SI1345936T1 - Method for producing the anticholinergic agent tiotropium bromide - Google Patents

Method for producing the anticholinergic agent tiotropium bromide

Info

Publication number
SI1345936T1
SI1345936T1 SI200130096T SI200130096T SI1345936T1 SI 1345936 T1 SI1345936 T1 SI 1345936T1 SI 200130096 T SI200130096 T SI 200130096T SI 200130096 T SI200130096 T SI 200130096T SI 1345936 T1 SI1345936 T1 SI 1345936T1
Authority
SI
Slovenia
Prior art keywords
producing
tiotropium bromide
anticholinergic agent
agent tiotropium
anticholinergic
Prior art date
Application number
SI200130096T
Other languages
English (en)
Slovenian (sl)
Inventor
Rolf Banholzer
Manfred Graulich
Sven Luettke
Andreas Mathes
Helmut Meissner
Peter Specht
Wolfgang Broeder
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7668836&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1345936(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg
Publication of SI1345936T1 publication Critical patent/SI1345936T1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
SI200130096T 2000-12-22 2001-12-12 Method for producing the anticholinergic agent tiotropium bromide SI1345936T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10064816A DE10064816A1 (de) 2000-12-22 2000-12-22 Verfahren zur Herstellung eines Anticholinergikums
PCT/EP2001/014566 WO2002051840A1 (de) 2000-12-22 2001-12-12 Verfahren zur herstellung des anticholinergikums tiotropiumbromid
EP01990546A EP1345936B1 (de) 2000-12-22 2001-12-12 Verfahren zur herstellung des anticholinergikums tiotropiumbromid

Publications (1)

Publication Number Publication Date
SI1345936T1 true SI1345936T1 (en) 2004-08-31

Family

ID=7668836

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130096T SI1345936T1 (en) 2000-12-22 2001-12-12 Method for producing the anticholinergic agent tiotropium bromide

Country Status (42)

Country Link
US (1) US6486321B2 (zh)
EP (2) EP1426373B1 (zh)
JP (1) JP4198991B2 (zh)
KR (1) KR100853109B1 (zh)
CN (2) CN1244581C (zh)
AR (1) AR033599A1 (zh)
AT (2) ATE337314T1 (zh)
AU (1) AU2002229650B2 (zh)
BG (1) BG66373B1 (zh)
BR (1) BRPI0116444B8 (zh)
CA (1) CA2433518C (zh)
CY (1) CY1105210T1 (zh)
CZ (1) CZ294958B6 (zh)
DE (3) DE10064816A1 (zh)
DK (2) DK1426373T3 (zh)
EA (1) EA005533B1 (zh)
EC (1) ECSP034652A (zh)
EE (1) EE04495B1 (zh)
EG (1) EG23914A (zh)
ES (2) ES2271722T3 (zh)
HK (2) HK1060570A1 (zh)
HR (1) HRP20030502B1 (zh)
HU (1) HU230320B1 (zh)
IL (2) IL156351A0 (zh)
ME (1) MEP40608A (zh)
MX (1) MXPA03005426A (zh)
MY (1) MY129525A (zh)
NO (1) NO327739B1 (zh)
NZ (1) NZ527066A (zh)
PE (1) PE20020755A1 (zh)
PL (1) PL202478B1 (zh)
PT (2) PT1345936E (zh)
RS (1) RS50271B (zh)
SA (1) SA01220589B1 (zh)
SI (1) SI1345936T1 (zh)
SK (1) SK287318B6 (zh)
TR (1) TR200401127T4 (zh)
TW (1) TWI234564B (zh)
UA (1) UA74409C2 (zh)
UY (1) UY27079A1 (zh)
WO (1) WO2002051840A1 (zh)
ZA (1) ZA200304707B (zh)

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US6852728B2 (en) 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020111363A1 (en) * 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
US20030013675A1 (en) * 2001-05-25 2003-01-16 Boehringer Ingelheim Pharma Kg Combination of an adenosine A2A-receptor agonist and tiotropium or a derivative thereof for treating obstructive airways and other inflammatory diseases
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
IL159238A0 (en) * 2001-06-22 2004-06-01 Boehringer Ingelheim Pharma Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
US6608055B2 (en) 2001-06-22 2003-08-19 Boehringer Ingelheim Pharma Kg Crystalline anticholinergic, processes for preparing it and its use for preparing a pharmaceutical composition
US20030018019A1 (en) * 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
US7405224B2 (en) * 2002-01-31 2008-07-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
US7311894B2 (en) * 2002-03-28 2007-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations containing an anticholinergic
WO2003084509A1 (en) * 2002-04-04 2003-10-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder formulations suitable for inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7084153B2 (en) * 2002-04-12 2006-08-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising steroids and a novel anticholinergic
US7417051B2 (en) * 2002-04-12 2008-08-26 Boehringer Ingelheim Pharma Gmbh & Co. Kg Medicaments comprising betamimetics and a novel anticholinergic
US7763280B2 (en) * 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
DE10345065A1 (de) * 2003-09-26 2005-04-14 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolformulierung für die Inhalation enthaltend ein Anticholinergikum
RS20060293A (en) * 2003-11-03 2008-08-07 Boehringer Ingelheim International Gmbh., Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same
SI2067779T1 (sl) * 2003-11-03 2013-08-30 Boehringer Ingelheim International Gmbh Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
RU2007144531A (ru) * 2005-05-02 2009-06-10 БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) Новые кристаллические формы тиотропийбромида
DK1881980T3 (da) 2005-05-02 2012-10-01 Boehringer Ingelheim Int Nye krystalline former af tiotropiumbromid
WO2006134021A2 (en) * 2005-06-15 2006-12-21 Boehringer Ingelheim International Gmbh Process for preparing tiotropium salts, tiotropium salts as such and pharmaceutical compositions thereof
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
CN1316245C (zh) * 2005-07-28 2007-05-16 山东齐都药业有限公司 托烷司琼合成中残留中间体托品醇的检测方法
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
EP2123650B1 (en) * 2005-12-19 2012-04-04 Sicor, Inc. Novel form of tiotropium bromide and process for preparation thereof
TW200734333A (en) * 2005-12-19 2007-09-16 Sicor Inc Pure and stable tiotropium bromide
CN100410254C (zh) * 2006-03-07 2008-08-13 南昌弘益科技有限公司 噻托溴铵无水物制备方法
US20080051582A1 (en) 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1882691A1 (en) * 2006-07-26 2008-01-30 CHIESI FARMACEUTICI S.p.A. Quinuclidine derivatives as M3 antagonists
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
EP2036898A2 (de) * 2007-09-13 2009-03-18 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von 1,3-Dioxolan-2Onen sowie von Carbonsäureestern durch Transacylierung unter Basischen Reaktionsbedingungen
CN105601628A (zh) * 2008-01-10 2016-05-25 基因里克斯(英国)有限公司 用于制备东莨菪醇酯的方法
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
CN101768158B (zh) * 2010-01-04 2013-05-29 南昌弘益科技有限公司 噻托溴铵无水物及其制备方法
CN101863885B (zh) * 2010-06-03 2012-05-30 南京金丹呈医药技术有限公司 一种噻托溴铵的制备方法
TR201007108A2 (tr) * 2010-08-25 2012-03-21 B�Lg�� Mahmut Yeni tiotropyum bromür kristali ve üretim yöntemi.@
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
PT2607351T (pt) * 2011-12-22 2017-05-26 Cerbios-Pharma S A Processo contínuo para a alquilação de aminas terciárias cíclicas
PT106142B (pt) 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
CZ305012B6 (cs) * 2012-03-30 2015-03-25 Zentiva, K.S. Způsob přípravy skopinesteru kyseliny di(2-thienyl)glykolové, intermediátu v syntéze tiotropium bromidu
CA2907566C (en) 2013-04-01 2023-08-22 Pulmatrix, Inc. Tiotropium dry powders
WO2018055642A1 (en) * 2016-09-23 2018-03-29 Gbr Laboratories Pvt. Ltd. A process for preparing tiotropium bromide and intermediates thereof
WO2019129801A1 (en) 2017-12-28 2019-07-04 Linnea S.A. Process for the purification of methyl-2,2-dithienylglycolate
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法

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DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5770738A (en) * 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions

Also Published As

Publication number Publication date
RS50271B (sr) 2009-07-15
ZA200304707B (en) 2004-04-20
DK1345936T3 (da) 2004-07-19
BG107910A (bg) 2004-02-27
DE10064816A1 (de) 2002-06-27
EA005533B1 (ru) 2005-04-28
BRPI0116444B8 (pt) 2021-05-25
YU50903A (sh) 2006-05-25
HK1096683A1 (en) 2007-06-08
UA74409C2 (uk) 2005-12-15
MXPA03005426A (es) 2005-04-20
HRP20030502A2 (en) 2005-04-30
ECSP034652A (es) 2003-07-25
SA01220589B1 (ar) 2006-10-31
CZ294958B6 (cs) 2005-04-13
EE200300309A (et) 2003-10-15
JP4198991B2 (ja) 2008-12-17
ATE266661T1 (de) 2004-05-15
PL202478B1 (pl) 2009-06-30
WO2002051840A1 (de) 2002-07-04
SK9352003A3 (en) 2003-10-07
EP1345936A1 (de) 2003-09-24
AR033599A1 (es) 2003-12-26
DK1426373T3 (da) 2006-12-18
HRP20030502B1 (en) 2011-09-30
TR200401127T4 (tr) 2004-07-21
AU2002229650B2 (en) 2006-12-21
CN1840529A (zh) 2006-10-04
KR100853109B1 (ko) 2008-08-21
DE50102299D1 (de) 2004-06-17
NZ527066A (en) 2004-12-24
PL361837A1 (en) 2004-10-04
EP1345936B1 (de) 2004-05-12
BRPI0116444B1 (pt) 2015-09-01
BR0116444A (pt) 2003-12-23
EP1426373A1 (de) 2004-06-09
HUP0301457A2 (hu) 2003-10-28
IL156351A (en) 2011-09-27
BG66373B1 (bg) 2013-10-31
IL156351A0 (en) 2004-01-04
EG23914A (en) 2007-12-30
DE50110835D1 (de) 2006-10-05
NO20032827L (no) 2003-06-20
SK287318B6 (sk) 2010-07-07
CN100393719C (zh) 2008-06-11
KR20030062439A (ko) 2003-07-25
CA2433518C (en) 2007-03-20
CZ20031685A3 (cs) 2003-10-15
CY1105210T1 (el) 2010-03-03
UY27079A1 (es) 2002-07-31
CN1244581C (zh) 2006-03-08
ATE337314T1 (de) 2006-09-15
PE20020755A1 (es) 2002-09-24
PT1426373E (pt) 2006-11-30
CN1481383A (zh) 2004-03-10
NO20032827D0 (no) 2003-06-20
EP1426373B1 (de) 2006-08-23
HUP0301457A3 (en) 2006-05-29
PT1345936E (pt) 2004-09-30
ES2271722T3 (es) 2007-04-16
US20020133010A1 (en) 2002-09-19
EA200300666A1 (ru) 2003-12-25
JP2004525099A (ja) 2004-08-19
TWI234564B (en) 2005-06-21
EE04495B1 (et) 2005-06-15
HU230320B1 (hu) 2016-01-28
HK1060570A1 (en) 2004-08-13
NO327739B1 (no) 2009-09-14
MEP40608A (en) 2011-02-10
CA2433518A1 (en) 2002-07-04
ES2221658T3 (es) 2005-01-01
MY129525A (en) 2007-04-30
US6486321B2 (en) 2002-11-26

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