP20030502A2 (en) 2005-04-30
CA2433518A1 (en) 2002-07-04
ATE337314T1 (de) 2006-09-15
CZ20031685A3 (cs) 2003-10-15
SK9352003A3 (en) 2003-10-07
EE04495B1 (et) 2005-06-15
JP4198991B2 (ja) 2008-12-17
MXPA03005426A (es) 2005-04-20
BG66373B1 (bg) 2013-10-31
AU2002229650B2 (en) 2006-12-21
YU50903A (sh) 2006-05-25
EA005533B1 (ru) 2005-04-28
TWI234564B (en) 2005-06-21
ES2271722T3 (es) 2007-04-16
MY129525A (en) 2007-04-30
KR20030062439A (ko) 2003-07-25
BR0116444A (pt) 2003-12-23
NO20032827L (no) 2003-06-20
SK287318B6 (sk) 2010-07-07
HU230320B1 (hu) 2016-01-28
DE50110835D1 (de) 2006-10-05
AR033599A1 (es) 2003-12-26
PT1426373E (pt) 2006-11-30
HK1060570A1 (en) 2004-08-13
CN100393719C (zh) 2008-06-11
HUP0301457A3 (en) 2006-05-29
BRPI0116444B8 (pt) 2021-05-25
ECSP034652A (es) 2003-07-25
ES2221658T3 (es) 2005-01-01
EP1345936B1 (de) 2004-05-12
EP1426373A1 (de) 2004-06-09
NO20032827D0 (no) 2003-06-20
JP2004525099A (ja) 2004-08-19
DK1426373T3 (da) 2006-12-18
HRP20030502B1 (en) 2011-09-30
CA2433518C (en) 2007-03-20
MEP40608A (en) 2011-02-10
ATE266661T1 (de) 2004-05-15
TR200401127T4 (tr) 2004-07-21
HUP0301457A2 (hu) 2003-10-28
DE10064816A1 (de) 2002-06-27
CN1840529A (zh) 2006-10-04
BG107910A (bg) 2004-02-27
US20020133010A1 (en) 2002-09-19
PL361837A1 (en) 2004-10-04
RS50271B (sr) 2009-07-15
DE50102299D1 (de) 2004-06-17
KR100853109B1 (ko) 2008-08-21
NZ527066A (en) 2004-12-24
WO2002051840A1 (de) 2002-07-04
ZA200304707B (en) 2004-04-20
EE200300309A (et) 2003-10-15
CN1244581C (zh) 2006-03-08
UY27079A1 (es) 2002-07-31
EG23914A (en) 2007-12-30
HK1096683A1 (en) 2007-06-08
EP1345936A1 (de) 2003-09-24
IL156351A (en) 2011-09-27
SA01220589B1 (ar) 2006-10-31

Similar Documents

Publication Publication Date Title
DK1345936T3 (da) Fremgangsmåde til fremstilling af anticholinergikummet tiotropiumbromid
DK1296935T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1296656T3 (da) Fremgangsmåde til fremstilling af et præparat
DK1326862T3 (da) Krystallinsk monohydrat af tiotropiumbromid, fremgangsmåde til fremstilling deraf og anvendelse deraf til fremstilling af et lægemiddel
DK1303478T3 (da) Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1309545T3 (da) Fremgangsmåde til fremstilling af alkylarylsulfonater
DK1309582T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1349580T4 (da) Fremgangsmåde til forbedring af stabiliteten af en farmaceutisk sammensætning
DK1345939T3 (da) Fremgangsmåde til fremstilling af sulfonamidsubstituerede imidazotriazinoner
DK1272489T3 (da) Fremgangsmåde til præparation af cabergolins krystallinske form I
DK1187833T3 (da) Fremgangsmåde til fremstilling af thiamethoxam
DK1808435T3 (da) Teknisk fremstilling af tiotropiumbromid
DK1296970T3 (da) Fremgangsmåde til fremstilling af citalopram
DK1682541T3 (da) Fremgangsmåde til fremstilling af tiotropiumsalte
DK1326836T3 (da) Fremgangsmåde til fremstilling af 3-amino-2-chlor-4-methylpyridin
DK1292586T3 (da) Fremgangsmåde til fremstilling af pyrazolopyrimidinoner
DK1294694T3 (da) Fremgangsmåde til fremstilling af quinolinderivater
NO20030515L (no) Fremgangsmåte for fremstilling av dinapsolin
NO20025465D0 (no) FremgangsmÕte for fremstilling av bifenylforbindelser
NO20024887L (no) FremgangsmÕte for fremstilling av benzokondenserte heterosykliske forbindelser
NO20023702D0 (no) Fremgangsmåte for fremstilling av 5-arylnikotinaldehyder
DK1282598T3 (da) Fremgangsmåde til fremstilling af sulfonyl-benzoylguanidiniumsalte
DK1274684T3 (da) Fremgangsmåde til fremstilling af aryl-pyridinylforbindelser
DK1399437T3 (da) Fremgangsmåde til fremstilling af triazolylmethyloxiraner
DK1395579T3 (da) Fremgangsmåde til fremstilling af triazolylmethyloxiraner