IL156310A0 - Method for preparing submicron particle suspensions - Google Patents
Method for preparing submicron particle suspensionsInfo
- Publication number
- IL156310A0 IL156310A0 IL15631001A IL15631001A IL156310A0 IL 156310 A0 IL156310 A0 IL 156310A0 IL 15631001 A IL15631001 A IL 15631001A IL 15631001 A IL15631001 A IL 15631001A IL 156310 A0 IL156310 A0 IL 156310A0
- Authority
- IL
- Israel
- Prior art keywords
- solvent
- submicron particle
- particle suspensions
- pharmaceutically
- solution
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000000725 suspension Substances 0.000 title abstract 3
- 239000002245 particle Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 3
- 238000010899 nucleation Methods 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25816000P | 2000-12-22 | 2000-12-22 | |
US09/874,799 US6607784B2 (en) | 2000-12-22 | 2001-06-05 | Microprecipitation method for preparing submicron suspensions |
US09/874,637 US6869617B2 (en) | 2000-12-22 | 2001-06-05 | Microprecipitation method for preparing submicron suspensions |
US09/874,499 US7037528B2 (en) | 2000-12-22 | 2001-06-05 | Microprecipitation method for preparing submicron suspensions |
US09/953,979 US6951656B2 (en) | 2000-12-22 | 2001-09-17 | Microprecipitation method for preparing submicron suspensions |
US10/035,821 US6977085B2 (en) | 2000-12-22 | 2001-10-19 | Method for preparing submicron suspensions with polymorph control |
US10/021,692 US6884436B2 (en) | 2000-12-22 | 2001-12-12 | Method for preparing submicron particle suspensions |
PCT/US2001/049737 WO2002055059A2 (en) | 2000-12-22 | 2001-12-20 | Method for preparing submicron particle suspensions |
Publications (1)
Publication Number | Publication Date |
---|---|
IL156310A0 true IL156310A0 (en) | 2004-01-04 |
Family
ID=27567644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL15631001A IL156310A0 (en) | 2000-12-22 | 2001-12-20 | Method for preparing submicron particle suspensions |
Country Status (16)
Country | Link |
---|---|
EP (2) | EP1347747B1 (es) |
JP (1) | JP4376518B2 (es) |
CN (1) | CN100512798C (es) |
AT (1) | ATE319432T1 (es) |
AU (2) | AU2002249836B2 (es) |
BR (1) | BR0116377A (es) |
CA (1) | CA2431705C (es) |
DE (1) | DE60117873T2 (es) |
DK (1) | DK1347747T3 (es) |
ES (1) | ES2260337T3 (es) |
HU (1) | HUP0501030A3 (es) |
IL (1) | IL156310A0 (es) |
MX (1) | MXPA03005496A (es) |
NO (1) | NO20032860L (es) |
NZ (1) | NZ526608A (es) |
WO (1) | WO2002055059A2 (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
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US20040022862A1 (en) * | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US8067032B2 (en) * | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
GB0216700D0 (en) * | 2002-07-18 | 2002-08-28 | Astrazeneca Ab | Process |
US20040028747A1 (en) * | 2002-08-06 | 2004-02-12 | Tucker Christopher J. | Crystalline drug particles prepared using a controlled precipitation process |
GB0302673D0 (en) | 2003-02-06 | 2003-03-12 | Astrazeneca Ab | Pharmaceutical formulations |
US7511079B2 (en) * | 2003-03-24 | 2009-03-31 | Baxter International Inc. | Methods and apparatuses for the comminution and stabilization of small particles |
BRPI0409929A (pt) * | 2003-04-29 | 2006-04-25 | Baxter Int | formulação para tornar uma droga antimicrobiana potente contra organismos normalmente considerados serem resistentes à droga |
US8986736B2 (en) | 2003-06-24 | 2015-03-24 | Baxter International Inc. | Method for delivering particulate drugs to tissues |
BRPI0414970A2 (pt) | 2003-06-24 | 2012-12-11 | Baxter Int | método para transporte de drogas ao cérebro |
KR101137785B1 (ko) * | 2003-07-18 | 2012-04-25 | 백스터 인터내셔널 인코포레이티드 | 제어된 상 분리에 의해 제조된 작은 구형 입자의 제조방법, 이용 방법 및 조성물 |
KR20060052849A (ko) * | 2003-08-06 | 2006-05-19 | 에자이 가부시키가이샤 | 약물 초미립자의 제조 방법 및 제조 장치 |
GB0327390D0 (en) * | 2003-11-25 | 2003-12-31 | Pfizer Ltd | Pharmaceutical formulations |
WO2005055983A2 (en) * | 2003-12-09 | 2005-06-23 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
AU2005209243A1 (en) * | 2004-01-29 | 2005-08-11 | Baxter Healthcare S.A. | Nanosuspensions of anti-retroviral agents for increased central nervous system delivery |
PL1731138T3 (pl) * | 2004-03-31 | 2016-10-31 | Drobnoziarnista dyspersja słabo rozpuszczalnego leku i sposób jej wytwarzania | |
KR20070037444A (ko) | 2004-06-15 | 2007-04-04 | 백스터 인터내셔널 인코포레이티드 | 고체 미립자성 치료제의 생체외 적용방법 |
DE102004031538A1 (de) * | 2004-06-29 | 2006-02-09 | Baxter International Inc., Deerfield | Pharmazeutische Darreichungsform zur oralen Verabreichung eines schwerlöslichen Wirkstoffs, Verfahren zu deren Herstellung und Kit |
BRPI0519088A2 (pt) * | 2004-12-15 | 2008-12-23 | Elan Pharma Int Ltd | formulaÇÕes de tacrolimo nanoparticuladas |
WO2006101972A2 (en) * | 2005-03-17 | 2006-09-28 | Elan Pharma International Limited | Injectable compositions of nanoparticulate immunosuppressive compounds |
DE102005053862A1 (de) * | 2005-11-04 | 2007-05-10 | Pharmasol Gmbh | Verfahren und Vorrichtung zur Herstellung hochfeiner Partikel sowie zur Beschichtung solcher Partikel |
CA2628630A1 (en) * | 2005-11-15 | 2007-05-24 | Baxter International Inc. | Compositions of lipoxygenase inhibitors |
WO2009111638A1 (en) | 2008-03-05 | 2009-09-11 | Baxter International Inc. | Compositions and methods for drug delivery |
DE102009008478A1 (de) * | 2009-02-11 | 2010-08-19 | PHAST Gesellschaft für pharmazeutische Qualitätsstandards mbH | Vorrichtung und Verfahren zur Herstellung pharmazeutisch hochfeiner Partikel sowie zur Beschichtung solcher Partikel in Mikroreaktoren |
US10952965B2 (en) | 2009-05-15 | 2021-03-23 | Baxter International Inc. | Compositions and methods for drug delivery |
AU2011232103B2 (en) | 2010-03-22 | 2013-10-24 | Instillo Gmbh | Method and device for producing microparticles or nanoparticles |
CN102384973B (zh) * | 2011-08-10 | 2014-09-10 | 华南理工大学 | 快速定量检测羟甲基糠醛的免疫层析试纸条及其制备方法 |
CN102268103B (zh) * | 2011-09-02 | 2013-06-05 | 中国海洋大学 | 一种壳聚糖醋酸盐的制备方法 |
US9248139B2 (en) * | 2011-12-21 | 2016-02-02 | Bristol-Myers Squibb Company | Co-processing method and formulations for HIV attachment inhibitor prodrug compound and excipients |
CN103212079A (zh) * | 2013-04-26 | 2013-07-24 | 陆媛 | 一种预防和/或治疗感冒的含服药物组合物及其应用 |
CN104905262B (zh) * | 2015-05-29 | 2017-12-22 | 湖北省农业科学院农产品加工与核农技术研究所 | 一种制备虫草灵芝复合制剂的方法 |
KR101725508B1 (ko) * | 2015-07-31 | 2017-04-11 | 국방과학연구소 | 헥사나이트로스틸벤 입자의 제조 방법과 그 장치 |
CN105969316B (zh) * | 2016-06-03 | 2020-11-10 | 宁海德宝立新材料有限公司 | 一种用于热敷的相变储热复合材料 |
CA3030308C (en) | 2016-07-29 | 2022-04-05 | The Board Of Trustees Of Western Michigan University | Magnetic nanoparticle-based gyroscopic sensor |
CN108031142A (zh) * | 2017-12-13 | 2018-05-15 | 上海合全药物研发有限公司 | 一种简化的利用湿磨来制备大量微晶种的装置及方法 |
CN115349630A (zh) * | 2022-06-20 | 2022-11-18 | 海宁凤鸣叶绿素有限公司 | 水分散性叶黄素微囊粉的制备方法 |
WO2024136660A1 (en) * | 2022-12-22 | 2024-06-27 | Nanomi B.V. | Process for preparing stable nanoparticle and composition thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1282405C (en) * | 1984-05-21 | 1991-04-02 | Michael R. Violante | Method for making uniformly sized particles from water-insoluble organic compounds |
US4826689A (en) * | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
US4606940A (en) * | 1984-12-21 | 1986-08-19 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
FR2634397B2 (fr) * | 1986-12-31 | 1991-04-19 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une proteine sous forme de nanoparticules |
IL86211A (en) * | 1987-05-04 | 1992-03-29 | Ciba Geigy Ag | Oral forms of administration for carbamazepine in the forms of stable aqueous suspension with delayed release and their preparation |
CA2044706C (en) * | 1990-06-15 | 2003-02-25 | Michael Midler Jr. | Crystallization method to improve crystal structure and size |
US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
GB9413202D0 (en) * | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
SE9403846D0 (sv) * | 1994-11-09 | 1994-11-09 | Univ Ohio State Res Found | Small particle formation |
KR19990001564A (ko) * | 1997-06-16 | 1999-01-15 | 유충식 | 용해도를 개선한 아졸계 항진균제 및 이를 함유하는 제제 |
FI973804A (fi) * | 1997-09-26 | 1999-03-27 | Orion Yhtymae Oy | Levosimendaanin oraalisia koostumuksia |
BR9814729A (pt) * | 1997-12-31 | 2002-01-08 | Choongwae Pharma Corp | Método e composição de uma preparação oral de itraconazol |
DE69914742T2 (de) * | 1998-05-29 | 2004-11-25 | Skyepharma Canada Inc., Verdun | Gegen hitzeeinwirkung geschützte mikropartikel und verfahren zur terminalen dampfsterilisation derselben |
TR200002217T2 (tr) * | 1998-07-17 | 2001-02-21 | Janssen Pharmaceutica N.V. | Bir mantar ilacı ve bir polimer ile kaplanmış bir çekirdeğe sahip taneler. |
JP2003531099A (ja) * | 1999-03-24 | 2003-10-21 | エフ エム シー コーポレーション | 改良された水溶解度をもつ医薬製剤 |
KR100331529B1 (ko) * | 1999-06-16 | 2002-04-06 | 민경윤 | 난용성 항진균제의 경구투여용 조성물 및 그의 제조 방법 |
-
2001
- 2001-12-20 HU HU0501030A patent/HUP0501030A3/hu unknown
- 2001-12-20 IL IL15631001A patent/IL156310A0/xx unknown
- 2001-12-20 NZ NZ526608A patent/NZ526608A/en not_active IP Right Cessation
- 2001-12-20 MX MXPA03005496A patent/MXPA03005496A/es active IP Right Grant
- 2001-12-20 CN CNB018211038A patent/CN100512798C/zh not_active Expired - Fee Related
- 2001-12-20 JP JP2002555793A patent/JP4376518B2/ja not_active Expired - Fee Related
- 2001-12-20 CA CA2431705A patent/CA2431705C/en not_active Expired - Fee Related
- 2001-12-20 AT AT01998077T patent/ATE319432T1/de active
- 2001-12-20 EP EP01998077A patent/EP1347747B1/en not_active Expired - Lifetime
- 2001-12-20 DE DE60117873T patent/DE60117873T2/de not_active Expired - Lifetime
- 2001-12-20 AU AU2002249836A patent/AU2002249836B2/en not_active Ceased
- 2001-12-20 DK DK01998077T patent/DK1347747T3/da active
- 2001-12-20 WO PCT/US2001/049737 patent/WO2002055059A2/en active Application Filing
- 2001-12-20 EP EP05077486A patent/EP1642571A3/en not_active Withdrawn
- 2001-12-20 ES ES01998077T patent/ES2260337T3/es not_active Expired - Lifetime
- 2001-12-20 BR BR0116377-9A patent/BR0116377A/pt not_active IP Right Cessation
-
2003
- 2003-06-20 NO NO20032860A patent/NO20032860L/no not_active Application Discontinuation
-
2006
- 2006-05-10 AU AU2006201943A patent/AU2006201943A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2002055059A2 (en) | 2002-07-18 |
EP1642571A2 (en) | 2006-04-05 |
WO2002055059A3 (en) | 2002-09-06 |
NO20032860D0 (no) | 2003-06-20 |
MXPA03005496A (es) | 2004-05-14 |
JP2004538249A (ja) | 2004-12-24 |
CA2431705A1 (en) | 2002-07-18 |
DE60117873T2 (de) | 2006-08-24 |
DE60117873D1 (de) | 2006-05-04 |
EP1642571A3 (en) | 2007-06-27 |
CN100512798C (zh) | 2009-07-15 |
HUP0501030A3 (en) | 2008-04-28 |
EP1347747A2 (en) | 2003-10-01 |
NZ526608A (en) | 2006-06-30 |
BR0116377A (pt) | 2005-12-13 |
NO20032860L (no) | 2003-08-21 |
EP1347747B1 (en) | 2006-03-08 |
AU2006201943A1 (en) | 2006-06-01 |
HUP0501030A2 (en) | 2007-02-28 |
ES2260337T3 (es) | 2006-11-01 |
ATE319432T1 (de) | 2006-03-15 |
DK1347747T3 (da) | 2006-04-10 |
CA2431705C (en) | 2010-10-05 |
CN1505503A (zh) | 2004-06-16 |
AU2002249836B2 (en) | 2006-12-14 |
JP4376518B2 (ja) | 2009-12-02 |
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