AR033599A1 - Procedimiento para la preparacion de bromuro de tiotropio y uso del tropenol y del ester tropenolico como materiales de partida para la preparacion del bromuro de tiotropio - Google Patents

Procedimiento para la preparacion de bromuro de tiotropio y uso del tropenol y del ester tropenolico como materiales de partida para la preparacion del bromuro de tiotropio

Info

Publication number
AR033599A1
AR033599A1 ARP010105885A ARP010105885A AR033599A1 AR 033599 A1 AR033599 A1 AR 033599A1 AR P010105885 A ARP010105885 A AR P010105885A AR P010105885 A ARP010105885 A AR P010105885A AR 033599 A1 AR033599 A1 AR 033599A1
Authority
AR
Argentina
Prior art keywords
bromide
preparation
tiotropio
formula
tropenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ARP010105885A
Other languages
English (en)
Inventor
Banholzer Rolf Dr
Luettke Sven Dr
Andreas Mathes
Helmut Meissner
Peter Specht
Broeder Wolfgang Dr
Manfred Graulich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR033599(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of AR033599A1 publication Critical patent/AR033599A1/es
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)

Abstract

Un procedimiento para la preparacion de bromuro de tiotropio de formula (1) en el cual el éster tropenolico de formula (2) se oxida para formar el éster escopínico de formula (3) y éste, mediante bromuro de metilo, se cuaterniza para dar bromuro de tiotropio de formula (1). También se describe el uso del tropenol de formula (4) y del éster tropenolico de formula (2), eventualmente en forma de sus sales por adicion de ácidos, como materiales de partida para la preparacion del bromuro de tiotropio de formula (1). Este procedimiento de síntesis para la preparacion de bromuro de tiotropio garantiza la puesta a disposicion del producto, no solo con un buen rendimiento, sino, en particular, con una extraordinaria pureza.
ARP010105885A 2000-12-22 2001-12-19 Procedimiento para la preparacion de bromuro de tiotropio y uso del tropenol y del ester tropenolico como materiales de partida para la preparacion del bromuro de tiotropio Pending AR033599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums

Publications (1)

Publication Number Publication Date
AR033599A1 true AR033599A1 (es) 2003-12-26

Family

ID=7668836

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105885A Pending AR033599A1 (es) 2000-12-22 2001-12-19 Procedimiento para la preparacion de bromuro de tiotropio y uso del tropenol y del ester tropenolico como materiales de partida para la preparacion del bromuro de tiotropio

Country Status (42)

Country Link
US (1) US6486321B2 (es)
EP (2) EP1426373B1 (es)
JP (1) JP4198991B2 (es)
KR (1) KR100853109B1 (es)
CN (2) CN100393719C (es)
AR (1) AR033599A1 (es)
AT (2) ATE266661T1 (es)
AU (1) AU2002229650B2 (es)
BG (1) BG66373B1 (es)
BR (1) BRPI0116444B8 (es)
CA (1) CA2433518C (es)
CY (1) CY1105210T1 (es)
CZ (1) CZ294958B6 (es)
DE (3) DE10064816A1 (es)
DK (2) DK1345936T3 (es)
EA (1) EA005533B1 (es)
EC (1) ECSP034652A (es)
EE (1) EE04495B1 (es)
EG (1) EG23914A (es)
ES (2) ES2271722T3 (es)
HK (2) HK1060570A1 (es)
HR (1) HRP20030502B1 (es)
HU (1) HU230320B1 (es)
IL (2) IL156351A0 (es)
ME (1) MEP40608A (es)
MX (1) MXPA03005426A (es)
MY (1) MY129525A (es)
NO (1) NO327739B1 (es)
NZ (1) NZ527066A (es)
PE (1) PE20020755A1 (es)
PL (1) PL202478B1 (es)
PT (2) PT1345936E (es)
RS (1) RS50271B (es)
SA (1) SA01220589B1 (es)
SI (1) SI1345936T1 (es)
SK (1) SK287318B6 (es)
TR (1) TR200401127T4 (es)
TW (1) TWI234564B (es)
UA (1) UA74409C2 (es)
UY (1) UY27079A1 (es)
WO (1) WO2002051840A1 (es)
ZA (1) ZA200304707B (es)

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US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
SI1682541T1 (sl) * 2003-11-03 2010-06-30 Boehringer Ingelheim Int Postopek za pripravo tiotropijevih soli
EP2083007B1 (de) * 2003-11-03 2013-04-24 Boehringer Ingelheim International Gmbh Tiotropiumsalze, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittelformulierungen
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JP5822831B2 (ja) 2009-08-07 2015-11-24 ジェネリクス・［ユーケー］・リミテッド チオトロピウム臭化物の無水物
CN101768158B (zh) * 2010-01-04 2013-05-29 南昌弘益科技有限公司 噻托溴铵无水物及其制备方法
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
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Also Published As

Publication number Publication date
HUP0301457A3 (en) 2006-05-29
EA200300666A1 (ru) 2003-12-25
SK9352003A3 (en) 2003-10-07
ES2271722T3 (es) 2007-04-16
UY27079A1 (es) 2002-07-31
HU230320B1 (hu) 2016-01-28
HK1060570A1 (en) 2004-08-13
NO20032827D0 (no) 2003-06-20
PL202478B1 (pl) 2009-06-30
MEP40608A (en) 2011-02-10
KR20030062439A (ko) 2003-07-25
CN1481383A (zh) 2004-03-10
CY1105210T1 (el) 2010-03-03
MXPA03005426A (es) 2005-04-20
HK1096683A1 (en) 2007-06-08
ZA200304707B (en) 2004-04-20
ATE266661T1 (de) 2004-05-15
EG23914A (en) 2007-12-30
PT1426373E (pt) 2006-11-30
KR100853109B1 (ko) 2008-08-21
CZ20031685A3 (cs) 2003-10-15
EP1345936A1 (de) 2003-09-24
EP1345936B1 (de) 2004-05-12
HUP0301457A2 (hu) 2003-10-28
BG107910A (bg) 2004-02-27
NO20032827L (no) 2003-06-20
SK287318B6 (sk) 2010-07-07
JP4198991B2 (ja) 2008-12-17
AU2002229650B2 (en) 2006-12-21
BRPI0116444B8 (pt) 2021-05-25
YU50903A (sh) 2006-05-25
US20020133010A1 (en) 2002-09-19
WO2002051840A1 (de) 2002-07-04
CN1244581C (zh) 2006-03-08
CZ294958B6 (cs) 2005-04-13
EA005533B1 (ru) 2005-04-28
CN100393719C (zh) 2008-06-11
EP1426373A1 (de) 2004-06-09
HRP20030502A2 (en) 2005-04-30
TWI234564B (en) 2005-06-21
EP1426373B1 (de) 2006-08-23
TR200401127T4 (tr) 2004-07-21
US6486321B2 (en) 2002-11-26
PT1345936E (pt) 2004-09-30
ECSP034652A (es) 2003-07-25
PL361837A1 (en) 2004-10-04
CA2433518A1 (en) 2002-07-04
BR0116444A (pt) 2003-12-23
NO327739B1 (no) 2009-09-14
CN1840529A (zh) 2006-10-04
RS50271B (sr) 2009-07-15
EE200300309A (et) 2003-10-15
SI1345936T1 (en) 2004-08-31
DE10064816A1 (de) 2002-06-27
ES2221658T3 (es) 2005-01-01
PE20020755A1 (es) 2002-09-24
UA74409C2 (uk) 2005-12-15
EE04495B1 (et) 2005-06-15
IL156351A0 (en) 2004-01-04
HRP20030502B1 (en) 2011-09-30
JP2004525099A (ja) 2004-08-19
DE50102299D1 (de) 2004-06-17
CA2433518C (en) 2007-03-20
DK1426373T3 (da) 2006-12-18
NZ527066A (en) 2004-12-24
IL156351A (en) 2011-09-27
ATE337314T1 (de) 2006-09-15
DE50110835D1 (de) 2006-10-05
SA01220589B1 (ar) 2006-10-31
BRPI0116444B1 (pt) 2015-09-01
BG66373B1 (bg) 2013-10-31
DK1345936T3 (da) 2004-07-19
MY129525A (en) 2007-04-30

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TH74207EX (th) โต๊ะ
TH18349S1 (th) ภาชนะบรรจุ
TH62750S (th) ภาชนะบรรจุ
TH66665S (th) ผนังสำเร็จรูป
TH20180S1 (th) ผนังสำเร็จรูป
TH51341EX (th) โต๊ะ
TH54742EX (th) ถังตกตะกอน
TH43636EX (th) ตัวกระจายน้ำสำหรับหัวจ่ายน้ำ
TH43635EX (th) หัวจ่ายน้ำ
TH45946EX (th) อิฐ
TH57256EX (th) เก้าอี้
TH50652EX (th) โคมไฟตั้งโต๊ะ

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